Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease

Neurobiology of Aging

Volumn 36, Issue 1, 2015, Pages 211-227

  Yan, Jing ^a   Liu, Xiang Hua ^a   Han, Ming Zhi ^a   Wang, Yu Meng ^a   Sun, Xu Lu ^a   Yu, Nuo ^a   Li, Ting ^a   Su, Bo ^a   Chen, Zhe Yu ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Amyloid ; APP PS1 transgenic mice; Drp1; GSK3 ; Learning and memory; Mitochondrial fragmentation; Neuronal apoptosis; TAT like polypeptide

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE 3; DYNAMIN; DYNAMIN RELATED PROTEIN 1; GLYCOGEN SYNTHASE KINASE 3BETA; POLYPEPTIDE; SERINE; THREONYLGLUTAMINYLSERYLSERYLGLYCYLLYSYLSERYLSERYLVALYLLEUCYLGLUTAMYLPSERYLLEUCYLVALYLGYCYLARGINYLASPARTYLLEUCYLLEUCYLPROLYL CYSTEINE; UNCLASSIFIED DRUG; DNM1L PROTEIN, MOUSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ADULT; ALZHEIMER DISEASE; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FEMALE; GENE OVEREXPRESSION; HIPPOCAMPAL CA1 REGION; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL FRAGMENTATION; MITOCHONDRIAL LENGTH; MITOCHONDRIAL LOCALIZATION; MOLECULAR MECHANICS; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; RECOGNITION; SPATIAL LEARNING; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; GENETICS; HIPPOCAMPUS; MEMORY; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PSYCHOLOGY; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DYNAMINS; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; MALE; MEMORY; MICE, TRANSGENIC; MITOCHONDRIAL DYNAMICS; NEURONS; PHOSPHORYLATION;

EID: 84920505804     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.08.005     Document Type: Article

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