The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase

Cell Research

Volumn 21, Issue 6, 2011, Pages 983-986

  Chen, Nan ^a,b   Rinner, Oliver ^a   Czernik, Dominika ^a   Nytko, Katarzyna J ^c   Zheng, Dan ^a   Stiehl, Daniel P ^c   Zamboni, Nicola ^a   Gstaiger, Matthias ^a   Frei, Christian ^a  

^a ETH ZURICH   (Switzerland)

^b SHANGHAI INSTITUTE OF APPLIED PHYSICS   (China)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DIOXYGENASE; EGLN3 PROTEIN, HUMAN; ENZYME INHIBITOR; PYRUVATE KINASE;

ANIMAL; CELL HYPOXIA; DROSOPHILA; DRUG ANTAGONISM; ENZYME ASSAY; GENETICS; HELA CELL; HUMAN; LETTER; METABOLISM; MOUSE; PROTEIN BINDING; RNA INTERFERENCE;

ANIMALS; CELL HYPOXIA; DIOXYGENASES; DROSOPHILA; ENZYME ASSAYS; ENZYME INHIBITORS; HELA CELLS; HUMANS; MICE; PROTEIN BINDING; PYRUVATE KINASE; RNA INTERFERENCE;

EID: 79960067091     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.66     Document Type: Letter

References (10)

1. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4:891-899. (Pubitemid 39472955)
2. Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008; 30:393-402. (Pubitemid 351681994)
3. Frei C, Edgar BA. Drosophila cyclin d/cdk4 requires hif-1 prolyl hydroxylase to drive cell growth. Dev Cell 2004; 6:241-251. (Pubitemid 38190364)
4. Masson N, Appelhoff RJ, Tuckerman JR, et al. The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin. FEBS Lett 2004; 570:166-170. (Pubitemid 38900976)
5. Christofk HR, Vander Heiden MG, Harris MH, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008; 452:230-233. (Pubitemid 351380249)
6. Mazurek S. Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 2010 Feb 13; doi:10.1016/j.biocel.2010.02.005
7. Dombrauckas JD, Santarsiero BD, Mesecar AD. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 2005; 44:9417-9429. (Pubitemid 40962040)
8. Berra E, Benizri E, Ginouves A, et al. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 2003; 22:4082-4090. (Pubitemid 37021737)
9. Nytko KJ, Spielmann P, Camenisch G, Wenger RH, Stiehl DP. Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins. Antioxid Redox Signal 2007; 9:1329-1338. (Pubitemid 47255012)
10. Couvelard A, Deschamps L, Rebours V, et al. Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors. Clin Cancer Res 2008; 14:6634-6639.