Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases

Nature Communications

Volumn 5, Issue , 2014, Pages

  Tarhonskaya, Hanna ^a   Rydzik, Anna M ^a   Leung, Ivanhoe K H ^a   Loik, Nikita D ^a   Chan, Mun Chiang ^a   Kawamura, Akane ^a   McCullagh, James S O ^a   Claridge, Timothy D W ^a   Flashman, Emily ^a   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; ASCORBIC ACID; FERRIC ION; FERROUS GLUCONATE; FERROUS ION; ISOENZYME; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SUCCINIC ACID; SUCCINIC SEMIALDEHYDE; 4 AMINOBUTYRIC ACID; ALCOHOL DEHYDROGENASE; ALPHA-HYDROXYGLUTARATE; GLUTARIC ACID DERIVATIVE; OXYGENASE;

CANCER; CATALYSIS; CELL ORGANELLE; ENZYME ACTIVITY; ION; MUTATION; OXIDATION; SUBSTRATE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENANTIOMER; ENZYME ACTIVATION; ENZYME METABOLISM; IN VITRO STUDY; PROTEIN DOMAIN;

ALCOHOL OXIDOREDUCTASES; ASCORBIC ACID; GAMMA-AMINOBUTYRIC ACID; GLUTARATES; OXYGENASES; SUCCINIC ACID;

EID: 84896753329     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4423     Document Type: Article

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