Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6357-6361

  Bharate, Sandip B ^a   Rodge, Atish ^a   Joshi, Rajendra K ^a   Kaur, Jaspreet ^a   Srinivasan, Shaila ^a   Senthil Kumar, S ^a   Kulkarni Almeida, Asha ^a   Balachandran, Sarala ^a   Balakrishnan, Arun ^a   Vishwakarma, Ram A ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Diacylphloroglucinols; FFAR1 agonist; GPR40 agonist; Type 2 diabetes

Indexed keywords

2,4 DIISOVALERYL PHLOROGLUCINOL; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; PHLOROGLUCINOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM; CHEMISTRY, PHARMACEUTICAL; CHO CELLS; CRICETINAE; CRICETULUS; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; FATTY ACIDS; HUMANS; LIGANDS; MODELS, CHEMICAL; PHLOROGLUCINOL; RATS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 56549098281     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.085     Document Type: Article

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