Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus candida: Comparison of clsi and European committee on antimicrobial susceptibility testing methods

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 11, 2011, Pages 2581-2584

  Pfaller, Michael A ^a   Watanabe, Naoaki ^b   Castanheira, Mariana ^a   Messer, Shawn A ^a   Jones, Ronald N ^a,c  

^a JMI LABORATORIES   (United States)

^b EISAI CO LTD   (Japan)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Novel antifungals; Susceptibility testing; Yeasts

Indexed keywords

ANTIFUNGAL AGENT; E 1210; UNCLASSIFIED DRUG;

ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BROTH DILUTION; CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CONTROLLED STUDY; EUROPEAN COMMITTEE ON ANTIMICROBIAL SUSCEPTIBILITY TESTING; FUNGUS GROWTH; INCUBATION TIME; INTERMETHOD COMPARISON; MINIMUM INHIBITORY CONCENTRATION; SPECIES DIFFERENCE; SPECTROPHOTOMETRY;

AMINOPYRIDINES; ANTIFUNGAL AGENTS; CANDIDA; CANDIDIASIS; DRUG DISCOVERY; EUROPE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; ISOXAZOLES; MICROBIAL SENSITIVITY TESTS;

EID: 80054695206     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr342     Document Type: Article

References (12)

1. Perlin DS. Antifungal drug resistance: do molecular methods provide a way forward? Curr Opin Infect Dis 2009; 22: 568-73.
2. Sun HY, Singh N. Characterisation of breakthrough invasive mycoses in echinocandin recipients: an evidence-based review. Int J Antimicrob Agents 2010; 35: 211-8.
3. Tsukahara K, Hata K, Nakamoto K et al. Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly. Mol Microbiol 2003; 48: 1029-42.
4. Umemura M, Okamoto M, Nakayama K et al. GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast. J Biol Chem 2003; 278: 23639-47.
5. Watanabe N, Horii T, Miyazaki M et al. E1210, a new broad-spectrum antifungal, inhibits glycosylphosphatidylinositol (GPI) biosynthesis and effects Candida albicans cell characteristics. In: Abstracts of the Fiftieth Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, MA, 2010. Abstract F1-841. American Society for Microbiology, Washington, DC, USA.
6. Clinical and Laboratory Standards Institute. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts-Third Edition: Approved Standard M27-A3. CLSI, Wayne, PA, USA, 2008.
7. Cuenca-Estrella M, Arendrup MC, Chryssanthou E et al. Multicentre determination of quality control strains and quality control ranges for antifungal susceptibility testing of yeasts and filamentous fungi using the methods of the Antifungal Susceptibility Testing Subcommittee of the European Committee on Antimicrobial Susceptibility Testing (AFST-EUCAST). Clin Microbiol Infect 2007; 13: 1018-22.
8. Rodriguez-Tudela JL, Arendrup MC, Barchiesi F et al. EUCAST definitive document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts. Clin Microbiol Infect 2008; 14: 398-405.
9. Pfaller MA, Andes D, Diekema DJ et al. Wild-type MIC distributions, epidemiological cutoff values and species-specific clinical breakpoints for fluconazole and Candida: time for harmonization of CLSI and EUCAST broth microdilution methods. Drug Resist Updat 2010; 13: 180-95.
10. Pfaller MA, Castanheira M, Diekema DJ et al. Comparison of European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Etest methods with the CLSI broth microdilution method for echinocandin susceptibility testing of Candida species. J Clin Microbiol 2010; 48: 1592-9.
11. Pfaller MA, Espinel-Ingroff A, Boyken L et al. Comparison of the broth microdilution (BMD) method of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) with the 24-h CLSI BMD method for fluconazole, posaconzole, and voriconazole susceptibility testing of Candida species using epidemiological cutoff values. J Clin Microbiol 2011; 49: 845-50.
12. Pfaller MA, Castanheira M, Messer SA et al. Echinocandin and triazole antifungal susceptibility profiles for Candida spp., Cryptococcus neoformans, and Aspergillus fumigatus: application of new CLSI clinical breakpoints and epidemiological cutoff values to characterize resistance in the SENTRY Antimicrobial Surveillance Program (2009). Diagn Microbiol Infect Dis 2011; 69: 45-50.