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Volumn 8, Issue 1, 2017, Pages

Nanogrid single-nucleus RNA sequencing reveals phenotypic diversity in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR RNA;

EID: 85027226013     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00244-w     Document Type: Article
Times cited : (95)

References (70)
  • 1
    • 84942917849 scopus 로고    scopus 로고
    • The first five years of single-cell cancer genomics and beyond
    • Navin, N. E. The first five years of single-cell cancer genomics and beyond. Genome Res. 25, 1499-1507 (2015).
    • (2015) Genome Res. , vol.25 , pp. 1499-1507
    • Navin, N.E.1
  • 2
    • 84958606331 scopus 로고    scopus 로고
    • Single-cell genome sequencing: Current state of the science
    • Gawad, C., Koh, W. & Quake, S. R. Single-cell genome sequencing: current state of the science. Nat. Rev. Genet. 17, 175-188 (2016).
    • (2016) Nat. Rev. Genet. , vol.17 , pp. 175-188
    • Gawad, C.1    Koh, W.2    Quake, S.R.3
  • 3
    • 84902668801 scopus 로고    scopus 로고
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
    • Patel, A. P. et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 344, 1396-1401 (2014).
    • (2014) Science , vol.344 , pp. 1396-1401
    • Patel, A.P.1
  • 4
    • 84963614956 scopus 로고    scopus 로고
    • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
    • Tirosh, I. et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 352, 189-196 (2016).
    • (2016) Science , vol.352 , pp. 189-196
    • Tirosh, I.1
  • 5
    • 84864880991 scopus 로고    scopus 로고
    • Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells
    • Ramskold, D. et al. Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells. Nat. Biotechnol. 30, 777-782 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 777-782
    • Ramskold, D.1
  • 6
    • 84900529199 scopus 로고    scopus 로고
    • Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
    • Treutlein, B. et al. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature 509, 371-375 (2014).
    • (2014) Nature , vol.509 , pp. 371-375
    • Treutlein, B.1
  • 7
    • 84914706587 scopus 로고    scopus 로고
    • Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing
    • Lee, M. C. et al. Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing. Proc. Natl Acad. Sci. USA 111, E4726-4735 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E4726-4735
    • Lee, M.C.1
  • 8
    • 84937573360 scopus 로고    scopus 로고
    • Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells
    • Kim, K. T. et al. Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells. Genome Biol. 16, 127 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 127
    • Kim, K.T.1
  • 9
    • 84929661801 scopus 로고    scopus 로고
    • Advances and applications of single-cell sequencing technologies
    • Wang, Y. & Navin, N. E. Advances and applications of single-cell sequencing technologies. Mol. Cell 58, 598-609 (2015).
    • (2015) Mol. Cell , vol.58 , pp. 598-609
    • Wang, Y.1    Navin, N.E.2
  • 10
    • 84887109584 scopus 로고    scopus 로고
    • Accounting for technical noise in single-cell RNA-seq experiments
    • Brennecke, P. et al. Accounting for technical noise in single-cell RNA-seq experiments. Nat. Methods 10, 1093-1095 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 1093-1095
    • Brennecke, P.1
  • 12
    • 84939162152 scopus 로고    scopus 로고
    • Scalable microfluidics for single-cell RNA printing and sequencing
    • Bose, S. et al. Scalable microfluidics for single-cell RNA printing and sequencing. Genome Biol. 16, 120 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 120
    • Bose, S.1
  • 13
    • 84988884535 scopus 로고    scopus 로고
    • An automated microwell platform for large-scale single cell RNA-Seq
    • Yuan, J. & Sims, P. A. An automated microwell platform for large-scale single cell RNA-Seq. Sci. Rep. 6, 33883 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 33883
    • Yuan, J.1    Sims, P.A.2
  • 14
    • 84922311090 scopus 로고    scopus 로고
    • Fodor SPa. Combinatorial labeling of single cells for gene expression cytometry
    • Fan, H. C. & Fu, G. K. Fodor SPa. Combinatorial labeling of single cells for gene expression cytometry. Science 347, 1258367-1258367 (2015).
    • (2015) Science , vol.347 , pp. 1258367
    • Fan, H.C.1    Fu, G.K.2
  • 15
    • 84929684999 scopus 로고    scopus 로고
    • Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
    • Macosko, E. Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202-1214 (2015).
    • (2015) Cell , vol.161 , pp. 1202-1214
    • Macosko, E.Z.1
  • 16
    • 84929684998 scopus 로고    scopus 로고
    • Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
    • Klein, A. M. et al. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell 161, 1187-1201 (2015).
    • (2015) Cell , vol.161 , pp. 1187-1201
    • Klein, A.M.1
  • 18
    • 84889686392 scopus 로고    scopus 로고
    • RNA-sequencing from single nuclei
    • Grindberg, R. V. et al. RNA-sequencing from single nuclei. Proc. Natl Acad. Sci. USA 110, 19802-19807 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 19802-19807
    • Grindberg, R.V.1
  • 20
    • 84906238686 scopus 로고    scopus 로고
    • Clonal evolution in breast cancer revealed by single nucleus genome sequencing
    • Wang, Y. et al. Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature 512, 155-160 (2014).
    • (2014) Nature , vol.512 , pp. 155-160
    • Wang, Y.1
  • 21
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • Navin, N. et al. Tumour evolution inferred by single-cell sequencing. Nature 472, 90-94 (2011).
    • (2011) Nature , vol.472 , pp. 90-94
    • Navin, N.1
  • 22
    • 84959361379 scopus 로고    scopus 로고
    • Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons
    • Krishnaswami, S. R. et al. Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons. Nat. Protoc. 11, 499-524 (2016).
    • (2016) Nat. Protoc. , vol.11 , pp. 499-524
    • Krishnaswami, S.R.1
  • 23
    • 84976276942 scopus 로고    scopus 로고
    • Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
    • Lake, B. B. et al. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. Science 352, 1586-1590 (2016).
    • (2016) Science , vol.352 , pp. 1586-1590
    • Lake, B.B.1
  • 24
    • 84980325679 scopus 로고    scopus 로고
    • Div-seq: Single-nucleus RNA-seq reveals dynamics of rare adult newborn neurons
    • Habib, N. et al. Div-seq: single-nucleus RNA-seq reveals dynamics of rare adult newborn neurons. Science 353, 925-928 (2016).
    • (2016) Science , vol.353 , pp. 925-928
    • Habib, N.1
  • 25
    • 84973299445 scopus 로고    scopus 로고
    • Nuclear RNA-seq of single neurons reveals molecular signatures of activation
    • Lacar, B. et al. Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat. Commun. 7, 11022 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 11022
    • Lacar, B.1
  • 26
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70 (2012).
    • (2012) Nature , vol.490 , pp. 61-70
  • 28
    • 0028600629 scopus 로고
    • Localization of pre-mRNA splicing in mammalian nuclei
    • Zhang, G., Taneja, K. L., Singer, R. H. & Green, M. R. Localization of pre-mRNA splicing in mammalian nuclei. Nature 372, 809-812 (1994).
    • (1994) Nature , vol.372 , pp. 809-812
    • Zhang, G.1    Taneja, K.L.2    Singer, R.H.3    Green, M.R.4
  • 29
    • 79957865299 scopus 로고    scopus 로고
    • Pre-mRNA splicing: Where and when in the nucleus
    • Han, J., Xiong, J., Wang, D. & Fu, X. D. Pre-mRNA splicing: where and when in the nucleus. Trends Cell Biol. 21, 336-343 (2011).
    • (2011) Trends Cell Biol. , vol.21 , pp. 336-343
    • Han, J.1    Xiong, J.2    Wang, D.3    Fu, X.D.4
  • 30
    • 84903574951 scopus 로고    scopus 로고
    • Bayesian approach to single-cell differential expression analysis
    • Kharchenko, P. V., Silberstein, L. & Scadden, D. T. Bayesian approach to single-cell differential expression analysis. Nat. Methods 11, 740-742 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 740-742
    • Kharchenko, P.V.1    Silberstein, L.2    Scadden, D.T.3
  • 31
    • 84872202078 scopus 로고    scopus 로고
    • GSVA: Gene set variation analysis for microarray and RNA-seq data
    • Hanzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14, 7 (2013).
    • (2013) BMC Bioinformatics , vol.14 , pp. 7
    • Hanzelmann, S.1    Castelo, R.2    Guinney, J.3
  • 32
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild, A. H. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006).
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.H.1
  • 33
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C. M. et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2000).
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 34
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann, B. D. et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J. Clin. Invest. 121, 2750-2767 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1
  • 35
    • 84951574149 scopus 로고    scopus 로고
    • MAST: A flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
    • Finak, G. et al. MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol. 16, 278 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 278
    • Finak, G.1
  • 37
    • 84888352905 scopus 로고    scopus 로고
    • A smart local moving algorithm for large-scale modularity-based community detection
    • Waltman, L. & van Eck, N. J. A smart local moving algorithm for large-scale modularity-based community detection. Eur. Phys. J. B 86, 471 (2013).
    • (2013) Eur. Phys. J. B , vol.86 , pp. 471
    • Waltman, L.1    Van Eck, N.J.A.2
  • 38
    • 57249084011 scopus 로고    scopus 로고
    • Visualizing high-dimensional data using t-SNE
    • Maaten, L. J. Pvd & Hinton, G. E. Visualizing high-dimensional data using t-SNE. J. Mach. Learn. Res. 9, 27 (2008).
    • (2008) J. Mach. Learn. Res. , vol.9 , pp. 27
    • Maaten, L.1    Hinton, G.E.2
  • 39
    • 0028839878 scopus 로고
    • Nuclear morphometry and DNA densitometry of human gliomas by image analysis
    • Yoshii, Y., Saito, A. & Nose, T. Nuclear morphometry and DNA densitometry of human gliomas by image analysis. J. Neurooncol. 26, 1-9 (1995).
    • (1995) J. Neurooncol. , vol.26 , pp. 1-9
    • Yoshii, Y.1    Saito, A.2    Nose, T.3
  • 42
    • 84900333051 scopus 로고    scopus 로고
    • Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
    • Lohr, J. G. et al. Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nat. Biotechnol. 32, 479-484 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 479-484
    • Lohr, J.G.1
  • 43
    • 85012271992 scopus 로고    scopus 로고
    • Seq-well: Portable, low-cost RNA sequencing of single cells at high throughput
    • Gierahn, T. M. et al. Seq-well: portable, low-cost RNA sequencing of single cells at high throughput. Nat. Methods 14, 395-398 (2017).
    • (2017) Nat. Methods , vol.14 , pp. 395-398
    • Gierahn, T.M.1
  • 44
    • 78649663247 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Disease entity or title of convenience?
    • Carey, L., Winer, E., Viale, G., Cameron, D. & Gianni, L. Triple-negative breast cancer: disease entity or title of convenience? Nat. Rev. Clin. Oncol. 7, 683-692 (2010).
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , pp. 683-692
    • Carey, L.1    Winer, E.2    Viale, G.3    Cameron, D.4    Gianni, L.5
  • 45
    • 79952679792 scopus 로고    scopus 로고
    • Directed therapy of subtypes of triple-negative breast cancer
    • Carey, L. A. Directed therapy of subtypes of triple-negative breast cancer. Oncologist 15, 49-56 (2010).
    • (2010) Oncologist , vol.15 , pp. 49-56
    • Carey, L.A.1
  • 46
    • 58149359842 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Risk factors to potential targets
    • Schneider, B. P. et al. Triple-negative breast cancer: risk factors to potential targets. Clin. Cancer Res. 14, 8010-8018 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 8010-8018
    • Schneider, B.P.1
  • 47
    • 84865727393 scopus 로고    scopus 로고
    • The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
    • Derrien, T. et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 22, 1775-1789 (2012).
    • (2012) Genome Res. , vol.22 , pp. 1775-1789
    • Derrien, T.1
  • 48
    • 84939171986 scopus 로고    scopus 로고
    • Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution
    • Cabili, M. N. et al. Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution. Genome Biol. 16, 20 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 20
    • Cabili, M.N.1
  • 49
    • 0033561361 scopus 로고    scopus 로고
    • Animal mitochondrial genomes
    • Boore, J. L. Animal mitochondrial genomes. Nucleic Acids Res. 27, 1767-1780 (1999).
    • (1999) Nucleic Acids Res. , vol.27 , pp. 1767-1780
    • Boore, J.L.1
  • 51
    • 84885467568 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis
    • Herazo-Maya, J. D. et al. Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci. Transl. Med. 5, 205ra136 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 205ra136
    • Herazo-Maya, J.D.1
  • 52
    • 84901978636 scopus 로고    scopus 로고
    • Target enrichment using parallel nanoliter quantitative PCR amplification
    • De Wilde, B. et al. Target enrichment using parallel nanoliter quantitative PCR amplification. BMC Genomics 15, 184 (2014).
    • (2014) BMC Genomics , vol.15 , pp. 184
    • De Wilde, B.1
  • 53
    • 84895069488 scopus 로고    scopus 로고
    • Quantitative single-cell RNA-seq with unique molecular identifiers
    • Islam, S. et al. Quantitative single-cell RNA-seq with unique molecular identifiers. Nat. Methods 11, 163-166 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 163-166
    • Islam, S.1
  • 54
    • 84891677425 scopus 로고    scopus 로고
    • Full-length RNA-seq from single cells using Smart-seq2
    • Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171-181 (2014).
    • (2014) Nat. Protoc. , vol.9 , pp. 171-181
    • Picelli, S.1
  • 55
    • 84988579306 scopus 로고    scopus 로고
    • Performance of genetic programming optimised Bowtie2 on genome comparison and analytic testing (GCAT) benchmarks
    • Langdon, W. B. Performance of genetic programming optimised Bowtie2 on genome comparison and analytic testing (GCAT) benchmarks. BioData Min. 8, 1 (2015).
    • (2015) BioData Min. , vol.8 , pp. 1
    • Langdon, W.B.1
  • 56
    • 79961123152 scopus 로고    scopus 로고
    • RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome
    • Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011).
    • (2011) BMC Bioinformatics , vol.12 , pp. 323
    • Li, B.1    Dewey, C.N.2
  • 57
    • 84876996918 scopus 로고    scopus 로고
    • TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
    • Kim, D. et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).
    • (2013) Genome Biol. , vol.14 , pp. R36
    • Kim, D.1
  • 58
    • 84865074382 scopus 로고    scopus 로고
    • RSeQC: Quality control of RNA-seq experiments
    • Wang, L., Wang, S. & Li, W. RSeQC: quality control of RNA-seq experiments. Bioinformatics 28, 2184-2185 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 2184-2185
    • Wang, L.1    Wang, S.2    Li, W.3
  • 59
    • 68549104404 scopus 로고    scopus 로고
    • The sequence alignment/map format and SAMtools
    • Li, H. et al. The sequence alignment/map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 60
    • 84876263777 scopus 로고    scopus 로고
    • EBSeq: An empirical Bayes hierarchical model for inference in RNA-seq experiments
    • Leng, N. et al. EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments. Bioinformatics 29, 1035-1043 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 1035-1043
    • Leng, N.1
  • 61
    • 84942354206 scopus 로고    scopus 로고
    • Molecular portraits revealing the heterogeneity of breast tumor subtypes defined using immunohistochemistry markers
    • Dai, X., Li, Y., Bai, Z. & Tang, X. Q. Molecular portraits revealing the heterogeneity of breast tumor subtypes defined using immunohistochemistry markers. Sci. Rep. 5, 14499 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 14499
    • Dai, X.1    Li, Y.2    Bai, Z.3    Tang, X.Q.4
  • 62
    • 84964478511 scopus 로고    scopus 로고
    • Genefu: An R/Bioconductor package for computation of gene expression-based signatures in breast cancer
    • Gendoo, D. M. et al. Genefu: an R/Bioconductor package for computation of gene expression-based signatures in breast cancer. Bioinformatics 32, 1097-1099 (2016).
    • (2016) Bioinformatics , vol.32 , pp. 1097-1099
    • Gendoo, D.M.1
  • 63
    • 84864579879 scopus 로고    scopus 로고
    • TNBCtype: A subtyping tool for triple-negative breast cancer
    • Chen, X. et al. TNBCtype: a subtyping tool for triple-negative breast cancer. Cancer Inform. 11, 147-156 (2012).
    • (2012) Cancer Inform. , vol.11 , pp. 147-156
    • Chen, X.1
  • 64
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , pp. e47
    • Ritchie, M.E.1
  • 65
    • 84921424816 scopus 로고    scopus 로고
    • A description of the molecular signatures database (MSigDB) web site
    • Liberzon, A. A description of the molecular signatures database (MSigDB) web site. Methods Mol. Biol. 1150, 153-160 (2014).
    • (2014) Methods Mol. Biol. , vol.1150 , pp. 153-160
    • Liberzon, A.1
  • 66
    • 84955328286 scopus 로고    scopus 로고
    • The molecular signatures database (MSigDB) hallmark gene set collection
    • Liberzon, A. et al. The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 1, 417-425 (2015).
    • (2015) Cell Syst. , vol.1 , pp. 417-425
    • Liberzon, A.1
  • 67
    • 79958135926 scopus 로고    scopus 로고
    • Molecular signatures database (MSigDB) 3.0
    • Liberzon, A. et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27, 1739-1740 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 1739-1740
    • Liberzon, A.1
  • 68
    • 0035985177 scopus 로고    scopus 로고
    • Identification of genes periodically expressed in the human cell cycle and their expression in tumors
    • Whitfield, M. L. et al. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol. Biol. Cell 13, 1977-2000 (2002).
    • (2002) Mol. Biol. Cell , vol.13 , pp. 1977-2000
    • Whitfield, M.L.1
  • 69
    • 84874321000 scopus 로고    scopus 로고
    • Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments
    • McDavid, A. et al. Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments. Bioinformatics 29, 461-467 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 461-467
    • McDavid, A.1


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