Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

Nature Communications

Volumn 7, Issue , 2016, Pages

  Langendorf, Christopher G ^a   Ngoei, Kevin R W ^a   Scott, John W ^a   Ling, Naomi X Y ^a   Issa, Sam M A ^a   Gorman, Michael A ^a   Parker, Michael W ^a   Sakamoto, Kei ^b   Oakhill, Jonathan S ^a   Kemp, Bruce E ^a,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c AUSTRALIAN CATHOLIC UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

5 (5 HYDROXYL ISOXAZOL 3 YL)FURAN 2 PHOSPHONIC ACID; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; AMP ACTIVATED PROTEIN KINASE ALPHA1; FURAN DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NUCLEOTIDE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 5-(5-HYDROXYLISOXAZOL-3-YL)FURAN-2-PHOSPHONIC ACID; ENZYME ACTIVATOR; ISOXAZOLE DERIVATIVE;

CRYSTAL STRUCTURE; DIABETES; DISEASE INCIDENCE; DRUG; ENZYME ACTIVITY; METABOLISM; PROTEIN;

ALLOSTERISM; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; COS 7 CELL LINE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG POTENTIATION; ENZYME ACTIVATION; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; PHOSPHORYLATION;

ALLOSTERIC REGULATION; AMP-ACTIVATED PROTEIN KINASES; BINDING SITES; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMANS; ISOXAZOLES; MODELS, MOLECULAR; ORGANOPHOSPHONATES; PHOSPHORYLATION;

EID: 84960416125     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10912     Document Type: Article

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