메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages 424-437

Translocator protein 18 kDa negatively regulates inflammation in microglia

Author keywords

Microglia; Neurodegeneration; Neuroinflammation; NF B; Translocator protein 18 kDa

Indexed keywords

BETA ACTIN; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOCHONDRIAL PROTEIN; OUTER MEMBRANE PROTEIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TRANSLOCATOR PROTEIN 18 KDA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; AUTACOID; BZRP PROTEIN, MOUSE;

EID: 84901258484     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-014-9540-6     Document Type: Article
Times cited : (87)

References (53)
  • 2
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • DOI 10.1038/nrn2038, PII NRN2038
    • Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69 (Pubitemid 46011999)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 5
    • 9644254411 scopus 로고    scopus 로고
    • In vivo detection of microglial activation in frontotemporal dementia
    • DOI 10.1002/ana.20332
    • Cagnin A, Rossor M, Sampson EL, Mackinnon T, Banati RB (2004) In vivo detection of microglial activation in frontotemporal dementia. Ann Neurol 56:894-897 (Pubitemid 39578457)
    • (2004) Annals of Neurology , vol.56 , Issue.6 , pp. 894-897
    • Cagnin, A.1    Rossor, M.2    Sampson, E.L.3    MacKinnon, T.4    Banati, R.B.5
  • 7
    • 42649115741 scopus 로고    scopus 로고
    • Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair
    • Chen MK, Guilarte TR (2008) Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacol Ther 118:1-17
    • (2008) Pharmacol Ther , vol.118 , pp. 1-17
    • Chen, M.K.1    Guilarte, T.R.2
  • 8
    • 78650234355 scopus 로고    scopus 로고
    • Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state
    • Choi J, Ifuku M, Noda M, Guilarte TR (2011) Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state. Glia 59:219-230
    • (2011) Glia , vol.59 , pp. 219-230
    • Choi, J.1    Ifuku, M.2    Noda, M.3    Guilarte, T.R.4
  • 9
    • 0036459335 scopus 로고    scopus 로고
    • Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging
    • DOI 10.1046/j.1460-9568.2002.01938.x
    • Cicchetti F, Brownell AL,Williams K, Chen YI, Livni E, Isacson O (2002) Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohisto-chemistry and PET imaging. Eur J Neurosci 15:991-998 (Pubitemid 35463634)
    • (2002) European Journal of Neuroscience , vol.15 , Issue.6 , pp. 991-998
    • Cicchetti, F.1    Brownell, A.L.2    Williams, K.3    Chen, Y.I.4    Livni, E.5    Isacson, O.6
  • 10
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • DOI 10.1016/S0896-6273(03)00568-3
    • Dauer W, Przedborski S (2003) Parkinson's disease: review mechanisms and models. Neuron 39:889-909 (Pubitemid 37130207)
    • (2003) Neuron , vol.39 , Issue.6 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 11
    • 0037461325 scopus 로고    scopus 로고
    • In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: Functional significance in drug ligand and cholesterol binding
    • DOI 10.1021/bi0267487
    • Delavoie F, Li H, Hardwick M, Robert JC, Giatzakis C, Péranzi G, Yao ZX, Maccario J, Lacapère JJ, Papadopoulos V (2003) In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding. Biochemistry 42:4506-4519 (Pubitemid 36457619)
    • (2003) Biochemistry , vol.42 , Issue.15 , pp. 4506-4519
    • Delavoie, F.1    Li, H.2    Hardwick, M.3    Robert, J.-C.4    Giatzakis, C.5    Peranzi, G.6    Yao, Z.-X.7    Maccario, J.8    Lacapere, J.-J.9    Papadopoulos, V.10
  • 13
    • 78751502344 scopus 로고    scopus 로고
    • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration
    • Gao HM, Zhou H, Zhang F, Wilson BC, Kam W, Hong JS (2011) HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. J Neurosci 31:1081-1092
    • (2011) J Neurosci , vol.31 , pp. 1081-1092
    • Gao, H.M.1    Zhou, H.2    Zhang, F.3    Wilson, B.C.4    Kam, W.5    Hong, J.S.6
  • 14
    • 0027343618 scopus 로고
    • Reactive glia as rivals in regulating neuronal survival
    • Giulian D (1993) Reactive glia as rivals in regulating neuronal survival. Glia 7:102-110
    • (1993) Glia , vol.7 , pp. 102-110
    • Giulian, D.1
  • 15
  • 17
    • 78650880194 scopus 로고    scopus 로고
    • Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease
    • Harms AS, Barnum CJ, Ruhn KA, Varghese S, Treviño I, Blesch A, Tansey MG (2011) Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease. Mol Ther 19:46-52
    • (2011) Mol Ther , vol.19 , pp. 46-52
    • Harms, A.S.1    Barnum, C.J.2    Ruhn, K.A.3    Varghese, S.4    Treviño, I.5    Blesch, A.6    Tansey, M.G.7
  • 18
    • 0036893189 scopus 로고    scopus 로고
    • Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells
    • DOI 10.1046/j.1471-4159.2002.01261.x
    • Jayakumar AR, Panickar KS, Norenberg MD (2002) Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. J Neurochem 83:1226-1234 (Pubitemid 35397132)
    • (2002) Journal of Neurochemistry , vol.83 , Issue.5 , pp. 1226-1234
    • Jayakumar, A.R.1    Panickar, K.S.2    Norenberg, M.D.3
  • 19
    • 84883612112 scopus 로고    scopus 로고
    • Brain inflammation: Facts and misconceptions
    • Jeong HK, Ji K, Min K, Joe EH (2013) Brain inflammation: facts and misconceptions. Exp Neurobiol 22:59-67
    • (2013) Exp Neurobiol , vol.22 , pp. 59-67
    • Jeong, H.K.1    Ji, K.2    Min, K.3    Joe, E.H.4
  • 20
    • 17644383671 scopus 로고    scopus 로고
    • Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis
    • Jordà EG, Jiménez A, Verdaguer E, Canudas AM, Folch J, Sureda FX, Camins A, Pallàs M (2005) Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis. Apoptosis 10:91-104
    • (2005) Apoptosis , vol.10 , pp. 91-104
    • Jordà, E.G.1    Jiménez, A.2    Verdaguer, E.3    Canudas, A.M.4    Folch, J.5    Sureda, F.X.6    Camins, A.7    Pallàs, M.8
  • 21
    • 84865489968 scopus 로고    scopus 로고
    • Suppression of nuclear factor-kappa B activation and inflammation in microglia by a physically-modified saline
    • Khasnavis S, Jana A, Roy A, Mazumder M, Bhushan B, Wood T, Ghosh S,Watson R, Pahan K (2012) Suppression of nuclear factor-kappa B activation and inflammation in microglia by a physically-modified saline. J Biol Chem 287:29529-29542
    • (2012) J Biol Chem , vol.287 , pp. 29529-29542
    • Khasnavis, S.1    Jana, A.2    Roy, A.3    Mazumder, M.4    Bhushan, B.5    Wood, T.6    Ghosh, S.7    Watson, R.8    Pahan, K.9
  • 24
    • 0034520395 scopus 로고    scopus 로고
    • Inflammatory regulators in Parkinson 's disease: INOS, lipocortin-1 and cyclooxygenases-1 and -2
    • Knott C, Stern G, Wilkin GP (2000) Inflammatory regulators in Parkinson 's disease: iNOS, lipocortin-1 and cyclooxygenases-1 and -2.Mol Cell Neurosci 16:724-727
    • (2000) Mol Cell Neurosci , vol.16 , pp. 724-727
    • Knott, C.1    Stern, G.2    Wilkin, G.P.3
  • 25
    • 0042737939 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor: Structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis
    • Lacapere JJ, Papadopoulos V (2003) Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 68:569-585
    • (2003) Steroids , vol.68 , pp. 569-585
    • Lacapere, J.J.1    Papadopoulos, V.2
  • 26
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • DOI 10.1002/1531-8249(199910)46:4<598::AID-ANA7
    • Langston JW, Forno LS, Tetrud J, Reeves AG, Kaplan JA, Karluk D (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyri dineexposure. Ann Neurol 46:598-605 (Pubitemid 29466438)
    • (1999) Annals of Neurology , vol.46 , Issue.4 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 27
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution andmorphology of microglia in the normal adult mouse brain
    • Lawson LJ, Perry VH, Dri P, Gordon S (1990) Heterogeneity in the distribution andmorphology of microglia in the normal adult mouse brain. Neuroscience 39:151-170
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 30
    • 84861331858 scopus 로고    scopus 로고
    • Alpha7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
    • Liu Y, Hu J, Wu J, Zhu C, Hui Y, Han Y, Huang Z, Ellsworth K, Fan W (2012) Alpha7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation. J Neuroinflammation 24:98-113
    • (2012) J Neuroinflammation , vol.24 , pp. 98-113
    • Liu, Y.1    Hu, J.2    Wu, J.3    Zhu, C.4    Hui, Y.5    Han, Y.6    Huang, Z.7    Ellsworth, K.8    Fan, W.9
  • 31
    • 0035710746 scopus 로고    scopus 로고
    • -delta deltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-delta delta C (T)) method. Methods 25:402-408 (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 32
    • 77957028140 scopus 로고    scopus 로고
    • Microglial activation and chronic neurodegeneration
    • Lull ME, Block ML (2010) Microglial activation and chronic neurodegeneration. Neurotherapeutics 7:354-365
    • (2010) Neurotherapeutics , vol.7 , pp. 354-365
    • Lull, M.E.1    Block, M.L.2
  • 33
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • DOI 10.1016/j.it.2004.09.015, PII S1471490604002959
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25:677-686 (Pubitemid 39457982)
    • (2004) Trends in Immunology , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 34
    • 79959689977 scopus 로고    scopus 로고
    • Role of purinergic signaling in neuro-immune cells and adult neural progenitors
    • Marta F, Davide L, Maria PA (2011) Role of purinergic signaling in neuro-immune cells and adult neural progenitors. Front Biosci 16:2326-2341
    • (2011) Front Biosci , vol.16 , pp. 2326-2341
    • Marta, F.1    Davide, L.2    Maria, P.A.3
  • 36
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958-969
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 38
    • 0036935553 scopus 로고    scopus 로고
    • An inflammatory review of Parkinson's disease
    • DOI 10.1016/S0301-0082(02)00127-2, PII S0301008202001272
    • Orr CF, Rowe DB, Halliday GM (2002) An inflammatory review of Parkinson's disease. Prog Neurobiol 68:325-340 (Pubitemid 36071510)
    • (2002) Progress in Neurobiology , vol.68 , Issue.5 , pp. 325-340
    • Orr, C.F.1    Rowe, D.B.2    Halliday, G.M.3
  • 41
    • 33644498858 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders
    • Papadopoulos V, Lecanu L, Brown RC, Han Z, Yao ZX (2006) Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders. Neuroscience 138:749-756
    • (2006) Neuroscience , vol.138 , pp. 749-756
    • Papadopoulos, V.1    Lecanu, L.2    Brown, R.C.3    Han, Z.4    Yao, Z.X.5
  • 42
    • 33745637954 scopus 로고    scopus 로고
    • Microglial activation correlates with severity in Huntington disease: A clinical and PET study
    • DOI 10.1212/01.wnl.0000222734.56412.17, PII 0000611420060613000008
    • Pavese N, Gerhard A, Tai YF, Ho AK, Turkheimer F, Barker RA, Brooks DJ, Piccini P (2006) Microglial activation correlates with severity in Huntington disease: a clinical and PETstudy.Neurology 66:1638-1643 (Pubitemid 43964614)
    • (2006) Neurology , vol.66 , Issue.11 , pp. 1638-1643
    • Pavese, N.1    Gerhard, A.2    Tai, Y.F.3    Ho, A.K.4    Turkheimer, F.5    Barker, R.A.6    Brooks, D.J.7    Piccini, P.8
  • 43
    • 33749560870 scopus 로고    scopus 로고
    • Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons
    • DOI 10.1159/000095115
    • Rick CE, Ebert A, Virag T, Bohn MC, Surmeier DJ (2006) Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons. Dev Neurosci 28:528-537 (Pubitemid 44532981)
    • (2006) Developmental Neuroscience , vol.28 , Issue.6 , pp. 528-537
    • Rick, C.E.1    Ebert, A.2    Virag, T.3    Bohn, M.C.4    Surmeier, D.J.5
  • 44
    • 33744960217 scopus 로고    scopus 로고
    • Up-regulation of microglial CD11b expression by nitric oxide
    • DOI 10.1074/jbc.M600236200
    • Roy A, Fung YK, Liu X, Pahan K (2006) Up-regulation of microglial CD11b expression by nitric oxide. J Biol Chem 281:14971-14980 (Pubitemid 43855201)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.21 , pp. 14971-14980
    • Roy, A.1    Fung, Y.K.2    Liu, X.3    Pahan, K.4
  • 46
    • 79955788943 scopus 로고    scopus 로고
    • An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia mediated inflammation
    • Saijo K, Collier JG, Li AC, Katzenellenbogen JA, Glass CK (2011) An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia mediated inflammation. Cell 145:584-595
    • (2011) Cell , vol.145 , pp. 584-595
    • Saijo, K.1    Collier, J.G.2    Li, A.C.3    Katzenellenbogen, J.A.4    Glass, C.K.5
  • 50
    • 0030781925 scopus 로고    scopus 로고
    • PK11195 binding to the peripheral benzodiazepine receptor as a marker of microgila activation in multiple sclerosis and experimental autoimmune encephalomyelitis
    • DOI 10.1002/(SICI)1097-4547(19971015)50:2<345::AID
    • Vowinckel E, Reutens D, Becher B, Verge G, Evans A, Owens T, Antel JP (1997) PK11195 binding to the peripheral benzodiazepine receptor as amarker ofmicroglia activation inmultiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res 50:345-353 (Pubitemid 27473649)
    • (1997) Journal of Neuroscience Research , vol.50 , Issue.2 , pp. 345-353
    • Vowinckel, E.1    Reutens, D.2    Becher, B.3    Verge, G.4    Evans, A.5    Owens, T.6    Antel, J.P.7
  • 52
    • 77956242222 scopus 로고    scopus 로고
    • Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions
    • Zhang F, Shi JS, Zhou H, Wilson B, Hong JS, Gao HM (2010) Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Mol Pharmacol 78:466-477
    • (2010) Mol Pharmacol , vol.78 , pp. 466-477
    • Zhang, F.1    Shi, J.S.2    Zhou, H.3    Wilson, B.4    Hong, J.S.5    Gao, H.M.6
  • 53
    • 84871318150 scopus 로고    scopus 로고
    • TSPO-specific ligand Vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation
    • Zhao YY, Yu JZ, Li QY,Ma CG, Lu CZ, Xiao BG (2011) TSPO-specific ligand Vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation. Neuron Glia Biol 7:187-197
    • (2011) Neuron Glia Biol , vol.7 , pp. 187-197
    • Zhao, Y.Y.1    Yu, J.Z.2    Li, Q.Y.3    Ma, C.G.4    Lu, C.Z.5    Xiao, B.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.