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Volumn 17, Issue 11, 2017, Pages 947-958

Recent advances in development of GPR40 modulators (FFA1/FFAR1): An emerging target for type 2 diabetes

Author keywords

Agonists; Antagonists; FFA1; FFAR1; GPR40; Insulin; Type 2 diabetes

Indexed keywords

G PROTEIN COUPLED RECEPTOR 40; ANTIDIABETIC AGENT; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR;

EID: 85025139662     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557517666170120152917     Document Type: Review
Times cited : (14)

References (99)
  • 1
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • [1] Saltiel, A.R.; Kahn, R.C. Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 2001, 414, 799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, R.C.2
  • 2
    • 0030971593 scopus 로고    scopus 로고
    • Effect of a new hypoglycemic agent, A-4166 [(−)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: Comparison with voglibose and glibenblamide
    • [2] Ikenoue, T.; Okazaki, K.; Fujitani, S.; Tsuchiya, Y.; Akiyoshi, M.; Maki, T.; Kondo, N. Effect of a new hypoglycemic agent, A-4166 [(−)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: comparison with voglibose and glibenblamide. Biol. Pharm. Bull., 1997, 20, 354-359.
    • (1997) Biol. Pharm. Bull. , vol.20 , pp. 354-359
    • Ikenoue, T.1    Okazaki, K.2    Fujitani, S.3    Tsuchiya, Y.4    Akiyoshi, M.5    Maki, T.6    Kondo, N.7
  • 3
    • 3142728651 scopus 로고    scopus 로고
    • The role of sulphonylureas in the management of type 2 diabetes mellitus
    • [3] Rendell, M. The role of sulphonylureas in the management of type 2 diabetes mellitus. Drugs, 2004, 64, 1339-1358.
    • (2004) Drugs , vol.64 , pp. 1339-1358
    • Rendell, M.1
  • 4
    • 0020578096 scopus 로고
    • Glibenclamide-associated hypoglycaemia: A report on 57 cases
    • [4] Asplund, K.; Wiholm, B.E.; Lithner, F. Glibenclamide-associated hypoglycaemia: a report on 57 cases. Diabetologia, 1983, 24, 412-417.
    • (1983) Diabetologia , vol.24 , pp. 412-417
    • Asplund, K.1    Wiholm, B.E.2    Lithner, F.3
  • 7
    • 11844298435 scopus 로고    scopus 로고
    • Marchetti, P. Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets
    • [7] Del Guerra, S.; Marselli, L.; Lupi, R.; Boggi, U.; Mosca, F.; Benzi, L.; Del Prato, S.; Marchetti, P. Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets. J. Diabetes Complicat., 2005, 19, 60-64.
    • (2005) J. Diabetes Complicat. , vol.19 , pp. 60-64
    • Del Guerra, S.1    Marselli, L.2    Lupi, R.3    Boggi, U.4    Mosca, F.5    Benzi, L.6    Del Prato, S.7
  • 8
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • [8] Drucker, D.J.; Nauck, M.A. The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet, 2006, 368, 1696-1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 9
    • 62349101426 scopus 로고    scopus 로고
    • GPR40 carboxylic acid receptor family and diabetes: A new drug target
    • [9] Telvekar, V.N.; Kundaikar, H.S. GPR40 carboxylic acid receptor family and diabetes: a new drug target. Curr. Drug Targets, 2008 10, 899-910.
    • (2008) Curr. Drug Targets , vol.10 , pp. 899-910
    • Telvekar, V.N.1    Kundaikar, H.S.2
  • 10
    • 0036688175 scopus 로고    scopus 로고
    • The use of constitutively active GPCRs in drug discovery and functional genomics. Nat
    • [10] Chalmers, D.T.; Behan, D.P. The use of constitutively active GPCRs in drug discovery and functional genomics. Nat. Rev. Drug Discov., 2002, 8, 599-608.
    • (2002) Rev. Drug Discov. , vol.8 , pp. 599-608
    • Chalmers, D.T.1    Behan, D.P.2
  • 11
    • 11844275233 scopus 로고    scopus 로고
    • Family of fatty acid binding receptors. DNA Cell
    • [11] Brown, A. J.; Jupe, S.; Briscoe, C. P. A family of fatty acid binding receptors. DNA Cell. Biol., 2005, 24, 54-61.
    • (2005) Biol. , vol.24 , pp. 54-61
    • Brown, A.J.1    Jupe, S.2    Briscoe, C.3
  • 14
    • 0037423719 scopus 로고    scopus 로고
    • A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
    • [14] Kotarsky, K.; Nilsson, N. E.; Flodgren, E.; Owman, C.; Olde, B. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem. Biophys. Res. Commun., 2003, 301, 406-410.
    • (2003) Biochem. Biophys. Res. Commun. , vol.301 , pp. 406-410
    • Kotarsky, K.1    Nilsson, N.E.2    Flodgren, E.3    Owman, C.4    Olde, B.5
  • 16
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    • [16] Nilsson, N.E.; Kotarsy, K.; Owman, C.; Olde, B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem. Biophys. Res. Commun., 2003, 303, 1047-1052.
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 1047-1052
    • Nilsson, N.E.1    Kotarsy, K.2    Owman, C.3    Olde, B.4
  • 17
    • 84891812539 scopus 로고    scopus 로고
    • Activation of GPR40 as a Therapeutic Target for the Treatment of Type 2 Diabetes
    • [17] Burant, C.F.; Activation of GPR40 as a Therapeutic Target for the Treatment of Type 2 Diabetes. Diabetes Care, 2013, 36, S175-S179.
    • (2013) Diabetes Care , vol.36 , pp. S175-S179
    • Burant, C.F.1
  • 18
    • 34347389002 scopus 로고    scopus 로고
    • The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1
    • [18] Zhang Y, Xu M, Zhang S. The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1. J. Mol. Endocrinol., 2007, 38, 651-661.
    • (2007) J. Mol. Endocrinol. , vol.38 , pp. 651-661
    • Zhang, Y.1    Xu, M.2    Zhang, S.3
  • 19
    • 70350561694 scopus 로고    scopus 로고
    • Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets
    • [19] Alquier T, Peyot ML, Latour MG. Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes, 2009, 58, 2607-2615.
    • (2009) Diabetes , vol.58 , pp. 2607-2615
    • Alquier, T.1    Peyot, M.L.2    Latour, M.G.3
  • 20
    • 34047177401 scopus 로고    scopus 로고
    • GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
    • [20] Latour MG, Alquier T, Oseid E. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes, 2007, 56, 1087-1094.
    • (2007) Diabetes , vol.56 , pp. 1087-1094
    • Latour, M.G.1    Alquier, T.2    Oseid, E.3
  • 21
    • 65549114432 scopus 로고    scopus 로고
    • Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
    • [21] Nagasumi K, Esaki R, Iwachidow K. Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes, 2009, 58, 1067-1076.
    • (2009) Diabetes , vol.58 , pp. 1067-1076
    • Nagasumi, K.1    Esaki, R.2    Iwachidow, K.3
  • 22
    • 84869468389 scopus 로고    scopus 로고
    • GPR40: A therapeutic target for mediating insulin secretion (Review)
    • [22] Feng, X.T.; Leng, J.; Xie, Z.; Li, S.L.; Zhao, W.; Tang, Q.L. GPR40: A therapeutic target for mediating insulin secretion (Review). Intl. J. Mol. Med., 2012, 30, 1261-1266.
    • (2012) Intl. J. Mol. Med. , vol.30 , pp. 1261-1266
    • Feng, X.T.1    Leng, J.2    Xie, Z.3    Li, S.L.4    Zhao, W.5    Tang, Q.L.6
  • 23
    • 84866129127 scopus 로고    scopus 로고
    • G protein-coupled receptor (GPR) 40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
    • [23] Ferdaoussi M, Bergeron V, Zarrouki B. G protein-coupled receptor (GPR) 40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Diabetologia, 2012, 55, 2682-2692.
    • (2012) Diabetologia , vol.55 , pp. 2682-2692
    • Ferdaoussi, M.1    Bergeron, V.2    Zarrouki, B.3
  • 25
    • 0030876806 scopus 로고    scopus 로고
    • The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation
    • [25] Stein, D.T.; Stevenson, B.E.; Chester, M.W.; Basit, M.; Daniels, M. B.; Turley, S.D.; Mcgarry, J.D. The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation. J. Clin. Invest., 1997, 100, 398-403.
    • (1997) J. Clin. Invest. , vol.100 , pp. 398-403
    • Stein, D.T.1    Stevenson, B.E.2    Chester, M.W.3    Basit, M.4    Daniels, M.B.5    Turley, S.D.6    McGarry, J.D.7
  • 26
    • 0031683543 scopus 로고    scopus 로고
    • Circulating fatty acids are essential for efficient glucosestimulated insulin secretion after prolonged fasting in humans
    • [26] Dobbins, R.L.; Chester, M.W.; Daniels, M.B.; Mcgarry, J.D.; Stein, D.T. Circulating fatty acids are essential for efficient glucosestimulated insulin secretion after prolonged fasting in humans. Diabetes, 1998, 47, 1613-1618.
    • (1998) Diabetes , vol.47 , pp. 1613-1618
    • Dobbins, R.L.1    Chester, M.W.2    Daniels, M.B.3    McGarry, J.D.4    Stein, D.T.5
  • 27
    • 0032102146 scopus 로고    scopus 로고
    • The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats
    • [27] Dobbins, R.L.; Chester, M.W.; Stevenson, B.E.; Daniels, M.B.; Stein, D.T.; Mcgarry, J.D. The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. J. Clin. Invest., 1998, 101, 2370-2376.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2370-2376
    • Dobbins, R.L.1    Chester, M.W.2    Stevenson, B.E.3    Daniels, M.B.4    Stein, D.T.5    McGarry, J.D.6
  • 28
    • 0036233109 scopus 로고    scopus 로고
    • Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans
    • [28] Gravena, C.; Mathias, P.C.; Ashcroft, S.J. Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans. J. Endocrinol., 2002, 173, 73-80.
    • (2002) J. Endocrinol. , vol.173 , pp. 73-80
    • Gravena, C.1    Mathias, P.C.2    Ashcroft, S.J.3
  • 29
    • 20944433543 scopus 로고    scopus 로고
    • The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
    • [29] Steneberg, P.; Rubins, N.; Bartoov-Shifman, R.; Walker, M.D.; Edlund, H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab., 2005, 1, 245-258.
    • (2005) Cell Metab. , vol.1 , pp. 245-258
    • Steneberg, P.1    Rubins, N.2    Bartoov-Shifman, R.3    Walker, M.D.4    Edlund, H.5
  • 30
    • 25144433441 scopus 로고    scopus 로고
    • Role of GPR40 in fatty acid action on the β cell line INS-1E. Biochem. Biophys
    • [30] Shapiro, H.; Shachar, S.; Sekler, I.; Herschfinkel, M.; Walker, M.D. Role of GPR40 in fatty acid action on the β cell line INS-1E. Biochem. Biophys. Res.Commun., 2005, 335, 97-104.
    • (2005) Res.Commun. , vol.335 , pp. 97-104
    • Shapiro, H.1    Shachar, S.2    Sekler, I.3    Herschfinkel, M.4    Walker, M.D.5
  • 31
    • 0025281303 scopus 로고
    • Yamamura, K.Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
    • [31] Miyazaki, J.; Araki, K.; Yamato, E.; Ikegami, H.; Asano, T.; Shibasaki, Y.; Oka, Y.; Yamamura, K.Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology, 1990, 127, 126-132.
    • (1990) Endocrinology , vol.127 , pp. 126-132
    • Miyazaki, J.1    Araki, K.2    Yamato, E.3    Ikegami, H.4    Asano, T.5    Shibasaki, Y.6    Oka, Y.7
  • 32
    • 0029071517 scopus 로고
    • Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu
    • [32] Newgard, C.B.; McGarry, J. D. Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu. Rev. Biochem., 1995, 64, 689-719.
    • (1995) Rev. Biochem. , vol.64 , pp. 689-719
    • Newgard, C.B.1    McGarry, J.D.2
  • 33
    • 20944433543 scopus 로고    scopus 로고
    • The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
    • [33] Steneberg, R.; Rubins, N.; Bartoov-Shifman, R.; Walker, M.D.; Edlund, H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab., 2005, 1, 245-258.
    • (2005) Cell Metab. , vol.1 , pp. 245-258
    • Steneberg, R.1    Rubins, N.2    Bartoov-Shifman, R.3    Walker, M.D.4    Edlund, H.5
  • 34
    • 53849146735 scopus 로고    scopus 로고
    • The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: Investigations using GPR40-knockout mice. Biochem. Soc
    • [34] Brownlie, R.; Mayers, R.M.; Pierce, J.A.; Marley, A.E.; Smith, D.M. The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: Investigations using GPR40-knockout mice. Biochem. Soc. Trans., 2008, 36, 950-954.
    • (2008) Trans. , vol.36 , pp. 950-954
    • Brownlie, R.1    Mayers, R.M.2    Pierce, J.A.3    Marley, A.E.4    Smith, D.M.5
  • 35
    • 34047177401 scopus 로고    scopus 로고
    • GPR40 is necessary but notsufficient for fatty acid stimulation of insulin secretion in vivo
    • [35] Latour, M.G.; Alquier, T.; Oseid, E.; Tremblay, C.; Jetton, T.L.; Luo, J.; Lin, D.C.H.; Poitout, V. GPR40 is necessary but notsufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes, 2007, 56, 1087-1094.
    • (2007) Diabetes , vol.56 , pp. 1087-1094
    • Latour, M.G.1    Alquier, T.2    Oseid, E.3    Tremblay, C.4    Jetton, T.L.5    Luo, J.6    Lin, D.C.H.7    Poitout, V.8
  • 36
    • 52249093427 scopus 로고    scopus 로고
    • The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding
    • [36] Kebede, M.; Alquier, T.; Latour, M. G.; Semache, M.; Tremblay, C.; Poitout, V. The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes, 2008, 57, 2432-2437.
    • (2008) Diabetes , vol.57 , pp. 2432-2437
    • Kebede, M.1    Alquier, T.2    Latour, M.G.3    Semache, M.4    Tremblay, C.5    Poitout, V.6
  • 41
    • 34248527694 scopus 로고    scopus 로고
    • Fatty acid receptors as new therapeutic targets for diabetes. Expert Opin. Ther
    • [41] Rayasam, G.V.; Tulasi, V.K.; Davis, J.A.; Bansal, V.S. Fatty acid receptors as new therapeutic targets for diabetes. Expert Opin. Ther. Targets, 2007, 11, 661-671.
    • (2007) Targets , vol.11 , pp. 661-671
    • Rayasam, G.V.1    Tulasi, V.K.2    Davis, J.A.3    Bansal, V.S.4
  • 42
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes-a matter of beta-cell life and death?
    • [42] Rhodes, C.J. Type 2 diabetes-a matter of beta-cell life and death? Science, 2005, 307, 380-384.
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.J.1
  • 44
    • 58149095589 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: Pharmacology and pathophysiological functions
    • [44] Stoddart, L.A.; Smith, N.J.; Milligan, G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol. Rev., 2008, 60, 405-417.
    • (2008) Pharmacol. Rev. , vol.60 , pp. 405-417
    • Stoddart, L.A.1    Smith, N.J.2    Milligan, G.3
  • 45
    • 69549111756 scopus 로고    scopus 로고
    • Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
    • [45] Wellendorph, P.; Johansen, L.D.; Brauner-Osborne, H. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol. Pharmacol., 2009, 76, 453-465.
    • (2009) Mol. Pharmacol. , vol.76 , pp. 453-465
    • Wellendorph, P.1    Johansen, L.D.2    Brauner-Osborne, H.3
  • 47
    • 67649331670 scopus 로고    scopus 로고
    • Progress in the discovery and development of small-molecule modulators of Gprotein-coupled receptor 40 (GPR40/FFA1/FFAR1): An emerging target for type 2 diabetes
    • [47] Bharate, S.B.; Nemmani, V.S.K.; Vishwakarma, R.A. Progress in the discovery and development of small-molecule modulators of Gprotein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes. Expert Opin. Ther. Patents, 2009, 19(2), 237-264.
    • (2009) Expert Opin. Ther. Patents , vol.19 , Issue.2 , pp. 237-264
    • Bharate, S.B.1    Nemmani, V.S.K.2    Vishwakarma, R.A.3
  • 49
    • 77955681257 scopus 로고    scopus 로고
    • Asymmetric syntheses of a GPR40 receptor agonist via diastereoselective and enantioselective conjugate alkynylation
    • [49] Woo, J.; Cui, S.; Walker, S.D.; Faul, M.M. Asymmetric syntheses of a GPR40 receptor agonist via diastereoselective and enantioselective conjugate alkynylation. Tetrahedron, 2010, 66, 4730-4737.
    • (2010) Tetrahedron , vol.66 , pp. 4730-4737
    • Woo, J.1    Cui, S.2    Walker, S.D.3    Faul, M.M.4
  • 54
    • 34347220548 scopus 로고    scopus 로고
    • Bidirectional, iterative approach to the structural delineation of the functional “Chemoprint” in GPR40 for agonist recognition
    • [54] Tikhonova I.G.; Sum C.S.; Neuman S.; Thomas C.J.; Raaka B.M.; Costanzi S.; and Gershengorn M.C. Bidirectional, iterative approach to the structural delineation of the functional “Chemoprint” in GPR40 for agonist recognition. J. Med. Chem., 2007, 50, 2981-2989.
    • (2007) J. Med. Chem. , vol.50 , pp. 2981-2989
    • Tikhonova, I.G.1    Sum, C.S.2    Neuman, S.3    Thomas, C.J.4    Raaka, B.M.5    Costanzi, S.6    Gershengorn, M.C.7
  • 55
    • 39149097541 scopus 로고    scopus 로고
    • Gershengorn, M.C. Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening
    • [55] Tikhonova, I.G.; Sum, C.S.; Neumann, S.; Engel, S.; Raaka, B.M.; Costanzi, S.; Gershengorn, M.C. Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening. J. Med. Chem., 2008, 51, 625-633.
    • (2008) J. Med. Chem. , vol.51 , pp. 625-633
    • Tikhonova, I.G.1    Sum, C.S.2    Neumann, S.3    Engel, S.4    Raaka, B.M.5    Costanzi, S.6
  • 56
    • 77951974594 scopus 로고    scopus 로고
    • Molecular docking and molecular dynamics simulation studies of GPR40 receptor-agonist interactions
    • [56] Lu, S.Y.; Jiang, Y.J.; Lv, J.; Wu, T.X.; Yu, Q.S.; Zhu, W.L. Molecular docking and molecular dynamics simulation studies of GPR40 receptor-agonist interactions. J. Mol. Graph. Model., 2010, 28, 766-774.
    • (2010) J. Mol. Graph. Model. , vol.28 , pp. 766-774
    • Lu, S.Y.1    Jiang, Y.J.2    Lv, J.3    Wu, T.X.4    Yu, Q.S.5    Zhu, W.L.6
  • 70
    • 0346041542 scopus 로고    scopus 로고
    • Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors
    • [70] Kotarsky, K.; Nilsson, N.E.; Olde, B.; Owman, C. Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors. Pharmacol. Toxicol., 2003, 93, 249-258.
    • (2003) Pharmacol. Toxicol. , vol.93 , pp. 249-258
    • Kotarsky, K.1    Nilsson, N.E.2    Olde, B.3    Owman, C.4
  • 85
    • 84857032603 scopus 로고    scopus 로고
    • GPR40-induced insulin secretion by the novel agonist TAK-875: First clinical findings in patients with type 2 diabetes. Diabetes Obes
    • [85] Araki, T; Hirayama, M; Hiroi, S, Kaku K. GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes. Diabetes Obes. Metab., 2012, 14, 271-278.
    • (2012) Metab. , vol.14 , pp. 271-278
    • Araki, T.1    Hirayama, M.2    Hiroi, S.3    Kaku, K.4
  • 86
    • 84873835561 scopus 로고    scopus 로고
    • Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes
    • [86] Kaku, K.; Araki, T.; Yoshinaka R. Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes. Diabetes Care, 2013, 36, 245-250.
    • (2013) Diabetes Care , vol.36 , pp. 245-250
    • Kaku, K.1    Araki, T.2    Yoshinaka, R.3
  • 93
    • 84969575766 scopus 로고    scopus 로고
    • Modulators of GPR40 as treatment for diabetes
    • [93] Abdel-Magid, A.F. Modulators of GPR40 as treatment for diabetes. ACS Med. Chem. Lett., 2014, 5, 954-955.
    • (2014) ACS Med. Chem. Lett. , vol.5 , pp. 954-955
    • Abdel-Magid, A.F.1
  • 99
    • 78049237651 scopus 로고    scopus 로고
    • A small molecule antagonist GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats
    • [99] DC260126, a small molecule antagonist GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed. Pharmacother., 2010, 64(9), 647-651.
    • (2010) Biomed. Pharmacother. , vol.64 , Issue.9 , pp. 647-651


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