A novel chalcone derivative attenuates the diabetes-induced renal injury via inhibition of high glucose-mediated inflammatory response and macrophage infiltration

Toxicology and Applied Pharmacology

Volumn 282, Issue 2, 2015, Pages 129-138

  Fang, Qilu ^a   Zhao, Leping ^a   Wang, Yi ^a   Zhang, Yali ^a   Li, Zhaoyu ^b   Pan, Yong ^a   Kanchana, Karvannan ^a   Wang, Jingying ^a   Tong, Chao ^a   Li, Dan ^a   Liang, Guang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Anti inflammation; Chalcone derivative; Diabetic nephropathy; Macrophage infiltration; MAPKs; NF B

Indexed keywords

CELL ADHESION MOLECULE; CHALCONE DERIVATIVE; CREATININE; GAMMA INTERFERON; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 33; INTERLEUKIN 6; L 6H 21; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL INFILTRATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DOWN REGULATION; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY PARENCHYMA; MACROPHAGE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TREATMENT DURATION; UREA NITROGEN BLOOD LEVEL; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; COMPLICATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUG EFFECTS; INFLAMMATION; KIDNEY; MALE; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL ADHESION; CELLS, CULTURED; CHALCONES; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; GLUCOSE; INFLAMMATION; KIDNEY; MALE; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NF-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84919948651     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.10.021     Document Type: Article

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