Imaging microglial activation with TSPO PET: Lighting up neurologic diseases?

Journal of Nuclear Medicine

Volumn 57, Issue 2, 2016, Pages 165-168

  Vivash, Lucy ^a   O'Brien, Terence J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

11C PK11195; Microglia; Neurology; Positron emission tomography; TSPO

Indexed keywords

AC 5216 C 11; CARRIER PROTEIN; DAA 1106 C 11; DAC C 11; DPA 713 C 11; DPA 714 F 18; FEDAA 1106 F 18; FEPPA F 18; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; PBR 06 F 18; PBR 111 F 18; PBR 28 C 11; RADIOLIGAND; SSR 180575 C 11; TRACER; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG; VINPOCETINE C 11; 4 AMINOBUTYRIC ACID RECEPTOR; RADIOPHARMACEUTICAL AGENT; TSPO PROTEIN, HUMAN;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; BRAIN DISEASE; CELL ACTIVATION; DRUG BINDING; HUMAN; IN VIVO STUDY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL NOISE RATIO; CHEMISTRY; MOLECULAR IMAGING; PROCEDURES; SCINTISCANNING;

HUMANS; MICROGLIA; MOLECULAR IMAGING; NERVOUS SYSTEM DISEASES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, GABA;

EID: 84958612615     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.114.141713     Document Type: Article

References (25)

1. Rupprecht R, Papadopoulos V, Rammes G, et al. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov. 2010;9:971-988.
2. Scarf AM, Kassiou M. The translocator protein. J Nucl Med. 2011;52:677-680.
3. Owen DR, Matthews PM. Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands. Int Rev Neurobiol. 2011;101:19-39.
4. Trapani A, Palazzo C, de Candia M, Lasorsa FM, Trapani G. Targeting of the translocator protein 18 kDa (TSPO): a valuable approach for nuclear and optical imaging of activated microglia. Bioconjug Chem. 2013;24:1415-1428.
5. 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline. J Nucl Med. 2011;52:107-114.
6. 18F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimi din-3-yl)acetamide. J Nucl Med. 2012;53:287-294.
7. 18F-fluoro-N-(2-phenoxyphenyl)acetamide. J Nucl Med. 2015;56:311-316.
8. Lyoo CH, Ikawa M, Liow JS, et al. Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binDing to translocator protein. J Nucl Med. 2015;56:701-706.
9. 11C]vinpocetine. Neuroimage. 2011;56:1111-1121.
10. 18F]FEDAA1106 and PET does not show increased binDing in Alzheimer's disease patients. Eur J Nucl Med Mol Imaging. 2013;40:921-931.
11. 18F-FEDAC: PET of the monkey brain and imaging of translocator protein (18 kDa) in the infarcted rat brain. J Nucl Med. 2010;51:1301-1309.
12. 11C]vinpocetine. Curr Radiopharm. 2012;5:19-28.
13. 11C]DAC-PET for noninvasively monitoring neuroinflammation and immunosuppressive therapy efficacy in rat experimental autoimmune encephalomyelitis model. J Neuroimmune Pharmacol. 2012;7:231-242.
14. Airas L, Dickens AM, Elo P, et al. In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. J Nucl Med. 2015;56:305-310.
15. 18F-PBR111 PET. J Nucl Med. 2014;55: 1112-1118.
16. Oh U, Fujita M, Ikonomidou VN, et al. Translocator protein PET imaging for glial activation in multiple sclerosis. J Neuroimmune Pharmacol. 2011;6:354-361.
17. 18F]FEDAA1106. EJNMMI Res. 2013;3:30.
18. Owen DR, Gunn RN, Rabiner EA, et al. Mixed-affinity binDing in humans with 18-kDa translocator protein ligands. J Nucl Med. 2011;52:24-32.
19. Owen DR, Yeo AJ, Gunn RN, et al. An 18-kDa translocator protein (TSPO) polymorphism explains differences in binDing affinity of the PET radioligand PBR28. J Cereb Blood Flow Metab. 2012;32:1-5.
20. 18F-PBR111 in healthy humans: a genetic polymorphism effect on in vivo binDing. J Nucl Med. 2013;54:1915-1923.
21. Lavisse S, Guillermier M, Herard AS, et al. Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging. J Neurosci. 2012;32:10809-10818.
22. 11C-labeled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomography. Eur J Nucl Med Mol Imaging. 2011;38:352-357.
23. 11C]ketoprofen methyl ester, for imagings of neuroinflammation. Nucl Med Biol. 2014;41:594-599.
24. Savonenko AV, Melnikova T, Wang Y, et al. Cannabinoid CB2 receptors in a mouse model of Abeta amyloidosis: immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation. PLoS One. 2015;10:e0129618.
25. Slavik R, Herde AM, Bieri D, et al. Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor. Eur J Med Chem. 2015;92:554-564.