Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat

Brain Research Bulletin

Volumn 96, Issue , 2013, Pages 45-53

  Zhang, Lan ^a   Zhao, Huiying ^d   Zhang, Xiangjian ^a,b,c   Chen, Linyu ^a   Zhao, Xumeng ^a   Bai, Xue ^a   Zhang, Jian ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Hebei Institute of Cardio Cerebral Vascular Diseases   (China)

^c Hebei Key Laboratory for Neurology   (China)

^d FIRST HOSPITAL OF SHIJIAZHUANG   (China)

Author keywords

Akt CREB; Bcl 2; BDNF; Claudin 5; Ischemic stroke; Neuroprotection; Nobiletin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CLAUDIN 5; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NOBILETIN; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; COGNITIVE DEFECT; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AKT/CREB; BCL-2; BDNF; ISCHEMIC STROKE; NEUROPROTECTION; NOBILETIN;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CLAUDIN-5; FLAVONES; GENES, BCL-2; MALE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84878791565     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2013.04.009     Document Type: Article

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