Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes

Bioscience, Biotechnology and Biochemistry

Volumn 76, Issue 10, 2012, Pages 1843-1848

  Ihara, Hideshi ^a   Yamamoto, Hideyuki ^a   Ida, Tomoaki ^a   Tsutsuki, Hiroyasu ^b   Sakamoto, Tatsuji ^a   Fujita, Tomoyuki ^c   Okada, Toshiya ^a   Kozaki, Shunji ^a  

^a Osaka Prefecture University   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c SHINSHU UNIVERSITY   (Japan)

Author keywords

Astrocytes; Neuroprotective agent; Nitric oxide; Polymethoxyflavone; Young citrus

Indexed keywords

ASTROCYTES; CONCENTRATION-DEPENDENT; CYTOKINES; IN-VIVO; INDUCIBLE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); LIPOPOLYSACCHARIDES; METHANOL EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; MRNA EXPRESSION; NEURODEGENERATION; NEURONAL DEATH; NEUROPROTECTIVE AGENTS; NOBILETIN; NUCLEAR FACTORS; ORAL ADMINISTRATION; POLYMETHOXYFLAVONE; YOUNG CITRUS;

CITRUS FRUITS; METHANOL; NEURONS; PHOSPHORYLATION; RATS;

NITRIC OXIDE;

FLAVONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; METHANOL; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE;

ACTIVE TRANSPORT; ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; CELL DEATH; CELL NUCLEUS; CHEMISTRY; CITRUS; CYTOLOGY; DRUG EFFECT; FRUIT; GENE EXPRESSION REGULATION; GENETICS; GERBIL; HIPPOCAMPUS; ISOLATION AND PURIFICATION; METABOLISM; NERVE CELL; PHOSPHORYLATION; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ASTROCYTES; CELL DEATH; CELL NUCLEUS; CITRUS; FLAVONES; FRUIT; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GERBILLINAE; HIPPOCAMPUS; LIPOPOLYSACCHARIDES; METHANOL; NEURONS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS;

CITRUS; CITRUS UNSHIU; MERIONES UNGUICULATUS; RATTUS;

EID: 84868553912     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.120215     Document Type: Article

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