The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

Cell

Volumn 167, Issue 5, 2016, Pages 1415-1429.e19

  Astle, William J ^a,b,c,d   Elding, Heather ^e,f   Jiang, Tao ^d   Allen, Dave ^g   Ruklisa, Dace ^a,b,c   Mann, Alice L ^e   Mead, Daniel ^e   Bouman, Heleen ^e   Riveros Mckay, Fernando ^e   Kostadima, Myrto A ^a,b,e   Lambourne, John J ^a,b   Sivapalaratnam, Suthesh ^a,h   Downes, Kate ^a,b   Kundu, Kousik ^a,e   Bomba, Lorenzo ^e   Berentsen, Kim ⁱ   Bradley, John R ^a,j   Daugherty, Louise C ^a,b   Delaneau, Olivier ^k   Freson, Kathleen ^l   Garner, Stephen F ^a,b   Grassi, Luigi ^a,b   Guerrero, Jose ^a,b   Haimel, Matthias ^a   Janssen Megens, Eva M ⁱ   Kaan, Anita ⁱ   Kamat, Mihir ^d   Kim, Bowon ⁱ   Mandoli, Amit ⁱ   Marchini, Jonathan ^m,n   Martens, Joost H A ⁱ   Meacham, Stuart ^a,b   Megy, Karyn ^a,b   O'Connell, Jared ^m,n   Petersen, Romina ^a,b   Sharifi, Nilofar ⁱ   Sheard, Simon M ^o   Staley, James R ^d   Tuna, Salih ^a   van der Ent, Martijn ⁱ   Walter, Klaudia ^e   Wang, Shuang Yin ⁱ   Wheeler, Eleanor ^e   Wilder, Steven P ^e   Iotchkova, Valentina ^e   Moore, Carmel ^d   Sambrook, Jennifer ^a,b,d   Stunnenberg, Hendrik G ⁱ   Di Angelantonio, Emanuele ^d,f,p   Kaptoge, Stephen ^d,f   Kuijpers, Taco W ^q,r   Carrillo de Santa Pau, Enrique ^s   Juan, David ^s   Rico, Daniel ^s,t   Valencia, Alfonso ^s   Chen, Lu ^a,e   Ge, Bing ^u   Vasquez, Louella ^e   Kwan, Tony ^u   Garrido Martín, Diego ^v,w   Watt, Stephen ^e   Yang, Ying ^e   Guigo, Roderic ^v,w,x   Beck, Stephan ^y   Paul, Dirk S ^d,y   Pastinen, Tomi ^u   Bujold, David ^u   Bourque, Guillaume ^u   Frontini, Mattia ^a,b,p   Danesh, John ^d,e,f,j,p   Roberts, David J ^z,aa   Ouwehand, Willem H ^a,b,e,f,p   Butterworth, Adam S ^d,f,p   Soranzo, Nicole ^a,e,f,p   more..

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^f Faculty of Science ^*  (United Kingdom)

^g Blood Research Group   (United Kingdom)

^h University of Geneva ^*  (United Kingdom)

ⁱ RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^j CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^k UNIVERSITY OF GENEVA   (Switzerland)

^l UNIVERSITY OF LEUVEN   (Belgium)

^m UNIVERSITY OF OXFORD   (United Kingdom)

ⁿ UNIVERSITY OF OXFORD   (United Kingdom)

^o UK BIOBANK   (United Kingdom)

^p ADDENBROOKE S HOSPITAL   (United Kingdom)

^q UNIVERSITY OF AMSTERDAM   (Netherlands)

^r Sanquin Research and Landsteiner Laboratory   (United Kingdom)

^s Centro Nacional de Investigaciones Oncológicas   (United Kingdom)

^t NEWCASTLE UNIVERSITY   (United Kingdom)

^u MCGILL UNIVERSITY   (Canada)

^v CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^w UNIVERSITAT POMPEU FABRA   (Spain)

^x Institut Hospital del Mar d'Investigacions Mediques (IMIM)   (United Kingdom)

^y UNIVERSITY COLLEGE LONDON   (United Kingdom)

^z UNIVERSITY OF OXFORD   (United Kingdom)

^aa CHURCHILL HOSPITAL   (United Kingdom)

more..

Author keywords

autoimmune diseases; blood; cardiovascular diseases; complex disease; epigenetics; genetics; hematology; hematopoiesis; Mendelian randomization

Indexed keywords

ALLELE; ARTICLE; AUTOIMMUNE DISEASE; BIOBANK; BLOOD CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEMATOPOIESIS; HUMAN; ISCHEMIC HEART DISEASE; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; CAUCASIAN; CELL DIFFERENTIATION; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HEMATOPOIETIC STEM CELL; IMMUNOPATHOLOGY; METABOLISM; PATHOLOGY; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; CELL DIFFERENTIATION; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNE SYSTEM DISEASES; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 84995752422     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.10.042     Document Type: Article

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