Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis

Arthritis and Rheumatism

Volumn 64, Issue 11, 2012, Pages 3522-3530

  Mikuls, Ted R ^a   Thiele, Geoffrey M ^a   Deane, Kevin D ^b   Payne, Jeffrey B ^a   O'Dell, James R ^a   Yu, Fang ^a   Sayles, Harlan ^a   Weisman, Michael H ^c   Gregersen, Peter K ^d   Buckner, Jane H ^e   Keating, Richard M ^f   Derber, Lezlie A ^b   Robinson, William H ^g,i   Holers, V Michael ^b   Norris, Jill M ^h  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^e BENAROYA RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

^g VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^h UNIVERSITY OF COLORADO   (United States)

ⁱ STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BACTERIUM ANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; HLA DR4 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RHEUMATOID FACTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUSOBACTERIUM NUCLEATUM; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PORPHYROMONAS; PORPHYROMONAS GINGIVALIS; PORPHYROMONAS INTERMEDIA; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADULT; AGED; ANTIBODIES, BACTERIAL; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; BACTEROIDACEAE INFECTIONS; COHORT STUDIES; FAMILY; FEMALE; HUMANS; LOGISTIC MODELS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; RISK FACTORS; SEROEPIDEMIOLOGIC STUDIES;

EID: 84867164849     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34595     Document Type: Article

References (46)

1. Eke PI, Thornton-Evans GO, Wei L, Borgnakke WS, Dye BA,. Accuracy of NHANES periodontal examination protocols. J Dent Res 2010; 89: 1208-13.
2. Albandar JM, Streckfus CF, Adesanya MR, Winn DM,. Cigar, pipe, and cigarette smoking as risk factors for periodontal disease and tooth loss. J Periodontol 2000; 71: 1874-81.
3. Bonfil JJ, Dillier FL, Mercier P, Reviron D, Foti B, Sambuc R, et al. A "case control" study on the role of HLA DR4 in severe periodontitis and rapidly progressive periodontitis: identification of types and subtypes using molecular biology (PCR.SSO). J Clin Periodontol 1999; 26: 77-84.
4. Calsina G, Ramon JM, Echeverria JJ,. Effects of smoking on periodontal tissues. J Clin Periodontol 2002; 29: 771-6.
5. Criswell LA, Merlino LA, Cerhan JR, Mikuls TR, Mudano AS, Burma M, et al. Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: results from the Iowa Women's Health Study. Am J Med 2002; 15: 465-71.
6. Gregersen PK, Silver J, Winchester RJ,. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-13.
7. Karlson EW, Lee IM, Cook NR, Manson JE, Buring JE, Hennekens CH,. A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals. Arthritis Rheum 1999; 42: 910-7.
8. Nepom GT, Nepom BS,. Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping. Rheum Dis Clin North Am 1992; 18: 785-92.
9. Wordsworth P, Pile KD, Buckely JD, Lanchbury JS, Ollier B, Lathrop M, et al. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. Am J Hum Genet 1992; 51: 585-91.
10. Assuma R, Oates T, Cochran D, Amar S, Graves DT,. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol 1998; 160: 403-9.
11. Delima AJ, Oates T, Assuma R, Schwartz Z, Cochran D, Amar S, et al. Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibit loss of tissue attachment in experimental periodontitis. J Clin Periodontol 2001; 28: 233-40.
12. Graves DT, Delima AJ, Assuma R, Amar S, Oates T, Cochran D,. Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis. J Periodontol 1998; 69: 1419-25.
13. Arkema EV, Karlson EW, Costenbader KH,. A prospective study of periodontal disease and risk of rheumatoid arthritis. J Rheumatol 2010; 37: 1800-4.
14. Demmer RT, Molitor JA, Jacobs DR Jr, Michalowicz BS,. Periodontal disease, tooth loss and incident rheumatoid arthritis: results from the First National Health and Nutrition Examination Survey and its epidemiological follow-up study. J Clin Periodontol 2011; 38: 998-1006.
15. Kasser UR, Gleissner C, Dehne F, Michel A, Willershausen-Zonnchen B, Bolten WW,. Risk for periodontal disease in patients with longstanding rheumatoid arthritis. Arthritis Rheum 1997; 40: 2248-51.
16. Mercado FB, Marshall RI, Klestov AC, Bartold PM,. Relationship between rheumatoid arthritis and periodontitis. J Periodontol 2001; 72: 779-87.
17. Dissick A, Redman RS, Jones M, Rangan BV, Reimold A, Griffiths GR, et al. Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol 2010; 81: 223-30.
18. McGraw WT, Potempa J, Farley D, Travis J,. Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun 1999; 67: 3248-56.
19. Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G,. Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 2004; 28: 311-8.
20. Kolfenbach JR, Deane KD, Derber LA, O'Donnell C, Weisman MH, Buckner JH, et al. A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA. Arthritis Rheum 2009; 61: 1735-42.
21. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
22. Bhatia SS, Majka DS, Kittelson JM, Parrish LA, Ferucci ED, Deane KD, et al. Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis. Ann Rheum Dis 2007; 66: 267-9.
23. Blicher B, Joshipura K, Eke P,. Validation of self-reported periodontal disease: a systematic review. J Dent Res 2005; 84: 881-90.
24. Deane KD, O'Donnell CI, Hueber W, Majka DS, Lazar AA, Derber LA, et al. The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arthritis Rheum 2010; 62: 3161-72.
25. Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004; 50: 380-6.
26. Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003; 48: 2741-9.
27. Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, et al. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 2009; 9: 38-42.
28. McArthur WP, Bloom C, Taylor M, Smith J, Wheeler T, Magnusson NI,. Antibody responses to suspected periodontal pathogens in elderly subjects with periodontal disease. J Clin Periodontol 1995; 22: 842-9.
29. Tsai CY, Wolff LF, Germaine G, Hodges J,. A rapid DNA probe test compared to culture methods for identification of subgingival plaque bacteria. J Clin Periodontol 2003; 30: 57-62.
30. Engvall E, Perlman P,. Enzyme-linked immunosorbent assay (ELISA): quantitative assay of immunoglobulin G. Immunochemistry 1971; 8: 871-4.
31. Curtis MA, Slaney JM, Carman RJ, Johnson NW,. Identification of the major surface protein antigens of Porphyromonas gingivalis using IgG antibody reactivity of periodontal case-control serum. Oral Microbiol Immunol 1991; 6: 321-6.
32. Bohnstedt S, Cullinan MP, Ford PJ, Palmer JE, Leishman SJ, Westerman B, et al. High antibody levels to P. gingivalis in cardiovascular disease. J Dent Res 2010; 89: 938-42.
33. Brennan RM, Genco RJ, Wilding GE, Hovey KM, Trevisan M, Wactawski-Wende J,. Bacterial species in subgingival plaque and oral bone loss in postmenopausal women. J Periodontol 2007; 78: 1051-61.
34. Mosca A, Miragliotta L, Iodice MA, Abbinante A, Miragliotta G,. Antimicrobial profiles of Prevotella spp. and Fusobacterium nucleatum isolated from periodontal infections in a selected area of southern Italy. Int J Antimicrob Agents 2007; 30: 521-4.
35. Kamaguch A, Nakayama K, Ohyama T, Watanabe T, Okamoto M, Baba H,. Coaggregation of Porphyromonas gingivalis and Prevotella intermedia. Microbiol Immunol 2001; 45: 649-56.
36. Hueber W, Tomooka BH, Zhao X, Kidd BA, Drijfhout JW, Fries JF, et al. Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines. Ann Rheum Dis 2007; 66: 712-9.
37. Van Dyke TE, Sheilesh D,. Risk factors for periodontitis. J Int Acad Periodontol 2005; 7: 3-7.
38. Snyderman R, McCarty GA,. Analogous mechanism of tissue destruction in rheumatoid arthritis and periodontal disease. In:, Genco R, Mergenhagen S, editors. Host-parasite interactions in periodontal diseases. Washington (DC): American Society for Microbiology; 1982. p. 354-62.
39. Hitchon CA, Chandad F, Ferucci ED, Willemze A, Ioan-Facsinay A, van der Woude D, et al. Antibodies to Porphyromonas gingivalis are associated with anticitrullinated protein antibodies in patients with rheumatoid arthritis and their relatives. J Rheumatol 2010; 37: 1105-12.
40. Ogrendik M, Kokino S, Ozdemir F, Bird PS, Hamlet S,. Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis. MedGenMed 2005; 7: 2.
41. Wegner N, Wait R, Sroka A, Eick S, Nguyen KA, Lundberg K, et al. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 2010; 62: 2662-72.
42. Snir O, Widhe M, von Spee C, Lindberg J, Padyukov L, Lundberg K, et al. Multiple antibody reactivities to citrullinated antigens in sera from rheumatoid arthritis patients: association with HLA- DRB1 alleles. Ann Rheum Dis 2009; 68: 736-43.
43. Sugawara K, Oikawa Y, Ouchi T,. Identification and properties of peptidylarginine deiminase from rabbit skeletal muscle. J Biochem 1982; 91: 1065-71.
44. Gargiulo AV, Robinson J, Toto PD, Gargiulo AW,. Identification of rheumatoid factor in periodontal disease. J Periodontol 1982; 53: 568-77.
45. Bonagura VR, Artandi SE, Davidson A, Randen I, Agostino N, Thompson K, et al. Mapping studies reveal unique epitopes on IgG recognized by rheumatoid arthritis-derived monoclonal rheumatoid factors. J Immunol 1993; 151: 3840-52.
46. Majka DS, Deane KD, Parrish LA, Lazar AA, Baron AE, Walker CW, et al. Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis. Ann Rheum Dis 2008; 67: 801-7.