메뉴 건너뛰기




Volumn 109, Issue 1-2, 2008, Pages 96-107

Brain microglia express steroid-converting enzymes in the mouse

Author keywords

Adiol; Cytokines; DHEA; Estrogen; LPS; Neurosteroids; PBR; Steroidogenesis

Indexed keywords

ANDROGEN; ANDROSTANEDIOL; ESTROGEN; MESSENGER RNA; PRASTERONE; STEROID 5ALPHA REDUCTASE 1; TESTOSTERONE 17BETA DEHYDROGENASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 40849111137     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2007.12.013     Document Type: Article
Times cited : (72)

References (86)
  • 1
    • 33746211330 scopus 로고    scopus 로고
    • Multiple pathways transmit neuroprotective effects of gonadal steroids
    • Bryant D.N., et al. Multiple pathways transmit neuroprotective effects of gonadal steroids. Endocrine 29 2 (2006) 199-207
    • (2006) Endocrine , vol.29 , Issue.2 , pp. 199-207
    • Bryant, D.N.1
  • 2
    • 20544469438 scopus 로고    scopus 로고
    • Gonadal hormone modulation of dendrites in the mammalian CNS
    • Cooke B.M., and Woolley C.S. Gonadal hormone modulation of dendrites in the mammalian CNS. J. Neurobiol. 64 1 (2005) 34-46
    • (2005) J. Neurobiol. , vol.64 , Issue.1 , pp. 34-46
    • Cooke, B.M.1    Woolley, C.S.2
  • 3
    • 17844407395 scopus 로고    scopus 로고
    • Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones
    • Garcia-Ovejero D., et al. Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones. Brain Res. Brain Res. Rev. 48 2 (2005) 273-286
    • (2005) Brain Res. Brain Res. Rev. , vol.48 , Issue.2 , pp. 273-286
    • Garcia-Ovejero, D.1
  • 4
    • 33749321675 scopus 로고    scopus 로고
    • Influence of sex steroid hormones on cerebrovascular function
    • Krause D.N., Duckles S.P., and Pelligrino D.A. Influence of sex steroid hormones on cerebrovascular function. J. Appl. Physiol. 101 4 (2006) 1252-1261
    • (2006) J. Appl. Physiol. , vol.101 , Issue.4 , pp. 1252-1261
    • Krause, D.N.1    Duckles, S.P.2    Pelligrino, D.A.3
  • 5
    • 33748702356 scopus 로고    scopus 로고
    • The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the female
    • Scharfman H.E., and MacLusky N.J. The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the female. Epilepsia 47 9 (2006) 1423-1440
    • (2006) Epilepsia , vol.47 , Issue.9 , pp. 1423-1440
    • Scharfman, H.E.1    MacLusky, N.J.2
  • 6
    • 0036376094 scopus 로고    scopus 로고
    • Estrogen actions throughout the brain
    • McEwen B. Estrogen actions throughout the brain. Recent Prog. Horm. Res. 57 (2002) 357-384
    • (2002) Recent Prog. Horm. Res. , vol.57 , pp. 357-384
    • McEwen, B.1
  • 7
    • 33645099949 scopus 로고    scopus 로고
    • Gonadal hormone modulation of hippocampal neurogenesis in the adult
    • Galea L.A., et al. Gonadal hormone modulation of hippocampal neurogenesis in the adult. Hippocampus 16 3 (2006) 225-232
    • (2006) Hippocampus , vol.16 , Issue.3 , pp. 225-232
    • Galea, L.A.1
  • 8
    • 0029798470 scopus 로고    scopus 로고
    • The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3 beta-hydroxysteroid dehydrogenase
    • Endoh A., et al. The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3 beta-hydroxysteroid dehydrogenase. J. Clin. Endocrinol. Metab. 81 10 (1996) 3558-3565
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , Issue.10 , pp. 3558-3565
    • Endoh, A.1
  • 9
    • 0029549897 scopus 로고
    • Adrenal androgen biosynthesis with special attention to P450c17
    • Mason J.I., Bird I.M., and Rainey W.E. Adrenal androgen biosynthesis with special attention to P450c17. Ann. NY Acad. Sci. 774 (1995) 47-58
    • (1995) Ann. NY Acad. Sci. , vol.774 , pp. 47-58
    • Mason, J.I.1    Bird, I.M.2    Rainey, W.E.3
  • 10
    • 33750042898 scopus 로고    scopus 로고
    • Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: insights from basic science and clinical studies
    • Turgeon J.L., et al. Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: insights from basic science and clinical studies. Endocr. Rev. 27 6 (2006) 575-605
    • (2006) Endocr. Rev. , vol.27 , Issue.6 , pp. 575-605
    • Turgeon, J.L.1
  • 11
    • 0030630595 scopus 로고    scopus 로고
    • Neurosteroids: of the nervous system, by the nervous system, for the nervous system
    • Baulieu E.E. Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog. Horm. Res. 52 (1997) 1-32
    • (1997) Recent Prog. Horm. Res. , vol.52 , pp. 1-32
    • Baulieu, E.E.1
  • 12
    • 0031432952 scopus 로고    scopus 로고
    • Neurosteroids in the hippocampus: neuronal plasticity and memory
    • Schumacher M., et al. Neurosteroids in the hippocampus: neuronal plasticity and memory. Stress 2 1 (1997) 65-78
    • (1997) Stress , vol.2 , Issue.1 , pp. 65-78
    • Schumacher, M.1
  • 13
    • 0026579057 scopus 로고
    • Neuroactive steroids
    • Paul S.M., and Purdy R.H. Neuroactive steroids. Faseb J. 6 6 (1992) 2311-2322
    • (1992) Faseb J. , vol.6 , Issue.6 , pp. 2311-2322
    • Paul, S.M.1    Purdy, R.H.2
  • 14
    • 0026509649 scopus 로고
    • Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance
    • Majewska M.D. Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 38 4 (1992) 379-395
    • (1992) Prog. Neurobiol. , vol.38 , Issue.4 , pp. 379-395
    • Majewska, M.D.1
  • 15
    • 33745837449 scopus 로고    scopus 로고
    • Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell
    • Tsutsui K. Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell. Cerebellum 5 2 (2006) 89-96
    • (2006) Cerebellum , vol.5 , Issue.2 , pp. 89-96
    • Tsutsui, K.1
  • 16
    • 2542520714 scopus 로고    scopus 로고
    • Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination
    • Schumacher M., et al. Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm. IGF Res. 14 Suppl. A (2004) S18-S33
    • (2004) Growth Horm. IGF Res. , vol.14 , Issue.SUPPL. A
    • Schumacher, M.1
  • 17
    • 0035876966 scopus 로고    scopus 로고
    • Brain aromatase is neuroprotective
    • Azcoitia I., et al. Brain aromatase is neuroprotective. J. Neurobiol. 47 4 (2001) 318-329
    • (2001) J. Neurobiol. , vol.47 , Issue.4 , pp. 318-329
    • Azcoitia, I.1
  • 18
    • 0033305132 scopus 로고    scopus 로고
    • Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain
    • Zwain I.H., and Yen S.S. Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology 140 8 (1999) 3843-3852
    • (1999) Endocrinology , vol.140 , Issue.8 , pp. 3843-3852
    • Zwain, I.H.1    Yen, S.S.2
  • 19
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi F. Immune function of microglia. Glia 36 2 (2001) 165-179
    • (2001) Glia , vol.36 , Issue.2 , pp. 165-179
    • Aloisi, F.1
  • 20
    • 33644869901 scopus 로고    scopus 로고
    • Inflammation and neurodegenerative diseases
    • Griffin W.S. Inflammation and neurodegenerative diseases. Am. J. Clin. Nutr. 83 2 (2006) 470S-474S
    • (2006) Am. J. Clin. Nutr. , vol.83 , Issue.2
    • Griffin, W.S.1
  • 21
    • 33748447845 scopus 로고    scopus 로고
    • Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
    • Kim Y.S., and Joh T.H. Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp. Mol. Med. 38 4 (2006) 333-347
    • (2006) Exp. Mol. Med. , vol.38 , Issue.4 , pp. 333-347
    • Kim, Y.S.1    Joh, T.H.2
  • 22
    • 9644310402 scopus 로고    scopus 로고
    • Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease
    • Raivich G., and Banati R. Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease. Brain Res. Brain Res. Rev. 46 3 (2004) 261-281
    • (2004) Brain Res. Brain Res. Rev. , vol.46 , Issue.3 , pp. 261-281
    • Raivich, G.1    Banati, R.2
  • 23
    • 10744229403 scopus 로고    scopus 로고
    • Steroid hormones and neurosteroids in normal and pathological aging of the nervous system
    • Schumacher M., et al. Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Prog. Neurobiol. 71 1 (2003) 3-29
    • (2003) Prog. Neurobiol. , vol.71 , Issue.1 , pp. 3-29
    • Schumacher, M.1
  • 24
    • 0031732983 scopus 로고    scopus 로고
    • Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence
    • Straub R.H., et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J. Clin. Endocrinol. Metab. 83 6 (1998) 2012-2017
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , Issue.6 , pp. 2012-2017
    • Straub, R.H.1
  • 25
    • 33645732447 scopus 로고    scopus 로고
    • Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line
    • Cutolo M., et al. Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line. Arthritis Res. Ther. 7 5 (2005) R1124-R1132
    • (2005) Arthritis Res. Ther. , vol.7 , Issue.5
    • Cutolo, M.1
  • 26
    • 0347719508 scopus 로고    scopus 로고
    • Immunomodulatory actions of gonadal steroids may be mediated by gonadotropin-releasing hormone
    • Jacobson J.D., and Ansari M.A. Immunomodulatory actions of gonadal steroids may be mediated by gonadotropin-releasing hormone. Endocrinology 145 1 (2004) 330-336
    • (2004) Endocrinology , vol.145 , Issue.1 , pp. 330-336
    • Jacobson, J.D.1    Ansari, M.A.2
  • 27
    • 33745615633 scopus 로고    scopus 로고
    • Inflammation and sex hormone metabolism
    • Schmidt M., et al. Inflammation and sex hormone metabolism. Ann. NY Acad. Sci. 1069 (2006) 236-246
    • (2006) Ann. NY Acad. Sci. , vol.1069 , pp. 236-246
    • Schmidt, M.1
  • 28
    • 14644399802 scopus 로고    scopus 로고
    • Metabolism of dehydroepiandrosterone by rodent brain cell lines: relationship between 7-hydroxylation and aromatization
    • Jellinck P.H., et al. Metabolism of dehydroepiandrosterone by rodent brain cell lines: relationship between 7-hydroxylation and aromatization. J. Steroid Biochem. Mol. Biol. 93 1 (2005) 81-86
    • (2005) J. Steroid Biochem. Mol. Biol. , vol.93 , Issue.1 , pp. 81-86
    • Jellinck, P.H.1
  • 29
    • 30944454658 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia
    • Jellinck P.H., et al. Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia. J. Steroid Biochem. Mol. Biol. 98 1 (2006) 41-47
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.98 , Issue.1 , pp. 41-47
    • Jellinck, P.H.1
  • 30
    • 34548497901 scopus 로고    scopus 로고
    • Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol-a steroid with inherent estrogenic properties
    • Jellinck P.H., Kaufmann M., Gottfried-Blackmore A., McEwen B.S., Jones G., and Bulloch K. Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol-a steroid with inherent estrogenic properties. J. Steroid Biochem. Mol. Biol. 107 3-5 (2007) 156-162
    • (2007) J. Steroid Biochem. Mol. Biol. , vol.107 , Issue.3-5 , pp. 156-162
    • Jellinck, P.H.1    Kaufmann, M.2    Gottfried-Blackmore, A.3    McEwen, B.S.4    Jones, G.5    Bulloch, K.6
  • 31
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • Bessis A., et al. Microglial control of neuronal death and synaptic properties. Glia 55 3 (2007) 233-238
    • (2007) Glia , vol.55 , Issue.3 , pp. 233-238
    • Bessis, A.1
  • 32
    • 26944453586 scopus 로고    scopus 로고
    • Like cops on the beat: the active role of resting microglia
    • Raivich G. Like cops on the beat: the active role of resting microglia. Trends Neurosci. 28 11 (2005) 571-573
    • (2005) Trends Neurosci. , vol.28 , Issue.11 , pp. 571-573
    • Raivich, G.1
  • 33
    • 0037307026 scopus 로고    scopus 로고
    • A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
    • Sasmono R.T., et al. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 101 3 (2003) 1155-1163
    • (2003) Blood , vol.101 , Issue.3 , pp. 1155-1163
    • Sasmono, R.T.1
  • 34
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • Sierra A., et al. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55 4 (2007) 412-424
    • (2007) Glia , vol.55 , Issue.4 , pp. 412-424
    • Sierra, A.1
  • 35
    • 0037320253 scopus 로고    scopus 로고
    • Molecular insights on the cerebral innate immune system
    • Rivest S. Molecular insights on the cerebral innate immune system. Brain Behav. Immun. 17 1 (2003) 13-19
    • (2003) Brain Behav. Immun. , vol.17 , Issue.1 , pp. 13-19
    • Rivest, S.1
  • 36
    • 0036176076 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptors and mitochondrial function
    • Casellas P., Galiegue S., and Basile A.S. Peripheral benzodiazepine receptors and mitochondrial function. Neurochem. Int. 40 6 (2002) 475-486
    • (2002) Neurochem. Int. , vol.40 , Issue.6 , pp. 475-486
    • Casellas, P.1    Galiegue, S.2    Basile, A.S.3
  • 37
    • 0016614316 scopus 로고
    • Interaction of delta-5-androstene-3beta, 17beta-diol with estradiol and dihydrotestosterone receptors in human myometrial and mammary cancer tissue
    • Poortman J., et al. Interaction of delta-5-androstene-3beta, 17beta-diol with estradiol and dihydrotestosterone receptors in human myometrial and mammary cancer tissue. J. Clin. Endocrinol. Metab. 40 3 (1975) 373-379
    • (1975) J. Clin. Endocrinol. Metab. , vol.40 , Issue.3 , pp. 373-379
    • Poortman, J.1
  • 38
    • 80052081651 scopus 로고    scopus 로고
    • progesterone as neuroprotective agents in the treatment of acute brain injuries
    • Stein D.G., Hoffman S.W., and Estrogen. progesterone as neuroprotective agents in the treatment of acute brain injuries. Pediatr. Rehabil. 6 1 (2003) 13-22
    • (2003) Pediatr. Rehabil. , vol.6 , Issue.1 , pp. 13-22
    • Stein, D.G.1    Hoffman, S.W.2    Estrogen3
  • 39
    • 0034483580 scopus 로고    scopus 로고
    • Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury
    • Wise P.M., et al. Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury. J Neurocytol 29 5-6 (2000) 401-410
    • (2000) J Neurocytol , vol.29 , Issue.5-6 , pp. 401-410
    • Wise, P.M.1
  • 40
    • 12144261036 scopus 로고    scopus 로고
    • Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration
    • Azcoitia I., et al. Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration. J. Neural Transm. 112 1 (2005) 171-176
    • (2005) J. Neural Transm. , vol.112 , Issue.1 , pp. 171-176
    • Azcoitia, I.1
  • 41
    • 0032910967 scopus 로고    scopus 로고
    • Dehydroepiandrosterone: biosynthesis and metabolism in the brain
    • Zwain I.H., and Yen S.S. Dehydroepiandrosterone: biosynthesis and metabolism in the brain. Endocrinology 140 2 (1999) 880-887
    • (1999) Endocrinology , vol.140 , Issue.2 , pp. 880-887
    • Zwain, I.H.1    Yen, S.S.2
  • 42
    • 0032515989 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids
    • Baulieu E.E., and Robel P. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc. Natl. Acad. Sci. U.S.A. 95 8 (1998) 4089-4091
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , Issue.8 , pp. 4089-4091
    • Baulieu, E.E.1    Robel, P.2
  • 43
    • 4744355194 scopus 로고    scopus 로고
    • Neurosteroids: the StAR protein in the brain
    • Sierra A. Neurosteroids: the StAR protein in the brain. J. Neuroendocrinol. 16 9 (2004) 787-793
    • (2004) J. Neuroendocrinol. , vol.16 , Issue.9 , pp. 787-793
    • Sierra, A.1
  • 44
    • 0034119678 scopus 로고    scopus 로고
    • The role of the StAR protein in steroidogenesis: challenges for the future
    • Stocco D.M. The role of the StAR protein in steroidogenesis: challenges for the future. J. Endocrinol. 164 3 (2000) 247-253
    • (2000) J. Endocrinol. , vol.164 , Issue.3 , pp. 247-253
    • Stocco, D.M.1
  • 45
    • 33744827673 scopus 로고    scopus 로고
    • Localization of StarD5 cholesterol binding protein
    • Rodriguez-Agudo D., et al. Localization of StarD5 cholesterol binding protein. J. Lipid Res. 47 6 (2006) 1168-1175
    • (2006) J. Lipid Res. , vol.47 , Issue.6 , pp. 1168-1175
    • Rodriguez-Agudo, D.1
  • 46
    • 0036936614 scopus 로고    scopus 로고
    • PBR, StAR, and PKA: partners in cholesterol transport in steroidogenic cells
    • Hauet T., et al. PBR, StAR, and PKA: partners in cholesterol transport in steroidogenic cells. Endocr. Res. 28 4 (2002) 395-401
    • (2002) Endocr. Res. , vol.28 , Issue.4 , pp. 395-401
    • Hauet, T.1
  • 47
    • 0033514002 scopus 로고    scopus 로고
    • Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis
    • Lacor P., et al. Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis. Brain Res. 815 1 (1999) 70-80
    • (1999) Brain Res. , vol.815 , Issue.1 , pp. 70-80
    • Lacor, P.1
  • 48
    • 0035231294 scopus 로고    scopus 로고
    • Role of the peripheral-type benzodiazepine receptor in adrenal and brain steroidogenesis
    • Brown R.C., and Papadopoulos V. Role of the peripheral-type benzodiazepine receptor in adrenal and brain steroidogenesis. Int. Rev. Neurobiol. 46 (2001) 117-143
    • (2001) Int. Rev. Neurobiol. , vol.46 , pp. 117-143
    • Brown, R.C.1    Papadopoulos, V.2
  • 49
    • 4644224402 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor and its clinical targeting
    • Decaudin D. Peripheral benzodiazepine receptor and its clinical targeting. Anticancer Drugs 15 8 (2004) 737-745
    • (2004) Anticancer Drugs , vol.15 , Issue.8 , pp. 737-745
    • Decaudin, D.1
  • 50
    • 0041809082 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor: a promising therapeutic drug target
    • Galiegue S., Tinel N., and Casellas P. The peripheral benzodiazepine receptor: a promising therapeutic drug target. Curr. Med. Chem. 10 16 (2003) 1563-1572
    • (2003) Curr. Med. Chem. , vol.10 , Issue.16 , pp. 1563-1572
    • Galiegue, S.1    Tinel, N.2    Casellas, P.3
  • 51
    • 33644498858 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders
    • Papadopoulos V., et al. Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders. Neuroscience 138 3 (2006) 749-756
    • (2006) Neuroscience , vol.138 , Issue.3 , pp. 749-756
    • Papadopoulos, V.1
  • 52
    • 0029915241 scopus 로고    scopus 로고
    • Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage
    • Carayon P., et al. Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Blood 87 8 (1996) 3170-3178
    • (1996) Blood , vol.87 , Issue.8 , pp. 3170-3178
    • Carayon, P.1
  • 53
    • 0036850086 scopus 로고    scopus 로고
    • Visualising microglial activation in vivo
    • Banati R.B. Visualising microglial activation in vivo. Glia 40 2 (2002) 206-217
    • (2002) Glia , vol.40 , Issue.2 , pp. 206-217
    • Banati, R.B.1
  • 54
    • 0027390233 scopus 로고
    • Modulation of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-8, and granulocyte/macrophage colony-stimulating factor expression in human monocytes by an endogenous anxiogenic benzodiazepine ligand, triakontatetraneuropeptide: evidence for a role of prostaglandins
    • Taupin V., et al. Modulation of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-8, and granulocyte/macrophage colony-stimulating factor expression in human monocytes by an endogenous anxiogenic benzodiazepine ligand, triakontatetraneuropeptide: evidence for a role of prostaglandins. Mol. Pharmacol. 43 1 (1993) 64-69
    • (1993) Mol. Pharmacol. , vol.43 , Issue.1 , pp. 64-69
    • Taupin, V.1
  • 55
    • 0027400847 scopus 로고
    • Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5-4864, a peripheral-type (p site) benzodiazepine ligand
    • Taupin V., et al. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5-4864, a peripheral-type (p site) benzodiazepine ligand. J. Neuroimmunol. 42 2 (1993) 177-185
    • (1993) J. Neuroimmunol. , vol.42 , Issue.2 , pp. 177-185
    • Taupin, V.1
  • 56
    • 0036829178 scopus 로고    scopus 로고
    • i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195
    • i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195. J. Neurochem. 83 3 (2002) 546-555
    • (2002) J. Neurochem. , vol.83 , Issue.3 , pp. 546-555
    • Choi, H.B.1
  • 57
    • 25144465870 scopus 로고    scopus 로고
    • Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats
    • Leonelli E., et al. Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats. Mech. Ageing Dev. 126 11 (2005) 1159-1163
    • (2005) Mech. Ageing Dev. , vol.126 , Issue.11 , pp. 1159-1163
    • Leonelli, E.1
  • 58
    • 17744386969 scopus 로고    scopus 로고
    • Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity
    • Veiga S., Azcoitia I., and Garcia-Segura L.M. Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity. J. Neurosci. Res. 80 1 (2005) 129-137
    • (2005) J. Neurosci. Res. , vol.80 , Issue.1 , pp. 129-137
    • Veiga, S.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 59
    • 0025972506 scopus 로고
    • In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects
    • Chensue S.W., et al. In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects. Am. J. Pathol. 138 2 (1991) 395-402
    • (1991) Am. J. Pathol. , vol.138 , Issue.2 , pp. 395-402
    • Chensue, S.W.1
  • 60
    • 0030043899 scopus 로고    scopus 로고
    • Immune-neuro-endocrine interactions: facts and hypotheses
    • Besedovsky H.O., and del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 17 1 (1996) 64-102
    • (1996) Endocr. Rev. , vol.17 , Issue.1 , pp. 64-102
    • Besedovsky, H.O.1    del Rey, A.2
  • 61
    • 33846296646 scopus 로고    scopus 로고
    • Corticosterone impairs the mRNA expression and activity of 3beta- and 17beta-hydroxysteroid dehydrogenases in adult rat Leydig cells
    • Badrinarayanan R., et al. Corticosterone impairs the mRNA expression and activity of 3beta- and 17beta-hydroxysteroid dehydrogenases in adult rat Leydig cells. Biochem. Cell. Biol. 84 5 (2006) 745-754
    • (2006) Biochem. Cell. Biol. , vol.84 , Issue.5 , pp. 745-754
    • Badrinarayanan, R.1
  • 62
    • 0029958795 scopus 로고    scopus 로고
    • Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro
    • Gao H.B., et al. Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro. Endocrinology 137 5 (1996) 1714-1718
    • (1996) Endocrinology , vol.137 , Issue.5 , pp. 1714-1718
    • Gao, H.B.1
  • 63
    • 18844381164 scopus 로고    scopus 로고
    • Minireview: cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potency
    • Agarwal A.K., and Auchus R.J. Minireview: cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potency. Endocrinology 146 6 (2005) 2531-2538
    • (2005) Endocrinology , vol.146 , Issue.6 , pp. 2531-2538
    • Agarwal, A.K.1    Auchus, R.J.2
  • 64
    • 0025773340 scopus 로고
    • Cytokine-mediated regulation of ovarian function. Tumor necrosis factor alpha inhibits gonadotropin-supported ovarian androgen biosynthesis
    • Andreani C.L., et al. Cytokine-mediated regulation of ovarian function. Tumor necrosis factor alpha inhibits gonadotropin-supported ovarian androgen biosynthesis. J. Biol. Chem. 266 11 (1991) 6761-6766
    • (1991) J. Biol. Chem. , vol.266 , Issue.11 , pp. 6761-6766
    • Andreani, C.L.1
  • 65
    • 0031412912 scopus 로고    scopus 로고
    • Differential effects of tumor necrosis factor-alpha and interleukin-1 on 3 beta-hydroxysteroid dehydrogenase/delta 5 → delta 4 isomerase expression in mouse Leydig cells
    • Xiong Y., and Hales D.B. Differential effects of tumor necrosis factor-alpha and interleukin-1 on 3 beta-hydroxysteroid dehydrogenase/delta 5 → delta 4 isomerase expression in mouse Leydig cells. Endocrine 7 3 (1997) 295-301
    • (1997) Endocrine , vol.7 , Issue.3 , pp. 295-301
    • Xiong, Y.1    Hales, D.B.2
  • 66
    • 0026046235 scopus 로고
    • Cytokine-mediated regulation of ovarian function: interleukin-1 inhibits gonadotropin-induced androgen biosynthesis
    • Hurwitz A., et al. Cytokine-mediated regulation of ovarian function: interleukin-1 inhibits gonadotropin-induced androgen biosynthesis. Endocrinology 129 3 (1991) 1250-1256
    • (1991) Endocrinology , vol.129 , Issue.3 , pp. 1250-1256
    • Hurwitz, A.1
  • 67
    • 0031767025 scopus 로고    scopus 로고
    • Nitric oxide is a mediator of the inhibitory effect of activated macrophages on production of androgen by the Leydig cell of the mouse
    • Pomerantz D.K., and Pitelka V. Nitric oxide is a mediator of the inhibitory effect of activated macrophages on production of androgen by the Leydig cell of the mouse. Endocrinology 139 3 (1998) 922-931
    • (1998) Endocrinology , vol.139 , Issue.3 , pp. 922-931
    • Pomerantz, D.K.1    Pitelka, V.2
  • 68
    • 0026459060 scopus 로고
    • Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression
    • Hales D.B. Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression. Endocrinology 131 5 (1992) 2165-2172
    • (1992) Endocrinology , vol.131 , Issue.5 , pp. 2165-2172
    • Hales, D.B.1
  • 69
    • 0028984601 scopus 로고
    • Tumor necrosis factor-alpha inhibition of 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) expression
    • Li X., et al. Tumor necrosis factor-alpha inhibition of 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) expression. Endocrinology 136 8 (1995) 3519-3526
    • (1995) Endocrinology , vol.136 , Issue.8 , pp. 3519-3526
    • Li, X.1
  • 70
    • 0029855613 scopus 로고    scopus 로고
    • Splenic macrophages can modify steroidogenesis of Leydig cells
    • Onami S., et al. Splenic macrophages can modify steroidogenesis of Leydig cells. Endocr. J. 43 5 (1996) 477-485
    • (1996) Endocr. J. , vol.43 , Issue.5 , pp. 477-485
    • Onami, S.1
  • 71
    • 0020625197 scopus 로고
    • Androstenedione metabolism in human alveolar macrophages
    • Milewich L., Kaimal V., and Toews G.B. Androstenedione metabolism in human alveolar macrophages. J. Clin. Endocrinol. Metab. 56 5 (1983) 920-924
    • (1983) J. Clin. Endocrinol. Metab. , vol.56 , Issue.5 , pp. 920-924
    • Milewich, L.1    Kaimal, V.2    Toews, G.B.3
  • 72
    • 0032935119 scopus 로고    scopus 로고
    • Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone
    • Kemppainen J.A., et al. Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone. Mol. Endocrinol. 13 3 (1999) 440-454
    • (1999) Mol. Endocrinol. , vol.13 , Issue.3 , pp. 440-454
    • Kemppainen, J.A.1
  • 73
    • 0029031815 scopus 로고
    • Expression and regulation of aromatase cytochrome P450 in THP 1 human myeloid leukaemia cells
    • Jakob F., et al. Expression and regulation of aromatase cytochrome P450 in THP 1 human myeloid leukaemia cells. Mol. Cell Endocrinol. 110 1-2 (1995) 27-33
    • (1995) Mol. Cell Endocrinol. , vol.110 , Issue.1-2 , pp. 27-33
    • Jakob, F.1
  • 74
    • 0002845980 scopus 로고    scopus 로고
    • Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages
    • Schmidt M., et al. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. J. Endocrinol. 164 2 (2000) 161-169
    • (2000) J. Endocrinol. , vol.164 , Issue.2 , pp. 161-169
    • Schmidt, M.1
  • 75
    • 0029552972 scopus 로고
    • Neuronal actions of dehydroepiandrosterone. Possible roles in brain development, aging, memory, and affect
    • Majewska M.D. Neuronal actions of dehydroepiandrosterone. Possible roles in brain development, aging, memory, and affect. Ann. NY Acad. Sci. 774 (1995) 111-120
    • (1995) Ann. NY Acad. Sci. , vol.774 , pp. 111-120
    • Majewska, M.D.1
  • 76
    • 0028309503 scopus 로고
    • Dehydroepiandrosterone (DHEA)-the multifunctional steroid. II. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action?
    • Regelson W., and Kalimi M. Dehydroepiandrosterone (DHEA)-the multifunctional steroid. II. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action?. Ann. NY Acad. Sci. 719 (1994) 564-575
    • (1994) Ann. NY Acad. Sci. , vol.719 , pp. 564-575
    • Regelson, W.1    Kalimi, M.2
  • 77
    • 0036846534 scopus 로고    scopus 로고
    • Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients
    • Weill-Engerer S., et al. Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients. J. Clin. Endocrinol. Metab. 87 11 (2002) 5138-5143
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.11 , pp. 5138-5143
    • Weill-Engerer, S.1
  • 78
    • 0347296102 scopus 로고    scopus 로고
    • In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients
    • Weill-Engerer S., et al. In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients. Brain Res. 969 1-2 (2003) 117-125
    • (2003) Brain Res. , vol.969 , Issue.1-2 , pp. 117-125
    • Weill-Engerer, S.1
  • 79
    • 0021794392 scopus 로고
    • Control of secretion and the function of C19-delta 5-steroids of the human adrenal gland
    • Adams J.B. Control of secretion and the function of C19-delta 5-steroids of the human adrenal gland. Mol. Cell Endocrinol. 41 1 (1985) 1-17
    • (1985) Mol. Cell Endocrinol. , vol.41 , Issue.1 , pp. 1-17
    • Adams, J.B.1
  • 80
    • 0032529840 scopus 로고    scopus 로고
    • Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells
    • Miyamoto H., et al. Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells. Proc. Natl. Acad. Sci. U.S.A. 95 19 (1998) 11083-11088
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , Issue.19 , pp. 11083-11088
    • Miyamoto, H.1
  • 81
    • 0020566654 scopus 로고
    • Binding and effects of 5 alpha-androstane-3 beta, 17 beta-diol in the male rat pituitary
    • Thieulant M.L., et al. Binding and effects of 5 alpha-androstane-3 beta, 17 beta-diol in the male rat pituitary. J. Steroid Biochem. 19 1A (1983) 241-246
    • (1983) J. Steroid Biochem. , vol.19 , Issue.1 A , pp. 241-246
    • Thieulant, M.L.1
  • 82
    • 0029992644 scopus 로고    scopus 로고
    • Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids
    • Baulieu E.E., and Robel P. Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids. J. Endocrinol. 150 Suppl. (1996) S221-S239
    • (1996) J. Endocrinol. , vol.150 , Issue.SUPPL
    • Baulieu, E.E.1    Robel, P.2
  • 83
    • 20744439234 scopus 로고    scopus 로고
    • Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency
    • Weidler C., et al. Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency. Arthritis Rheum. 52 6 (2005) 1721-1729
    • (2005) Arthritis Rheum. , vol.52 , Issue.6 , pp. 1721-1729
    • Weidler, C.1
  • 84
    • 0028302689 scopus 로고
    • Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines
    • Hennebold J.D., and Daynes R.A. Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines. Endocrinology 135 1 (1994) 67-75
    • (1994) Endocrinology , vol.135 , Issue.1 , pp. 67-75
    • Hennebold, J.D.1    Daynes, R.A.2
  • 85
    • 36749090210 scopus 로고    scopus 로고
    • Characterization of a cerebellar granule progenitor cell line, EtC.1, and its responsiveness to 17-beta-estradiol
    • Gottfried-Blackmore A., Croft G., Clark J., McEwen B.S., Jellinck P.H., and Bulloch K. Characterization of a cerebellar granule progenitor cell line, EtC.1, and its responsiveness to 17-beta-estradiol. Brain Res. 186 1 (2007) 29-40
    • (2007) Brain Res. , vol.186 , Issue.1 , pp. 29-40
    • Gottfried-Blackmore, A.1    Croft, G.2    Clark, J.3    McEwen, B.S.4    Jellinck, P.H.5    Bulloch, K.6
  • 86
    • 45549085016 scopus 로고    scopus 로고
    • A. Sierra, A. Gottfried-Blackmore, T.A. Milner, B.S. McEwen, K. Bulloch, Steroid hormone receptor expression and function in microglia, Glia, doi:10.1002/glia.20644, Published Online: Feb 19, 2008.
    • A. Sierra, A. Gottfried-Blackmore, T.A. Milner, B.S. McEwen, K. Bulloch, Steroid hormone receptor expression and function in microglia, Glia, doi:10.1002/glia.20644, Published Online: Feb 19, 2008.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.