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Volumn 14, Issue , 2018, Pages 7-19

A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration

Author keywords

Alzheimer's disease; Drp 1; Fission and fusion; Mitochondria; Neurodegeneration; amyloid

Indexed keywords

AMYLOID BETA PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; CASPASE 3; HYDROGEN PEROXIDE; ROTENONE;

EID: 85027689640     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2017.08.010     Document Type: Article
Times cited : (119)

References (75)
  • 1
    • 33746256557 scopus 로고    scopus 로고
    • Mitochondrial alterations in Alzheimer's disease
    • Baloyannis, S.J., Mitochondrial alterations in Alzheimer's disease. J. Alzheimers Dis. 9 (2006), 119–126.
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 119-126
    • Baloyannis, S.J.1
  • 2
    • 25444474703 scopus 로고    scopus 로고
    • Mitochondria take center stage in aging and neurodegeneration
    • Beal, M.F., Mitochondria take center stage in aging and neurodegeneration. Ann. Neurol. 58 (2005), 495–505.
    • (2005) Ann. Neurol. , vol.58 , pp. 495-505
    • Beal, M.F.1
  • 3
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin, M.T., Beal, M.F., Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443 (2006), 787–795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 5
    • 84872532360 scopus 로고    scopus 로고
    • Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease
    • Zhu, X., Perry, G., Smith, M.A., Wang, X., Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J. Alzheimers Dis. 33:Suppl. 1 (2013), S253–S262.
    • (2013) J. Alzheimers Dis. , vol.33 , pp. S253-S262
    • Zhu, X.1    Perry, G.2    Smith, M.A.3    Wang, X.4
  • 6
    • 84884879594 scopus 로고    scopus 로고
    • Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease
    • Yan, M.H., Wang, X., Zhu, X., Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic. Biol. Med 62 (2013), 90–101.
    • (2013) Free Radic. Biol. Med , vol.62 , pp. 90-101
    • Yan, M.H.1    Wang, X.2    Zhu, X.3
  • 7
    • 51349163907 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in the axons of vertebrate peripheral neurons
    • Amiri, M., Hollenbeck, P.J., Mitochondrial biogenesis in the axons of vertebrate peripheral neurons. Dev. Neurobiol. 68 (2008), 1348–1361.
    • (2008) Dev. Neurobiol. , vol.68 , pp. 1348-1361
    • Amiri, M.1    Hollenbeck, P.J.2
  • 8
    • 0028047262 scopus 로고
    • Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria
    • Bereiter-Hahn, J., Voth, M., Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria. Microsc. Res Tech. 27 (1994), 198–219.
    • (1994) Microsc. Res Tech. , vol.27 , pp. 198-219
    • Bereiter-Hahn, J.1    Voth, M.2
  • 10
    • 0037455575 scopus 로고    scopus 로고
    • Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    • Chen, H., Detmer, S.A., Ewald, A.J., Griffin, E.E., Fraser, S.E., Chan, D.C., Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 160 (2003), 189–200.
    • (2003) J. Cell Biol. , vol.160 , pp. 189-200
    • Chen, H.1    Detmer, S.A.2    Ewald, A.J.3    Griffin, E.E.4    Fraser, S.E.5    Chan, D.C.6
  • 12
    • 0036906665 scopus 로고    scopus 로고
    • Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins
    • Legros, F., Lombes, A., Frachon, P., Rojo, M., Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol. Biol. Cell 13 (2002), 4343–4354.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 4343-4354
    • Legros, F.1    Lombes, A.2    Frachon, P.3    Rojo, M.4
  • 13
    • 0037089084 scopus 로고    scopus 로고
    • Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo
    • Rojo, M., Legros, F., Chateau, D., Lombes, A., Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J. Cell Sci. 115 (2002), 1663–1674.
    • (2002) J. Cell Sci. , vol.115 , pp. 1663-1674
    • Rojo, M.1    Legros, F.2    Chateau, D.3    Lombes, A.4
  • 14
    • 0035057837 scopus 로고    scopus 로고
    • Control of mitochondrial morphology by a human mitofusin
    • Santel, A., Fuller, M.T., Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114 (2001), 867–874.
    • (2001) J. Cell Sci. , vol.114 , pp. 867-874
    • Santel, A.1    Fuller, M.T.2
  • 15
    • 44649129342 scopus 로고    scopus 로고
    • The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells
    • Gandre-Babbe, S., van der Bliek, A.M., The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol. Biol. Cell 19 (2008), 2402–2412.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2402-2412
    • Gandre-Babbe, S.1    van der Bliek, A.M.2
  • 16
    • 0141592470 scopus 로고    scopus 로고
    • hFis1, a novel component of the mammalian mitochondrial fission machinery
    • James, D.I., Parone, P.A., Mattenberger, Y., Martinou, J.C., hFis1, a novel component of the mammalian mitochondrial fission machinery. J. Biol. Chem. 278 (2003), 36373–36379.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36373-36379
    • James, D.I.1    Parone, P.A.2    Mattenberger, Y.3    Martinou, J.C.4
  • 17
    • 78650167618 scopus 로고    scopus 로고
    • Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
    • Otera, H., Wang, C., Cleland, M.M., Setoguchi, K., Yokota, S., Youle, R.J., Mihara, K., Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J. Cell Biol. 191 (2010), 1141–1158.
    • (2010) J. Cell Biol. , vol.191 , pp. 1141-1158
    • Otera, H.1    Wang, C.2    Cleland, M.M.3    Setoguchi, K.4    Yokota, S.5    Youle, R.J.6    Mihara, K.7
  • 18
    • 0035166814 scopus 로고    scopus 로고
    • Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
    • Smirnova, E., Griparic, L., Shurland, D.L., van der Bliek, A.M., Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol. Biol. Cell 12 (2001), 2245–2256.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2245-2256
    • Smirnova, E.1    Griparic, L.2    Shurland, D.L.3    van der Bliek, A.M.4
  • 19
    • 0043092647 scopus 로고    scopus 로고
    • The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1
    • Yoon, Y., Krueger, E.W., Oswald, B.J., McNiven, M.A., The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol. Cell Biol. 23 (2003), 5409–5420.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 5409-5420
    • Yoon, Y.1    Krueger, E.W.2    Oswald, B.J.3    McNiven, M.A.4
  • 20
    • 79955623510 scopus 로고    scopus 로고
    • During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
    • Gomes, L.C., Di Benedetto, G., Scorrano, L., During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat. Cell Biol. 13 (2011), 589–598.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 589-598
    • Gomes, L.C.1    Di Benedetto, G.2    Scorrano, L.3
  • 21
    • 80052711240 scopus 로고    scopus 로고
    • Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress
    • Liu, X., Hajnoczky, G., Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress. Cell Death Differ. 18 (2011), 1561–1572.
    • (2011) Cell Death Differ. , vol.18 , pp. 1561-1572
    • Liu, X.1    Hajnoczky, G.2
  • 22
    • 78049361603 scopus 로고    scopus 로고
    • H2O2-induced mitochondrial fragmentation in C2C12 myocytes
    • Fan, X., Hussien, R., Brooks, G.A., H2O2-induced mitochondrial fragmentation in C2C12 myocytes. Free Radic. Biol. Med. 49 (2010), 1646–1654.
    • (2010) Free Radic. Biol. Med. , vol.49 , pp. 1646-1654
    • Fan, X.1    Hussien, R.2    Brooks, G.A.3
  • 23
    • 53049099984 scopus 로고    scopus 로고
    • Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress
    • Jendrach, M., Mai, S., Pohl, S., Voth, M., Bereiter-Hahn, J., Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress. Mitochondrion 8 (2008), 293–304.
    • (2008) Mitochondrion , vol.8 , pp. 293-304
    • Jendrach, M.1    Mai, S.2    Pohl, S.3    Voth, M.4    Bereiter-Hahn, J.5
  • 24
    • 79952520044 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins
    • Wu, S., Zhou, F., Zhang, Z., Xing, D., Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins. FEBS J. 278 (2011), 941–954.
    • (2011) FEBS J. , vol.278 , pp. 941-954
    • Wu, S.1    Zhou, F.2    Zhang, Z.3    Xing, D.4
  • 26
    • 0043166392 scopus 로고    scopus 로고
    • Dynamics of mitochondrial morphology in healthy cells and during apoptosis
    • Karbowski, M., Youle, R.J., Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ. 10 (2003), 870–880.
    • (2003) Cell Death Differ. , vol.10 , pp. 870-880
    • Karbowski, M.1    Youle, R.J.2
  • 28
    • 84926258887 scopus 로고    scopus 로고
    • Disturbed mitochondrial dynamics and neurodegenerative disorders
    • Burte, F., Carelli, V., Chinnery, P.F., Yu-Wai-Man, P., Disturbed mitochondrial dynamics and neurodegenerative disorders. Nat. Rev. Neurol. 11 (2015), 11–24.
    • (2015) Nat. Rev. Neurol. , vol.11 , pp. 11-24
    • Burte, F.1    Carelli, V.2    Chinnery, P.F.3    Yu-Wai-Man, P.4
  • 30
    • 58049218922 scopus 로고    scopus 로고
    • Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
    • Wang, X., Su, B., Siedlak, S.L., Moreira, P.I., Fujioka, H., Wang, Y., Casadesus, G., Zhu, X., Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc. Natl. Acad. Sci. USA 105 (2008), 19318–19323.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 19318-19323
    • Wang, X.1    Su, B.2    Siedlak, S.L.3    Moreira, P.I.4    Fujioka, H.5    Wang, Y.6    Casadesus, G.7    Zhu, X.8
  • 31
    • 64249133725 scopus 로고    scopus 로고
    • S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
    • Cho, D.H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., Lipton, S.A., S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324 (2009), 102–105.
    • (2009) Science , vol.324 , pp. 102-105
    • Cho, D.H.1    Nakamura, T.2    Fang, J.3    Cieplak, P.4    Godzik, A.5    Gu, Z.6    Lipton, S.A.7
  • 33
    • 67650732998 scopus 로고    scopus 로고
    • Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
    • Wang, X., Su, B., Lee, H.G., Li, X., Perry, G., Smith, M.A., Zhu, X., Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J. Neurosci. 29 (2009), 9090–9103.
    • (2009) J. Neurosci. , vol.29 , pp. 9090-9103
    • Wang, X.1    Su, B.2    Lee, H.G.3    Li, X.4    Perry, G.5    Smith, M.A.6    Zhu, X.7
  • 34
    • 79751537405 scopus 로고    scopus 로고
    • Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons
    • Calkins, M.J., Reddy, P.H., Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons. Biochim. Biophys. Acta 1812 (2011), 507–513.
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 507-513
    • Calkins, M.J.1    Reddy, P.H.2
  • 35
    • 85010858921 scopus 로고    scopus 로고
    • Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease
    • Xu, L.L., Shen, Y., Wang, X., Wei, L.F., Wang, P., Yang, H., Wang, C.F., Xie, Z.H., Bi, J.Z., Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease. Neuroreport 28 (2017), 222–228.
    • (2017) Neuroreport , vol.28 , pp. 222-228
    • Xu, L.L.1    Shen, Y.2    Wang, X.3    Wei, L.F.4    Wang, P.5    Yang, H.6    Wang, C.F.7    Xie, Z.H.8    Bi, J.Z.9
  • 36
    • 81255190781 scopus 로고    scopus 로고
    • Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
    • Calkins, M.J., Manczak, M., Mao, P., Shirendeb, U., Reddy, P.H., Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Hum. Mol. Genet. 20 (2011), 4515–4529.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 4515-4529
    • Calkins, M.J.1    Manczak, M.2    Mao, P.3    Shirendeb, U.4    Reddy, P.H.5
  • 37
    • 84863245760 scopus 로고    scopus 로고
    • Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease
    • Trushina, E., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T.M., et al. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PloS One, 7, 2012, e32737.
    • (2012) PloS One , vol.7 , pp. e32737
    • Trushina, E.1    Nemutlu, E.2    Zhang, S.3    Christensen, T.4    Camp, J.5    Mesa, J.6    Siddiqui, A.7    Tamura, Y.8    Sesaki, H.9    Wengenack, T.M.10
  • 38
  • 41
    • 67649399288 scopus 로고    scopus 로고
    • Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
    • Dagda, R.K., Cherra, S.J. 3rd, Kulich, S.M., Tandon, A., Park, D., Chu, C.T., Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284 (2009), 13843–13855.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13843-13855
    • Dagda, R.K.1    Cherra, S.J.2    Kulich, S.M.3    Tandon, A.4    Park, D.5    Chu, C.T.6
  • 42
    • 84859709003 scopus 로고    scopus 로고
    • Mitochondria-specific accumulation of amyloid beta induces mitochondrial dysfunction leading to apoptotic cell death
    • Cha, M.Y., Han, S.H., Son, S.M., Hong, H.S., Choi, Y.J., Byun, J., Mook-Jung, I., Mitochondria-specific accumulation of amyloid beta induces mitochondrial dysfunction leading to apoptotic cell death. PLoS One, 7, 2012, e34929.
    • (2012) PLoS One , vol.7 , pp. e34929
    • Cha, M.Y.1    Han, S.H.2    Son, S.M.3    Hong, H.S.4    Choi, Y.J.5    Byun, J.6    Mook-Jung, I.7
  • 43
    • 0041819756 scopus 로고    scopus 로고
    • Glutamate decreases mitochondrial size and movement in primary forebrain neurons
    • Rintoul, G.L., Filiano, A.J., Brocard, J.B., Kress, G.J., Reynolds, I.J., Glutamate decreases mitochondrial size and movement in primary forebrain neurons. J. Neurosci. 23 (2003), 7881–7888.
    • (2003) J. Neurosci. , vol.23 , pp. 7881-7888
    • Rintoul, G.L.1    Filiano, A.J.2    Brocard, J.B.3    Kress, G.J.4    Reynolds, I.J.5
  • 44
    • 79959987510 scopus 로고    scopus 로고
    • Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
    • Rambold, A.S., Kostelecky, B., Elia, N., Lippincott-Schwartz, J., Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc. Natl. Acad. Sci. USA 108 (2011), 10190–10195.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 10190-10195
    • Rambold, A.S.1    Kostelecky, B.2    Elia, N.3    Lippincott-Schwartz, J.4
  • 45
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green, D.R., Kroemer, G., The pathophysiology of mitochondrial cell death. Science 305 (2004), 626–629.
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 47
    • 57349100367 scopus 로고    scopus 로고
    • Mitofusin 2 tethers endoplasmic reticulum to mitochondria
    • de Brito, O.M., Scorrano, L., Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456 (2008), 605–610.
    • (2008) Nature , vol.456 , pp. 605-610
    • de Brito, O.M.1    Scorrano, L.2
  • 50
    • 71849083948 scopus 로고    scopus 로고
    • Abnormal mitochondrial dynamics and neurodegenerative diseases
    • Su, B., Wang, X., Zheng, L., Perry, G., Smith, M.A., Zhu, X., Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys. Acta 1802 (2010), 135–142.
    • (2010) Biochim Biophys. Acta , vol.1802 , pp. 135-142
    • Su, B.1    Wang, X.2    Zheng, L.3    Perry, G.4    Smith, M.A.5    Zhu, X.6
  • 51
    • 34249689057 scopus 로고    scopus 로고
    • Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
    • Taguchi, N., Ishihara, N., Jofuku, A., Oka, T., Mihara, K., Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J. Biol. Chem. 282 (2007), 11521–11529.
    • (2007) J. Biol. Chem. , vol.282 , pp. 11521-11529
    • Taguchi, N.1    Ishihara, N.2    Jofuku, A.3    Oka, T.4    Mihara, K.5
  • 52
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • Markesbery, W.R., Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23 (1997), 134–147.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 58
    • 23044506102 scopus 로고    scopus 로고
    • Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions
    • Verstreken, P., Ly, C.V., Venken, K.J., Koh, T.W., Zhou, Y., Bellen, H.J., Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 47 (2005), 365–378.
    • (2005) Neuron , vol.47 , pp. 365-378
    • Verstreken, P.1    Ly, C.V.2    Venken, K.J.3    Koh, T.W.4    Zhou, Y.5    Bellen, H.J.6
  • 59
    • 84880710379 scopus 로고    scopus 로고
    • Keeping mitochondria in shape: a matter of life and death
    • Scorrano, L., Keeping mitochondria in shape: a matter of life and death. Eur. J. Clin. Investig. 43 (2013), 886–893.
    • (2013) Eur. J. Clin. Investig. , vol.43 , pp. 886-893
    • Scorrano, L.1
  • 61
    • 33745274726 scopus 로고    scopus 로고
    • Mitochondria: dynamic organelles in disease, aging, and development
    • Chan, D.C., Mitochondria: dynamic organelles in disease, aging, and development. Cell 125 (2006), 1241–1252.
    • (2006) Cell , vol.125 , pp. 1241-1252
    • Chan, D.C.1
  • 62
    • 33745952665 scopus 로고    scopus 로고
    • Mitochondrial trafficking to synapses in cultured primary cortical neurons
    • Chang, D.T., Honick, A.S., Reynolds, I.J., Mitochondrial trafficking to synapses in cultured primary cortical neurons. J. Neurosci. 26 (2006), 7035–7045.
    • (2006) J. Neurosci. , vol.26 , pp. 7035-7045
    • Chang, D.T.1    Honick, A.S.2    Reynolds, I.J.3
  • 63
    • 30544452263 scopus 로고    scopus 로고
    • The axonal transport of mitochondria
    • Hollenbeck, P.J., Saxton, W.M., The axonal transport of mitochondria. J. Cell Sci. 118 (2005), 5411–5419.
    • (2005) J. Cell Sci. , vol.118 , pp. 5411-5419
    • Hollenbeck, P.J.1    Saxton, W.M.2
  • 64
    • 0033535345 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event
    • Martinou, I., Desagher, S., Eskes, R., Antonsson, B., Andre, E., Fakan, S., Martinou, J.C., The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event. J. Cell Biol. 144 (1999), 883–889.
    • (1999) J. Cell Biol. , vol.144 , pp. 883-889
    • Martinou, I.1    Desagher, S.2    Eskes, R.3    Antonsson, B.4    Andre, E.5    Fakan, S.6    Martinou, J.C.7
  • 66
    • 0037007227 scopus 로고    scopus 로고
    • Mitochondria are morphologically and functionally heterogeneous within cells
    • Collins, T.J., Berridge, M.J., Lipp, P., Bootman, M.D., Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J. 21 (2002), 1616–1627.
    • (2002) EMBO J. , vol.21 , pp. 1616-1627
    • Collins, T.J.1    Berridge, M.J.2    Lipp, P.3    Bootman, M.D.4
  • 67
    • 1242307475 scopus 로고    scopus 로고
    • Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis
    • Karbowski, M., Arnoult, D., Chen, H., Chan, D.C., Smith, C.L., Youle, R.J., Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J. Cell Biol. 164 (2004), 493–499.
    • (2004) J. Cell Biol. , vol.164 , pp. 493-499
    • Karbowski, M.1    Arnoult, D.2    Chen, H.3    Chan, D.C.4    Smith, C.L.5    Youle, R.J.6
  • 68
    • 69449096141 scopus 로고    scopus 로고
    • Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease
    • Massaad, C.A., Washington, T.M., Pautler, R.G., Klann, E., Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 106 (2009), 13576–13581.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 13576-13581
    • Massaad, C.A.1    Washington, T.M.2    Pautler, R.G.3    Klann, E.4
  • 69
    • 33646922865 scopus 로고    scopus 로고
    • Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice
    • Esposito, L., Raber, J., Kekonius, L., Yan, F., Yu, G.Q., Bien-Ly, N., Puolivali, J., Scearce-Levie, K., Masliah, E., Mucke, L., Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J. Neurosci. 26 (2006), 5167–5179.
    • (2006) J. Neurosci. , vol.26 , pp. 5167-5179
    • Esposito, L.1    Raber, J.2    Kekonius, L.3    Yan, F.4    Yu, G.Q.5    Bien-Ly, N.6    Puolivali, J.7    Scearce-Levie, K.8    Masliah, E.9    Mucke, L.10
  • 70
    • 77955509429 scopus 로고    scopus 로고
    • Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes
    • Makino, A., Scott, B.T., Dillmann, W.H., Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes. Diabetologia 53 (2010), 1783–1794.
    • (2010) Diabetologia , vol.53 , pp. 1783-1794
    • Makino, A.1    Scott, B.T.2    Dillmann, W.H.3
  • 71
    • 84876312885 scopus 로고    scopus 로고
    • A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity
    • Qi, X., Qvit, N., Su, Y.C., Mochly-Rosen, D., A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J. Cell Sci. 126 (2013), 789–802.
    • (2013) J. Cell Sci. , vol.126 , pp. 789-802
    • Qi, X.1    Qvit, N.2    Su, Y.C.3    Mochly-Rosen, D.4
  • 72
    • 84986612733 scopus 로고    scopus 로고
    • Abeta-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis
    • Kim, D.I., Lee, K.H., Gabr, A.A., Choi, G.E., Kim, J.S., Ko, S.H., Han, H.J., Abeta-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis. Biochim. Biophys. Acta 1863 (2016), 2820–2834.
    • (2016) Biochim. Biophys. Acta , vol.1863 , pp. 2820-2834
    • Kim, D.I.1    Lee, K.H.2    Gabr, A.A.3    Choi, G.E.4    Kim, J.S.5    Ko, S.H.6    Han, H.J.7
  • 73
    • 80055078418 scopus 로고    scopus 로고
    • The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention
    • Bonda, D.J., Smith, M.A., Perry, G., Lee, H.G., Wang, X., Zhu, X., The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention. Curr. Pharm. Des. 17 (2011), 3374–3380.
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 3374-3380
    • Bonda, D.J.1    Smith, M.A.2    Perry, G.3    Lee, H.G.4    Wang, X.5    Zhu, X.6
  • 75
    • 84920505804 scopus 로고    scopus 로고
    • Blockage of GSK3beta-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease
    • Yan, J., Liu, X.H., Han, M.Z., Wang, Y.M., Sun, X.L., Yu, N., Li, T., Su, B., Chen, Z.Y., Blockage of GSK3beta-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease. Neurobiol. Aging 36 (2015), 211–227.
    • (2015) Neurobiol. Aging , vol.36 , pp. 211-227
    • Yan, J.1    Liu, X.H.2    Han, M.Z.3    Wang, Y.M.4    Sun, X.L.5    Yu, N.6    Li, T.7    Su, B.8    Chen, Z.Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.