Blockade of myeloid differentiation protein 2 prevents obesity-induced inflammation and nephropathy

Journal of Cellular and Molecular Medicine

Volumn 21, Issue 12, 2017, Pages 3776-3786

  Fang, Qilu ^a,b   Wang, Lintao ^a   Yang, Daona ^b   Chen, Xiong ^a   Shan, Xiaoou ^c   Zhang, Yali ^a   Lum, Hazel ^a   Wang, Jingying ^a   Zhong, Peng ^a   Liang, Guang ^a   Wang, Yi ^a,b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b The Affiliated Cangnan Hospital of Wenzhou Medical University   (China)

^c THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

free fatty acid; inflammation; myeloid differentiation 2; obesity; renal injury

Indexed keywords

BIOLOGICAL FACTOR; BOVINE SERUM ALBUMIN; CD68 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CREATININE; CURCUMIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; L 6H21; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MYELOID DIFFERENTIATION PROTEIN 2; NEUTRALIZING ANTIBODY; PALMITIC ACID; PEPTIDES AND PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; 2,3-DIMETHOXY-4'-ETHOXYCHALCONE; ANTIINFLAMMATORY AGENT; CHALCONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LY96 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN MD 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL ADHESION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; HYPERLIPIDEMIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY MASS; LIPID DIET; MACROPHAGE; MALE; MOUSE; NEPHRITIS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DEFICIENCY; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; KNOCKOUT MOUSE; MESANGIUM CELL; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CHALCONES; DIET, HIGH-FAT; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HYPERLIPIDEMIAS; KIDNEY; LYMPHOCYTE ANTIGEN 96; MACROPHAGES; MALE; MESANGIAL CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NEPHRITIS; NF-KAPPA B; OBESITY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

EID: 85026665363     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.13287     Document Type: Article

References (37)

1. Hsu CY, McCulloch CE, Iribarren C, et al. Body mass index and risk for end-stage renal disease. Ann Intern Med. 2006; 144: 21–8.
2. Redon J, Lurbe E. The kidney in obesity. Curr Hypertens Rep. 2015; 17: 555.
3. Wu Y, Liu Z, Xiang Z, et al. Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. Endocrinology. 2006; 147: 44–50.
4. Sarafidis PA. Obesity, insulin resistance and kidney disease risk: insights into the relationship. Curr Opin Nephrol Hypertens. 2008; 17: 450–6.
5. Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112: 1796–808.
6. Stienstra R, van Diepen JA, Tack CJ, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci USA. 2011; 108: 15324–9.
7. Decleves AE, Mathew AV, Cunard R, et al. AMPK mediates the initiation of kidney disease induced by a high-fat diet. J Am Soc Nephrol. 2011; 22: 1846–55.
8. Kim F, Pham M, Luttrell I, et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res. 2007; 100: 1589–96.
9. Kim JE, Lee MH, Nam DH, et al. Celastrol, an NF-kappaB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice. PLoS One. 2013; 8: e62068.
10. Coimbra TM, Janssen U, Grone HJ, et al. Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney Int. 2000; 57: 167–82.
11. Fang Q, Deng L, Wang L, et al. Inhibition of mitogen-activated protein kinases/nuclear factor kappaB-dependent inflammation by a novel chalcone protects the kidney from high fat diet-induced injuries in mice. J Pharmacol Exp Ther. 2015; 355: 235–46.
12. Hellmann J, Zhang MJ, Tang Y, et al. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. J Immunol. 2013; 191: 1383–92.
13. Shen H, Eguchi K, Kono N, et al. Saturated fatty acid palmitate aggravates neointima formation by promoting smooth muscle phenotypic modulation. Arterioscler Thromb Vasc Biol. 2013; 33: 2596–607.
14. Huang S, Rutkowsky JM, Snodgrass RG, et al. Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways. J Lipid Res. 2012; 53: 2002–13.
15. Lee JY, Sohn KH, Rhee SH, et al. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem. 2001; 276: 16683–9.
16. Schaeffler A, Gross P, Buettner R, et al. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity. Immunology. 2009; 126: 233–45.
17. Kennedy A, Martinez K, Chuang CC, et al. Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications. J Nutr. 2009; 139: 1–4.
18. Gupta S, Knight AG, Gupta S, et al. Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J Neurochem. 2012; 120: 1060–71.
19. Tian H, Liu C, Zou X, et al. MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells. Nutrients. 2015; 7: 3483–96.
20. Maloney E, Sweet IR, Hockenbery DM, et al. Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arterioscler Thromb Vasc Biol. 2009; 29: 1370–5.
21. Jia L, Vianna CR, Fukuda M, Berglund ED, Liu C, Tao C, et al. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance. Nat Commun. 2014; 5: 3878.
22. Hedayat M, Netea MG, Rezaei N. Targeting of Toll-like receptors: a decade of progress in combating infectious diseases. Lancet Infect Dis. 2011; 11: 702–12.
23. Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med. 2007; 13: 460–9.
24. Jialal I, Kaur H, Devaraj S. Toll-like receptor status in obesity and metabolic syndrome: a translational perspective. J Clin Endocrinol Metab. 2014; 99: 39–48.
25. Lee JY, Ye J, Gao Z, et al. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J Biol Chem. 2003; 278: 37041–51.
26. Lee JY, Zhao L, Youn HS, et al. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem. 2004; 279: 16971–9.
27. Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Investig. 2006; 116: 3015–25.
28. Wu J, Li J, Cai Y, et al. Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents. J Med Chem. 2011; 54: 8110–23.
29. Fang Q, Zhao L, Wang Y, et al. A novel chalcone derivative attenuates the diabetes-induced renal injury via inhibition of high glucose-mediated inflammatory response and macrophage infiltration. Toxicol Appl Pharmacol. 2015; 282: 129–38.
30. Bourgeois F, Alexiu A, Lemonnier D. Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice. Br J Nutr. 1983; 49: 17–26.
31. Takahashi M, Ikemoto S, Ezaki O. Effect of the fat/carbohydrate ratio in the diet on obesity and oral glucose tolerance in C57BL/6J mice. J Nutr Sci Vitaminol (Tokyo). 1999; 45: 583–93.
32. Wang Y, Shan X, Chen G, et al. MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br J Pharmacol. 2015; 172: 4391–405.
33. Martinez-Morua A, Soto-Urquieta MG, Franco-Robles E, et al. Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice. J Asian Nat Prod Res. 2013; 15: 905–15.
34. Tu CT, Han B, Yao QY, et al. Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression. Int Immunopharmacol. 2012; 12: 151–7.
35. Tu CT, Yao QY, Xu BL, et al. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. Food Chem Toxicol. 2012; 50: 3343–51.
36. Jiang T, Wang Z, Proctor G, et al. Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway. J Biol Chem. 2005; 280: 32317–25.
37. Sieber J, Jehle AW. Free Fatty acids and their metabolism affect function and survival of podocytes. Front Endocrinol (Lausanne). 2014; 5: 186.