Asymmetric syntheses of a GPR40 receptor agonist via diastereoselective and enantioselective conjugate alkynylation

Tetrahedron

Volumn 66, Issue 26, 2010, Pages 4730-4737

  Woo, Jacqueline C S ^a   Cui, Sheng ^a   Walker, Shawn D ^a   Faul, Margaret M ^a  

^a AMGEN INC   (United States)

Author keywords

Alkynyl acid; Cinchonidine; Conjugate addition; Diastereoselective; Enantioselective; GPR40; Oxazepanedione; Zincate

Indexed keywords

CINCHONIDINE; EPHEDRINE; G PROTEIN COUPLED RECEPTOR 40; G PROTEIN COUPLED RECEPTOR 40 AGONIST; HORMONE RECEPTOR STIMULATING AGENT; OXAZEPINE DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ALKYNYLATION; ARTICLE; ASYMMETRIC SYNTHESIS; CHEMICAL REACTION; CHIRALITY; CONJUGATION; DIASTEREOISOMER; DRUG STRUCTURE; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 77955681257     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.04.019     Document Type: Article

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