In vivo assessment of brain white matter inflammation in multiple sclerosis with 18F-PBR111 PET

Journal of Nuclear Medicine

Volumn 55, Issue 7, 2014, Pages 1112-1118

  Colasanti, Alessandro ^a,b   Guo, Qi ^b,c   Muhlert, Nils ^d,e   Giannetti, Paolo ^a   Onega, Mayca ^b   Newbould, Rexford D ^b   Ciccarelli, Olga ^d   Rison, Stuart ^f   Thomas, Charlotte ^f   Nicholas, Richard ^a,f   Muraro, Paolo A ^a   Malik, Omar ^f   Owen, David R ^a   Piccini, Paola ^a   Gunn, Roger N ^a,b   Rabiner, Eugenii A ^b,c   Matthews, Paul M ^a,g  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Imanova Ltd   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e CARDIFF UNIVERSITY   (United Kingdom)

^f IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^g GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Lesion; Microglia; MTR; Multiple sclerosis; PET; TSPO

Indexed keywords

PBR 111 F 18; TRACER; UNCLASSIFIED DRUG; 2-(6-CHLORO-2-(4-(3-FLUOROPROPOXY)PHENYL)IMIDAZO(1,2-A)PYRIDIN-3-YL)-N,N-DIETHYLACETAMIDE; PYRIDINE DERIVATIVE;

ADULT; AGED; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE; HUMAN; IN VIVO STUDY; INNATE IMMUNITY; LIGAND BINDING; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OPEN STUDY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOISOTOPE DISTRIBUTION; TEST RETEST RELIABILITY; TSPO GENE; WHITE MATTER LESION; CASE CONTROL STUDY; IMMUNOLOGY; INFLAMMATION; MACROPHAGE; MICROGLIA; MIDDLE AGED; PATHOLOGY; REPRODUCIBILITY; SCINTISCANNING; WHITE MATTER;

ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; HUMANS; INFLAMMATION; MACROPHAGES; MALE; MICROGLIA; MIDDLE AGED; MULTIPLE SCLEROSIS; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; REPRODUCIBILITY OF RESULTS; WHITE MATTER;

EID: 84904114479     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.135129     Document Type: Article

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