Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

Journal of Cerebral Blood Flow and Metabolism

Volumn 37, Issue 8, 2017, Pages 2679-2690

  Owen, David R ^a   Narayan, Nehal ^b   Wells, Lisa ^a   Healy, Luke ^c   Smyth, Erica ^a   Rabiner, Eugenii A ^a,d   Galloway, Dylan ^e   Williams, John B ^e   Lehr, Joshua ^e   Mandhair, Harpreet ^b   Peferoen, Laura AN ^f   Taylor, Peter C ^b   Amor, Sandra ^f,g   Antel, Jack P ^c   Matthews, Paul M ^a,h   Moore, Craig S ^e  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^f VU UNIVERSITY AMSTERDAM   (Netherlands)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^h IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

inflammation; macrophages; microglia; neurodegeneration; Positron emission tomography

Indexed keywords

CARRIER PROTEIN; RADIOLIGAND; 4 AMINOBUTYRIC ACID RECEPTOR; ACETAMIDE DERIVATIVE; BZRP PROTEIN, MOUSE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LIPOPOLYSACCHARIDE; N-(2-METHOXYBENZYL)-N-(4-PHENOXYPYRIDIN-3-YL)ACETAMIDE; PROTEIN BINDING; PYRIDINE DERIVATIVE; TSPO PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE; MICROGLIA; MONOCYTE; MOUSE; NERVE DEGENERATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; WESTERN BLOTTING; ADULT; ANIMAL; BONE MARROW CELL; BRAIN; C57BL MOUSE; CELL CULTURE; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; SPECIES DIFFERENCE; YOUNG ADULT;

ACETAMIDES; ADULT; ANIMALS; BRAIN; CELLS, CULTURED; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE, INBRED C57BL; MICROGLIA; MIDDLE AGED; MYELOID CELLS; PROTEIN BINDING; PYRIDINES; RECEPTORS, GABA; SPECIES SPECIFICITY; YOUNG ADULT;

EID: 85026354141     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1177/0271678X17710182     Document Type: Article

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