Medicinal plants as protective strategies against parkinson’s disease

Current Pharmaceutical Design

Volumn 23, Issue 28, 2017, Pages 4180-4188

  Mazo, Natalia Areiza ^a   Echeverria, Valentina ^b,c   Cabezas, Ricardo ^a   Ávila Rodriguez, Marco ^a   Tarasov, Vadim V ^d   Yarla, Nagendra S ^e   Aliev, Gjumrakch ^f,g,h   Barreto, George E ^a,i  

^a PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^b UNIVERSIDAD SAN SEBASTIÁN   (Chile)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d I M SECHENOV FIRST MOSCOW STATE MEDICAL UNIVERSITY   (Russian Federation)

^e GITAM UNIVERSITY   (India)

^f GALLY International Biomedical Research Consulting LLC   (United States)

^g University of Atlanta   (United States)

^h INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

ⁱ UNIVERSIDAD AUTÓNOMA DE CHILE   (Chile)

Author keywords

Dopaminergic neurons; Neuroprotective fruits; Parkinson s disease; Phytochemicals; Signaling pathways; Transcription factors

Indexed keywords

ANTHOCYANIN; DOPA DECARBOXYLASE INHIBITOR; FLAVONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOTHIOCYANIC ACID; LEVODOPA; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE; NARINGENIN; NOBILETIN; PLANT MEDICINAL PRODUCT; POLYMETHOXYLFLAVONE; REACTIVE OXYGEN METABOLITE; SULFORAPHANE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; ANTIPARKINSON AGENT; FREE RADICAL; NEUROPROTECTIVE AGENT;

AGING; ANTIINFLAMMATORY ACTIVITY; BIOSYNTHESIS; CELL SURVIVAL; DEVELOPMENTAL DELAY; DOPAMINERGIC NERVE CELL; FRUIT; HUMAN; MEDICINAL PLANT; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PI3K/AKT SIGNALING; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; RISK FACTOR; THERAPY EFFECT; ANIMAL; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION; METABOLISM; PATHOPHYSIOLOGY;

ANIMALS; ANTIOXIDANTS; ANTIPARKINSON AGENTS; DOPAMINERGIC NEURONS; FREE RADICALS; HUMANS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PARKINSON DISEASE; PLANT PREPARATIONS; PLANTS, MEDICINAL; REACTIVE OXYGEN SPECIES;

EID: 85026505069     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612823666170316142803     Document Type: Review

References (85)

1. Lees AJ, Hardy J, Revesz T. Parkinson’s disease. Lancet 2009; 373:2055-66.
2. Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008; 4: 89-96.
3. Zhang XY, Yao JK. Oxidative stress and therapeutic implications in psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 2013; 46: 197-9.
4. Cabezas R, Avila MF, Torrente D, et al. Natural antioxidants in dementia: an overview. In: ed.eds., Diet and Nutrition in Dementia and cognitive decline series book. Academic Press, 2014.
5. Esposito E, Rotilio D, Di Matteo V, Di Giulio C, Cacchio M, Algeri S. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging 2002; 23: 719-35.
6. Lau FC, Bielinski DF, Joseph JA. Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J Neurosci Res 2007; 85: 1010-7.
7. Spencer JP. Flavonoids: modulators of brain function? Br J Nutr, 2008; 99 E Suppl 1: ES60-77.
8. Joseph JA, Shukitt-Hale B, Lau FC. Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Ann N Y Acad Sci 2007; 1100: 470-85.
9. Jurado-Coronel JC, Avila-Rodriguez M, Echeverria V, et al. Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease. CNS Neurol Disord Drug Targets 2016; 15:292-300.
10. Albarracin SL, Stab B, Casas Z, et al. Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci 2012; 15:1-9.
11. Blasa M, Gennari L, Angelino D, Ninfali P. Fruit and vegetable antioxidants in health. In: ed. eds., Bioactive Foods in Promoting Health. Elsevier 2010; pp. 37-58.
12. Sutachan JJ, Casas Z, Albarracin SL, et al. Cellular and molecular mechanisms of antioxidants in Parkinson’s disease. Nutr Neurosci 2012; 15: 120-6.
13. Choi DK, Koppula S, Suk K. Inhibitors of microglial neurotoxicity:focus on natural products. Molecules 2011; 16: 1021-43.
14. Essa MM, Vijayan RK, Castellano-Gonzalez G, Memon MA, Braidy N, Guillemin GJ. Neuroprotective effect of natural products against Alzheimer’s disease. Neurochem Res 2012; 37: 1829-42.
15. Mythri RB, Harish G, Bharath MM. Therapeutic potential of natural products in Parkinson’s disease. Recent Pat Endocr Metab Immune Drug Discov 2012; 6: 181-200.
16. Cabezas R, Avila M, Gonzalez J, et al. Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease. Front Cell Neurosci 2014; 8: 211.
17. Dexter DT, Jenner P. Parkinson disease: from pathology to molecular disease mechanisms. Free Radic Biol Med 2013; 62:132-44.
18. Dos Santos AB, Barreto GE, Kohlmeier KA. Treatment of sleeping disorders should be considered in clinical management of Parkinson’s disease. Front Aging Neurosci 2014; 6: 273.
19. dos Santos AB, Kohlmeier KA, Barreto GE. Are sleep disturbances preclinical markers of Parkinson’s disease? Neurochem Res 2015; 40: 421-7.
20. Barreto G, White RE, Ouyang Y, Xu L, Giffard RG. Astrocytes:targets for neuroprotection in stroke. Cent Nerv Syst Agents Med Chem 2011; 11: 164-73.
21. Barreto GE, Gonzalez J, Torres Y, Morales L. Astrocytic-neuronal crosstalk: implications for neuroprotection from brain injury. Neurosci Res, 2011; 71: 107-13.
22. Barreto GE, Guedes RC. Polyphenols and neurodegenerative diseases. Nutr Neurosci 2012; 15: 92-3.
23. Cabezas R, Avila MF, Gonzalez J, El-Bacha RS, Barreto GE. PDGF-BB protects mitochondria from rotenone in T98G cells. Neurotox Res 2015; 27: 355-67.
24. Cabezas R, El-Bacha RS, Gonzalez J, Barreto GE. Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone. Neurosci Res 2012; 74: 80-90.
25. Chaturvedi RK, Flint Beal M. Mitochondrial diseases of the brain. Free Radic Biol Med 2013; 63: 1-29.
26. Federico A, Cardaioli E, Da Pozzo P, Formichi P, Gallus GN, Radi E. Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci 2012; 322: 254-62.
27. Jellinger KA. How close are we to revealing the etiology of Parkinson’s disease? Expert Rev Neurother 2015; 15: 1105-7.
28. Blesa J, Trigo-Damas I, Quiroga-Varela A, Jackson-Lewis VR. Oxidative stress and Parkinson’s disease. Front Neuroanat 2015; 9:91.
29. Abeti R, Abramov AY. Mitochondrial Ca(2+) in neurodegenerative disorders. Pharmacol Res 2015; 99: 377-81.
30. Petrucci S, Arena G, Valente EM. Genetics and Molecular Biology of Parkinson Disease. In: ed. eds., Movement Disorders. Elsevier 2015; pp. 342-257.
31. Mythri RB, Venkateshappa C, Harish G, et al. Evaluation of markers of oxidative stress, antioxidant function and astrocytic proliferation in the striatum and frontal cortex of Parkinson’s disease brains. Neurochem Res 2011; 36: 1452-63.
32. Ruszkiewicz J, Albrecht J. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Neurochem Int 2015; 88: 66-72.
33. Dey A, Nath DJ. Possible Anti-Parkinson’s Disease Therapeutics From Nature: A Review. In: ed. eds., Studies in Natural Products Chemistry. Elsevier 2015; pp. 447-520.
34. Sun AG, Lin AQ, Huang SY, Huo D, Cong CH. Identification of potential drugs for Parkinson’s disease based on a sub-pathway method. Int J Neurosci 2016; 126: 318-25.
35. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84.
36. Halliwell B. Biochemistry of oxidative stress. Biochem Soc Trans 2007; 35: 1147-50.
37. Patel VP, Chu CT. Nuclear transport, oxidative stress, and neurodegeneration. Int J Clin Exp Pathol 2011; 4: 215-29.
38. Carocho M, Ferreira IC. A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food Chem Toxicol 2013; 51: 15-25.
39. Sandoval-Acuna C, Ferreira J, Speisky H Polyphenols and mitochondria: an update on their increasingly emerging ROSscavenging independent actions. Arch Biochem Biophys 2014; 559: 75-90.
40. Cui Y, Wu J, Jung SC, et al. Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation. Biol Pharm Bull 2010; 33: 1814-21.
41. Ebrahimi A, Schluesener H. Natural polyphenols against neurodegenerative disorders: potentials and pitfalls. Ageing Res Rev 2012; 11: 329-45.
42. Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis 2009; 16: 85-91.
43. Schroeder EK, Kelsey NA, Doyle J, et al. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid Redox Signal 2009; 11: 469-80.
44. Spencer JP. The impact of flavonoids on memory: physiological and molecular considerations. Chem Soc Rev 2009; 38: 1152-61.
45. Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP. The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 2008; 3: 115-26.
46. Forman HJ, Augusto O, Brigelius-Flohe R, et al. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med 2015; 78: 233-5.
47. Halliwell B. Cell culture, oxidative stress, and antioxidants:avoiding pitfalls. Biomed J 2014; 37: 99-105.
48. Seifried HE, Anderson DE, Fisher EI, Milner JA. A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem 2007; 18: 567-79.
49. Nazam Ansari M, Bhandari U, Islam F, Tripathi CD. Evaluation of antioxidant and neuroprotective effect of ethanolic extract of Embelia ribes Burm in focal cerebral ischemia/reperfusion-induced oxidative stress in rats. Fundam Clin Pharmacol 2008; 22: 305-14.
50. Echeverria V, Alex Grizzell J, Barreto GE. Neuroinflammation: A Therapeutic Target of Cotinine for the Treatment of Psychiatric Disorders? Curr Pharm Des 2016; 22: 1324-33.
51. Leszek J, Barreto GE, Gasiorowski K, Koutsouraki E, Avila-Rodrigues M, Aliev G. Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System. CNS Neurol Disord Drug Targets 2016; 15: 329-36.
52. Blach-Olszewska Z, Zaczynska E, Gustaw-Rothenberg K, et al. The Innate Immunity in Alzheimer Disease- Relevance to Pathogenesis and Therapy. Curr Pharm Des 2015; 21: 3582-8.
53. Barreto GE, Iarkov A, Moran VE. Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease. Front Aging Neurosci 2014; 6: 340.
54. Spencer JP, Vafeiadou K, Williams RJ, Vauzour D. Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med 2012; 33: 83-97.
55. Vauzour D, Martinsen A, Laye S. Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects? Neurochem Int 2015; 89: 63-74.
56. Bornsek SM, Ziberna L, Polak T, et al. Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells. Food Chem 2012; 134: 1878-84.
57. Campos-Esparza MR, Sanchez-Gomez MV, Matute C. Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols. Cell Calcium 2009; 45: 358-68.
58. Kim HG, Ju MS, Shim JS, et al. Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson’s disease models. Br J Nutr 2010; 104: 8-16.
59. Shih PH, Chan YC, Liao JW, Wang MF, Yen GC. Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer’s disease. J Nutr Biochem 2010; 21: 598-605.
60. Vuong T, Matar C, Ramassamy C, Haddad PS. Biotransformed blueberry juice protects neurons from hydrogen peroxide-induced oxidative stress and mitogen-activated protein kinase pathway alterations. Br J Nutr 2010; 104: 656-63.
61. Shukitt-Hale B, Lau FC, Carey AN, et al. Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutr Neurosci 2008; 11: 172-82.
62. Fujishita K, Ozawa T, Shibata K, et al. Grape seed extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms. Cell Mol Neurobiol 2009; 29: 1121-9.
63. Wang YJ, Thomas P, Zhong JH, et al. Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer’s disease mouse. Neurotox Res 2009; 15: 3-14.
64. Zhang L, Zhao H, Zhang X, et al. Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat. Brain Res Bull 2013; 96: 45-53.
65. Ihara H, Yamamoto H, Ida T, et al. Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes. Biosci Biotechnol Biochem 2012; 76: 1843-8.
66. Vafeiadou K, Vauzour D, Lee HY, Rodriguez-Mateos A, Williams RJ, Spencer JP. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch Biochem Biophys 2009; 484: 100-9.
67. Rojanathammanee L, Puig KL, Combs CK. Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease. J Nutr 2013; 143: 597-605.
68. Xia E, He X, Li H, Wu S, Li S, Deng G. Biological Activities of Polyphenols from Grapes. In: ed.eds., olyphenols in Human Health and Disease 2013; pp. 47-58.
69. Meng XL, Yang JY, Chen GL, et al. Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships. Chem Biol Interact 2008; 174: 51-9.
70. Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases:a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004; 68: 320-44.
71. Erlund I. Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res 2004; 24: 851-74.
72. Lee JM, Johnson JA. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol 2004; 37:139-43.
73. Lin Y, Shi R, Wang X, Shen HM. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets 2008; 8: 634-46.
74. Qiao H, Zhang X, Zhu C, et al. Luteolin downregulates TLR4, TLR5, NF-kappaB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia. Brain Res 2012; 1448: 71-81.
75. Singh S, Vrishni S, Singh BK, Rahman I, Kakkar P. Nrf2-ARE stress response mechanism: a control point in oxidative stressmediated dysfunctions and chronic inflammatory diseases. Free Radic Res 2010; 44: 1267-88.
76. Denzer I, Munch G, Friedland K. Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds. Pharmacol Res 2016; 103: 80-94.
77. Zeng X, Zhou X, Cui L, et al. The fruits of wampee inhibit H2O2- induced apoptosis in PC12 cells via the NF-kappaB pathway and regulation of cellular redox status. Molecules 2014; 19: 7368-87.
78. Goyarzu P, Malin DH, Lau FC, et al. Blueberry supplemented diet:effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr Neurosci 2004; 7: 75-83.
79. Fahrig T, Gerlach I, Horvath E. A synthetic derivative of the natural product rocaglaol is a potent inhibitor of cytokine-mediated signaling and shows neuroprotective activity in vitro and in animal models of Parkinson’s disease and traumatic brain injury. Mol Pharmacol 2005; 67: 1544-55.
80. Davinelli S, Bertoglio JC, Zarrelli A, Pina R, Scapagnini G. A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin-Maqui Berry Extract (Delphinol(R)) on Oxidative Stress Biomarkers. J Am Coll Nutr 2015; 34 Suppl 1: 28-33.
81. Krikorian R, Shidler MD, Nash TA, et al. Blueberry supplementation improves memory in older adults. J Agric Food Chem 2010; 58: 3996-4000.
82. Krikorian R, Boespflug EL, Fleck DE, et al. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem 2012; 60: 5736-42.
83. Sokolov AN, Pavlova MA, Klosterhalfen S, Enck P. Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behavior. Neurosci Biobehav Rev 2013; 37: 2445-53.
84. Desideri G, Kwik-Uribe C, Grassi D, et al. Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study. Hypertension 2012; 60: 794-801.
85. Mastroiacovo D, Kwik-Uribe C, Grassi D, et al. Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study--a randomized controlled trial. Am J Clin Nutr 2015; 101: 538-48.