-
1
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
[1] Saltiel, A.R.; Kahn, R.C. Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 2001, 414, 799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, R.C.2
-
2
-
-
0030971593
-
Effect of a new hypoglycemic agent, A-4166 [(−)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: Comparison with voglibose and glibenblamide
-
[2] Ikenoue, T.; Okazaki, K.; Fujitani, S.; Tsuchiya, Y.; Akiyoshi, M.; Maki, T.; Kondo, N. Effect of a new hypoglycemic agent, A-4166 [(−)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: comparison with voglibose and glibenblamide. Biol. Pharm. Bull., 1997, 20, 354-359.
-
(1997)
Biol. Pharm. Bull.
, vol.20
, pp. 354-359
-
-
Ikenoue, T.1
Okazaki, K.2
Fujitani, S.3
Tsuchiya, Y.4
Akiyoshi, M.5
Maki, T.6
Kondo, N.7
-
3
-
-
3142728651
-
The role of sulphonylureas in the management of type 2 diabetes mellitus
-
[3] Rendell, M. The role of sulphonylureas in the management of type 2 diabetes mellitus. Drugs, 2004, 64, 1339-1358.
-
(2004)
Drugs
, vol.64
, pp. 1339-1358
-
-
Rendell, M.1
-
4
-
-
0020578096
-
Glibenclamide-associated hypoglycaemia: A report on 57 cases
-
[4] Asplund, K.; Wiholm, B.E.; Lithner, F. Glibenclamide-associated hypoglycaemia: a report on 57 cases. Diabetologia, 1983, 24, 412-417.
-
(1983)
Diabetologia
, vol.24
, pp. 412-417
-
-
Asplund, K.1
Wiholm, B.E.2
Lithner, F.3
-
6
-
-
12244287074
-
Sulfonylurea induced beta-cell apoptosis in cultured human islets
-
[6] Maedler, K.; Carr, R. D.; Bosco, D.; Zuellig, R. A.; Berney, T.; Donath, M. Y. Sulfonylurea induced beta-cell apoptosis in cultured human islets. J. Clin. Endocrinol. Metab., 2005, 90, 501-506.
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 501-506
-
-
Maedler, K.1
Carr, R.D.2
Bosco, D.3
Zuellig, R.A.4
Berney, T.5
Donath, M.Y.6
-
7
-
-
11844298435
-
Marchetti, P. Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets
-
[7] Del Guerra, S.; Marselli, L.; Lupi, R.; Boggi, U.; Mosca, F.; Benzi, L.; Del Prato, S.; Marchetti, P. Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets. J. Diabetes Complicat., 2005, 19, 60-64.
-
(2005)
J. Diabetes Complicat.
, vol.19
, pp. 60-64
-
-
Del Guerra, S.1
Marselli, L.2
Lupi, R.3
Boggi, U.4
Mosca, F.5
Benzi, L.6
Del Prato, S.7
-
8
-
-
33846006173
-
The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
[8] Drucker, D.J.; Nauck, M.A. The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet, 2006, 368, 1696-1705.
-
(2006)
Lancet
, vol.368
, pp. 1696-1705
-
-
Drucker, D.J.1
Nauck, M.A.2
-
9
-
-
62349101426
-
GPR40 carboxylic acid receptor family and diabetes: A new drug target
-
[9] Telvekar, V.N.; Kundaikar, H.S. GPR40 carboxylic acid receptor family and diabetes: a new drug target. Curr. Drug Targets, 2008 10, 899-910.
-
(2008)
Curr. Drug Targets
, vol.10
, pp. 899-910
-
-
Telvekar, V.N.1
Kundaikar, H.S.2
-
10
-
-
0036688175
-
The use of constitutively active GPCRs in drug discovery and functional genomics. Nat
-
[10] Chalmers, D.T.; Behan, D.P. The use of constitutively active GPCRs in drug discovery and functional genomics. Nat. Rev. Drug Discov., 2002, 8, 599-608.
-
(2002)
Rev. Drug Discov.
, vol.8
, pp. 599-608
-
-
Chalmers, D.T.1
Behan, D.P.2
-
11
-
-
11844275233
-
Family of fatty acid binding receptors. DNA Cell
-
[11] Brown, A. J.; Jupe, S.; Briscoe, C. P. A family of fatty acid binding receptors. DNA Cell. Biol., 2005, 24, 54-61.
-
(2005)
Biol.
, vol.24
, pp. 54-61
-
-
Brown, A.J.1
Jupe, S.2
Briscoe, C.3
-
12
-
-
0037838892
-
The Orphan G Proteincoupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids
-
[12] Briscoe, C.P.; Tadayyon, M.; Andrews, J.L.; Benson, W.G.; Chambers, J.K.; Eilert, M.M.; Ellis, C.; Elshourbagy, N. A.; Goetz, A. S.; Minnick, D. T.; Murdock, P. R.; Sauls, H. R. Jr.; Shabon, U.; Spinage, L.D.; Strum, J. C.; Szekeres, P. G.; Tan, K. B.; Way, J. M.; Ignar, D. M.; Wilson, S.; Muir, A. The Orphan G Proteincoupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids. J. Biol. Chem., 2003, 278, 11303-11311.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11303-11311
-
-
Briscoe, C.P.1
Tadayyon, M.2
Andrews, J.L.3
Benson, W.G.4
Chambers, J.K.5
Eilert, M.M.6
Ellis, C.7
Elshourbagy, N.A.8
Goetz, A.S.9
Minnick, D.T.10
Murdock, P.R.11
Sauls, H.R.12
Shabon, U.13
Spinage, L.D.14
Strum, J.C.15
Szekeres, P.G.16
Tan, K.B.17
Way, J.M.18
Ignar, D.M.19
Wilson, S.20
Muir, A.21
more..
-
13
-
-
0037434991
-
Free fatty acids regulate insulin secretion from pancreatic
-
[13] Itoh, Y.; Kawamata, Y.; Harada, M.; Kobayashi, M.; Fujii, R.; Fukusumi, S.; Ogi, K.; Hosoya, M.; Tanaka, Y.; Uejima, H.; Tanaka, H.; Maruyama, M.; Satoh, R.; Okubo, S.; Kizawa, H.; Komatsu, H.; Matsumura, F.; Noguchi, Y.; Shinohara, T.; Hinuma, S.; Fujisawa, Y.; Fujino, M. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40. Nature, 2003, 422, 173-176.
-
(2003)
Nature
, vol.422
, pp. 173-176
-
-
Itoh, Y.1
Kawamata, Y.2
Harada, M.3
Kobayashi, M.4
Fujii, R.5
Fukusumi, S.6
Ogi, K.7
Hosoya, M.8
Tanaka, Y.9
Uejima, H.10
Tanaka, H.11
Maruyama, M.12
Satoh, R.13
Okubo, S.14
Kizawa, H.15
Komatsu, H.16
Matsumura, F.17
Noguchi, Y.18
Shinohara, T.19
Hinuma, S.20
Fujisawa, Y.21
Fujino, M.22
more..
-
14
-
-
0037423719
-
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
-
[14] Kotarsky, K.; Nilsson, N. E.; Flodgren, E.; Owman, C.; Olde, B. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem. Biophys. Res. Commun., 2003, 301, 406-410.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.301
, pp. 406-410
-
-
Kotarsky, K.1
Nilsson, N.E.2
Flodgren, E.3
Owman, C.4
Olde, B.5
-
15
-
-
0038491435
-
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
-
[15] Le Poul, E.; Loison, C.; Struyf, S.; Springael, J.Y.; Lannoy, V.; Decobecq, M.E.; Brezillon, S.; Dupriez, V.; Vassart, G.; Van Damme, J.; Parmentier, M.; Detheux, M. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J. Biol. Chem., 2003, 278, 25481-25489.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25481-25489
-
-
Le Poul, E.1
Loison, C.2
Struyf, S.3
Springael, J.Y.4
Lannoy, V.5
Decobecq, M.E.6
Brezillon, S.7
Dupriez, V.8
Vassart, G.9
Van Damme, J.10
Parmentier, M.11
Detheux, M.12
-
16
-
-
0037453280
-
Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
-
[16] Nilsson, N.E.; Kotarsy, K.; Owman, C.; Olde, B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem. Biophys. Res. Commun., 2003, 303, 1047-1052.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.303
, pp. 1047-1052
-
-
Nilsson, N.E.1
Kotarsy, K.2
Owman, C.3
Olde, B.4
-
17
-
-
84891812539
-
Activation of GPR40 as a Therapeutic Target for the Treatment of Type 2 Diabetes
-
[17] Burant, C.F.; Activation of GPR40 as a Therapeutic Target for the Treatment of Type 2 Diabetes. Diabetes Care, 2013, 36, S175-S179.
-
(2013)
Diabetes Care
, vol.36
, pp. S175-S179
-
-
Burant, C.F.1
-
18
-
-
34347389002
-
The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1
-
[18] Zhang Y, Xu M, Zhang S. The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1. J. Mol. Endocrinol., 2007, 38, 651-661.
-
(2007)
J. Mol. Endocrinol.
, vol.38
, pp. 651-661
-
-
Zhang, Y.1
Xu, M.2
Zhang, S.3
-
19
-
-
70350561694
-
Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets
-
[19] Alquier T, Peyot ML, Latour MG. Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes, 2009, 58, 2607-2615.
-
(2009)
Diabetes
, vol.58
, pp. 2607-2615
-
-
Alquier, T.1
Peyot, M.L.2
Latour, M.G.3
-
20
-
-
34047177401
-
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
-
[20] Latour MG, Alquier T, Oseid E. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes, 2007, 56, 1087-1094.
-
(2007)
Diabetes
, vol.56
, pp. 1087-1094
-
-
Latour, M.G.1
Alquier, T.2
Oseid, E.3
-
21
-
-
65549114432
-
Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
-
[21] Nagasumi K, Esaki R, Iwachidow K. Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes, 2009, 58, 1067-1076.
-
(2009)
Diabetes
, vol.58
, pp. 1067-1076
-
-
Nagasumi, K.1
Esaki, R.2
Iwachidow, K.3
-
22
-
-
84869468389
-
GPR40: A therapeutic target for mediating insulin secretion (Review)
-
[22] Feng, X.T.; Leng, J.; Xie, Z.; Li, S.L.; Zhao, W.; Tang, Q.L. GPR40: A therapeutic target for mediating insulin secretion (Review). Intl. J. Mol. Med., 2012, 30, 1261-1266.
-
(2012)
Intl. J. Mol. Med.
, vol.30
, pp. 1261-1266
-
-
Feng, X.T.1
Leng, J.2
Xie, Z.3
Li, S.L.4
Zhao, W.5
Tang, Q.L.6
-
23
-
-
84866129127
-
G protein-coupled receptor (GPR) 40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
-
[23] Ferdaoussi M, Bergeron V, Zarrouki B. G protein-coupled receptor (GPR) 40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Diabetologia, 2012, 55, 2682-2692.
-
(2012)
Diabetologia
, vol.55
, pp. 2682-2692
-
-
Ferdaoussi, M.1
Bergeron, V.2
Zarrouki, B.3
-
24
-
-
33646395425
-
Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: Evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion
-
[24] Tomita, T.; Masuzaki, H.; Iwakura, H.; Fujikura, J.; Noguchi, M.; Tanaka, T.; Ebihara, K.; Kawamura, J.; Komoto, I.; Kawaguchi, Y.; Fujimoto, K.; Doi, R.; Shimada, Y.; Hosoda, K.; Imamura, M.; Nakao, K. Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion. Diabetologia, 2006, 49, 962-968.
-
(2006)
Diabetologia
, vol.49
, pp. 962-968
-
-
Tomita, T.1
Masuzaki, H.2
Iwakura, H.3
Fujikura, J.4
Noguchi, M.5
Tanaka, T.6
Ebihara, K.7
Kawamura, J.8
Komoto, I.9
Kawaguchi, Y.10
Fujimoto, K.11
Doi, R.12
Shimada, Y.13
Hosoda, K.14
Imamura, M.15
Nakao, K.16
-
25
-
-
0030876806
-
The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation
-
[25] Stein, D.T.; Stevenson, B.E.; Chester, M.W.; Basit, M.; Daniels, M. B.; Turley, S.D.; Mcgarry, J.D. The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation. J. Clin. Invest., 1997, 100, 398-403.
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 398-403
-
-
Stein, D.T.1
Stevenson, B.E.2
Chester, M.W.3
Basit, M.4
Daniels, M.B.5
Turley, S.D.6
McGarry, J.D.7
-
26
-
-
0031683543
-
Circulating fatty acids are essential for efficient glucosestimulated insulin secretion after prolonged fasting in humans
-
[26] Dobbins, R.L.; Chester, M.W.; Daniels, M.B.; Mcgarry, J.D.; Stein, D.T. Circulating fatty acids are essential for efficient glucosestimulated insulin secretion after prolonged fasting in humans. Diabetes, 1998, 47, 1613-1618.
-
(1998)
Diabetes
, vol.47
, pp. 1613-1618
-
-
Dobbins, R.L.1
Chester, M.W.2
Daniels, M.B.3
McGarry, J.D.4
Stein, D.T.5
-
27
-
-
0032102146
-
The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats
-
[27] Dobbins, R.L.; Chester, M.W.; Stevenson, B.E.; Daniels, M.B.; Stein, D.T.; Mcgarry, J.D. The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. J. Clin. Invest., 1998, 101, 2370-2376.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 2370-2376
-
-
Dobbins, R.L.1
Chester, M.W.2
Stevenson, B.E.3
Daniels, M.B.4
Stein, D.T.5
McGarry, J.D.6
-
28
-
-
0036233109
-
Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans
-
[28] Gravena, C.; Mathias, P.C.; Ashcroft, S.J. Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans. J. Endocrinol., 2002, 173, 73-80.
-
(2002)
J. Endocrinol.
, vol.173
, pp. 73-80
-
-
Gravena, C.1
Mathias, P.C.2
Ashcroft, S.J.3
-
29
-
-
20944433543
-
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
-
[29] Steneberg, P.; Rubins, N.; Bartoov-Shifman, R.; Walker, M.D.; Edlund, H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab., 2005, 1, 245-258.
-
(2005)
Cell Metab.
, vol.1
, pp. 245-258
-
-
Steneberg, P.1
Rubins, N.2
Bartoov-Shifman, R.3
Walker, M.D.4
Edlund, H.5
-
30
-
-
25144433441
-
Role of GPR40 in fatty acid action on the β cell line INS-1E. Biochem. Biophys
-
[30] Shapiro, H.; Shachar, S.; Sekler, I.; Herschfinkel, M.; Walker, M.D. Role of GPR40 in fatty acid action on the β cell line INS-1E. Biochem. Biophys. Res.Commun., 2005, 335, 97-104.
-
(2005)
Res.Commun.
, vol.335
, pp. 97-104
-
-
Shapiro, H.1
Shachar, S.2
Sekler, I.3
Herschfinkel, M.4
Walker, M.D.5
-
31
-
-
0025281303
-
Yamamura, K.Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
-
[31] Miyazaki, J.; Araki, K.; Yamato, E.; Ikegami, H.; Asano, T.; Shibasaki, Y.; Oka, Y.; Yamamura, K.Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology, 1990, 127, 126-132.
-
(1990)
Endocrinology
, vol.127
, pp. 126-132
-
-
Miyazaki, J.1
Araki, K.2
Yamato, E.3
Ikegami, H.4
Asano, T.5
Shibasaki, Y.6
Oka, Y.7
-
32
-
-
0029071517
-
Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu
-
[32] Newgard, C.B.; McGarry, J. D. Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu. Rev. Biochem., 1995, 64, 689-719.
-
(1995)
Rev. Biochem.
, vol.64
, pp. 689-719
-
-
Newgard, C.B.1
McGarry, J.D.2
-
33
-
-
20944433543
-
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
-
[33] Steneberg, R.; Rubins, N.; Bartoov-Shifman, R.; Walker, M.D.; Edlund, H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab., 2005, 1, 245-258.
-
(2005)
Cell Metab.
, vol.1
, pp. 245-258
-
-
Steneberg, R.1
Rubins, N.2
Bartoov-Shifman, R.3
Walker, M.D.4
Edlund, H.5
-
34
-
-
53849146735
-
The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: Investigations using GPR40-knockout mice. Biochem. Soc
-
[34] Brownlie, R.; Mayers, R.M.; Pierce, J.A.; Marley, A.E.; Smith, D.M. The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: Investigations using GPR40-knockout mice. Biochem. Soc. Trans., 2008, 36, 950-954.
-
(2008)
Trans.
, vol.36
, pp. 950-954
-
-
Brownlie, R.1
Mayers, R.M.2
Pierce, J.A.3
Marley, A.E.4
Smith, D.M.5
-
35
-
-
34047177401
-
GPR40 is necessary but notsufficient for fatty acid stimulation of insulin secretion in vivo
-
[35] Latour, M.G.; Alquier, T.; Oseid, E.; Tremblay, C.; Jetton, T.L.; Luo, J.; Lin, D.C.H.; Poitout, V. GPR40 is necessary but notsufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes, 2007, 56, 1087-1094.
-
(2007)
Diabetes
, vol.56
, pp. 1087-1094
-
-
Latour, M.G.1
Alquier, T.2
Oseid, E.3
Tremblay, C.4
Jetton, T.L.5
Luo, J.6
Lin, D.C.H.7
Poitout, V.8
-
36
-
-
52249093427
-
The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding
-
[36] Kebede, M.; Alquier, T.; Latour, M. G.; Semache, M.; Tremblay, C.; Poitout, V. The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes, 2008, 57, 2432-2437.
-
(2008)
Diabetes
, vol.57
, pp. 2432-2437
-
-
Kebede, M.1
Alquier, T.2
Latour, M.G.3
Semache, M.4
Tremblay, C.5
Poitout, V.6
-
37
-
-
50949128408
-
Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice
-
[37] Tan, C.P.; Feng, Y.; Zhou, Y.P.; Eiermann, G.J.; Petrov, A.; Zhou, C.Y.; Lin, S.N.; Salituro, G.; Meinke, P.; Mosley, R.; Akiyama, T.E.; Einstein, M.; Kumar, S.; Berger, J.P.; Mills, S.G.; Thornberry, N. A.; Yang, L.H.; Howard, A.D. Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes, 2008, 57, 2211-2219.
-
(2008)
Diabetes
, vol.57
, pp. 2211-2219
-
-
Tan, C.P.1
Feng, Y.2
Zhou, Y.P.3
Eiermann, G.J.4
Petrov, A.5
Zhou, C.Y.6
Lin, S.N.7
Salituro, G.8
Meinke, P.9
Mosley, R.10
Akiyama, T.E.11
Einstein, M.12
Kumar, S.13
Berger, J.P.14
Mills, S.G.15
Thornberry, N.A.16
Yang, L.H.17
Howard, A.D.18
-
38
-
-
65549114432
-
Overexpression of GPR40 in pancreatic
-
[38] Nagasumi, K.; Esaki, R.; Iwachidow, K.; Yasuhara, Y.; Ogi, K.; Tanaka, H.; Nakata, M.; Yano, T.; Shimakawa, K.; Taketomi, S.; Takeuchi, K.; Odaka, H.; Kaisho, Y. Overexpression of GPR40 in pancreatic β-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes, 2009, 58, 1067-1076.
-
(2009)
Diabetes
, vol.58
, pp. 1067-1076
-
-
Nagasumi, K.1
Esaki, R.2
Iwachidow, K.3
Yasuhara, Y.4
Ogi, K.5
Tanaka, H.6
Nakata, M.7
Yano, T.8
Shimakawa, K.9
Taketomi, S.10
Takeuchi, K.11
Odaka, H.12
Kaisho, Y.13
-
39
-
-
58149100292
-
Lack of FFAR1/GPR40 does not protect mice from high-fat dietinduced metabolic disease
-
[39] Lan, H.; Hoos, L.M.; Liu, L.; Tetzloffl, G.; Hu, W.W.; Abbondanzo, S.J.; Vassileva, G.; Gustafson, E.L.; Hedrick, J.A.; Davis, H.R Lack of FFAR1/GPR40 does not protect mice from high-fat dietinduced metabolic disease. Diabetes, 2008, 57, 2999-3006.
-
(2008)
Diabetes
, vol.57
, pp. 2999-3006
-
-
Lan, H.1
Hoos, L.M.2
Liu, L.3
Tetzloffl, G.4
Hu, W.W.5
Abbondanzo, S.J.6
Vassileva, G.7
Gustafson, E.L.8
Hedrick, J.A.9
Davis, H.R.10
-
40
-
-
70350561694
-
Deletion of GPR40 impairs glucoseinduced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets
-
[40] Alquier, T.; Peyot, M.L.; Latour, M.G.; Kebede, M.; Sorensen, C.M.; Gesta, S.; Kahn, C.R.; Smith, R.D.; Jetton, T.L.; Metz, T.O.; Prentki, M.; Poitout, V. Deletion of GPR40 impairs glucoseinduced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes, 2009, 58, 2607-2615.
-
(2009)
Diabetes
, vol.58
, pp. 2607-2615
-
-
Alquier, T.1
Peyot, M.L.2
Latour, M.G.3
Kebede, M.4
Sorensen, C.M.5
Gesta, S.6
Kahn, C.R.7
Smith, R.D.8
Jetton, T.L.9
Metz, T.O.10
Prentki, M.11
Poitout, V.12
-
41
-
-
34248527694
-
Fatty acid receptors as new therapeutic targets for diabetes. Expert Opin. Ther
-
[41] Rayasam, G.V.; Tulasi, V.K.; Davis, J.A.; Bansal, V.S. Fatty acid receptors as new therapeutic targets for diabetes. Expert Opin. Ther. Targets, 2007, 11, 661-671.
-
(2007)
Targets
, vol.11
, pp. 661-671
-
-
Rayasam, G.V.1
Tulasi, V.K.2
Davis, J.A.3
Bansal, V.S.4
-
42
-
-
12344323484
-
Type 2 diabetes-a matter of beta-cell life and death?
-
[42] Rhodes, C.J. Type 2 diabetes-a matter of beta-cell life and death? Science, 2005, 307, 380-384.
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
43
-
-
1842844414
-
Decreased beta-cell mass in diabetes
-
[43] Donath, M.Y.; Halban, P.A. Decreased beta-cell mass in diabetes: Significance, mechanisms and therapeutic implications. Diabetologia, 2004, 47, 581-589.
-
(2004)
Significance, Mechanisms and Therapeutic Implications. Diabetologia
, vol.47
, pp. 581-589
-
-
Donath, M.Y.1
Halban, P.A.2
-
44
-
-
58149095589
-
International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: Pharmacology and pathophysiological functions
-
[44] Stoddart, L.A.; Smith, N.J.; Milligan, G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol. Rev., 2008, 60, 405-417.
-
(2008)
Pharmacol. Rev.
, vol.60
, pp. 405-417
-
-
Stoddart, L.A.1
Smith, N.J.2
Milligan, G.3
-
45
-
-
69549111756
-
Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
-
[45] Wellendorph, P.; Johansen, L.D.; Brauner-Osborne, H. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol. Pharmacol., 2009, 76, 453-465.
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 453-465
-
-
Wellendorph, P.1
Johansen, L.D.2
Brauner-Osborne, H.3
-
46
-
-
33745607930
-
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules
-
[46] Briscoe, C. P.; Peat, A. J.; McKeown, S. C.; Corbett, D. F.; Goetz, A. S.; Littleton, T. R.; McCoy, D. C.; Kenakin, T. P.; Andrews, J. L.; Ammala, C.; Fornwald, J. A.; Ignar, D. M.; Jenkinson, S. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br. J. Pharmacol., 2006, 148, 619-628.
-
(2006)
Br. J. Pharmacol.
, vol.148
, pp. 619-628
-
-
Briscoe, C.P.1
Peat, A.J.2
McKeown, S.C.3
Corbett, D.F.4
Goetz, A.S.5
Littleton, T.R.6
McCoy, D.C.7
Kenakin, T.P.8
Andrews, J.L.9
Ammala, C.10
Fornwald, J.A.11
Ignar, D.M.12
Jenkinson, S.13
-
47
-
-
67649331670
-
Progress in the discovery and development of small-molecule modulators of Gprotein-coupled receptor 40 (GPR40/FFA1/FFAR1): An emerging target for type 2 diabetes
-
[47] Bharate, S.B.; Nemmani, V.S.K.; Vishwakarma, R.A. Progress in the discovery and development of small-molecule modulators of Gprotein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes. Expert Opin. Ther. Patents, 2009, 19(2), 237-264.
-
(2009)
Expert Opin. Ther. Patents
, vol.19
, Issue.2
, pp. 237-264
-
-
Bharate, S.B.1
Nemmani, V.S.K.2
Vishwakarma, R.A.3
-
48
-
-
85025132382
-
-
World Patent WO2005/086661 A2
-
[48] Akerman, M.; Houze, J.; Daniel, C.H.; Liu, J.; Luo, J.; Medina, J. C.; Qiu, W.; Reagan, J.F.; Sharma, R.; Shuttleworth, S.J.; Sun, Y.; Zhang, J.; Zhu, L. World Patent WO2005/086661 A2, 2005.
-
(2005)
-
-
Akerman, M.1
Houze, J.2
Daniel, C.H.3
Liu, J.4
Luo, J.5
Medina, J.C.6
Qiu, W.7
Reagan, J.F.8
Sharma, R.9
Shuttleworth, S.J.10
Sun, Y.11
Zhang, J.12
Zhu, L.13
-
49
-
-
77955681257
-
Asymmetric syntheses of a GPR40 receptor agonist via diastereoselective and enantioselective conjugate alkynylation
-
[49] Woo, J.; Cui, S.; Walker, S.D.; Faul, M.M. Asymmetric syntheses of a GPR40 receptor agonist via diastereoselective and enantioselective conjugate alkynylation. Tetrahedron, 2010, 66, 4730-4737.
-
(2010)
Tetrahedron
, vol.66
, pp. 4730-4737
-
-
Woo, J.1
Cui, S.2
Walker, S.D.3
Faul, M.M.4
-
50
-
-
79251476856
-
Development of a suitable salt form for a GPR40 receptor agonist
-
[50] Morrison, H.; Jona, J.; Walker, S.D.; J. Woo, J.; Li, L.; Fang, J.; Development of a suitable salt form for a GPR40 receptor agonist. Org. Process Res. Dev., 2011, 15, 104-111.
-
(2011)
Org. Process Res. Dev.
, vol.15
, pp. 104-111
-
-
Morrison, H.1
Jona, J.2
Walker, S.D.3
Woo, J.4
Li, L.5
Fang, J.6
-
51
-
-
33144463383
-
Peat, A.J. Synthesis and activity of small molecule GPR40 agonists
-
[51] Garrido, D.M.; Corbett, D.F.; Dwornik, K.A.; Goetz, A.S.; Littleton, T.R.; McKeown, S.C.; Mills, W.Y.; Smalley, T.L.; Briscoe, C.P.; Peat, A.J. Synthesis and activity of small molecule GPR40 agonists. Bioorg. Med. Chem. Lett., 2006, 16, 1840-1845.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 1840-1845
-
-
Garrido, D.M.1
Corbett, D.F.2
Dwornik, K.A.3
Goetz, A.S.4
Littleton, T.R.5
McKeown, S.C.6
Mills, W.Y.7
Smalley, T.L.8
Briscoe, C.P.9
-
52
-
-
33847104280
-
Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor
-
[52] McKeown, S.C.; Corbett, D.F.; Goetz, A.S.; Littleton, T.R.; Bigham, E.; Briscoe, C.P.; Peat, A.J.; Watson, S.P.; Hickey, D.M.B. Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor. Bioorg. Med. Chem. Lett., 2007, 17, 1584-1589.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 1584-1589
-
-
McKeown, S.C.1
Corbett, D.F.2
Goetz, A.S.3
Littleton, T.R.4
Bigham, E.5
Briscoe, C.P.6
Peat, A.J.7
Watson, S.P.8
Hickey, D.9
-
53
-
-
59849110228
-
Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat
-
[53] Doshi, L.S.; Brahma, M.K.; Sayyed, S.G.; Dixit, A.V.; Chandak, P.G.; Pamidiboina, V.; Motiwala, H.F.; Sharma, S.D.; Nemmani, K.V.S. Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat. Metabol. Clin. Experiment., 2009, 58, 333-343.
-
(2009)
Metabol. Clin. Experiment.
, vol.58
, pp. 333-343
-
-
Doshi, L.S.1
Brahma, M.K.2
Sayyed, S.G.3
Dixit, A.V.4
Chandak, P.G.5
Pamidiboina, V.6
Motiwala, H.F.7
Sharma, S.D.8
Nemmani, K.V.S.9
-
54
-
-
34347220548
-
Bidirectional, iterative approach to the structural delineation of the functional “Chemoprint” in GPR40 for agonist recognition
-
[54] Tikhonova I.G.; Sum C.S.; Neuman S.; Thomas C.J.; Raaka B.M.; Costanzi S.; and Gershengorn M.C. Bidirectional, iterative approach to the structural delineation of the functional “Chemoprint” in GPR40 for agonist recognition. J. Med. Chem., 2007, 50, 2981-2989.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 2981-2989
-
-
Tikhonova, I.G.1
Sum, C.S.2
Neuman, S.3
Thomas, C.J.4
Raaka, B.M.5
Costanzi, S.6
Gershengorn, M.C.7
-
55
-
-
39149097541
-
Gershengorn, M.C. Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening
-
[55] Tikhonova, I.G.; Sum, C.S.; Neumann, S.; Engel, S.; Raaka, B.M.; Costanzi, S.; Gershengorn, M.C. Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening. J. Med. Chem., 2008, 51, 625-633.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 625-633
-
-
Tikhonova, I.G.1
Sum, C.S.2
Neumann, S.3
Engel, S.4
Raaka, B.M.5
Costanzi, S.6
-
56
-
-
77951974594
-
Molecular docking and molecular dynamics simulation studies of GPR40 receptor-agonist interactions
-
[56] Lu, S.Y.; Jiang, Y.J.; Lv, J.; Wu, T.X.; Yu, Q.S.; Zhu, W.L. Molecular docking and molecular dynamics simulation studies of GPR40 receptor-agonist interactions. J. Mol. Graph. Model., 2010, 28, 766-774.
-
(2010)
J. Mol. Graph. Model.
, vol.28
, pp. 766-774
-
-
Lu, S.Y.1
Jiang, Y.J.2
Lv, J.3
Wu, T.X.4
Yu, Q.S.5
Zhu, W.L.6
-
57
-
-
34250879091
-
Synthesis and biological evaluation of 3-Aryl-3-(4-phenoxy)
-
[57] Song, F.; Lu, S.; Gunnet, J.; Xu, J. Z.; Wines, P.; Proost, J.; Liang, Y.; Baumann, C.; Lenhard, J.; Murray, W.V.; Demarest, K.T.; Kuo, G.H. Synthesis and biological evaluation of 3-Aryl-3-(4-phenoxy)-propionic acid as a novel series of g protein-coupled receptor 40 agonists. J. Med. Chem., 2007, 50, 2807-2817.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 2807-2817
-
-
Song, F.1
Lu, S.2
Gunnet, J.3
Xu, J.Z.4
Wines, P.5
Proost, J.6
Liang, Y.7
Baumann, C.8
Lenhard, J.9
Murray, W.V.10
Demarest, K.T.11
Kuo, G.H.12
-
58
-
-
67649337581
-
-
World Patent WO2007033002, March 22
-
[58] Akerman, M.; Brown, S.; Houze, J.B.; Liu, J.; Zhihua, M.A.; Medina, J.C.; Qiu, W.; Schmott, M.J.; Wang, Y.; Zhu, L. Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propionic acids useful for treating metabolic disorders. World Patent WO2007033002, March 22, 2007.
-
(2007)
Conformationally Constrained 3-(4-Hydroxy-Phenyl)-Substituted-Propionic Acids Useful for Treating Metabolic Disorders
-
-
Akerman, M.1
Brown, S.2
Houze, J.B.3
Liu, J.4
Zhihua, M.A.5
Medina, J.C.6
Qiu, W.7
Schmott, M.J.8
Wang, Y.9
Zhu, L.10
-
60
-
-
67649307441
-
-
World Patent WO2007/131620 A2, Nov. 22
-
[60] Defossa, E.; Goerlitzer, J.; Klabunde, T.; Drosou, V.; Stengelin, S.; Haschke, G.; Herling, A.; Bartoschek, S.; 4,5-diphenyl-pyrimidinylamino substituted carboxylic acids, method for the production and use thereof as medicaments. World Patent WO2007/131620 A2, Nov. 22, 2007.
-
(2007)
4,5-Diphenyl-Pyrimidinylamino Substituted Carboxylic Acids, Method for the Production and Use Thereof as Medicaments
-
-
Defossa, E.1
Goerlitzer, J.2
Klabunde, T.3
Drosou, V.4
Stengelin, S.5
Haschke, G.6
Herling, A.7
Bartoschek, S.8
-
61
-
-
67649358484
-
-
World Patent WO 2007/131622 A1, Nov. 22
-
[61] Defossa, E.; Follmann, M.; Klabunde, T.; Drosou, V.; Hessler, G.; Stengelin, S.; Haschke, G.; Herling, A.; Bartoschek, S. Phenylamino-benzoxazole substituted carboxylic acids, method for their production and use thereof as medicaments. World Patent WO 2007/131622 A1, Nov. 22, 2007.
-
(2007)
Phenylamino-Benzoxazole Substituted Carboxylic Acids, Method for Their Production and Use Thereof as Medicaments
-
-
Defossa, E.1
Follmann, M.2
Klabunde, T.3
Drosou, V.4
Hessler, G.5
Stengelin, S.6
Haschke, G.7
Herling, A.8
Bartoschek, S.9
-
62
-
-
67649337583
-
-
World Patent WO2007106469 A2, Sept. 20
-
[62] Sharma, R.; Akerman, M.; Cardozo, M.; Li, A.R; Liu, J.; Liu, J.; Ma, Z.; Medina, J.; Schmitt, M.J.; Sun, Y.; Wang, Y.; Wang, Z.; Zhu, Z. Bicyclic carboxylic acid derivatives useful for treating metabolic disorders. World Patent WO2007106469 A2, Sept. 20, 2007.
-
(2007)
Bicyclic Carboxylic Acid Derivatives Useful for Treating Metabolic Disorders
-
-
Sharma, R.1
Akerman, M.2
Cardozo, M.3
Li, A.R.4
Liu, J.5
Liu, J.6
Ma, Z.7
Medina, J.8
Schmitt, M.J.9
Sun, Y.10
Wang, Y.11
Wang, Z.12
Zhu, Z.13
-
63
-
-
67649307438
-
-
World Patent, WO2007/ 136572 A2, Nov. 29
-
[63] Ge, M.; He, J.; Lau, F.W.; Liang, G.; Lin, S.; Liu, W.; Walsh, S.; Yang, L. Antidiabetic bicyclic compounds. World Patent, WO2007/ 136572 A2, Nov. 29, 2007.
-
(2007)
Antidiabetic Bicyclic Compounds
-
-
Ge, M.1
He, J.2
Lau, F.W.3
Liang, G.4
Lin, S.5
Liu, W.6
Walsh, S.7
Yang, L.8
-
64
-
-
67649364737
-
-
World Patent, WO2007/049050 A2, May 03
-
[64] Owman, C.; Olde, B.; Rome, D.; Sterner, O. Therapeutic modulators of GPR40. World Patent, WO2007/049050 A2, May 03, 2007.
-
(2007)
Therapeutic Modulators of GPR40
-
-
Owman, C.1
Olde, B.2
Rome, D.3
Sterner, O.4
-
65
-
-
67649384848
-
-
World Patent WO2007123225, Nov. 01
-
[65] Negoro, K.; Iwasaki, F.; Ohnuki, K.; Kurosaki, T.; Yonetoku, Y.; Asai, N.; Yoshida, S.; Soga, T. Oxadiazolidinedione compound. World Patent WO2007123225, Nov. 01, 2007.
-
(2007)
Oxadiazolidinedione Compound
-
-
Negoro, K.1
Iwasaki, F.2
Ohnuki, K.3
Kurosaki, T.4
Yonetoku, Y.5
Asai, N.6
Yoshida, S.7
Soga, T.8
-
66
-
-
56749163623
-
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type ii diabetes
-
[66] Christiansen, E.; Urban, C.; Merten, N.; Liebscher, K.; Karlsen, K. K.; Hamacher, A.; Spinrath, A.; Bond, A.D.; Drewke, C.; Ullrich, S.; Kassack, M.U.; Kostenis, E.; Ulven, T. Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type ii diabetes. J. Med. Chem., 2008, 51, 7061-7064.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 7061-7064
-
-
Christiansen, E.1
Urban, C.2
Merten, N.3
Liebscher, K.4
Karlsen, K.K.5
Hamacher, A.6
Spinrath, A.7
Bond, A.D.8
Drewke, C.9
Ullrich, S.10
Kassack, M.U.11
Kostenis, E.12
Ulven, T.13
-
67
-
-
56549098281
-
Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists
-
[67] Bharate, S.B.; Rodge, A.; Joshi, R.K.; Kaur, J.; Srinivasan, S.; Kumar, S.S.; Almeida, A.K.; Balachandran, S.; Balakrishnan, A.; Vishwakarma, R.A. Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. Bioorg. Med. Chem. Lett., 2008, 18, 6357-6361.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 6357-6361
-
-
Bharate, S.B.1
Rodge, A.2
Joshi, R.K.3
Kaur, J.4
Srinivasan, S.5
Kumar, S.S.6
Almeida, A.K.7
Balachandran, S.8
Balakrishnan, A.9
Vishwakarma, R.A.10
-
68
-
-
85025135776
-
-
Aug. 11
-
[68] Brown, S.P.; Dransfield, P.J.; Fu, Z.; Houze, J.; Jiao, X.Y.; Kohn, T.J.; Pattaropong, V.; Vimolratana, M.; Schitt, M.J.; Substituted biphenyl GPR40 modulators. U.S. Patent 7,572,934 B2, Aug. 11, 2009.
-
(2009)
Substituted Biphenyl GPR40 Modulators
-
-
Brown, S.P.1
Dransfield, P.J.2
Fu, Z.3
Houze, J.4
Jiao, X.Y.5
Kohn, T.J.6
Pattaropong, V.7
Vimolratana, M.8
Schitt, M.J.9
-
69
-
-
85025135776
-
-
April 1
-
[69] Brown, S.P.; Cao, Q.; Dransfield, P.J.; Du, X.; Houze, J.; Jiao, X.Y.; Kohn, T.J.; Lai, S.; Li, A.R.; Lin, D.; Luo, J.; Medina, J.C. Substituted biphenyl GPR40 modulators. World Patent WO2009/048572 A1, April 16, 2009.
-
(2009)
Substituted Biphenyl GPR40 Modulators
, pp. 6
-
-
Brown, S.P.1
Cao, Q.2
Dransfield, P.J.3
Du, X.4
Houze, J.5
Jiao, X.Y.6
Kohn, T.J.7
Lai, S.8
Li, A.R.9
Lin, D.10
Luo, J.11
Medina, J.C.12
-
70
-
-
0346041542
-
Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors
-
[70] Kotarsky, K.; Nilsson, N.E.; Olde, B.; Owman, C. Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors. Pharmacol. Toxicol., 2003, 93, 249-258.
-
(2003)
Pharmacol. Toxicol.
, vol.93
, pp. 249-258
-
-
Kotarsky, K.1
Nilsson, N.E.2
Olde, B.3
Owman, C.4
-
71
-
-
74049162863
-
Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonist
-
[71] Zhou, C.; Tang, C.; Chang, E.; Ge, M.; Lin, S.; Cline, E.; Tan, C.P.; Feng, Y.; Zhou, Y.P.; Eiermann, G. J.; Petrov, A.; Salituro, G.; Meinke, P.; Mosley, R.; Akiyama, T. E.; Einstein, M.; Kumar, S.; Berger, J.; Howard, A.D.; Thornberry, N.; Mills, S.G.; Yang, L.; Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonist. Bioorg. Med. Chem. Lett., 2010, 20, 1298-1301.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 1298-1301
-
-
Zhou, C.1
Tang, C.2
Chang, E.3
Ge, M.4
Lin, S.5
Cline, E.6
Tan, C.P.7
Feng, Y.8
Zhou, Y.P.9
Eiermann, G.J.10
Petrov, A.11
Salituro, G.12
Meinke, P.13
Mosley, R.14
Akiyama, T.E.15
Einstein, M.16
Kumar, S.17
Berger, J.18
Howard, A.D.19
Thornberry, N.20
Mills, S.G.21
Yang, L.22
more..
-
72
-
-
85025123699
-
-
Mar. 30
-
[72] Brown, S.P.; Dransfield, P.; Houze, J.B.; Liu, J.; Liu, J.; Ma, Z.; Medina, J.C.; Pattaropong, V.; Schmitt, M.J.; Sharma, R.; Wang, Y. Benzo-fused compounds for use in treating metabolic disorders. US patent, 7,687,526 B2, Mar. 30, 2010.
-
(2010)
Benzo-Fused Compounds for Use in Treating Metabolic Disorders
-
-
Brown, S.P.1
Dransfield, P.2
Houze, J.B.3
Liu, J.4
Liu, J.5
Ma, Z.6
Medina, J.C.7
Pattaropong, V.8
Schmitt, M.J.9
Sharma, R.10
Wang, Y.11
-
73
-
-
77958099021
-
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469
-
[73] Christiansen, E.; Due-Hansen, M.E.; Urban, C.; Merten, N.; Pfleiderer, M.; Karlsen, K. K.; Rasmussen, S.S.; Steensgaard, M.; Hamacher, A.; Schmidt, J.; Drewke, C.; Petersen, R.K. Kristiansen, K.; Ullrich, S.; Kostenis, E.; Kassack, M.U.; Ulven, T. Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469. ACS Med. Chem. Lett., 2010, 1, 345-349.
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, pp. 345-349
-
-
Christiansen, E.1
Due-Hansen, M.E.2
Urban, C.3
Merten, N.4
Pfleiderer, M.5
Karlsen, K.K.6
Rasmussen, S.S.7
Steensgaard, M.8
Hamacher, A.9
Schmidt, J.10
Drewke, C.11
Petersen, R.K.12
Kristiansen, K.13
Ullrich, S.14
Kostenis, E.15
Kassack, M.U.16
Ulven, T.17
-
74
-
-
85025127377
-
-
Apr. 22
-
[74] Brown, S.P.; Dransfield, P.; Du, X.; Fu, Z.; Houze, J.B.; Jiao, X.Y.; Lai, S.; Li, A.R.; Liu, J.; Ma, Z.; Medina, J.C.; Pattaropong, V.; Shen, W.; Vimolratana, M.; Wang, Y.; Wang, Z.; Yu, M.; Zhu, L. Spirocyclic GPR40 modulators. World Patent, WO2010/045258 A2, Apr. 22, 2010.
-
(2010)
Spirocyclic GPR40 Modulators
-
-
Brown, S.P.1
Dransfield, P.2
Du, X.3
Fu, Z.4
Houze, J.B.5
Jiao, X.Y.6
Lai, S.7
Li, A.R.8
Liu, J.9
Ma, Z.10
Medina, J.C.11
Pattaropong, V.12
Shen, W.13
Vimolratana, M.14
Wang, Y.15
Wang, Z.16
Yu, M.17
Zhu, L.18
-
75
-
-
85025127377
-
-
Aug. 4
-
[75] Brown, S.P.; Dransfield, P.; Du, X.; Fu, Z.; Houze, J.B.; Jiao, X.Y.; Lai, S.; Li, A.R.; Liu, J.; Ma, Z.; Medina, J.C.; Pattaropong, V.; Shen, W.; Vimolratana, M.; Wang, Y.; Wang, Z.; Yu, M.; Zhu, L. Spirocyclic GPR40 modulators. US patent, US 2011/0190330 A1, Aug. 4, 2011.
-
(2011)
Spirocyclic GPR40 Modulators
-
-
Brown, S.P.1
Dransfield, P.2
Du, X.3
Fu, Z.4
Houze, J.B.5
Jiao, X.Y.6
Lai, S.7
Li, A.R.8
Liu, J.9
Ma, Z.10
Medina, J.C.11
Pattaropong, V.12
Shen, W.13
Vimolratana, M.14
Wang, Y.15
Wang, Z.16
Yu, M.17
Zhu, L.18
-
76
-
-
85025139435
-
-
Aug. 23
-
[76] Beck, H.; Dransfield, P.J.; Fu, Z.; Houze, J.B.; Jiao, X.Y.; Kohn, T.J.; Lai, S.; Liu, J.; Liu, J.; Ma, Z.; Medina, J.C.; Schmitt, M.J.; Sharma, R.; Shen, W.; Vimolratana, M.; Wang, Y.; Wang, Z. Heterocyclic GPR40 modulators. US Patent, 8,003,648 B2, Aug. 23, 2011.
-
(2011)
Heterocyclic GPR40 Modulators
-
-
Beck, H.1
Dransfield, P.J.2
Fu, Z.3
Houze, J.B.4
Jiao, X.Y.5
Kohn, T.J.6
Lai, S.7
Liu, J.8
Liu, J.9
Ma, Z.10
Medina, J.C.11
Schmitt, M.J.12
Sharma, R.13
Shen, W.14
Vimolratana, M.15
Wang, Y.16
Wang, Z.17
-
77
-
-
84874275604
-
-
Oct. 4
-
[77] Brown, S.P.; Cao, Q.; Dransfield, P.J.; Du, X.; Fu, Z.; Houze, J.; Jiao, X.Y.; Kim, Y.J.; Kohn, T.J.; Lai, S.; Li, A.R.; Lin, D.; Liu, J.; Luo, J.; Medina, J.C.; Reagan, J.D.; Pattaropong, V.; Schwarz, M.; Shen, W.; Su, Y.; Swaminath, G.; Vimolratana, M.; Wang, Y.; Xiong, Y.; Yang, L.; Yu, M.; Zhang, J.; Zhu, L. Substituted biphenyl GPR40 modulators. U.S. Patent 8,030,354 B2, Oct. 4, 2011.
-
(2011)
Substituted Biphenyl GPR40 Modulators
-
-
Brown, S.P.1
Cao, Q.2
Dransfield, P.J.3
Du, X.4
Fu, Z.5
Houze, J.6
Jiao, X.Y.7
Kim, Y.J.8
Kohn, T.J.9
Lai, S.10
Li, A.R.11
Lin, D.12
Liu, J.13
Luo, J.14
Medina, J.C.15
Reagan, J.D.16
Pattaropong, V.17
Schwarz, M.18
Shen, W.19
Su, Y.20
Swaminath, G.21
Vimolratana, M.22
Wang, Y.23
Xiong, Y.24
Yang, L.25
Yu, M.26
Zhang, J.27
Zhu, L.28
more..
-
78
-
-
85025125946
-
-
Dec. 29
-
[78] Keil, S.; Defossa, E.; Dietrich, V.; Stengelin, S.; Herling, A.; Haschke, G.; Klabunde, T. Heterocyclic substituted methoxyphenyl derivatives having an oxo group, method for producing same, and use thereof as GPR40 Receptor modulators. World Patent WO 2011/161030 A1, Dec. 29, 2011.
-
(2011)
Heterocyclic Substituted Methoxyphenyl Derivatives Having an Oxo Group, Method for Producing Same, and Use Thereof as GPR40 Receptor Modulators
-
-
Keil, S.1
Defossa, E.2
Dietrich, V.3
Stengelin, S.4
Herling, A.5
Haschke, G.6
Klabunde, T.7
-
79
-
-
85025154449
-
-
Dec. 22
-
[79] Joisen, H.B.; Clader, J.W.; Greenlee, W.J.; Mayer, M.J.; Herr, R.J.; Davis, J.L.; Deng, K.; Hsia, M.; Wan, S. Bridged and fused heterocyclic antidiabetic compounds. US Patent, US 2011/0312995 A1, Dec. 22, 2011.
-
(2011)
Bridged and Fused Heterocyclic Antidiabetic Compounds
-
-
Joisen, H.B.1
Clader, J.W.2
Greenlee, W.J.3
Mayer, M.J.4
Herr, R.J.5
Davis, J.L.6
Deng, K.7
Hsia, M.8
Wan, S.9
-
80
-
-
85025149720
-
-
Dec. 22
-
[80] Joisen, H.B.; Clader, J.W.; Stamford, A.; Greenlee, W.J.; Mayer, M.J.; Davis, J.L.; Hsia, M.; Wan, S. Pentafluorosulpholane-containing antidiabetic compounds. US Patent, US 2011/0313008 A1, Dec. 22, 2011.
-
(2011)
Pentafluorosulpholane-Containing Antidiabetic Compounds
-
-
Joisen, H.B.1
Clader, J.W.2
Stamford, A.3
Greenlee, W.J.4
Mayer, M.J.5
Davis, J.L.6
Hsia, M.7
Wan, S.8
-
81
-
-
79956141358
-
3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists
-
[81] Walsh, S.P.; Severino, A.; Zhou, C.; He, J.; Liang, G.B.; Tan, C. P.; Cao, J.; Eiermann, G. J.; Xu, L.; Salituro, G.; Howard, A. D.; Mills, S.G.; Yang, L. 3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists. Bioorg. Med. Chem. Lett., 2011, 21, 3390-3394.
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 3390
-
-
Walsh, S.P.1
Severino, A.2
Zhou, C.3
He, J.4
Liang, G.B.5
Tan, C.P.6
Cao, J.7
Eiermann, G.J.8
Xu, L.9
Salituro, G.10
Howard, A.D.11
Mills, S.G.12
Yang, L.13
-
82
-
-
79952261037
-
Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists
-
[82] Sasaki, S.; Kitamura, S.; Negoro, N.; Suzuki, M.; Tsujihata, Y.; Suzuki, N.; Santou, T.; Kanzaki, N.; Harada, M.; Tanaka, Y.; Kobayashi, M.; Tada, N.; Funami, M.; Tanaka, T.; Yamamoto, Y.; Fukatsu, K.; Yasuma, T.; Momose, Y. Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists. J. Med. Chem., 2011, 54, 1365-1378.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 1365-1378
-
-
Sasaki, S.1
Kitamura, S.2
Negoro, N.3
Suzuki, M.4
Tsujihata, Y.5
Suzuki, N.6
Santou, T.7
Kanzaki, N.8
Harada, M.9
Tanaka, Y.10
Kobayashi, M.11
Tada, N.12
Funami, M.13
Tanaka, T.14
Yamamoto, Y.15
Fukatsu, K.16
Yasuma, T.17
Momose, Y.18
-
83
-
-
77956500937
-
Discovery of TAK-875: A potent, selective, and orally bioavailable GPR40 agonist
-
[83] Negoro, N.; Sasaki, S.; Mikami, S.; Ito, M.; Suzuki, M.; Tsujihata, Y.; Ito, R.; Miyazaki, T.; Ito, R.; Harada, A.; Takeuchi, K.; Suzuki, N.; Miyazaki, J.; Santou, T.; Odani, T.; Kanzaki, N.; Funami, M.; Tanaka, T.; Kogame, A.; Matsunaga, S.; Yasuma, T.; Momose, Y. Discovery of TAK-875: A potent, selective, and orally bioavailable GPR40 agonist ACS Med. Chem. Lett., 2010, 1, 290-294.
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, pp. 290-294
-
-
Negoro, N.1
Sasaki, S.2
Mikami, S.3
Ito, M.4
Suzuki, M.5
Tsujihata, Y.6
Ito, R.7
Miyazaki, T.8
Ito, R.9
Harada, A.10
Takeuchi, K.11
Suzuki, N.12
Miyazaki, J.13
Santou, T.14
Odani, T.15
Kanzaki, N.16
Funami, M.17
Tanaka, T.18
Kogame, A.19
Matsunaga, S.20
Yasuma, T.21
Momose, Y.22
more..
-
84
-
-
84860285388
-
Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic acids: Discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent
-
[84] Negoro, N.; Sasaki, S.; Mikami, S.; Ito, M.; Tsujihata, Y.; Ito, R.; Suzuki, M.; Takeuchi, K.; Suzuki, N.; Miyazaki, J.; Santou, T.; Odani, T.; Kanzaki, N.; Funami, M.; Morohashi, A.; Nonaka, M.; Matsunaga, S.; Yasuma, T.; Momose, Y.; Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic acids: Discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent. J. Med. Chem., 2012, 55, 3960-3974.
-
(2012)
J. Med. Chem.
, vol.55
, pp. 3960-3974
-
-
Negoro, N.1
Sasaki, S.2
Mikami, S.3
Ito, M.4
Tsujihata, Y.5
Ito, R.6
Suzuki, M.7
Takeuchi, K.8
Suzuki, N.9
Miyazaki, J.10
Santou, T.11
Odani, T.12
Kanzaki, N.13
Funami, M.14
Morohashi, A.15
Nonaka, M.16
Matsunaga, S.17
Yasuma, T.18
Momose, Y.19
-
85
-
-
84857032603
-
GPR40-induced insulin secretion by the novel agonist TAK-875: First clinical findings in patients with type 2 diabetes. Diabetes Obes
-
[85] Araki, T; Hirayama, M; Hiroi, S, Kaku K. GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes. Diabetes Obes. Metab., 2012, 14, 271-278.
-
(2012)
Metab.
, vol.14
, pp. 271-278
-
-
Araki, T.1
Hirayama, M.2
Hiroi, S.3
Kaku, K.4
-
86
-
-
84873835561
-
Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes
-
[86] Kaku, K.; Araki, T.; Yoshinaka R. Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes. Diabetes Care, 2013, 36, 245-250.
-
(2013)
Diabetes Care
, vol.36
, pp. 245-250
-
-
Kaku, K.1
Araki, T.2
Yoshinaka, R.3
-
87
-
-
85025176937
-
-
Agonists of GPR40, Jan 26
-
[87] Rao, R.; Arumugam, N.; Ansari, M.; Gudla, C.; Pachiyappan, S.; Ramalingam, M.; George, J.; Arul, G.F.; Bommegowda, Y.; Angupillai, S.K.; kottamalai, R.; Jidugu, P.; Rao, S.D. Agonists of GPR40. World Patent WO2012/011125 A1, Jan 26, 2012.
-
(2012)
-
-
Rao, R.1
Arumugam, N.2
Ansari, M.3
Gudla, C.4
Pachiyappan, S.5
Ramalingam, M.6
George, J.7
Arul, G.F.8
Bommegowda, Y.9
Angupillai, S.K.10
Kottamalai, R.11
Jidugu, P.12
Rao, S.D.13
-
88
-
-
85025173784
-
-
Jan. 12
-
[88] Defossa, E.; Keil, S.; Dietrich, V.; Stengelin, S.; Herling, A.; Haschke, G.; Klabunde, T.; Fischer, H.J. (2-aryloxy-acetylamino)-phenyl propionic acid derivatives, methods for producing same and use thereof as pharmaceuticals. World Patent WO2012/004269 A1, Jan. 12, 2012.
-
(2012)
(2-Aryloxy-Acetylamino)-Phenyl Propionic Acid Derivatives, Methods for Producing Same and Use Thereof as Pharmaceuticals
-
-
Defossa, E.1
Keil, S.2
Dietrich, V.3
Stengelin, S.4
Herling, A.5
Haschke, G.6
Klabunde, T.7
Fischer, H.J.8
-
89
-
-
84860270451
-
Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G proteincoupled receptor 40 agonists for the treatment of type 2 diabetes
-
[89] Mikami, S.; Kitamura, S.; Negoro, N.; Sasaki, S.; Suzuki, M.; Tsujihata, Y.; Miyazaki, T.; Ito, R.; Suzuki, N.; Miyazaki, J.; Santou, T.; Kanzaki, N.; Funami, M.; Tanaka, T.; Yasuma, T.; Momose, Y. Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G proteincoupled receptor 40 agonists for the treatment of type 2 diabetes. J. Med. Chem., 2012, 55, 3756-3776.
-
(2012)
J. Med. Chem.
, vol.55
, pp. 3756-3776
-
-
Mikami, S.1
Kitamura, S.2
Negoro, N.3
Sasaki, S.4
Suzuki, M.5
Tsujihata, Y.6
Miyazaki, T.7
Ito, R.8
Suzuki, N.9
Miyazaki, J.10
Santou, T.11
Kanzaki, N.12
Funami, M.13
Tanaka, T.14
Yasuma, T.15
Momose, Y.16
-
90
-
-
84978504649
-
-
Feb. 9
-
[90] Negoro, K.; Ohnuki, K.; Yonetoku, Y.; Kuramoto, K.; Urano, Y.; Watanabe, H. Carboxylic acid compound. US patent, US 2012/ 0035196 A1, Feb. 9, 2012.
-
(2012)
Carboxylic Acid Compound. US Patent
-
-
Negoro, K.1
Ohnuki, K.2
Yonetoku, Y.3
Kuramoto, K.4
Urano, Y.5
Watanabe, H.6
-
92
-
-
84978507495
-
-
May 22
-
[92] Hernandez, A.S.; Ellsworth, B.A.; Ewing, W.R.; Chen, B. Dihydropyrazole GPR40 Modulators, WO 2014/078608 Al. May 22, 2014.
-
(2014)
Dihydropyrazole GPR40 Modulators
-
-
Hernandez, A.S.1
Ellsworth, B.A.2
Ewing, W.R.3
Chen, B.4
-
93
-
-
84969575766
-
Modulators of GPR40 as treatment for diabetes
-
[93] Abdel-Magid, A.F. Modulators of GPR40 as treatment for diabetes. ACS Med. Chem. Lett., 2014, 5, 954-955.
-
(2014)
ACS Med. Chem. Lett.
, vol.5
, pp. 954-955
-
-
Abdel-Magid, A.F.1
-
94
-
-
84924677753
-
Discovery of DS-1558: A potent and orally bioavailable GPR40 agonist
-
[94] Takano, R., Yoshida, M.; Inoue, M.; Honda, T.; Nakashima, R.; Matsumoto, K.; Yano, Ogata T.; Watanabe, N.; Hirouchi, M.; Yoneyama, T.; Ito, S.; Toda, N.T.; Discovery of DS-1558: A potent and orally bioavailable GPR40 agonist. ACS Med. Chem. Lett., 2015, 6, 266-270.
-
(2015)
ACS Med. Chem. Lett.
, vol.6
, pp. 266-270
-
-
Takano, R.1
Yoshida, M.2
Inoue, M.3
Honda, T.4
Nakashima, R.5
Matsumoto, K.6
Yano, O.T.7
Watanabe, N.8
Hirouchi, M.9
Yoneyama, T.10
Ito, S.11
Toda, N.T.12
-
95
-
-
84962189595
-
Discovery of a potent free fatty acid 1 receptor agonist with low lipophilicity, low polar surface area, and robust in vivo efficacy
-
[95] Hansen, S.V.F.; Christiansen, E.; Urban, C.; Hudson, B.D.; Stocker, C.J.; Due-Hansen, M.E.; Wargent, E.T.; Shimpukade, B.; Almeida, R.; Ejsing, C.S.; Cawthorne, M.A.; Kassack, M.U.; Milligan, G.; Ulven, T. Discovery of a potent free fatty acid 1 receptor agonist with low lipophilicity, low polar surface area, and robust in vivo efficacy. J. Med. Chem., 2016, 59, 2841-2846.
-
(2016)
J. Med. Chem.
, vol.59
, pp. 2841-2846
-
-
Hansen, S.V.F.1
Christiansen, E.2
Urban, C.3
Hudson, B.D.4
Stocker, C.J.5
Due-Hansen, M.E.6
Wargent, E.T.7
Shimpukade, B.8
Almeida, R.9
Ejsing, C.S.10
Cawthorne, M.A.11
Kassack, M.U.12
Milligan, G.13
Ulven, T.14
-
96
-
-
84971669611
-
-
Christiansen, E.; Hudson, B.D.; Hansen, A.H.; Milligan, G.; Ulven, T. Development and characterization of a potent free fatty acid receptor 1 (FFA1) Fluorescent Tracer. DOI: 10.1021/acs.jmedchem. 6b00202.
-
Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer
-
-
Christiansen, E.1
Hudson, B.D.2
Hansen, A.H.3
Milligan, G.4
Ulven, T.5
-
97
-
-
64249111493
-
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin
-
[97] Humphries, P.S.; Benbow, J.W.; Bonin, P.D.; Boyer, D.; Doran, S.D.; Frisbie, R.K.; Piotrowski, D.W.; Balan, G.; Bechle, B.M.; Conn, E.L.; Dirico, K.J.; Oliver, R. M.; Soeller, W.C.; Southers, J.A.; Yang, X. Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists. Bioorg. Med. Chem. Lett., 2009, 19, 2400-2403.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 2400-2403
-
-
Humphries, P.S.1
Benbow, J.W.2
Bonin, P.D.3
Boyer, D.4
Doran, S.D.5
Frisbie, R.K.6
Piotrowski, D.W.7
Balan, G.8
Bechle, B.M.9
Conn, E.L.10
Dirico, K.J.11
Oliver, R.M.12
Soeller, W.C.13
Southers, J.A.14
Yang, X.15
-
98
-
-
70449722784
-
Novel class of antagonists for the FFAs receptor GPR40. Biochem
-
[98] Hu, H.; He, L.Y.; Gong, Z.; Li, N.; Lu, Y.N.; Zhai, Q.W.; Liu, H.; Jiang, H.L.; Zhu, W.L., Wang, H.Y. A novel class of antagonists for the FFAs receptor GPR40. Biochem. Biophys. Res. Commun., 2009, 390(3), 557-563.
-
(2009)
Biophys. Res. Commun.
, vol.390
, Issue.3
, pp. 557-563
-
-
Hu, H.1
He, L.Y.2
Gong, Z.3
Li, N.4
Lu, Y.N.5
Zhai, Q.W.6
Liu, H.7
Jiang, H.L.8
Zhu, W.L.9
Wang, H.10
-
99
-
-
78049237651
-
A small molecule antagonist GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats
-
[99] DC260126, a small molecule antagonist GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed. Pharmacother., 2010, 64(9), 647-651.
-
(2010)
Biomed. Pharmacother.
, vol.64
, Issue.9
, pp. 647-651
-
-
|