The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Dite, Toby A ^a   Ling, Naomi X Y ^a   Scott, John W ^a,b   Hoque, Ashfaqul ^a   Galic, Sandra ^a   Parker, Benjamin L ^c   Ngoei, Kevin R W ^a   Langendorf, Christopher G ^a   O'Brien, Matthew T ^a   Kundu, Mondira ^d   Viollet, Benoit ^e,f,g   Steinberg, Gregory R ^h   Sakamoto, Kei ^i,j   Kemp, Bruce E ^a,b   Oakhill, Jonathan S ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTRALIAN CATHOLIC UNIVERSITY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e INSTITUT COCHIN   (France)

^f CNRS   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h MCMASTER UNIVERSITY   (Canada)

ⁱ UNIVERSITY OF DUNDEE   (United Kingdom)

^j NESTLÉ RESEARCH CENTER   (Switzerland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; P21 ACTIVATED KINASE 2; PHENFORMIN; SERINE THREONINE PROTEIN KINASE ULK1; THREONINE; PYRONE DERIVATIVE; SALICYLIC ACID DERIVATIVE; THIOPHENE DERIVATIVE;

ACTIVATION ENERGY; CELLS AND CELL COMPONENTS; DRUG; ENZYME; ENZYME ACTIVITY; GENETIC ANALYSIS; HOMEOSTASIS; METABOLISM; PROTEIN; SALICYLATE;

ALLOSTERISM; AMPK SIGNALING; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL CYCLE REGULATION; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEK293T CELL LINE; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; METABOLIC STRESS; MOUSE; MYRISTYLATION; NONHUMAN; PHOSPHOPROTEOMICS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOICHIOMETRY; ANIMAL; AUTOPHAGY; BIOLOGICAL MODEL; CHLOROCEBUS AETHIOPS; CV-1 CELL LINE; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; CERCOPITHECUS AETHIOPS; COS CELLS; HEK293 CELLS; HOMEOSTASIS; HUMANS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PYRONES; SALICYLATES; STRESS, PHYSIOLOGICAL; THIOPHENES;

EID: 85029584631     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00628-y     Document Type: Article

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