Saturated fatty acid palmitate aggravates neointima formation by promoting smooth muscle phenotypic modulation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 33, Issue 11, 2013, Pages 2596-2607

  Shen, Hua ^a   Eguchi, Kosei ^a   Kono, Nozomu ^c   Fujiu, Katsuhito ^a,b   Matsumoto, Sahohime ^a   Shibata, Munehiko ^a   Oishi Tanaka, Yumiko ^d   Komuro, Issei ^a   Arai, Hiroyuki ^c   Nagai, Ryozo ^a,e   Manabe, Ichiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

fatty acid; inflammation; lipotoxicity; phenotypic modulation; reactive oxygen species; smooth muscle; toll like receptor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KRUPPEL LIKE FACTOR 5; MATRIX METALLOPROTEINASE; MYELOID DIFFERENTIATION FACTOR 88; MYOCARDIN; MYOSIN HEAVY CHAIN; PALMITIC ACID ETHYL ESTER; PLATELET DERIVED GROWTH FACTOR B; PROTEIN; PROTEIN ACTA2; PROTEIN MYH11; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; STROMELYSIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SRF; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; BLOOD VESSEL INJURY; CAROTID ARTERY LIGATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; INFLAMMATION; MALE; MEDIATOR RELEASE; MOUSE; NEOINTIMA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION;

FATTY ACID; INFLAMMATION; LIPOTOXICITY; PHENOTYPIC MODULATION; REACTIVE OXYGEN SPECIES; SMOOTH MUSCLE; TOLL-LIKE RECEPTOR;

ANIMALS; CAROTID ARTERY INJURIES; DISEASE MODELS, ANIMAL; FATTY ACIDS; LIGATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; MYOCYTES, SMOOTH MUSCLE; NADH, NADPH OXIDOREDUCTASES; NEOINTIMA; OBESITY; PALMITATES; PHENOTYPE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84887051458     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.113.302099     Document Type: Article

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