Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease

Journal of Nutritional Biochemistry

Volumn 21, Issue 7, 2010, Pages 598-605

  Shih, Ping Hsiao ^a   Chan, Yin Ching ^b   Liao, Jiunn Wang ^a   Wang, Ming Fu ^b   Yen, Gow Chin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b PROVIDENCE UNIVERSITY   (Taiwan)

Author keywords

Amyloid; Anthocyanin; MAPK; Mulberry; Nrf2; SAMP8

Indexed keywords

ALANINE AMINOTRANSFERASE; AMYLOID BETA PROTEIN; ANTHOCYANIN; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; MULBERRY EXTRACT; PHENOL DERIVATIVE; TRANSCRIPTION FACTOR NF E2; TRANSCRIPTION FACTOR NRF2; TRIACYLGLYCEROL; ISOPROSTANE DERIVATIVE; PLANT EXTRACT;

AGING; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AVOIDANCE BEHAVIOR; BODY WEIGHT; BRAIN; CHOLESTEROL BLOOD LEVEL; COGNITION; CONTROLLED STUDY; DIET; DIET SUPPLEMENTATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME REGULATION; GENE EXPRESSION; LEARNING; LIPID OXIDATION; LIVER; LIVER FUNCTION; LIVER PROTECTION; MALE; MEMORY; MORUS ATROPURPUREA; MOUSE; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PROTEIN TRANSPORT; SENESCENCE ACCELERATED MOUSE; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; CHEMISTRY; COGNITION DISORDERS; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; FRUIT; METABOLISM; MORUS; PHYTOTHERAPY; RANDOMIZATION;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTHOCYANINS; ANTIOXIDANTS; BRAIN; COGNITION DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; ISOPROSTANES; LEARNING; LIPIDS; LIVER; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MORUS; NF-E2 TRANSCRIPTION FACTOR; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN TRANSPORT; RANDOM ALLOCATION; AMYLOID BETA-PEPTIDES;

ANIMALIA; MORUS (ANGIOSPERM); MORUS ATROPURPUREA; MUS;

EID: 77953808751     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.03.008     Document Type: Article

References (53)

1. Candore G., Balistreri C.R., Listi F., Grimaldi M.P., Vasto S., Colonna-Romano G. Immunogenetics, gender, and longevity. Ann N Y Acad Sci 2006, 1089:516-537.
2. Sansoni P., Vescovini R., Fagnoni F., Biasini C., Zanni F., Zanlari L. The immune system in extreme longevity. Exp Gerontol 2008, 43:61-65.
3. Barzilai N., Atzmon G., Derby C.A., Bauman J.M., Lipton R.B. A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology 2006, 67:2170-2175.
4. Mehta P.D. Amyloid beta protein as a marker or risk factor of Alzheimer's disease. Curr Alzheimer Res 2007, 4:359-363.
5. Feng Z., Hu W., Teresky A.K., Hernando E., Cordon-Cardo C., Levine A.J. Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci U S A 2007, 104:16633-16638.
6. Finkel T., Serrano M., Blasco M.A. The common biology of cancer and ageing. Nature 2007, 448:767-774.
7. Dominguez L.J., Barbagallo M. The cardiometabolic syndrome and sarcopenic obesity in older persons. J Cardiometab Syndr 2007, 2:183-189.
8. Thomas S., Rich M.W. Epidemiology, pathophysiology, and prognosis of heart failure in the elderly. Heart Fail Clin 2007, 3:381-387.
9. Furie K.L., Smith E.E. Metabolic syndrome: a target for preventing leukoaraiosis and age-related dementia?. Neurology 2007, 69:951-952.
10. Maggi S., Noale M., Zambon A., Limongi F., Romanato G., Crepaldi G. Validity of the ATP III diagnostic criteria for the metabolic syndrome in an elderly Italian Caucasian population. The Italian Longitudinal Study on Aging. Atherosclerosis 2008, 197:877-882.
11. Takeda T., Hosokawa M., Higuchi K., Hosono M., Akiguchi I., Katoh H.A. novel murine model of aging, Senescence-Accelerated Mouse (SAM). Arch Gerontol Geriatr 1994, 19:185-192.
12. Butterfield D.A., Poon H.F. The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease. Exp Gerontol 2005, 40:774-783.
13. Chen C.C., Wang M.F., Liu M.H., Lin W.T., Yang S.K. Effects of age on plasma levels of calcium-regulating hormones and bone status in male SAMP8 mice. Chin J Physiol 2004, 47:7-14.
14. Liao J.W., Hsu C.K., Wang M.F., Hsu W.M., Chan Y.C. Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice. Br J Nutr 2006, 96:400-407.
15. Shimmyo Y., Kihara T., Akaike A., Niidome T., Sugimoto H. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochim Biophys Acta 2008, 1780:819-825.
16. Andallu B., Varadacharyulu N.C. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta 2003, 338:3-10.
17. Sakagami H., Asano K., Satoh K., Takahashi K., Kobayashi M., Koga N., et al. Anti-stress, anti-HIV and vitamin C-synergized radical scavenging activity of mulberry juice fractions. In Vivo 2007, 21:499-505.
18. Heo S.I., Jin Y.S., Jung M.J., Wang M.H. Antidiabetic properties of 2,5-dihydroxy-4,3′-di(beta-d-glucopyranosyloxy)-trans-stilbene from mulberry (Morus bombycis koidzumi) root in streptozotocin-induced diabetic rats. J Med Food 2007, 10:602-607.
19. Andres-Lacueva C., Shukitt-Hale B., Galli R.L., Jauregui O., Lamuela-Raventos R.M., Joseph J.A. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci 2005, 8:111-120.
20. Niidome T., Takahashi K., Goto Y., Goh S., Tanaka N., Kamei K. Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity. Neuroreport 2007, 18:813-816.
21. Dai Q., Borenstein A.R., Wu Y., Jackson J.C., Larson E.B. Fruit and vegetable juices and Alzheimer's disease: the Kame Project. Am J Med 2006, 119:751-759.
22. Toor R.K., Savage G.P. Antioxidant activity in different fractions of tomatoes. Food Res Int 2005, 38:487-494.
23. Lee C.P., Yen G.C. Antioxidant activity and bioactive compounds of tea seed (Camellia oleifera Abel.) oil. J Agric Food Chem 2006, 54:779-784.
24. Lawrence R.A., Burk R.F. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 1976, 71:952-958.
25. Bellomo G., Mirabelli F., DiMonte D., Richelmi P., Thor H., Orrenius C. Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone). Biochem Pharmacol 1987, 36:1313-1320.
26. Habig W.H., Pabst M.J., Fleischner G., Gatmaitan Z., Arias I.M., Jakoby W.B. The identity of glutathione S-transferase B with ligandin, a major binding protein of liver. Proc Natl Acad Sci U S A 1974, 71:3879-3882.
27. Cohen G., Dembiec D., Marcus J. Measurement of catalase activity in tissue extracts. Anal Biochem 1970, 34:30-38.
28. Anantharaju A., Feller A., Chedid A. Aging liver. A review. Gerontology 2002, 48:343-353.
29. Kwak M.K., Wakabayashi N., Itoh K., Motohashi H., Yamamoto M., Kensler T.W. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 2003, 278:8135-8145.
30. Suh J.H., Shenvi S.V., Dixon B.M., Liu H., Jaiswal A.K., Liu R.M. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A 2004, 101:3381-3386.
31. Shih P.H., Yen G.C. Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway. Biogerontology 2007, 8:71-80.
32. Yokozawa T., Kim H.Y., Kim H.J., Okubo T., Chu D.C., Juneja L.R. Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process. Br J Nutr 2007, 97:1187-1195.
33. Willis L.M., Shukitt-Hale B., Joseph J.A. Recent advances in berry supplementation and age-related cognitive decline. Curr Opin Clin Nutr Metab Care 2009, 12:91-94.
34. Tarozzi A., Merlicco A., Morroni F., Franco F., Cantelli-Forti G., Teti G. Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity. Neuroreport 2008, 19:1483-1486.
35. Shin W.H., Park S.J., Kim E.J. Protective effect of anthocyanins in middle cerebral artery occlusion and reperfusion model of cerebral ischemia in rats. Life Sci 2006, 79:130-137.
36. Rahman M.M., Ichiyanagi T., Komiyama T., Sato S., Konishi T. Effects of anthocyanins on psychological stress-induced oxidative stress and neurotransmitter status. J Agric Food Chem 2008, 56:7545-7550.
37. Williams C.M., El Mohsen M.A., Vauzour D., Rendeiro C., Butler L.T., Ellis J.A. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med 2008, 45:295-305.
38. Walton M.C., Lentle R.G., Reynolds G.W., Kruger M.C., McGhie T.K. Anthocyanin absorption and antioxidant status in pigs. J Agric Food Chem 2006, 54:7940-7946.
39. Moranska I., Jurczyk K., Klosinska E., Wisniewski K., Karpinska E., Wawrzynowicz-Syczewska M., et al. Relationship of serum alanine aminotransferase (ALT) to body weight, age and sex in blood donors population. Wiad Lek 2004, 57:427-430.
40. Elinav E., Ben-Dov I.Z., Ackerman E., Kiderman A., Glikberg F., Shapira Y., et al. Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern. Am J Gastroenterol 2005, 100:2201-2204.
41. Vila L., Roglans N., Alegret M., Camins A., Pallas M., Sanchez R.M., et al. Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression. J Gerontol A Biol Sci Med Sci 2007, 62:1219-1227.
42. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1912.
43. Dent P., Yacoub A., Fisher P.B., Hagan M.P., Grant S. MAPK pathways in radiation responses. Oncogene 2003, 22:5885-5896.
44. Keum Y.S., Han Y.H., Liew C., Kim J.H., Xu C., Yuan X., et al. Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes. Pharm Res 2006, 23:2586-2594.
45. Spencer J.P. The interactions of flavonoids within neuronal signalling pathways. Genes Nutr 2007, 2:257-273.
46. Spencer J.P. Flavonoids: modulators of brain function?. Br J Nutr 2008, 99(E Suppl 1):ES60-ES77.
47. Abidi P., Leers-Sucheta S., Cortez Y., Han J., Azhar S. Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats. Aging Cell 2008, 7:168-178.
48. Chen C., Kong A.N. Dietary chemopreventive compounds and ARE/EpRE signaling. Free Radic Biol Med 2004, 36:1505-1516.
49. Suzuki M., Betsuyaku T., Ito Y., Nagai K., Nasuhara Y., Kaga K., et al. Downregulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2008, 39:673-682.
50. Butterfield D.A., Drake J., Pocernich C., Castegna A. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol Med 2001, 7:548-554.
51. Yamada K., Tanaka T., Han D., Senzaki K., Kameyama T., Nabeshima T. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci 1999, 11:83-90.
52. Riviere C., Richard T., Vitrac X., Merillon J.M., Valls J., Monti J.P. New polyphenols active on beta-amyloid aggregation. Bioorg Med Chem Lett 2008, 18:828-831.
53. Haque A.M., Hashimoto M., Katakura M., Hara Y., Shido O. Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats. J Nutr Biochem 2008, 19:619-626.