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Volumn 15, Issue 3, 2016, Pages 329-336

Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: Role of brain innate immune system

Author keywords

Microglia; Neurodegenerative disorders; Neuroinflammation; Oxidative stress; Toll like receptors

Indexed keywords

CD11B ANTIGEN; CD14 ANTIGEN; CD200 ANTIGEN; CD200 RECEPTOR; CD36 ANTIGEN; CD47 ANTIGEN; CHAPERONIN 60; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1BETA; INTERLEUKIN 6; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER RECEPTOR A; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 6; CYTOKINE;

EID: 84961577153     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527315666160202125914     Document Type: Article
Times cited : (153)

References (102)
  • 1
    • 5644271409 scopus 로고    scopus 로고
    • Role of Microglia in Central Nervous System Infections
    • Rock RB, et al., Role of Microglia in Central Nervous System Infections. Clinical Microbiology Reviews 2004; 17(4): 942-964.
    • (2004) Clinical Microbiology Reviews , vol.17 , Issue.4 , pp. 942-964
    • Rock, R.B.1
  • 2
    • 0033305132 scopus 로고    scopus 로고
    • Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain
    • Zwain, I.H. and S.S.C. Yen, Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain. Endocrinology 1999; 140(8): 3843-3852.
    • (1999) Endocrinology , vol.140 , Issue.8 , pp. 3843-3852
    • Zwain, I.H.1    Yen, S.S.C.2
  • 3
    • 82955168362 scopus 로고    scopus 로고
    • Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation
    • Bélanger M, I. Allaman, and P.J. Magistretti, Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation. Cell Metabolism 2011; 14(6): 724-738.
    • (2011) Cell Metabolism , vol.14 , Issue.6 , pp. 724-738
    • Bélanger, M.1    Allaman, I.2    Magistretti, P.J.3
  • 4
    • 84857324023 scopus 로고    scopus 로고
    • Substrate Micropatterning as a New in Vitro Cell Culture System to Study Myelination
    • Liazoghli D, et al., Substrate Micropatterning as a New in Vitro Cell Culture System to Study Myelination. ACS Chemical Neuroscience 2012; 3(2): 90-95.
    • (2012) ACS Chemical Neuroscience , vol.3 , Issue.2 , pp. 90-95
    • Liazoghli, D.1
  • 5
    • 84861037984 scopus 로고    scopus 로고
    • Immune System in the Brain: A Modulatory Role on Dendritic Spine Morphophysiology?
    • Bitzer-Quintero, O.K. and I. González-Burgos, Immune System in the Brain: A Modulatory Role on Dendritic Spine Morphophysiology? Neural Plasticity 2012; 2012.
    • (2012) Neural Plasticity , pp. 2012
    • Bitzer-Quintero, O.K.1    González-Burgos, I.2
  • 6
    • 84884246344 scopus 로고    scopus 로고
    • Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain
    • Ramesh G, A.G. MacLean, and M.T. Philipp, Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain. Mediators of Inflammation 2013; 2013.
    • (2013) Mediators of Inflammation , pp. 2013
    • Ramesh, G.1    Maclean, A.G.2    Philipp, M.T.3
  • 7
    • 84901806613 scopus 로고    scopus 로고
    • Shared Mechanisms of Neurodegeneration in Alzheimer's Disease and Parkinson's Disease
    • Xie A, et al., Shared Mechanisms of Neurodegeneration in Alzheimer's Disease and Parkinson's Disease. BioMed Research International 2014; 2014.
    • (2014) Biomed Research International , pp. 2014
    • Xie, A.1
  • 8
    • 34547565168 scopus 로고    scopus 로고
    • Nutritional intervention in brain aging: Reducing the effects of inflammation and oxidative stress
    • Lau FC, B. Shukitt-Hale, and J.A. Joseph, Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress. Subcell Biochem 2007; 42: 299-318.
    • (2007) Subcell Biochem , vol.42 , pp. 299-318
    • Lau, F.C.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 9
    • 33745758241 scopus 로고    scopus 로고
    • Inflammation and dementia: Epidemiologic evidence
    • Peila, R. and L.J. Launer, Inflammation and dementia: epidemiologic evidence. Acta Neurol Scand Suppl 2006; 185: 102-6.
    • (2006) Acta Neurol Scand Suppl , vol.185 , pp. 102-106
    • Peila, R.1    Launer, L.J.2
  • 10
    • 84961568698 scopus 로고    scopus 로고
    • The Israel Society for Neuroscience 18th Annual Meeting
    • Abstracts
    • Abstracts The Israel Society for Neuroscience 18th Annual Meeting. Journal of Molecular Neuroscience 2009; 39(1): 1-132.
    • (2009) Journal of Molecular Neuroscience , vol.39 , Issue.1 , pp. 1-132
  • 11
    • 77954865635 scopus 로고    scopus 로고
    • Systemic inflammatory cells fight off neurodegenerative disease
    • Schwartz, M. and R. Shechter, Systemic inflammatory cells fight off neurodegenerative disease. Nat Rev Neurol 2010; 6(7): 405-10.
    • (2010) Nat Rev Neurol , vol.6 , Issue.7 , pp. 405-410
    • Schwartz, M.1    Shechter, R.2
  • 12
    • 42749097973 scopus 로고    scopus 로고
    • Immunity to self and self-maintenance: A unified theory of brain pathologies
    • Schwartz, M. and Y. Ziv, Immunity to self and self-maintenance: a unified theory of brain pathologies. Trends Immunol 2008; 29(5): 211-9.
    • (2008) Trends Immunol , vol.29 , Issue.5 , pp. 211-219
    • Schwartz, M.1    Ziv, Y.2
  • 13
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: Too much or too little?
    • Lucin, K.M. and T. Wyss-Coray, Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 2009; 64(1): 110-22.
    • (2009) Neuron , vol.64 , Issue.1 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 14
    • 84911453156 scopus 로고    scopus 로고
    • Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus
    • Ashraf GM, et al., Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus. CNS & neurological disorders drug targets 2014; 13(7): 1280-1293.
    • (2014) CNS & Neurological Disorders Drug Targets , vol.13 , Issue.7 , pp. 1280-1293
    • Ashraf, G.M.1
  • 15
    • 84921911946 scopus 로고    scopus 로고
    • Proteomics approaches to understand linkage between Alzheimer's disease and type 2 diabetes mellitus
    • Mirza Z, et al., Proteomics approaches to understand linkage between Alzheimer's disease and type 2 diabetes mellitus. CNS & neurological disorders drug targets 2014; 13(2): 213-225.
    • (2014) CNS & Neurological Disorders Drug Targets , vol.13 , Issue.2 , pp. 213-225
    • Mirza, Z.1
  • 16
    • 84889860617 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial damage and neurodegenerative diseases
    • Guo C, et al., Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res 2013; 8(21): 2003-14.
    • (2013) Neural Regen Res , vol.8 , Issue.21 , pp. 2003-2014
    • Guo, C.1
  • 17
    • 33750292972 scopus 로고    scopus 로고
    • Cell death in the nervous system
    • Bredesen DE, R.V. Rao, and P. Mehlen, Cell death in the nervous system. Nature 2006; 443(7113): 796-802.
    • (2006) Nature , vol.443 , Issue.7113 , pp. 796-802
    • Bredesen, D.E.1    Rao, R.V.2    Mehlen, P.3
  • 18
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways in neurodegeneration
    • Rubinsztein DC, The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 2006; 443(7113): 780-6.
    • (2006) Nature , vol.443 , Issue.7113 , pp. 780-786
    • Rubinsztein, D.C.1
  • 19
    • 66449130960 scopus 로고    scopus 로고
    • Regulation of innate immune responses in the brain
    • Rivest S, Regulation of innate immune responses in the brain. Nat Rev Immunol 2009; 9(6): 429-39.
    • (2009) Nat Rev Immunol , vol.9 , Issue.6 , pp. 429-439
    • Rivest, S.1
  • 20
    • 33747349769 scopus 로고    scopus 로고
    • Debate: "is increasing neuroinflammation beneficial for neural repair?"
    • Crutcher KA, et al., Debate: "is increasing neuroinflammation beneficial for neural repair?". J Neuroimmune Pharmacol 2006; 1(3): 195-211.
    • (2006) J Neuroimmune Pharmacol , vol.1 , Issue.3 , pp. 195-211
    • Crutcher, K.A.1
  • 21
    • 43949114888 scopus 로고    scopus 로고
    • Can the immune system be harnessed to repair the CNS?
    • Popovich, P.G. and E.E. Longbrake, Can the immune system be harnessed to repair the CNS? Nat Rev Neurosci 2008; 9(6): 481-93.
    • (2008) Nat Rev Neurosci , vol.9 , Issue.6 , pp. 481-493
    • Popovich, P.G.1    Longbrake, E.E.2
  • 22
    • 35348966882 scopus 로고    scopus 로고
    • Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention
    • Tansey MG, M.K. McCoy, and T.C. Frank-Cannon, Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol 2007; 208(1): 1-25.
    • (2007) Exp Neurol , vol.208 , Issue.1 , pp. 1-25
    • Tansey, M.G.1    McCoy, M.K.2    Frank-Cannon, T.C.3
  • 24
    • 84925643755 scopus 로고    scopus 로고
    • Protection after stroke: Cellular effectors of neurovascular unit integrity
    • Posada-Duque RA, G.E. Barreto, and G.P. Cardona-Gomez, Protection after stroke: cellular effectors of neurovascular unit integrity. Front Cell Neurosci 2014; 8: 231.
    • (2014) Front Cell Neurosci , vol.8 , pp. 231
    • Posada-Duque, R.A.1    Barreto, G.E.2    Cardona-Gomez, G.P.3
  • 25
    • 84919767830 scopus 로고    scopus 로고
    • Spatial, Temporal, and Functional Aspects of Macrophages during "The Good, the Bad, and the Ugly" Phases of Inflammation
    • Harris RA, Spatial, Temporal, and Functional Aspects of Macrophages during "The Good, the Bad, and the Ugly" Phases of Inflammation. Front Immunol 2014; 5: 612.
    • (2014) Front Immunol , vol.5 , pp. 612
    • Harris, R.A.1
  • 26
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
    • Block, M.L. and J.S. Hong, Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 2005; 76(2): 77-98.
    • (2005) Prog Neurobiol , vol.76 , Issue.2 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 27
    • 34548822734 scopus 로고    scopus 로고
    • The role of anti-inflammatory agents in Parkinson's disease
    • McGeer, E.G. and P.L. McGeer, The role of anti-inflammatory agents in Parkinson's disease. CNS Drugs 2007; 21(10): 789-97.
    • (2007) CNS Drugs , vol.21 , Issue.10 , pp. 789-797
    • McGeer, E.G.1    McGeer, P.L.2
  • 28
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • Mrak, R.E. and W.S. Griffin, Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 2005; 26(3): 349-54.
    • (2005) Neurobiol Aging , vol.26 , Issue.3 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 29
    • 84905447142 scopus 로고    scopus 로고
    • Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
    • Cabezas R, et al., Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease. Front Cell Neurosci 2014; 8: 211.
    • (2014) Front Cell Neurosci , vol.8 , pp. 211
    • Cabezas, R.1
  • 30
    • 22944484112 scopus 로고    scopus 로고
    • The Immune System, Involvement in Neurodegenerative Diseases, Ageing and Cancer
    • Booy E, et al., The Immune System, Involvement in Neurodegenerative Diseases, Ageing and Cancer. Current Medicinal Chemistry anti-inflammatory & anti-allergy agents 2013; 4(4): 349-352.
    • (2013) Current Medicinal Chemistry Anti-Inflammatory & Anti-Allergy Agents , vol.4 , Issue.4 , pp. 349-352
    • Booy, E.1
  • 31
    • 72449204160 scopus 로고    scopus 로고
    • Does neuroinflammation fan the flame in neurodegenerative diseases?
    • Frank-Cannon TC, et al., Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 2009; 4: 47.
    • (2009) Mol Neurodegener , vol.4 , pp. 47
    • Frank-Cannon, T.C.1
  • 32
    • 55949106066 scopus 로고    scopus 로고
    • Cytokines in CNS Inflammation and Disease
    • T.E.C., M. Lane, C. Bergmann, and T. Wyss-Coray, Editors, Springer: New York
    • Tansey, M.G. and T. Wyss-Coray, Cytokines in CNS Inflammation and Disease, in Central Nervous System Diseases and Inflammation, T.E.C., M. Lane, C. Bergmann, and T. Wyss-Coray, Editors. 2008, Springer: New York. p. 59-106.
    • (2008) Central Nervous System Diseases and Inflammation , pp. 59-106
    • Tansey, M.G.1    Wyss-Coray, T.2
  • 33
    • 84904580418 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators regulate reactive microglia after penetrating brain injury
    • Barreto GE, M. Santos-Galindo, and L.M. Garcia-Segura, Selective estrogen receptor modulators regulate reactive microglia after penetrating brain injury. Front Aging Neurosci 2014; 6: 132.
    • (2014) Front Aging Neurosci , vol.6 , pp. 132
    • Barreto, G.E.1    Santos-Galindo, M.2    Garcia-Segura, L.M.3
  • 34
    • 84899867952 scopus 로고    scopus 로고
    • Targeting microglial activation in stroke therapy: Pharmacological tools and gender effects
    • Chen Y, et al., Targeting microglial activation in stroke therapy: pharmacological tools and gender effects. Curr Med Chem 2014; 21(19): 2146-55.
    • (2014) Curr Med Chem , vol.21 , Issue.19 , pp. 2146-2155
    • Chen, Y.1
  • 35
    • 84907021020 scopus 로고    scopus 로고
    • Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-alpha activation
    • Lee EJ, et al., Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-alpha activation. J Immunol 2014; 193(5): 2384-93.
    • (2014) J Immunol , vol.193 , Issue.5 , pp. 2384-2393
    • Lee, E.J.1
  • 36
    • 85078512554 scopus 로고    scopus 로고
    • MicroRNA-424 Protects Against Focal Cerebral Ischemia and Reperfusion Injury in Mice by Suppressing Oxidative Stress
    • Liu P, et al., MicroRNA-424 Protects Against Focal Cerebral Ischemia and Reperfusion Injury in Mice by Suppressing Oxidative Stress. Stroke 2014;
    • (2014) Stroke
    • Liu, P.1
  • 37
    • 84897464560 scopus 로고    scopus 로고
    • PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury
    • Stoica BA, et al., PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury. J Neurotrauma 2014; 31(8): 758-72.
    • (2014) J Neurotrauma , vol.31 , Issue.8 , pp. 758-772
    • Stoica, B.A.1
  • 38
    • 84880768767 scopus 로고    scopus 로고
    • Unique transcriptome signature of mouse microglia
    • Beutner C, et al., Unique transcriptome signature of mouse microglia. Glia 2013; 61(9): 1429-42.
    • (2013) Glia , vol.61 , Issue.9 , pp. 1429-1442
    • Beutner, C.1
  • 39
    • 30444443297 scopus 로고    scopus 로고
    • Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys
    • Miklossy J, et al., Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys. Exp Neurol 2006; 197(2): 275-83.
    • (2006) Exp Neurol , vol.197 , Issue.2 , pp. 275-283
    • Miklossy, J.1
  • 40
    • 33745548105 scopus 로고    scopus 로고
    • Early activation, motility, and homing of neonatal microglia to injured neurons does not require protein synthesis
    • Kurpius D, et al., Early activation, motility, and homing of neonatal microglia to injured neurons does not require protein synthesis. Glia 2006; 54(1): 58-70.
    • (2006) Glia , vol.54 , Issue.1 , pp. 58-70
    • Kurpius, D.1
  • 41
    • 77953608972 scopus 로고    scopus 로고
    • JNK inhibition and inflammation after cerebral ischemia
    • Benakis C, C. Bonny, and L. Hirt, JNK inhibition and inflammation after cerebral ischemia. Brain Behav Immun 2010; 24(5): 800-11.
    • (2010) Brain Behav Immun , vol.24 , Issue.5 , pp. 800-811
    • Benakis, C.1    Bonny, C.2    Hirt, L.3
  • 42
    • 84961583906 scopus 로고    scopus 로고
    • Contribution of Microglial Activation as Compelling Target for the Treatment of Acute Trauatic Brain Injury
    • Chio CC, M.T. Lin, and C.P. Chang, Contribution of Microglial Activation as Compelling Target for the Treatment of Acute Trauatic Brain Injury. Curr Med Chem 2014;
    • (2014) Curr Med Chem
    • Chio, C.C.1    Lin, M.T.2    Chang, C.P.3
  • 43
    • 64349105022 scopus 로고    scopus 로고
    • Differential gene expression in LPS/IFNgamma activated microglia and macrophages: In vitro versus in vivo
    • Schmid CD, et al., Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo. J Neurochem 2009; 109 Suppl 1: 117-25.
    • (2009) J Neurochem , vol.109 , pp. 117-125
    • Schmid, C.D.1
  • 44
    • 79959999864 scopus 로고    scopus 로고
    • Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia
    • Xiong X, et al., Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia. Stroke 2011; 42(7): 2026-32.
    • (2011) Stroke , vol.42 , Issue.7 , pp. 2026-2032
    • Xiong, X.1
  • 45
    • 80052361500 scopus 로고    scopus 로고
    • Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury
    • Barreto GE, et al., Astrocytic-neuronal crosstalk: implications for neuroprotection from brain injury. Neurosci Res 2011; 71(2): 107-13.
    • (2011) Neurosci Res , vol.71 , Issue.2 , pp. 107-113
    • Barreto, G.E.1
  • 46
    • 84868691367 scopus 로고    scopus 로고
    • Mitochondrial functions in astrocytes: Neuroprotective implications from oxidative damage by rotenone
    • Cabezas R, et al., Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone. Neurosci Res 2012; 74(2): 80-90.
    • (2012) Neurosci Res , vol.74 , Issue.2 , pp. 80-90
    • Cabezas, R.1
  • 47
    • 84902242573 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation
    • Drose S, U. Brandt, and I. Wittig, Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation. Biochim Biophys Acta 2014; 1844(8): 1344-54.
    • (2014) Biochim Biophys Acta , vol.1844 , Issue.8 , pp. 1344-1354
    • Drose, S.1    Brandt, U.2    Wittig, I.3
  • 48
    • 84901841671 scopus 로고    scopus 로고
    • Characterisation of the active/de-active transition of mitochondrial complex I
    • Babot M, et al., Characterisation of the active/de-active transition of mitochondrial complex I. Biochim Biophys Acta 2014; 1837(7): 1083-92.
    • (2014) Biochim Biophys Acta , vol.1837 , Issue.7 , pp. 1083-1092
    • Babot, M.1
  • 49
    • 84929499007 scopus 로고    scopus 로고
    • Protecting the mitochondrial powerhouse
    • Scheibye-Knudsen M, et al., Protecting the mitochondrial powerhouse. Trends Cell Biol 2014;
    • (2014) Trends Cell Biol
    • Scheibye-Knudsen, M.1
  • 50
    • 84893834710 scopus 로고    scopus 로고
    • Oxidative stress and metabolic syndrome: Cause or consequence of Alzheimer's disease?
    • Luque-Contreras D, et al., Oxidative stress and metabolic syndrome: cause or consequence of Alzheimer's disease? Oxid Med Cell Longev 2014; 2014: 497802.
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 497802
    • Luque-Contreras, D.1
  • 51
    • 84893852238 scopus 로고    scopus 로고
    • Early onset Alzheimer's disease and oxidative stress
    • Meraz-Rios MA, et al., Early onset Alzheimer's disease and oxidative stress. Oxid Med Cell Longev 2014; 2014: 375968.
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 375968
    • Meraz-Rios, M.A.1
  • 52
    • 84897954482 scopus 로고    scopus 로고
    • Brain metabolic dysfunction at the core of Alzheimer's disease
    • de la Monte, S.M. and M. Tong, Brain metabolic dysfunction at the core of Alzheimer's disease. Biochem Pharmacol 2014; 88(4): 548-59.
    • (2014) Biochem Pharmacol , vol.88 , Issue.4 , pp. 548-559
    • De La Monte, S.M.1    Tong, M.2
  • 53
    • 33646160622 scopus 로고    scopus 로고
    • The (Un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease
    • Moreira PI, et al., The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease. Mech Ageing Dev 2006; 127(6): 501-6.
    • (2006) Mech Ageing Dev , vol.127 , Issue.6 , pp. 501-506
    • Moreira, P.I.1
  • 54
    • 84856729444 scopus 로고    scopus 로고
    • Effects of natural antioxidants in neurodegenerative disease
    • Albarracin SL, et al., Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci 2012; 15(1): 1-9.
    • (2012) Nutr Neurosci , vol.15 , Issue.1 , pp. 1-9
    • Albarracin, S.L.1
  • 55
    • 33645775687 scopus 로고    scopus 로고
    • Antioxidant protection and neurodegenerative disease: The role of amyloid-beta and tau
    • Castellani RJ, et al., Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. Am J Alzheimers Dis Other Demen 2006; 21(2): 126-30.
    • (2006) Am J Alzheimers Dis Other Demen , vol.21 , Issue.2 , pp. 126-130
    • Castellani, R.J.1
  • 56
    • 33646855957 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer disease: Pathognomonic but not pathogenic
    • Castellani RJ, et al., Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathol 2006; 111(6): 503-9.
    • (2006) Acta Neuropathol , vol.111 , Issue.6 , pp. 503-509
    • Castellani, R.J.1
  • 57
    • 33947503437 scopus 로고    scopus 로고
    • Cortical biochemistry in MCI and Alzheimer disease: Lack of correlation with clinical diagnosis
    • Forman MS, et al., Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis. Neurology 2007; 68(10): 757-63.
    • (2007) Neurology , vol.68 , Issue.10 , pp. 757-763
    • Forman, M.S.1
  • 58
    • 0037085011 scopus 로고    scopus 로고
    • Alzheimer's disease and oxygen radicals: New insights
    • Pratico D, Alzheimer's disease and oxygen radicals: new insights. Biochem Pharmacol 2002; 63(4): 563-7.
    • (2002) Biochem Pharmacol , vol.63 , Issue.4 , pp. 563-567
    • Pratico, D.1
  • 59
    • 0036829434 scopus 로고    scopus 로고
    • Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain
    • Smith MA, et al., Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radic Biol Med 2002; 33(9): 1194-9.
    • (2002) Free Radic Biol Med , vol.33 , Issue.9 , pp. 1194-1199
    • Smith, M.A.1
  • 60
    • 84862627255 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of antioxidants in Parkinson's disease
    • Sutachan JJ, et al., Cellular and molecular mechanisms of antioxidants in Parkinson's disease. Nutr Neurosci 2012; 15(3): 120-6.
    • (2012) Nutr Neurosci , vol.15 , Issue.3 , pp. 120-126
    • Sutachan, J.J.1
  • 61
    • 84929138425 scopus 로고    scopus 로고
    • Implication of Oxidative Stress-Induced Oncogenic Signaling Pathways as a Treatment Strategy for Neurodegeneration and Cancer
    • Laher, Editor, Springer Berlin Heidelberg
    • Aliev G, et al., Implication of Oxidative Stress-Induced Oncogenic Signaling Pathways as a Treatment Strategy for Neurodegeneration and Cancer, in Systems Biology of Free Radicals and Antioxidants, I. Laher, Editor. 2011, Springer Berlin Heidelberg. p. 2325-2347.
    • (2011) Systems Biology of Free Radicals and Antioxidants, I , pp. 2325-2347
    • Aliev, G.1
  • 62
    • 84929138301 scopus 로고    scopus 로고
    • The Three-Vessel Occlusion as a Model of Vascular Dementia – Oxidative Stress and Mitochondrial Failure as an Indicator of Brain Hypoperfusion
    • Laher, Editor, Springer Berlin Heidelberg
    • Aliev G, et al., The Three-Vessel Occlusion as a Model of Vascular Dementia – Oxidative Stress and Mitochondrial Failure as an Indicator of Brain Hypoperfusion, in Systems Biology of Free Radicals and Antioxidants, I. Laher, Editor. 2009, Springer Berlin Heidelberg. p. 2023-2032.
    • (2009) Systems Biology of Free Radicals and Antioxidants, I , pp. 2023-2032
    • Aliev, G.1
  • 63
    • 84940915833 scopus 로고    scopus 로고
    • PDGF-BB Protects Mitochondria from Rotenone in T98G Cells
    • Cabezas R, et al., PDGF-BB Protects Mitochondria from Rotenone in T98G Cells. Neurotox Res 2014;
    • (2014) Neurotox Res
    • Cabezas, R.1
  • 65
    • 84889602162 scopus 로고    scopus 로고
    • Novel Ocimum sanctum compounds modulate stress response: Role of CRF, POMC, GR and HSP-70 in the hypothalamus and pituitary of rats
    • Ahmad A, et al., Novel Ocimum sanctum compounds modulate stress response: Role of CRF, POMC, GR and HSP-70 in the hypothalamus and pituitary of rats. Medicinal Plants - International Journal of Phytomedicines and Related Industries 2013; 5(4).
    • (2013) Medicinal Plants - International Journal of Phytomedicines and Related Industries , vol.5 , Issue.4
    • Ahmad, A.1
  • 66
    • 84862825882 scopus 로고    scopus 로고
    • Novel Ocimumoside A and B as anti-stress agents: Modulation of brain monoamines and antioxidant systems in chronic unpredictable stress model in rats
    • Ahmad A, et al., Novel Ocimumoside A and B as anti-stress agents: modulation of brain monoamines and antioxidant systems in chronic unpredictable stress model in rats. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 2012; 19(7): 639-647.
    • (2012) Phytomedicine: International Journal of Phytotherapy and Phytopharmacology , vol.19 , Issue.7 , pp. 639-647
    • Ahmad, A.1
  • 67
    • 84904106826 scopus 로고    scopus 로고
    • Evidence of Inflammatory System Involvement in Parkinsons Disease
    • Chao Y, S.C. Wong, and E.K. Tan, Evidence of Inflammatory System Involvement in Parkinsons Disease. BioMed Research International 2014; 2014.
    • (2014) Biomed Research International , pp. 2014
    • Chao, Y.1    Wong, S.C.2    Tan, E.K.3
  • 68
    • 84901767734 scopus 로고    scopus 로고
    • Chronic Inflammation and Cytokines in the Tumor Microenvironment
    • Landskron G, et al., Chronic Inflammation and Cytokines in the Tumor Microenvironment. Journal of Immunology Research 2014; 2014.
    • (2014) Journal of Immunology Research , pp. 2014
    • Landskron, G.1
  • 69
    • 84891645473 scopus 로고    scopus 로고
    • Structural insights from GRP78-NF-kappaB binding interactions: A computational approach to understand a possible neuroprotective pathway in brain injuries
    • Avila MF, et al., Structural insights from GRP78-NF-kappaB binding interactions: a computational approach to understand a possible neuroprotective pathway in brain injuries. J Theor Biol 2014; 345: 43-51.
    • (2014) J Theor Biol , vol.345 , pp. 43-51
    • Avila, M.F.1
  • 71
    • 35848963223 scopus 로고    scopus 로고
    • Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease
    • Walter S, et al., Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cell Physiol Biochem 2007; 20(6): 947-56.
    • (2007) Cell Physiol Biochem , vol.20 , Issue.6 , pp. 947-956
    • Walter, S.1
  • 72
    • 0028946146 scopus 로고
    • Reciprocal control of inflammatory cytokines, IL- 1 and IL-6, and beta-amyloid production in cultures
    • Del Bo R, et al., Reciprocal control of inflammatory cytokines, IL- 1 and IL-6, and beta-amyloid production in cultures. Neurosci Lett 1995; 188(1): 70-4.
    • (1995) Neurosci Lett , vol.188 , Issue.1 , pp. 70-74
    • Del Bo, R.1
  • 73
    • 0005775566 scopus 로고
    • Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells
    • Goldgaber D, et al., Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A 1989; 86(19): 7606-10.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.19 , pp. 7606-7610
    • Goldgaber, D.1
  • 74
    • 0034643895 scopus 로고    scopus 로고
    • Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells
    • Misonou H, M. Morishima-Kawashima, and Y. Ihara, Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry 2000; 39(23): 6951-9.
    • (2000) Biochemistry , vol.39 , Issue.23 , pp. 6951-6959
    • Misonou, H.1    Morishima-Kawashima, M.2    Ihara, Y.3
  • 75
    • 84899821025 scopus 로고    scopus 로고
    • Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease
    • Aliev G, et al., Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease. Curr Med Chem 2014; 21(19):2208-17.
    • (2014) Curr Med Chem , vol.21 , Issue.19 , pp. 2208-2217
    • Aliev, G.1
  • 76
    • 0029076397 scopus 로고
    • Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide
    • Yan SD, et al., Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nat Med 1995; 1(7): 693-9.
    • (1995) Nat Med , vol.1 , Issue.7 , pp. 693-699
    • Yan, S.D.1
  • 77
    • 84903304059 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
    • Wang X, et al., Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta 2014; 1842(8): 1240-7.
    • (2014) Biochim Biophys Acta , vol.1842 , Issue.8 , pp. 1240-1247
    • Wang, X.1
  • 78
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury
    • Lehnardt S, Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia 2010; 58(3): 253-63.
    • (2010) Glia , vol.58 , Issue.3 , pp. 253-263
    • Lehnardt, S.1
  • 79
    • 60449109146 scopus 로고    scopus 로고
    • Toll-like receptors in neurodegeneration
    • Okun E, et al., Toll-like receptors in neurodegeneration. Brain Res Rev 2009; 59(2): 278-92.
    • (2009) Brain Res Rev , vol.59 , Issue.2 , pp. 278-292
    • Okun, E.1
  • 80
    • 84880199810 scopus 로고    scopus 로고
    • Toll-like receptor 3 expression in glia and neurons alters in response to white matter injury in preterm infants
    • Vontell R, et al., Toll-like receptor 3 expression in glia and neurons alters in response to white matter injury in preterm infants. Dev Neurosci 2013; 35(2-3): 130-9.
    • (2013) Dev Neurosci , vol.35 , Issue.2-3 , pp. 130-139
    • Vontell, R.1
  • 81
    • 84876812790 scopus 로고    scopus 로고
    • Increased expression of toll-like receptor 4 on neurons after surgery in aged rats
    • Wang Y, H.J. He, and W. Ouyang, Increased expression of toll-like receptor 4 on neurons after surgery in aged rats. CNS Neurosci Ther 2013; 19(5): 358-60.
    • (2013) CNS Neurosci Ther , vol.19 , Issue.5 , pp. 358-360
    • Wang, Y.1    He, H.J.2    Ouyang, W.3
  • 82
    • 56549116047 scopus 로고    scopus 로고
    • Toll-like receptor and RIG-I-like receptor signaling
    • Kawai, T. and S. Akira, Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci 2008; 1143: 1-20.
    • (2008) Ann N Y Acad Sci , vol.1143 , pp. 1-20
    • Kawai, T.1    Akira, S.2
  • 83
    • 84961678115 scopus 로고    scopus 로고
    • Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway
    • Dai XJ, et al., Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway. Cell Stress Chaperones 2014;
    • (2014) Cell Stress Chaperones
    • Dai, X.J.1
  • 84
    • 40449097556 scopus 로고    scopus 로고
    • A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS
    • Lehnardt S, et al., A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. J Neurosci 2008; 28(10): 2320-31.
    • (2008) J Neurosci , vol.28 , Issue.10 , pp. 2320-2331
    • Lehnardt, S.1
  • 85
    • 80855124110 scopus 로고    scopus 로고
    • Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury
    • Zhang Z, et al., Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury. Neuroimmunomodulation 2012; 19(1): 10-9.
    • (2012) Neuroimmunomodulation , vol.19 , Issue.1 , pp. 10-19
    • Zhang, Z.1
  • 86
    • 34247471687 scopus 로고    scopus 로고
    • Innate immune receptor expression in normal brain aging
    • Letiembre M, et al., Innate immune receptor expression in normal brain aging. Neuroscience 2007; 146(1): 248-54.
    • (2007) Neuroscience , vol.146 , Issue.1 , pp. 248-254
    • Letiembre, M.1
  • 87
    • 84898037632 scopus 로고    scopus 로고
    • Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia
    • Christensen LB, et al., Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia. J Neuroinflammation 2014; 11: 70.
    • (2014) J Neuroinflammation , vol.11 , pp. 70
    • Christensen, L.B.1
  • 88
    • 84897842773 scopus 로고    scopus 로고
    • Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging
    • Qian F, et al., Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging (Albany NY) 2014; 6(2): 131-9.
    • (2014) Aging (Albany NY) , vol.6 , Issue.2 , pp. 131-139
    • Qian, F.1
  • 89
    • 84881251933 scopus 로고    scopus 로고
    • Microglia during development and aging
    • Harry GJ, Microglia during development and aging. Pharmacol Ther 2013; 139(3): 313-26.
    • (2013) Pharmacol Ther , vol.139 , Issue.3 , pp. 313-326
    • Harry, G.J.1
  • 90
    • 80053289163 scopus 로고    scopus 로고
    • Toll-like receptors are key players in neurodegeneration
    • Arroyo DS, et al., Toll-like receptors are key players in neurodegeneration. Int Immunopharmacol 2011; 11(10): 1415-21.
    • (2011) Int Immunopharmacol , vol.11 , Issue.10 , pp. 1415-1421
    • Arroyo, D.S.1
  • 91
    • 0037387147 scopus 로고    scopus 로고
    • A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation
    • Bamberger ME, et al., A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci 2003; 23(7): 2665-74.
    • (2003) J Neurosci , vol.23 , Issue.7 , pp. 2665-2674
    • Bamberger, M.E.1
  • 92
    • 70349323417 scopus 로고    scopus 로고
    • CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation
    • Reed-Geaghan EG, et al., CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci 2009; 29(38): 11982-92.
    • (2009) J Neurosci , vol.29 , Issue.38 , pp. 11982-11992
    • Reed-Geaghan, E.G.1
  • 93
    • 49349097868 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal
    • Tang SC, et al., Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol 2008; 213(1): 114-21.
    • (2008) Exp Neurol , vol.213 , Issue.1 , pp. 114-121
    • Tang, S.C.1
  • 94
    • 84896734547 scopus 로고    scopus 로고
    • Biological role of Toll-like receptor-4 in the brain
    • Trotta T, et al., Biological role of Toll-like receptor-4 in the brain. J Neuroimmunol 2014; 268(1-2): 1-12.
    • (2014) J Neuroimmunol , vol.268 , Issue.1-2 , pp. 1-12
    • Trotta, T.1
  • 95
    • 84871296103 scopus 로고    scopus 로고
    • Sequence variants of toll like receptor 4 and lateonset Alzheimer's disease
    • Chen YC, et al., Sequence variants of toll like receptor 4 and lateonset Alzheimer's disease. PLoS One 2012; 7(12): e50771.
    • (2012) Plos One , vol.7 , Issue.12
    • Chen, Y.C.1
  • 96
    • 79961134149 scopus 로고    scopus 로고
    • TLR4 mutation reduces microglial activation, increases Abeta deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
    • Song M, et al., TLR4 mutation reduces microglial activation, increases Abeta deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease. J Neuroinflammation 2011; 8: 92.
    • (2011) J Neuroinflammation , vol.8 , pp. 92
    • Song, M.1
  • 97
    • 28444494743 scopus 로고    scopus 로고
    • Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease
    • Minoretti P, et al., Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Neurosci Lett 2006; 391(3): 147-9.
    • (2006) Neurosci Lett , vol.391 , Issue.3 , pp. 147-149
    • Minoretti, P.1
  • 98
    • 35348860696 scopus 로고    scopus 로고
    • Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    • Tang SC, et al., Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 2007; 104(34): 13798-803.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.34 , pp. 13798-13803
    • Tang, S.C.1
  • 99
    • 34247545017 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke
    • Caso JR, et al., Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 2007; 115(12): 1599-608.
    • (2007) Circulation , vol.115 , Issue.12 , pp. 1599-1608
    • Caso, J.R.1
  • 100
    • 84863338224 scopus 로고    scopus 로고
    • Neuroprotection from stroke in the absence of MHCI or PirB
    • Adelson JD, et al., Neuroprotection from stroke in the absence of MHCI or PirB. Neuron 2012; 73(6): 1100-7.
    • (2012) Neuron , vol.73 , Issue.6 , pp. 1100-1107
    • Adelson, J.D.1
  • 101
    • 70349794451 scopus 로고    scopus 로고
    • Immune proteins in brain development and synaptic plasticity
    • Boulanger LM, Immune proteins in brain development and synaptic plasticity. Neuron 2009; 64(1): 93-109.
    • (2009) Neuron , vol.64 , Issue.1 , pp. 93-109
    • Boulanger, L.M.1
  • 102
    • 36849076770 scopus 로고    scopus 로고
    • The classical complement cascade mediates CNS synapse elimination
    • Stevens B, et al., The classical complement cascade mediates CNS synapse elimination. Cell 2007; 131(6): 1164-78.
    • (2007) Cell , vol.131 , Issue.6 , pp. 1164-1178
    • Stevens, B.1


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