Can rheumatoid arthritis be prevented?

Best Practice and Research: Clinical Rheumatology

Volumn 27, Issue 4, 2013, Pages 467-485

  Deane, Kevin D ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Pathophysiology; Preclinical disease; Prediction; Prevention; Rheumatoid arthritis

Indexed keywords

ABATACEPT; AUTOANTIBODY; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; DEXAMETHASONE; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN A; METHOTREXATE; METHYLPREDNISOLONE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PLACEBO; RHEUMATOID FACTOR; RITUXIMAB; TOBACCO SMOKE;

ALCOHOL CONSUMPTION; ARTHRALGIA; ARTICLE; CARDIOVASCULAR RISK; COST EFFECTIVENESS ANALYSIS; DISEASE ACTIVITY; DISEASE COURSE; DISEASE DURATION; DRUG SAFETY; DRUG TOLERABILITY; FRAMINGHAM RISK SCORE; HLA SYSTEM; HUMAN; IMMUNOMODULATION; INSULIN DEPENDENT DIABETES MELLITUS; LIFE STRESS; LIFESTYLE MODIFICATION; OUTCOME ASSESSMENT; PALINDROMIC RHEUMATISM; PERIODONTAL DISEASE; PHENOTYPE; PORPHYROMONAS GINGIVALIS; PREDICTION; PREDICTIVE VALUE; PREVENTION STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; RHEUMATOLOGY; RISK ASSESSMENT; RISK FACTOR; SINGLE DRUG DOSE; SMOKING CESSATION; T LYMPHOCYTE ACTIVATION;

PATHOPHYSIOLOGY; PRECLINICAL DISEASE; PREDICTION; PREVENTION; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; HUMANS; RISK ASSESSMENT;

EID: 85027956586     PISSN: 15216942     EISSN: 15321770     Source Type: Journal    
DOI: 10.1016/j.berh.2013.09.002     Document Type: Review

References (143)

1. C.G. Helmick, D.T. Felson, R.C. Lawrence, S. Gabriel, R. Hirsch, and C.K. Kwoh Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part I Arthritis & Rheumatism 58 1 2007 15 25
2. C.S. Crowson, E.L. Matteson, E. Myasoedova, C.J. Michet, F.C. Ernste, and K.J. Warrington The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases Arthritis & Rheumatism 63 3 2011 633 639
3. H. Birnbaum, C. Pike, R. Kaufman, M. Marynchenko, Y. Kidolezi, and M. Cifaldi Societal cost of rheumatoid arthritis patients in the US Current Medical Research and Opinion 26 1 2010 77 90
4. M. van den Broek, T.W. Huizinga, B.A. Dijkmans, and C.F. Allaart Drug-free remission: is it already possible? Current Opinion in Rheumatology 23 3 2011 266 272
5. F.H. Prince, V.P. Bykerk, N.A. Shadick, B. Lu, J. Cui, and M. Frits Sustained rheumatoid arthritis remission is uncommon in clinical practice Arthritis Research & Therapy 14 2 2012 R68
6. D.M. Gerlag, K. Raza, L.G. van Baarsen, E. Brouwer, C.D. Buckley, and G.R. Burmester EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis Annals of the Rheumatic 71 5 2012 638 641
7. F.C. Arnett, S.M. Edworthy, D.A. Bloch, D.J. McShane, J.F. Fries, and N.S. Cooper The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis & Rheumatism 31 3 1988 315 324
8. D. Aletaha, T. Neogi, A.J. Silman, J. Funovits, D.T. Felson, and C.O. Bingham III 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League against rheumatism collaborative initiative Arthritis & Rheumatism 62 9 2010 2569 2581
9. K. Aho, T. Palosuo, V. Raunio, P. Puska, A. Aromaa, and J.T. Salonen When does rheumatoid disease start? Arthritis & Rheumatism 28 5 1985 485 489
10. A. del Puente, W.C. Knowler, D.J. Pettitt, and P.H. Bennett The incidence of rheumatoid arthritis is predicted by rheumatoid factor titer in a longitudinal population study Arthritis & Rheumatism 31 10 1988 1239 1244
11. A.J. Silman, E. Hennessy, and B. Ollier Incidence of rheumatoid arthritis in a genetically predisposed population British Journal of Rheumatology 31 6 1992 365 368
12. S. Rantapaa-Dahlqvist, B.A. de Jong, E. Berglin, G. Hallmans, G. Wadell, and H. Stenlund Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis Arthritis & Rheumatism 48 10 2003 2741 2749
13. M.M. Nielen, D. van Schaardenburg, H.W. Reesink, R.J. van de Stadt, I.E. van der Horst-Bruinsma, and M.H. de Koning Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors Arthritis & Rheumatism 50 2 2004 380 386
14. D.S. Majka, K.D. Deane, L.A. Parrish, A.A. Lazar, A.E. Baron, and C.W. Walker Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis Annals of the Rheumatic 67 6 2008 801 807
15. S. Rantapaa-Dahlqvist, K. Boman, A. Tarkowski, and G. Hallmans Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis Annals of the Rheumatic 66 1 2007 121 123
16. M.M. Nielen, D. van Schaardenburg, H.W. Reesink, J.W. Twisk, R.J. van de Stadt, and I.E. van der Horst-Bruinsma Increased levels of C-reactive protein in serum from blood donors before the onset of rheumatoid arthritis Arthritis & Rheumatism 50 8 2004 2423 2427
17. L.B. Chibnik, L.A. Mandl, K.H. Costenbader, P.H. Schur, and E.W. Karlson Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritis The Journal of Rheumatology 36 4 2009 706 711
18. E.W. Karlson, L.B. Chibnik, S.S. Tworoger, I.M. Lee, J.E. Buring, and N.A. Shadick Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies Arthritis & Rheumatism 60 3 2009 641 652
19. K.D. Deane, C.I. O'Donnell, W. Hueber, D.S. Majka, A.A. Lazar, and L.A. Derber The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner Arthritis & Rheumatism 62 11 2010 3161 3172
20. H. Kokkonen, I. Soderstrom, J. Rocklov, G. Hallmans, K. Lejon, and S. Rantapaa Dahlqvist Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis Arthritis & Rheumatism 62 2 2010 383 391
21. K.T. Jorgensen, A. Wiik, M. Pedersen, C.J. Hedegaard, B.F. Vestergaard, and R.E. Gislefoss Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors Annals of the Rheumatic 67 6 2008 860 866
22. K. Aho, M. Heliovaara, J. Maatela, T. Tuomi, and T. Palosuo Rheumatoid factors antedating clinical rheumatoid arthritis The Journal of Rheumatology 18 9 1991 1282 1284
23. K. Aho, T. Palosuo, M. Heliovaara, P. Knekt, P. Alha, and R. von Essen Antifilaggrin antibodies within "normal" range predict rheumatoid arthritis in a linear fashion The Journal of Rheumatology 27 12 2000 2743 2746
24. K. Aho, T. Palosuo, P. Knekt, P. Alha, A. Aromaa, and M. Heliovaara Serum C-reactive protein does not predict rheumatoid arthritis The Journal of Rheumatology 27 5 2000 1136 1138
25. K. Aho, T. Palosuo, V. Raunio, and T. Tuomi The timing of rheumatoid factor seroconversions Arthritis & Rheumatism 30 6 1987 719 720
26. M.M. Nielen, D. van Schaardenburg, H.W. Reesink, J.W. Twisk, R.J. van de Stadt, and I.E. van der Horst-Bruinsma Simultaneous development of acute phase response and autoantibodies in preclinical rheumatoid arthritis Annals of the Rheumatic 65 4 2006 535 537
27. M.K. Demoruelle, M.C. Parish, L.A. Derber, J.R. Kolfenbach, J.M. Hughes-Austin, and M.H. Weisman Anti-cyclic citrullinated peptide assays differ in subjects at elevated risk for rheumatoid arthritis and subjects with established disease Arthritis & Rheumatism 2013
28. J.R. Kolfenbach, K.D. Deane, L.A. Derber, C.I. O'Donnell, W.R. Gilliland, and J.D. Edison Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis Arthritis & Rheumatism 2010
29. L. Klareskog, J. Ronnelid, K. Lundberg, L. Padyukov, and L. Alfredsson Immunity to citrullinated proteins in rheumatoid arthritis Annual Review of Immunology 26 2008 651 675
30. A. Ercan, J. Cui, D.E. Chatterton, K.D. Deane, M.M. Hazen, and W. Brintnell Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis Arthritis & Rheumatism 62 8 2010 2239 2248
31. L.G. van Baarsen, W.H. Bos, F. Rustenburg, T.C. van der Pouw Kraan, G.J. Wolbink, and B.A. Dijkmans Gene expression profiling in autoantibody-positive patients with arthralgia predicts development of arthritis Arthritis & Rheumatism 62 3 2010 694 704
32. H. Kokkonen, M. Mullazehi, E. Berglin, G. Hallmans, G. Wadell, and J. Ronnelid Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis Arthritis Research & Therapy 13 1 2011 R13
33. P. Suwannalai, H.U. Scherer, D. van der Woude, A. Ioan-Facsinay, C.M. Jol-van der Zijde, and M.J. van Tol Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens Annals of the Rheumatic 70 2 2011 373 379
34. J. Sokolove, R. Bromberg, K.D. Deane, L.J. Lahey, L.A. Derber, and P.E. Chandra Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis PLoS One 7 5 2012 e35296
35. M. Brink, M. Hansson, L. Mathsson, P.J. Jakobsson, R. Holmdahl, and G. Hallmans Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis Arthritis & Rheumatism 2013
36. L.A. van de Stadt, A.R. van der Horst, M.H. de Koning, W.H. Bos, G.J. Wolbink, and R.J. van de Stadt The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia Annals of the Rheumatic 70 1 2011 128 133
37. G.A. Schellekens, B.A. de Jong, F.H. van den Hoogen, L.B. van de Putte, and W.J. van Venrooij Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies The Journal of Clinical Investigation 101 1 1998 273 281
38. G.A. Schellekens, H. Visser, B.A. de Jong, F.H. van den Hoogen, J.M. Hazes, and F.C. Breedveld The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide Arthritis & Rheumatism 43 1 2000 155 163
39. M. Brink, M. Hansson, L. Mathsson, P.J. Jakobsson, R. Holmdahl, and G. Hallmans Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis Arthritis and Rheumatism 65 4 2013 899 910
40. Y.Y. Gent, A.E. Voskuyl, R.W. Kloet, D. van Schaardenburg, O.S. Hoekstra, and B.A. Dijkmans Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: findings of a prospective pilot study Arthritis & Rheumatism 64 1 2012 62 66
41. M.K. Demoruelle, M.H. Weisman, P.L. Simonian, D.A. Lynch, P.B. Sachs, and I.F. Pedraza Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis & Rheumatism 64 6 2012 1756 1761
42. M.G. van de Sande, M.J. de Hair, C. van der Leij, P.L. Klarenbeek, W.H. Bos, and M.D. Smith Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase Annals of the Rheumatic 70 5 2011 772 777
43. A. Krabben, W. Stomp, D.M. van der Heijde, J.A. van Nies, J.L. Bloem, and T.W. Huizinga MRI of hand and foot joints of patients with anticitrullinated peptide antibody positive arthralgia without clinical arthritis Annals of the Rheumatic Diseases 2013
44. J.R. Kolfenbach, K.D. Deane, L.A. Derber, C. O'Donnell, M.H. Weisman, and J.H. Buckner A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA Arthritis & Rheumatism 61 12 2009 1735 1742
45. A.M. Gizinski, M. Mascolo, J.L. Loucks, A. Kervitsky, R.T. Meehan, and K.K. Brown Rheumatoid arthritis (RA)-specific autoantibodies in patients with interstitial lung disease and absence of clinically apparent articular RA Clinical Rheumatology 28 5 2009 611 613
46. A. Fischer, J.J. Solomon, R.M. du Bois, K.D. Deane, A.L. Olson, and E.R. Fernandez-Perez Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease Respiratory Medicine 106 7 2012 1040 1047
47. N. Wegner, K. Lundberg, A. Kinloch, B. Fisher, V. Malmstrom, and M. Feldmann Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis Immunological Reviews 233 1 2010 34 54
48. T.R. Mikuls, G.M. Thiele, K.D. Deane, J.B. Payne, J.R. O'Dell, and F. Yu Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis Arthritis and Rheumatism 64 11 2012 3522 3530
49. J.U. Scher, C. Ubeda, M. Equinda, R. Khanin, Y. Buischi, and A. Viale Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis Arthritis & Rheumatism 2012
50. T. Rashid, and A. Ebringer Rheumatoid arthritis is linked to Proteus-the evidence Clinical Rheumatology 26 7 2007 1036 1043
51. M.M. Newkirk, R. Goldbach-Mansky, B.W. Senior, J. Klippel, H.R. Schumacher Jr., and H.S. El-Gabalawy Elevated levels of IgM and IgA antibodies to Proteus mirabilis and IgM antibodies to Escherichia coli are associated with early rheumatoid factor (RF)-positive rheumatoid arthritis Rheumatology (Oxford) 44 11 2005 1433 1441
52. K. Aho, and M. Heliovaara Risk factors for rheumatoid arthritis Annals of Medicine 36 4 2004 242 251
53. J. Bowes, and A. Barton Recent advances in the genetics of RA susceptibility Rheumatology (Oxford) 47 4 2008 399 402
54. A.J. Silman, and J.E. Pearson Epidemiology and genetics of rheumatoid arthritis Arthritis Research 4 Suppl. 3 2002 S265 S272
55. E.W. Karlson, and K. Deane Environmental and gene-environment interactions and risk of rheumatoid arthritis Rheumatic Disease Clinics of North America 38 2 2012 405 426
56. K. Hemminki, X. Li, J. Sundquist, and K. Sundquist Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions Arthritis & Rheumatism 60 3 2009 661 668
57. L. Klareskog, P.K. Gregersen, and T.W. Huizinga Prevention of autoimmune rheumatic disease: state of the art and future perspectives Annals of the Rheumatic 69 12 2010 2062 2066
58. H. Kallberg, S. Jacobsen, C. Bengtsson, M. Pedersen, L. Padyukov, and P. Garred Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies Annals of the Rheumatic 68 2 2009 222 227
59. D. Di Giuseppe, A. Wallin, M. Bottai, J. Askling, and A. Wolk Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women Annals of the Rheumatic 2013
60. D. Makrygiannakis, E. af Klint, I.E. Lundberg, R. Lofberg, A.K. Ulfgren, and L. Klareskog Citrullination is an inflammation-dependent process Annals of the Rheumatic 65 9 2006 1219 1222
61. D. Makrygiannakis, M. Hermansson, A.K. Ulfgren, A.P. Nicholas, A.J. Zendman, and A. Eklund Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells Annals of the Rheumatic 2008
62. J.A. Hill, D.A. Bell, W. Brintnell, D. Yue, B. Wehrli, and A.M. Jevnikar Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice The Journal of Experimental Medicine 205 4 2008 967 979
63. L. Klareskog, P. Stolt, K. Lundberg, H. Kallberg, C. Bengtsson, and J. Grunewald A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination Arthritis & Rheumatism 54 1 2006 38 46
64. N. Wegner, R. Wait, A. Sroka, S. Eick, K.A. Nguyen, and K. Lundberg Peptidylarginine deiminase from porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: Implications for autoimmunity in rheumatoid arthritis Arthritis & Rheumatism 2010
65. P.L. Meroni, E. Raschi, C. Testoni, A. Tincani, and G. Balestrieri Antiphospholipid antibodies and the endothelium Rheumatic Disease Clinics of North America 27 3 2001 587 602
66. K.M. Devreese Antiphospholipid antibodies: evaluation of the thrombotic risk Thrombosis Research 130 Suppl. 1 2012 S37 S40
67. K.P. Liang, H.M. Kremers, C.S. Crowson, M.R. Snyder, T.M. Therneau, and V.L. Roger Autoantibodies and the risk of cardiovascular events The Journal of Rheumatology 36 11 2009 2462 2469
68. W.H. Bos, G.J. Wolbink, M. Boers, G.J. Tijhuis, N. de Vries, and I.E. van der Horst-Bruinsma Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study Annals of the Rheumatic 69 3 2010 490 494
69. L.A. van de Stadt, B.I. Witte, W.H. Bos, and D. van Schaardenburg A prediction rule for the development of arthritis in seropositive arthralgia patients Annals of the Rheumatic 2012
70. A.L. Feitsma, R.E. Toes, A.B. Begovich, A.P. Chokkalingam, R.R. de Vries, and T.W. Huizinga Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients Rheumatology (Oxford) 46 7 2007 1092 1095
71. M. Johansson, L. Arlestig, G. Hallmans, and S. Rantapaa-Dahlqvist PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease Arthritis Research & Therapy 8 1 2006 R19
72. E.W. Karlson, B. Ding, B.T. Keenan, K. Liao, K.H. Costenbader, and L. Klareskog Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis Arthritis Care & Research 2013
73. T.H. Dent Predicting the risk of coronary heart disease I. The use of conventional risk markers Atherosclerosis 213 2 2010 345 351
74. C. Hernandez-Garcia, E. Vargas, L. Abasolo, C. Lajas, B. Bellajdell, and I.C. Morado Lag time between onset of symptoms and access to rheumatology care and DMARD therapy in a cohort of patients with rheumatoid arthritis The Journal of Rheumatology 27 10 2000 2323 2328
75. D.P. Symmons, and A.J. Silman The norfolk arthritis register (NOAR) Clinical and Experimental Rheumatology 21 5 Suppl. 31 2003 S94 S99
76. J. van Aken, J.H. van Bilsen, C.F. Allaart, T.W. Huizinga, and F.C. Breedveld The leiden early arthritis clinic Clinical and Experimental Rheumatology 21 5 Suppl. 31 2003 S100 S105
77. D. Aletaha, F.C. Breedveld, and J.S. Smolen The need for new classification criteria for rheumatoid arthritis Arthritis & Rheumatism 52 11 2005 3333 3336
78. H. van Dongen, J. van Aken, L.R. Lard, K. Visser, H.K. Ronday, and H.M. Hulsmans Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial Arthritis & Rheumatism 56 5 2007 1424 1432
79. K.P. Machold, R. Landewe, J.S. Smolen, T.A. Stamm, D.M. van der Heijde, and K.N. Verpoort The stop arthritis very early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis Annals of the Rheumatic 69 3 2010 495 502
80. S.M. Verstappen, M.J. McCoy, C. Roberts, N.E. Dale, A.B. Hassell, and D.P. Symmons Beneficial effects of a 3-week course of intramuscular glucocorticoid injections in patients with very early inflammatory polyarthritis: results of the STIVEA trial Annals of the Rheumatic 69 3 2010 503 509
81. J.A. Avina-Zubieta, G. Galindo-Rodriguez, S. Newman, M.E. Suarez-Almazor, and A.S. Russell Long-term effectiveness of antimalarial drugs in rheumatic diseases Annals of the Rheumatic 57 10 1998 582 587
82. L. Gonzalez-Lopez, J.I. Gamez-Nava, G. Jhangri, A.S. Russell, and M.E. Suarez-Almazor Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials The Journal of Rheumatology 27 1 2000 41 46
83. L. Gonzalez-Lopez, J.I. Gamez-Nava, G.S. Jhangri, C. Ramos-Remus, A.S. Russell, and M.E. Suarez-Almazor Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism The Journal of Rheumatology 26 3 1999 540 545
84. A. Powell, P. Davis, N. Jones, and A.S. Russell Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients The Journal of Rheumatology 35 6 2008 992 994
85. R. Sanmarti, J.D. Canete, and G. Salvador Palindromic rheumatism and other relapsing arthritis Best Practice & Research Clinical Rheumatology 18 5 2004 647 661
86. P. Hanonen, T. Mottonen, and M. Oka Treatment of palindromic rheumatism with chloroquine British Medical Journal 294 6582 1987 1289
87. S.J. Katz, and A.S. Russell Palindromic rheumatism: a pre-rheumatoid arthritis state? The Journal of Rheumatology 39 10 2012 1912 1913
88. G.S. Firestein Immunologic mechanisms in the pathogenesis of rheumatoid arthritis J Clinical Rheumatology 11 3 Suppl. 2005 S39 S44
89. W.P. Arend, and G.S. Firestein Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis Nature Reviews Rheumatology 8 10 2012 573 586
90. W.H. Bos, B.A. Dijkmans, M. Boers, R.J. van de Stadt, and D. van Schaardenburg Effect of dexamethasone on autoantibody levels and arthritis development in patients with arthralgia: a randomised trial Annals of the Rheumatic Diseases 69 3 2010 571 574
91. S. Chitale, and R. Moots Abatacept: the first T lymphocyte co-stimulation modulator, for the treatment of rheumatoid arthritis Nature Reviews Rheumatology 8 1 2008 115 122
92. S. Kalia, and J.P. Dutz New concepts in antimalarial use and mode of action in dermatology Dermatologic Therapy 20 4 2007 160 174
93. S.J. Katz, and A.S. Russell Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action Current Opinion in Rheumatology 23 3 2011 278 281
94. T.G. Benedek Methotrexate: from its introduction to non-oncologic therapeutics to anti-TNF-alpha Clinical and Experimental Rheumatology 28 5 Suppl. 61 2010 S3 S8
95. K. Lundberg, A. Kinloch, B.A. Fisher, N. Wegner, R. Wait, and P. Charles Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase Arthritis & Rheumatism 58 10 2008 3009 3019
96. P.M. Machado, R. Koevoets, C. Bombardier, and D.M. van der Heijde The value of magnetic resonance imaging and ultrasound in undifferentiated arthritis: a systematic review The Journal of Rheumatology 87 2011 31 37
97. R.J. Wakefield, M.J. Green, H. Marzo-Ortega, P.G. Conaghan, W.W. Gibbon, and D. McGonagle Should oligoarthritis be reclassified? ultrasound reveals a high prevalence of subclinical disease Annals of the Rheumatic 63 4 2004 382 385
98. J.R. Kolfenbach, K.D. Deane, L.A. Derber, C. O'Donnell, M.H. Weisman, and J.H. Buckner A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA Arthritis Care & Research 61 12 2009 1735 1742
99. H.S. El-Gabalawy, D.B. Robinson, D. Hart, B. Elias, J. Markland, and C.A. Peschken Immunogenetic risks of anti-cyclical citrullinated peptide antibodies in a North American Native population with rheumatoid arthritis and their first-degree relatives The Journal of Rheumatology 36 6 2009 1130 1135
100. L. Barra, M. Scinocca, S. Saunders, R. Bhayana, S. Rohekar, and M. Racape Anti-citrullinated protein antibodies (ACPA) in unaffected first degree relatives of rheumatoid arthritis patients Arthritis & Rheumatism 2013
101. P. Achenbach, E. Bonifacio, K. Koczwara, and A.G. Ziegler Natural history of type 1 diabetes Diabetes 54 Suppl. 2 2005 S25 S31
102. N. Bizzaro The predictive significance of autoantibodies in organ-specific autoimmune diseases Clinical Reviews in Allergy & Immunology 34 3 2008 326 331
103. C.M. Kishiyama, H.P. Chase, and J.M. Barker Prevention strategies for type 1 diabetes Reviews in Endocrine and Metabolic Disorders 7 3 2006 215 224
104. J.S. Skyler, C.J. Greenbaum, J.M. Lachin, E. Leschek, L. Rafkin-Mervis, and P. Savage Type 1 diabetes TrialNet-an international collaborative clinical trials network Annals of the New York Academy of Sciences 1150 2008 14 24
105. M.R. Arbuckle, M.T. McClain, M.V. Rubertone, R.H. Scofield, G.J. Dennis, and J.A. James Development of autoantibodies before the clinical onset of systemic lupus erythematosus The New England Journal of Medicine 349 16 2003 1526 1533
106. K.D. Deane, C.I. O'Donnell, W. Hueber, D.S. Majka, A.A. Lazar, and L.A. Derber The number of elevated cytokines/chemokines in pre-clinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner Arthritis & Rheumatism 2010
107. P.K. Gregersen, J. Silver, and R.J. Winchester The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis Arthritis & Rheumatism 30 11 1987 1205 1213
108. O.J. Rullo, and B.P. Tsao Recent insights into the genetic basis of systemic lupus erythematosus Annals of the Rheumatic 72 Suppl. 2 2013 ii56 ii61
109. J. Zikherman, and A. Weiss Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease The Journal of Clinical Investigation 121 12 2011 4618 4621
110. K. Nakano, J.W. Whitaker, D.L. Boyle, W. Wang, and G.S. Firestein DNA methylome signature in rheumatoid arthritis Annals of the Rheumatic 72 1 2013 110 117
111. M. De Santis, and C. Selmi The therapeutic potential of epigenetics in autoimmune diseases Clinical Reviews in Allergy & Immunology 42 1 2012 92 101
112. A. Del Puente, W.C. Knowler, D.J. Pettitt, and P.H. Bennett High incidence and prevalence of rheumatoid arthritis in Pima Indians American Journal of Epidemiology 129 6 1989 1170 1178
113. E.D. Ferucci, D.W. Templin, and A.P. Lanier Rheumatoid arthritis in American Indians and Alaska Natives: a review of the literature Seminars in Arthritis and Rheumatism 34 4 2005 662 667
114. M.A. Dooley, and S.L. Hogan Environmental epidemiology and risk factors for autoimmune disease Current Opinion in Rheumatology 15 2 2003 99 103
115. G.S. Cooper, C.G. Parks, E.L. Treadwell, E.W. St Clair, G.S. Gilkeson, and P.L. Cohen Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States Lupus 11 3 2002 161 167
116. L. Klareskog, L. Padyukov, and L. Alfredsson Smoking as a trigger for inflammatory rheumatic diseases Current Opinion in Rheumatology 19 1 2007 49 54
117. J.E. Oliver, and A.J. Silman Risk factors for the development of rheumatoid arthritis Scandinavian Journal of Rheumatology 35 3 2006 169 174
118. M.W. Cunningham Streptococcus and rheumatic fever Current Opinion in Rheumatology 24 4 2012 408 416
119. L. Guillevin Infections in vasculitis Best Practice & Research Clinical Rheumatology 27 1 2013 19 31
120. D. Morris, and R.D. Inman Reactive arthritis: developments and challenges in diagnosis and treatment Current Rheumatology Reports 14 5 2012 390 394
121. J.D. Reveille Genetics of spondyloarthritis-beyond the MHC Nature Reviews Rheumatology 8 5 2012 296 304
122. J.A. James, and J.M. Robertson Lupus and epstein-barr Current Opinion in Rheumatology 24 4 2012 383 388
123. B. Lu, D.H. Solomon, K.H. Costenbader, B.T. Keenan, L.B. Chibnik, and E.W. Karlson Alcohol consumption and markers of inflammation in women with pre-clinical rheumatoid arthritis Arthritis & Rheumatism 2010
124. G. Chodick, H. Amital, Y. Shalem, E. Kokia, A.D. Heymann, and A. Porath Persistence with statins and onset of rheumatoid arthritis: a population-based cohort study PLoS Medicine 7 9 2010 e1000336
125. H.J. de Jong, O.H. Klungel, L. van Dijk, R.J. Vandebriel, H.G. Leufkens, and J.W. van der Laan Use of statins is associated with an increased risk of rheumatoid arthritis Annals of the Rheumatic 71 5 2012 648 654
126. D.S. Rampton The influence of stress on the development and severity of immune-mediated diseases The Journal of Rheumatology 88 2011 43 47
127. T. Korpilahde, M. Heliovaara, P. Knekt, J. Marniemi, A. Aromaa, and K. Aho Smoking history and serum cotinine and thiocyanate concentrations as determinants of rheumatoid factor in non-rheumatoid subjects Rheumatology (Oxford) 43 11 2004 1424 1428
128. T. Tuomi, M. Heliovaara, T. Palosuo, and K. Aho Smoking, lung function, and rheumatoid factors Annals of the Rheumatic 49 10 1990 753 756
129. S.S. Bhatia, D.S. Majka, J.M. Kittelson, L.A. Parrish, E.D. Ferucci, and K.D. Deane Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis Annals of the Rheumatic 66 2 2007 267 269
130. E.W. Karlson, S.C. Chang, J. Cui, L.B. Chibnik, P.A. Fraser, and I. De Vivo Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis Annals of the Rheumatic 69 1 2010 54 60
131. J.J. Anderson, G. Wells, A.C. Verhoeven, and D.T. Felson Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration Arthritis & Rheumatism 43 1 2000 22 29
132. L.R. Lard, H. Visser, I. Speyer, I.E. vander Horst-Bruinsma, A.H. Zwinderman, and F.C. Breedveld Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies American Journal of Medicine 111 6 2001 446 451
133. T. Mottonen, P. Hannonen, M. Korpela, M. Nissila, H. Kautiainen, and J. Ilonen Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis Arthritis & Rheumatism 46 4 2002 894 898
134. V.P. Nell, K.P. Machold, G. Eberl, T.A. Stamm, M. Uffmann, and J.S. Smolen Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis Rheumatology (Oxford) 43 7 2004 906 914
135. A. Finckh, M.H. Liang, C.M. van Herckenrode, and P. de Pablo Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: a meta-analysis Arthritis & Rheumatism 55 6 2006 864 872
136. J.J. Cush Early rheumatoid arthritis - is there a window of opportunity? The Journal of Rheumatology 80 2007 1 7
137. D. van der Woude, A. Young, K. Jayakumar, B.J. Mertens, R.E. Toes, and D. van der Heijde Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from two large early arthritis cohorts Arthritis & Rheumatism 60 8 2009 2262 2271
138. M.P. van der Linden, S. le Cessie, K. Raza, D. van der Woude, R. Knevel, and T.W. Huizinga Long-term impact of delay in assessment of patients with early arthritis Arthritis & Rheumatism 62 12 2010 3537 3546
139. R. Thomas Dendritic cells and the promise of antigen-specific therapy in rheumatoid arthritis Arthritis Research & Therapy 15 1 2013 204
140. E.C. Koffeman, M. Genovese, D. Amox, E. Keogh, E. Santana, and E.L. Matteson Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial Arthritis & Rheumatism 60 11 2009 3207 3216
141. H.S. El-Gabalawy, D.B. Robinson, I. Smolik, D. Hart, B. Elias, and K. Wong Familial clustering of the serum cytokine profile in the relatives of rheumatoid arthritis patients Arthritis & Rheumatism 2012
142. F. Novotny, S. Haeny, P. Hudelson, M. Escher, and A. Finckh Primary prevention of rheumatoid arthritis: a qualitative study in a high-risk population Joint Bone Spine 2013
143. N. Agmon-Levin, and C. Selmi The autoimmune side of heart and lung diseases Clinical Reviews in Allergy & Immunology 44 1 2013 1 5