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Volumn 38, Issue 3, 2017, Pages 173-188

Menopausal hormone therapy and type 2 diabetes prevention: Evidence, mechanisms, and clinical implications

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; GESTAGEN; GLUCOSE; INSULIN;

EID: 85021742726     PISSN: None     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/er.2016-1146     Document Type: Review
Times cited : (213)

References (140)
  • 1
    • 84941702063 scopus 로고    scopus 로고
    • Prevalence of and trends in diabetes among adults in the United States, 1988-2012
    • Menke A, Casagrande S, Geiss L, Cowie CC. Prevalence of and trends in diabetes among adults in the United States, 1988-2012. JAMA. 2015;314(10):1021-1029
    • (2015) JAMA , vol.314 , Issue.10 , pp. 1021-1029
    • Menke, A.1    Casagrande, S.2    Geiss, L.3    Cowie, C.C.4
  • 2
    • 0031682105 scopus 로고    scopus 로고
    • Effect of postmenopausal hormone therapy on glucose and insulin concentrations. PEPI Investigators. Postmenopausal Estrogen/Progestin Interventions
    • Espeland MA, Hogan PE, Fineberg SE, Howard G, Schrott H, Waclawiw MA, Bush TL. Effect of postmenopausal hormone therapy on glucose and insulin concentrations. PEPI Investigators. Postmenopausal Estrogen/Progestin Interventions. Diabetes Care. 1998;21(10):1589-1595
    • (1998) Diabetes Care , vol.21 , Issue.10 , pp. 1589-1595
    • Espeland, M.A.1    Hogan, P.E.2    Fineberg, S.E.3    Howard, G.4    Schrott, H.5    Waclawiw, M.A.6    Bush, T.L.7
  • 3
    • 0037422848 scopus 로고    scopus 로고
    • Heart and Estrogen/progestin Replacement Study. Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial
    • Kanaya AM, Herrington D, VittinghoffE, Lin F, Grady D, Bittner V, Cauley JA, Barrett-Connor E; Heart and Estrogen/progestin Replacement Study. Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2003;138(1):1-9
    • (2003) Ann Intern Med , vol.138 , Issue.1 , pp. 1-9
    • Kanaya, A.M.1    Herrington, D.2    Vittinghoff, E.3    Lin, F.4    Grady, D.5    Bittner, V.6    Cauley, J.A.7    Barrett-Connor, E.8
  • 5
    • 4143116880 scopus 로고    scopus 로고
    • Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial
    • Margolis KL, Bonds DE, Rodabough RJ, Tinker L, Phillips LS, Allen C, Bassford T, Burke G, Torrens J, Howard BV; Women's Health Initiative Investigators. Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial. Diabetologia. 2004; 47(7):1175-1187
    • (2004) Diabetologia , vol.47 , Issue.7 , pp. 1175-1187
    • Margolis, K.L.1    Bonds, D.E.2    Rodabough, R.J.3    Tinker, L.4    Phillips, L.S.5    Allen, C.6    Bassford, T.7    Burke, G.8    Torrens, J.9    Howard, B.V.10
  • 6
    • 33746862148 scopus 로고    scopus 로고
    • Meta-analysis: effect of hormonereplacement therapy on components of the metabolic syndrome in postmenopausal women
    • Salpeter SR, Walsh JM, Ormiston TM, Greyber E, Buckley NS, Salpeter EE. Meta-analysis: effect of hormonereplacement therapy on components of the metabolic syndrome in postmenopausal women. Diabetes Obes Metab. 2006;8(5):538-554
    • (2006) Diabetes Obes Metab , vol.8 , Issue.5 , pp. 538-554
    • Salpeter, S.R.1    Walsh, J.M.2    Ormiston, T.M.3    Greyber, E.4    Buckley, N.S.5    Salpeter, E.E.6
  • 7
    • 84959525603 scopus 로고    scopus 로고
    • Menopause management-getting clinical care back on track
    • Manson JE, Kaunitz AM. Menopause management-getting clinical care back on track. N Engl J Med. 2016; 374(9):803-806
    • (2016) N Engl J Med , vol.374 , Issue.9 , pp. 803-806
    • Manson, J.E.1    Kaunitz, A.M.2
  • 10
    • 84861335162 scopus 로고    scopus 로고
    • Importance of oestrogen receptors to preserve functional b-cell mass in diabetes
    • Tiano JP, Mauvais-Jarvis F. Importance of oestrogen receptors to preserve functional b-cell mass in diabetes. Nat Rev Endocrinol. 2012;8(6):342-351
    • (2012) Nat Rev Endocrinol , vol.8 , Issue.6 , pp. 342-351
    • Tiano, J.P.1    Mauvais-Jarvis, F.2
  • 11
    • 84878632677 scopus 로고    scopus 로고
    • The role of estrogens in control of energy balance and glucose homeostasis
    • Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev. 2013;34(3):309-338
    • (2013) Endocr Rev , vol.34 , Issue.3 , pp. 309-338
    • Mauvais-Jarvis, F.1    Clegg, D.J.2    Hevener, A.L.3
  • 12
    • 84859532410 scopus 로고    scopus 로고
    • Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging
    • Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ; STRAW + 10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab. 2012;97(4):1159-1168
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.4 , pp. 1159-1168
    • Harlow, S.D.1    Gass, M.2    Hall, J.E.3    Lobo, R.4    Maki, P.5    Rebar, R.W.6    Sherman, S.7    Sluss, P.M.8    de Villiers, T.J.9
  • 13
    • 84949254798 scopus 로고    scopus 로고
    • Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome
    • Hevener AL, Clegg DJ, Mauvais-Jarvis F. Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome. Mol Cell Endocrinol. 2015;418(Pt 3): 306-321
    • (2015) Mol Cell Endocrinol , vol.418 , pp. 306-321
    • Hevener, A.L.1    Clegg, D.J.2    Mauvais-Jarvis, F.3
  • 14
    • 84994715869 scopus 로고    scopus 로고
    • Role of Sex Steroids in b cell function, growth, and survival
    • Mauvais-Jarvis F. Role of Sex Steroids in b cell function, growth, and survival. Trends Endocrinol Metab. 2016; 27(12):844-855
    • (2016) Trends Endocrinol Metab , vol.27 , Issue.12 , pp. 844-855
    • Mauvais-Jarvis, F.1
  • 15
    • 85011551520 scopus 로고    scopus 로고
    • The effect of selective estrogen receptor modulators on type 2 diabetes onset in women: basic and clinical insights
    • In press
    • Xu B, Lovre D, Mauvais-Jarvis F. The effect of selective estrogen receptor modulators on type 2 diabetes onset in women: basic and clinical insights. J Diabetes Complications. 2017;S1056-8727(16)30827-3. In press
    • (2017) J Diabetes Complications
    • Xu, B.1    Lovre, D.2    Mauvais-Jarvis, F.3
  • 16
    • 84936972158 scopus 로고    scopus 로고
    • Effect of selective estrogen receptor modulators on metabolic homeostasis
    • Xu B, Lovre D, Mauvais-Jarvis F. Effect of selective estrogen receptor modulators on metabolic homeostasis. Biochimie. 2016;124:92-97
    • (2016) Biochimie , vol.124 , pp. 92-97
    • Xu, B.1    Lovre, D.2    Mauvais-Jarvis, F.3
  • 17
    • 0038645816 scopus 로고    scopus 로고
    • The emergence of the metabolic syndrome with menopause
    • Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003;88(6): 2404-2411
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.6 , pp. 2404-2411
    • Carr, M.C.1
  • 19
    • 0026755484 scopus 로고
    • Sex-and menopauseassociated changes in body-fat distribution
    • Ley CJ, Lees B, Stevenson JC. Sex-and menopauseassociated changes in body-fat distribution. Am J Clin Nutr. 1992;55(5):950-954
    • (1992) Am J Clin Nutr , vol.55 , Issue.5 , pp. 950-954
    • Ley, C.J.1    Lees, B.2    Stevenson, J.C.3
  • 21
    • 0028959586 scopus 로고
    • Age-and menopause-associated variations in body composition and fat distribution in healthy women as measured by dualenergy X-ray absorptiometry
    • Svendsen OL, Hassager C, Christiansen C. Age-and menopause-associated variations in body composition and fat distribution in healthy women as measured by dualenergy X-ray absorptiometry. Metabolism. 1995;44(3):369-373
    • (1995) Metabolism , vol.44 , Issue.3 , pp. 369-373
    • Svendsen, O.L.1    Hassager, C.2    Christiansen, C.3
  • 22
    • 0033962727 scopus 로고    scopus 로고
    • Effect of menopausal status on body composition and abdominal fat distribution
    • Toth MJ, Tchernof A, Sites CK, Poehlman ET. Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes Relat Metab Disord. 2000;24(2):226-231
    • (2000) Int J Obes Relat Metab Disord , vol.24 , Issue.2 , pp. 226-231
    • Toth, M.J.1    Tchernof, A.2    Sites, C.K.3    Poehlman, E.T.4
  • 24
    • 47249146881 scopus 로고    scopus 로고
    • Increased visceral fat and decreased energy expenditure during the menopausal transition
    • Lovejoy JC, Champagne CM, de Jonge L, Xie H, Smith SR. Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes. 2008;32(6):949-958
    • (2008) Int J Obes , vol.32 , Issue.6 , pp. 949-958
    • Lovejoy, J.C.1    Champagne, C.M.2    de Jonge, L.3    Xie, H.4    Smith, S.R.5
  • 25
    • 66449086930 scopus 로고    scopus 로고
    • Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity
    • Rogers NH, Perfield JW II, Strissel KJ, Obin MS, Greenberg AS. Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology. 2009; 150(5):2161-2168
    • (2009) Endocrinology , vol.150 , Issue.5 , pp. 2161-2168
    • Rogers, N.H.1    Perfield, J.W.2    Strissel, K.J.3    Obin, M.S.4    Greenberg, A.S.5
  • 26
    • 0033749264 scopus 로고    scopus 로고
    • Increased adipose tissue in male and female estrogen receptor-alpha knockout mice
    • Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci USA. 2000;97(23):12729-12734
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.23 , pp. 12729-12734
    • Heine, P.A.1    Taylor, J.A.2    Iwamoto, G.A.3    Lubahn, D.B.4    Cooke, P.S.5
  • 30
    • 0026021161 scopus 로고
    • Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14(3):173-194
    • (1991) Diabetes Care , vol.14 , Issue.3 , pp. 173-194
    • DeFronzo, R.A.1    Ferrannini, E.2
  • 31
    • 84863254758 scopus 로고    scopus 로고
    • Does menopause increase diabetes risk? Strategies for diabetes prevention in midlife women
    • Kim C. Does menopause increase diabetes risk? Strategies for diabetes prevention in midlife women. Womens Health (Lond). 2012;8(2):155-167
    • (2012) Womens Health (Lond) , vol.8 , Issue.2 , pp. 155-167
    • Kim, C.1
  • 34
    • 84880062642 scopus 로고    scopus 로고
    • Changes in cardiovascular risk factors by hysterectomy status with and without oophorectomy: Study of Women's Health Across the Nation
    • Matthews KA, Gibson CJ, El Khoudary SR, Thurston RC. Changes in cardiovascular risk factors by hysterectomy status with and without oophorectomy: Study of Women's Health Across the Nation. J Am Coll Cardiol. 2013;62(3):191-200
    • (2013) J Am Coll Cardiol , vol.62 , Issue.3 , pp. 191-200
    • Matthews, K.A.1    Gibson, C.J.2    El Khoudary, S.R.3    Thurston, R.C.4
  • 35
    • 85008193401 scopus 로고    scopus 로고
    • Association between changes in oestradiol and folliclestimulating hormone levels during the menopausal transition and risk of diabetes
    • [published online ahead of print December 14, 2016]
    • Park SK, Harlow SD, Zheng H, Karvonen-Gutierrez C, Thurston RC, Ruppert K, Janssen I, Randolph JF Jr. Association between changes in oestradiol and folliclestimulating hormone levels during the menopausal transition and risk of diabetes [published online ahead of print December 14, 2016]. Diabet Med. doi: 10.1111/dme.13301
    • Diabet Med
    • Park, S.K.1    Harlow, S.D.2    Zheng, H.3    Karvonen-Gutierrez, C.4    Thurston, R.C.5    Ruppert, K.6    Janssen, I.7    Randolph, J.F.8
  • 37
    • 85010460574 scopus 로고    scopus 로고
    • Association between earlier age at natural menopause and risk of diabetes in middle-aged and older Chinese women: The Dongfeng-Tongji cohort study
    • [published online ahead of print January 24, 2017]
    • Shen L, Song L, Li H, Liu B, Zheng X, Zhang L, Yuan J, Liang Y, Wang Y. Association between earlier age at natural menopause and risk of diabetes in middle-aged and older Chinese women: The Dongfeng-Tongji cohort study [published online ahead of print January 24, 2017]. Diabetes Metab. doi: 10.1016/j.diabet.2016.12.011
    • Diabetes Metab
    • Shen, L.1    Song, L.2    Li, H.3    Liu, B.4    Zheng, X.5    Zhang, L.6    Yuan, J.7    Liang, Y.8    Wang, Y.9
  • 38
    • 0030707863 scopus 로고    scopus 로고
    • Menopause in normal and uncomplicated NIDDM women: physical and emotional symptoms and hormone profile
    • Malacara JM, Huerta R, Rivera B, Esparza S, Fajardo ME. Menopause in normal and uncomplicated NIDDM women: physical and emotional symptoms and hormone profile. Maturitas. 1997;28(1):35-45
    • (1997) Maturitas , vol.28 , Issue.1 , pp. 35-45
    • Malacara, J.M.1    Huerta, R.2    Rivera, B.3    Esparza, S.4    Fajardo, M.E.5
  • 39
    • 84896731556 scopus 로고    scopus 로고
    • Bilateral oophorectomy and the risk of incident diabetes in postmenopausal women
    • Appiah D, Winters SJ, Hornung CA. Bilateral oophorectomy and the risk of incident diabetes in postmenopausal women. Diabetes Care. 2014;37(3):725-733
    • (2014) Diabetes Care , vol.37 , Issue.3 , pp. 725-733
    • Appiah, D.1    Winters, S.J.2    Hornung, C.A.3
  • 41
    • 0028408959 scopus 로고
    • Comparison of estimates of insulin sensitivity in pre-and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test
    • Lindheim SR, Buchanan TA, Duffy DM, Vijod MA, Kojima T, Stanczyk FZ, Lobo RA. Comparison of estimates of insulin sensitivity in pre-and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J Soc Gynecol Investig. 1994;1(2):150-154
    • (1994) J Soc Gynecol Investig , vol.1 , Issue.2 , pp. 150-154
    • Lindheim, S.R.1    Buchanan, T.A.2    Duffy, D.M.3    Vijod, M.A.4    Kojima, T.5    Stanczyk, F.Z.6    Lobo, R.A.7
  • 42
    • 0027164529 scopus 로고
    • The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women
    • Walton C, Godsland IF, Proudler AJ, Wynn V, Stevenson JC. The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women. Eur J Clin Invest. 1993;23(8):466-473
    • (1993) Eur J Clin Invest , vol.23 , Issue.8 , pp. 466-473
    • Walton, C.1    Godsland, I.F.2    Proudler, A.J.3    Wynn, V.4    Stevenson, J.C.5
  • 44
    • 0343191487 scopus 로고    scopus 로고
    • Effect of menopausal status on insulin-stimulated glucose disposal: comparison of middle-aged premenopausal and early postmenopausal women
    • Toth MJ, Sites CK, Eltabbakh GH, Poehlman ET. Effect of menopausal status on insulin-stimulated glucose disposal: comparison of middle-aged premenopausal and early postmenopausal women. Diabetes Care. 2000; 23(6):801-806
    • (2000) Diabetes Care , vol.23 , Issue.6 , pp. 801-806
    • Toth, M.J.1    Sites, C.K.2    Eltabbakh, G.H.3    Poehlman, E.T.4
  • 45
    • 66449105068 scopus 로고    scopus 로고
    • Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice
    • Riant E, Waget A, Cogo H, Arnal JF, Burcelin R, Gourdy P. Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. Endocrinology. 2009;150(5):2109-2117
    • (2009) Endocrinology , vol.150 , Issue.5 , pp. 2109-2117
    • Riant, E.1    Waget, A.2    Cogo, H.3    Arnal, J.F.4    Burcelin, R.5    Gourdy, P.6
  • 46
    • 78649331876 scopus 로고    scopus 로고
    • Acute effects of 17 b-estradiol and genistein on insulin sensitivity and spatial memory in aged ovariectomized female rats
    • Alonso A, González-Pardo H, Garrido P, Conejo NM, Llaneza P, Díaz F, Del Rey CG, González C. Acute effects of 17 b-estradiol and genistein on insulin sensitivity and spatial memory in aged ovariectomized female rats. Age (Dordr). 2010;32(4):421-434
    • (2010) Age (Dordr) , vol.32 , Issue.4 , pp. 421-434
    • Alonso, A.1    González-Pardo, H.2    Garrido, P.3    Conejo, N.M.4    Llaneza, P.5    Díaz, F.6    Del Rey, C.G.7    González, C.8
  • 47
    • 84873040492 scopus 로고    scopus 로고
    • Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance
    • Zhu L, Brown WC, Cai Q, Krust A, Chambon P, McGuinness OP, Stafford JM. Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance. Diabetes. 2013;62(2):424-434
    • (2013) Diabetes , vol.62 , Issue.2 , pp. 424-434
    • Zhu, L.1    Brown, W.C.2    Cai, Q.3    Krust, A.4    Chambon, P.5    McGuinness, O.P.6    Stafford, J.M.7
  • 54
    • 0033793584 scopus 로고    scopus 로고
    • Oophorectomy promotes islet amyloid formation in a transgenic mouse model of type II diabetes
    • Kahn SE, Andrikopoulos S, Verchere CB, Wang F, Hull RL, Vidal J. Oophorectomy promotes islet amyloid formation in a transgenic mouse model of type II diabetes. Diabetologia. 2000;43(10):1309-1312
    • (2000) Diabetologia , vol.43 , Issue.10 , pp. 1309-1312
    • Kahn, S.E.1    Andrikopoulos, S.2    Verchere, C.B.3    Wang, F.4    Hull, R.L.5    Vidal, J.6
  • 55
    • 0027934601 scopus 로고
    • Sexual difference in the incidence of diabetes mellitus in Otsuka-Long-Evans-Tokushima-Fatty rats: effects of castration and sex hormone replacement on its incidence
    • Shi K, Mizuno A, Sano T, Ishida K, Shima K. Sexual difference in the incidence of diabetes mellitus in Otsuka-Long-Evans-Tokushima-Fatty rats: effects of castration and sex hormone replacement on its incidence. Metabolism. 1994;43(10):1214-1220
    • (1994) Metabolism , vol.43 , Issue.10 , pp. 1214-1220
    • Shi, K.1    Mizuno, A.2    Sano, T.3    Ishida, K.4    Shima, K.5
  • 57
    • 0026016699 scopus 로고
    • Sexual dimorphism of pancreatic beta-cell degeneration in transgenic mice expressing an insulin-ras hybrid gene
    • Efrat S. Sexual dimorphism of pancreatic beta-cell degeneration in transgenic mice expressing an insulin-ras hybrid gene. Endocrinology. 1991;128(2):897-901
    • (1991) Endocrinology , vol.128 , Issue.2 , pp. 897-901
    • Efrat, S.1
  • 58
    • 77149165088 scopus 로고    scopus 로고
    • Minireview: estrogenic protection of beta-cell failure in metabolic diseases
    • Liu S, Mauvais-Jarvis F. Minireview: estrogenic protection of beta-cell failure in metabolic diseases. Endocrinology. 2010;151(3):859-864
    • (2010) Endocrinology , vol.151 , Issue.3 , pp. 859-864
    • Liu, S.1    Mauvais-Jarvis, F.2
  • 59
    • 70349649964 scopus 로고    scopus 로고
    • Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival
    • Liu S, Le May C, Wong WP, Ward RD, Clegg DJ, Marcelli M, Korach KS, Mauvais-Jarvis F. Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes. 2009;58(10):2292-2302
    • (2009) Diabetes , vol.58 , Issue.10 , pp. 2292-2302
    • Liu, S.1    Le May, C.2    Wong, W.P.3    Ward, R.D.4    Clegg, D.J.5    Marcelli, M.6    Korach, K.S.7    Mauvais-Jarvis, F.8
  • 61
    • 84999470765 scopus 로고    scopus 로고
    • Estrogen complexes improve the unfolded protein response and prevent ER-stress induced beta cell failure in Akita mice
    • Xu B, Allard C, Mauvais-Jarvis F. Estrogen complexes improve the unfolded protein response and prevent ER-stress induced beta cell failure in Akita mice. Diabetes. 2015;64:A35
    • (2015) Diabetes , vol.64
    • Xu, B.1    Allard, C.2    Mauvais-Jarvis, F.3
  • 62
    • 0030596338 scopus 로고    scopus 로고
    • Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus-a genetically programmed failure of the beta cell to compensate for insulin resistance
    • Polonsky KS, Sturis J, Bell GI. Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus-a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med. 1996;334(12):777-783
    • (1996) N Engl J Med , vol.334 , Issue.12 , pp. 777-783
    • Polonsky, K.S.1    Sturis, J.2    Bell, G.I.3
  • 63
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest. 2006;116(7):1802-1812
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 64
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104(6):787-794
    • (1999) J Clin Invest , vol.104 , Issue.6 , pp. 787-794
    • Weyer, C.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 65
    • 84915817059 scopus 로고    scopus 로고
    • All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause
    • Labrie F. All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause. J Steroid Biochem Mol Biol. 2015;145: 133-138
    • (2015) J Steroid Biochem Mol Biol , vol.145 , pp. 133-138
    • Labrie, F.1
  • 66
    • 0242457714 scopus 로고    scopus 로고
    • Sources of estrogen and their importance
    • Simpson ER. Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 2003;86(3-5):225-230
    • (2003) J Steroid Biochem Mol Biol , vol.86 , Issue.3-5 , pp. 225-230
    • Simpson, E.R.1
  • 68
    • 62449284696 scopus 로고    scopus 로고
    • Nonhuman primates as models for human adrenal androgen production: function and dysfunction
    • Abbott DH, Bird IM. Nonhuman primates as models for human adrenal androgen production: function and dysfunction. Rev Endocr Metab Disord. 2009;10(1): 33-42
    • (2009) Rev Endocr Metab Disord , vol.10 , Issue.1 , pp. 33-42
    • Abbott, D.H.1    Bird, I.M.2
  • 69
    • 0028792229 scopus 로고
    • Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    • Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab. 1995;80(12): 3689-3698
    • (1995) J Clin Endocrinol Metab , vol.80 , Issue.12 , pp. 3689-3698
    • Morishima, A.1    Grumbach, M.M.2    Simpson, E.R.3    Fisher, C.4    Qin, K.5
  • 71
    • 84908596824 scopus 로고    scopus 로고
    • Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism
    • Chen Z, Wang O, Nie M, Elison K, Zhou D, Li M, Jiang Y, XiaW, Meng X, Chen S, Xing X. Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism. Mol Cell Endocrinol. 2015;399: 32-42
    • (2015) Mol Cell Endocrinol , vol.399 , pp. 32-42
    • Chen, Z.1    Wang, O.2    Nie, M.3    Elison, K.4    Zhou, D.5    Li, M.6    Jiang, Y.7    Xia, W.8    Meng, X.9    Chen, S.10    Xing, X.11
  • 72
    • 85019617184 scopus 로고    scopus 로고
    • Associations of steroid sex hormones and sex hormonebinding globulin with the risk of type 2 diabetes in women: a population-based cohort study and metaanalysis
    • Muka T, Nano J, Jaspers L, Meun C, Bramer WM, Hofman A, Dehghan A, KavousiM, Laven JS, Franco OH. Associations of steroid sex hormones and sex hormonebinding globulin with the risk of type 2 diabetes in women: a population-based cohort study and metaanalysis. Diabetes 2016;66(3):577-586
    • (2016) Diabetes , vol.66 , Issue.3 , pp. 577-586
    • Muka, T.1    Nano, J.2    Jaspers, L.3    Meun, C.4    Bramer, W.M.5    Hofman, A.6    Dehghan, A.7    Kavousi, M.8    Laven, J.S.9    Franco, O.H.10
  • 73
    • 34548490716 scopus 로고    scopus 로고
    • Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study
    • Ding EL, Song Y, Manson JE, Rifai N, Buring JE, Liu S. Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study. Diabetologia. 2007;50(10):2076-2084
    • (2007) Diabetologia , vol.50 , Issue.10 , pp. 2076-2084
    • Ding, E.L.1    Song, Y.2    Manson, J.E.3    Rifai, N.4    Buring, J.E.5    Liu, S.6
  • 74
    • 70449113365 scopus 로고    scopus 로고
    • The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women
    • Kalyani RR, Franco M, Dobs AS, Ouyang P, Vaidya D, Bertoni A, Gapstur SM, Golden SH. The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women. J Clin Endocrinol Metab. 2009;94(11): 4127-4135
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.11 , pp. 4127-4135
    • Kalyani, R.R.1    Franco, M.2    Dobs, A.S.3    Ouyang, P.4    Vaidya, D.5    Bertoni, A.6    Gapstur, S.M.7    Golden, S.H.8
  • 75
    • 85019565954 scopus 로고    scopus 로고
    • Is estradiol a biomarker of type 2 diabetes risk in postmenopausal women?
    • Mauvais-Jarvis F. Is estradiol a biomarker of type 2 diabetes risk in postmenopausal women? Diabetes. 2017;66(3):568-570
    • (2017) Diabetes , vol.66 , Issue.3 , pp. 568-570
    • Mauvais-Jarvis, F.1
  • 76
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 78
    • 0034950083 scopus 로고    scopus 로고
    • Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism
    • Lobo RA, Bush T, Carr BR, Pickar JH. Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism. Fertil Steril. 2001;76(1):13-24
    • (2001) Fertil Steril , vol.76 , Issue.1 , pp. 13-24
    • Lobo, R.A.1    Bush, T.2    Carr, B.R.3    Pickar, J.H.4
  • 79
    • 0035808009 scopus 로고    scopus 로고
    • Estrogen in the Prevention of Atherosclerosis Trial Research Group. Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebocontrolled trial
    • Hodis HN, Mack WJ, Lobo RA, Shoupe D, Sevanian A, Mahrer PR, Selzer RH, Liu Cr CR, Liu Ch CH, Azen SP Estrogen in the Prevention of Atherosclerosis Trial Research Group. Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebocontrolled trial. Ann Intern Med. 2001;135(11):939-953
    • (2001) Ann Intern Med , vol.135 , Issue.11 , pp. 939-953
    • Hodis, H.N.1    Mack, W.J.2    Lobo, R.A.3    Shoupe, D.4    Sevanian, A.5    Mahrer, P.R.6    Selzer, R.H.7    Liu Cr, C.R.8    Liu Ch, C.H.9    Azen, S.P.10
  • 81
    • 69949113593 scopus 로고    scopus 로고
    • Menopausal hormone therapy and new-onset diabetes in the French Etude Epidemiologique de Femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort
    • de Lauzon-Guillain B, Fournier A, Fabre A, Simon N, Mesrine S, Boutron-Ruault MC, Balkau B, Clavel-Chapelon F. Menopausal hormone therapy and new-onset diabetes in the French Etude Epidemiologique de Femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort. Diabetologia. 2009;52(10):2092-2100
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2092-2100
    • de Lauzon-Guillain, B.1    Fournier, A.2    Fabre, A.3    Simon, N.4    Mesrine, S.5    Boutron-Ruault, M.C.6    Balkau, B.7    Clavel-Chapelon, F.8
  • 83
    • 84902360940 scopus 로고    scopus 로고
    • Combined estrogen replacement therapy on metabolic control in postmenopausal women with diabetes mellitus
    • Xu Y, Lin J, Wang S, Xiong J, Zhu Q. Combined estrogen replacement therapy on metabolic control in postmenopausal women with diabetes mellitus. Kaohsiung J Med Sci. 2014;30(7):350-361
    • (2014) Kaohsiung J Med Sci , vol.30 , Issue.7 , pp. 350-361
    • Xu, Y.1    Lin, J.2    Wang, S.3    Xiong, J.4    Zhu, Q.5
  • 84
    • 0035142209 scopus 로고    scopus 로고
    • Conjugated equine estrogen improves glycemic control and blood lipoproteins in postmenopausal women with type 2 diabetes
    • Friday KE, Dong C, Fontenot RU. Conjugated equine estrogen improves glycemic control and blood lipoproteins in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab. 2001;86(1):48-52
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.1 , pp. 48-52
    • Friday, K.E.1    Dong, C.2    Fontenot, R.U.3
  • 85
    • 0031022548 scopus 로고    scopus 로고
    • Estrogen replacement therapy decreases hyperandrogenicity and improves glucose homeostasis and plasma lipids in postmenopausal women with noninsulin-dependent diabetes mellitus
    • Andersson B, Mattsson LA, Hahn L, Mårin P, Lapidus L, Holm G, Bengtsson BA, Björntorp P. Estrogen replacement therapy decreases hyperandrogenicity and improves glucose homeostasis and plasma lipids in postmenopausal women with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1997;82(2): 638-643
    • (1997) J Clin Endocrinol Metab , vol.82 , Issue.2 , pp. 638-643
    • Andersson, B.1    Mattsson, L.A.2    Hahn, L.3    Mårin, P.4    Lapidus, L.5    Holm, G.6    Bengtsson, B.A.7    Björntorp, P.8
  • 86
    • 8544267912 scopus 로고    scopus 로고
    • Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM
    • Brussaard HE, Gevers Leuven JA, Frölich M, Kluft C, Krans HM. Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM. Diabetologia. 1997;40(7):843-849
    • (1997) Diabetologia , vol.40 , Issue.7 , pp. 843-849
    • Brussaard, H.E.1    Gevers Leuven, J.A.2    Frölich, M.3    Kluft, C.4    Krans, H.M.5
  • 88
    • 0028035119 scopus 로고
    • The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women
    • Lindheim SR, Duffy DM, Kojima T, Vijod MA, Stanczyk FZ, Lobo RA. The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women. Fertil Steril. 1994;62(6):1176-1180
    • (1994) Fertil Steril , vol.62 , Issue.6 , pp. 1176-1180
    • Lindheim, S.R.1    Duffy, D.M.2    Kojima, T.3    Vijod, M.A.4    Stanczyk, F.Z.5    Lobo, R.A.6
  • 89
    • 33744980859 scopus 로고    scopus 로고
    • Association of serum proinsulin with hormone replacement therapy in nondiabetic older women: the Rancho Bernardo Study
    • Kim DJ, Barrett-Connor E. Association of serum proinsulin with hormone replacement therapy in nondiabetic older women: the Rancho Bernardo Study. Diabetes Care. 2006;29(3):618-624
    • (2006) Diabetes Care , vol.29 , Issue.3 , pp. 618-624
    • Kim, D.J.1    Barrett-Connor, E.2
  • 91
    • 0033940910 scopus 로고    scopus 로고
    • Recent insights into the varying activity of estrogens
    • Dey M, Lyttle CR, Pickar JH. Recent insights into the varying activity of estrogens. Maturitas. 2000;34(Suppl 2): S25-S33
    • (2000) Maturitas , vol.34 , pp. S25-S33
    • Dey, M.1    Lyttle, C.R.2    Pickar, J.H.3
  • 93
    • 18844482960 scopus 로고
    • Hormone therapy by percutaneous route. Physiological bases. Clinical applications [in French]
    • Mauvais-Jarvis P, Bercovici JP. Hormone therapy by percutaneous route. Physiological bases. Clinical applications [in French]. Therapeutique. 1972;48(5):403-406
    • (1972) Therapeutique , vol.48 , Issue.5 , pp. 403-406
    • Mauvais-Jarvis, P.1    Bercovici, J.P.2
  • 96
    • 0019975473 scopus 로고
    • Effects of percutaneous estradiol and conjugated estrogens on the level of plasma proteins and triglycerides in postmenopausal women
    • Elkik F, Gompel A, Mercier-Bodard C, Kuttenn F, Guyenne PN, Corvol P, Mauvais-Jarvis P. Effects of percutaneous estradiol and conjugated estrogens on the level of plasma proteins and triglycerides in postmenopausal women. Am J Obstet Gynecol. 1982;143(8): 888-892
    • (1982) Am J Obstet Gynecol , vol.143 , Issue.8 , pp. 888-892
    • Elkik, F.1    Gompel, A.2    Mercier-Bodard, C.3    Kuttenn, F.4    Guyenne, P.N.5    Corvol, P.6    Mauvais-Jarvis, P.7
  • 97
    • 0026072558 scopus 로고
    • Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins
    • Walsh BW, SchiffI, Rosner B, Greenberg L, Ravnikar V, Sacks FM. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med. 1991;325(17): 1196-1204
    • (1991) N Engl J Med , vol.325 , Issue.17 , pp. 1196-1204
    • Walsh, B.W.1    Schiff, I.2    Rosner, B.3    Greenberg, L.4    Ravnikar, V.5    Sacks, F.M.6
  • 98
    • 0027364409 scopus 로고
    • A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin
    • Lindheim SR, Presser SC, DitkoffEC, Vijod MA, Stanczyk FZ, Lobo RA. A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin. Fertil Steril. 1993; 60(4):664-667
    • (1993) Fertil Steril , vol.60 , Issue.4 , pp. 664-667
    • Lindheim, S.R.1    Presser, S.C.2    Ditkoff, E.C.3    Vijod, M.A.4    Stanczyk, F.Z.5    Lobo, R.A.6
  • 99
    • 0028146949 scopus 로고
    • The effects of hormonal replacement therapy on insulin sensitivity in surgically postmenopausal cynomolgus monkeys (Macaca fascicularis)
    • Cefalu WT, Wagner JD, Bell-Farrow AD, Wang ZQ, Adams MR, Toffolo G, Cobelli C. The effects of hormonal replacement therapy on insulin sensitivity in surgically postmenopausal cynomolgus monkeys (Macaca fascicularis). Am J Obstet Gynecol. 1994;171(2): 440-445
    • (1994) Am J Obstet Gynecol , vol.171 , Issue.2 , pp. 440-445
    • Cefalu, W.T.1    Wagner, J.D.2    Bell-Farrow, A.D.3    Wang, Z.Q.4    Adams, M.R.5    Toffolo, G.6    Cobelli, C.7
  • 100
    • 0027537995 scopus 로고
    • Hormone replacement therapy alters insulin sensitivity in young women with premature ovarian failure
    • Elkind-Hirsch KE, Sherman LD, Malinak R. Hormone replacement therapy alters insulin sensitivity in young women with premature ovarian failure. J Clin Endocrinol Metab. 1993;76(2):472-475
    • (1993) J Clin Endocrinol Metab , vol.76 , Issue.2 , pp. 472-475
    • Elkind-Hirsch, K.E.1    Sherman, L.D.2    Malinak, R.3
  • 101
    • 0027171431 scopus 로고
    • Insulin resistance, secretion, and elimination in postmenopausal women receiving oral or transdermal hormone replacement therapy
    • Godsland IF, Gangar K, Walton C, Cust MP, Whitehead MI, Wynn V, Stevenson JC. Insulin resistance, secretion, and elimination in postmenopausal women receiving oral or transdermal hormone replacement therapy. Metabolism. 1993;42(7):846-853
    • (1993) Metabolism , vol.42 , Issue.7 , pp. 846-853
    • Godsland, I.F.1    Gangar, K.2    Walton, C.3    Cust, M.P.4    Whitehead, M.I.5    Wynn, V.6    Stevenson, J.C.7
  • 102
    • 0033062351 scopus 로고    scopus 로고
    • Influence of continuous combined estradiol-norethisterone acetate preparations on insulin sensitivity in postmenopausal nondiabetic women
    • Kimmerle R, Heinemann L, Heise T, Bender R, Weyer C, Hirschberger S, Berger M. Influence of continuous combined estradiol-norethisterone acetate preparations on insulin sensitivity in postmenopausal nondiabetic women. Menopause. 1999;6(1):36-42
    • (1999) Menopause , vol.6 , Issue.1 , pp. 36-42
    • Kimmerle, R.1    Heinemann, L.2    Heise, T.3    Bender, R.4    Weyer, C.5    Hirschberger, S.6    Berger, M.7
  • 103
    • 0034042573 scopus 로고    scopus 로고
    • Effects of oral and transdermal 17beta-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women
    • Spencer CP, Godsland IF, Cooper AJ, Ross D, Whitehead MI, Stevenson JC. Effects of oral and transdermal 17beta-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women. Metabolism. 2000;49(6):742-747
    • (2000) Metabolism , vol.49 , Issue.6 , pp. 742-747
    • Spencer, C.P.1    Godsland, I.F.2    Cooper, A.J.3    Ross, D.4    Whitehead, M.I.5    Stevenson, J.C.6
  • 104
    • 0024452874 scopus 로고
    • Carbohydrate metabolism during hormonal substitution therapy
    • De Cleyn K, Buytaert P, Coppens M. Carbohydrate metabolism during hormonal substitution therapy. Maturitas. 1989;11(3):235-242
    • (1989) Maturitas , vol.11 , Issue.3 , pp. 235-242
    • De Cleyn, K.1    Buytaert, P.2    Coppens, M.3
  • 105
    • 0031041621 scopus 로고    scopus 로고
    • Hormone replacement therapy with dydrogesterone and 17 betaoestradiol: effects on serum lipoproteins and glucose tolerance during 24 month follow up
    • Crook D, Godsland IF, Hull J, Stevenson JC. Hormone replacement therapy with dydrogesterone and 17 betaoestradiol: effects on serum lipoproteins and glucose tolerance during 24 month follow up. Br J Obstet Gynaecol. 1997;104(3):298-304
    • (1997) Br J Obstet Gynaecol , vol.104 , Issue.3 , pp. 298-304
    • Crook, D.1    Godsland, I.F.2    Hull, J.3    Stevenson, J.C.4
  • 107
  • 108
    • 0032768676 scopus 로고    scopus 로고
    • Beneficial effect of hormone replacement therapy on weight loss in obese menopausal women
    • Chmouliovsky L, Habicht F, James RW, Lehmann T, Campana A, Golay A. Beneficial effect of hormone replacement therapy on weight loss in obese menopausal women. Maturitas. 1999;32(3):147-153
    • (1999) Maturitas , vol.32 , Issue.3 , pp. 147-153
    • Chmouliovsky, L.1    Habicht, F.2    James, R.W.3    Lehmann, T.4    Campana, A.5    Golay, A.6
  • 109
    • 0041878902 scopus 로고    scopus 로고
    • Body composition, visceral fat distribution and fat oxidation in postmenopausal women using oral or transdermal oestrogen
    • dos Reis CM, de Melo NR, Meirelles ES, Vezozzo DP, Halpern A. Body composition, visceral fat distribution and fat oxidation in postmenopausal women using oral or transdermal oestrogen. Maturitas. 2003;46(1): 59-68
    • (2003) Maturitas , vol.46 , Issue.1 , pp. 59-68
    • dos Reis, C.M.1    de Melo, N.R.2    Meirelles, E.S.3    Vezozzo, D.P.4    Halpern, A.5
  • 110
    • 0032168320 scopus 로고    scopus 로고
    • The route of estrogen replacement therapy confers divergent effects on substrate oxidation and body composition in postmenopausal women
    • O'Sullivan AJ, Crampton LJ, Freund J, Ho KK. The route of estrogen replacement therapy confers divergent effects on substrate oxidation and body composition in postmenopausal women. J Clin Invest. 1998;102(5): 1035-1040
    • (1998) J Clin Invest , vol.102 , Issue.5 , pp. 1035-1040
    • O'Sullivan, A.J.1    Crampton, L.J.2    Freund, J.3    Ho, K.K.4
  • 112
    • 0029156689 scopus 로고
    • Estrogen, lipid oxidation, and body fat
    • O'Sullivan AJ, Hoffman DM, Ho KK. Estrogen, lipid oxidation, and body fat. N Engl J Med. 1995;333(10): 669-670
    • (1995) N Engl J Med , vol.333 , Issue.10 , pp. 669-670
    • O'Sullivan, A.J.1    Hoffman, D.M.2    Ho, K.K.3
  • 114
    • 0036812279 scopus 로고    scopus 로고
    • Effects of estrogen replacement therapy on abdominal fat compartments as related to glucose and lipid metabolism in early postmenopausal women
    • Mattiasson I, Rendell M, Törnquist C, Jeppsson S, Hulthén UL. Effects of estrogen replacement therapy on abdominal fat compartments as related to glucose and lipid metabolism in early postmenopausal women. Horm Metab Res. 2002;34(10):583-588
    • (2002) Horm Metab Res , vol.34 , Issue.10 , pp. 583-588
    • Mattiasson, I.1    Rendell, M.2    Törnquist, C.3    Jeppsson, S.4    Hulthén, U.L.5
  • 115
    • 18844456034 scopus 로고    scopus 로고
    • The effect of hormone replacement therapy on body composition, body fat distribution, and insulin sensitivity in menopausal women: a randomized, double-blind, placebo-controlled trial
    • Sites CK, L'Hommedieu GD, Toth MJ, Brochu M, Cooper BC, Fairhurst PA. The effect of hormone replacement therapy on body composition, body fat distribution, and insulin sensitivity in menopausal women: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2005;90(5):2701-2707
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.5 , pp. 2701-2707
    • Sites, C.K.1    L'Hommedieu, G.D.2    Toth, M.J.3    Brochu, M.4    Cooper, B.C.5    Fairhurst, P.A.6
  • 116
    • 39049097269 scopus 로고    scopus 로고
    • Insulin secretion and clearance after subacute estradiol administration in postmenopausal women
    • Van Pelt RE, Schwartz RS, Kohrt WM. Insulin secretion and clearance after subacute estradiol administration in postmenopausal women. J Clin Endocrinol Metab. 2008; 93(2):484-490
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.2 , pp. 484-490
    • Van Pelt, R.E.1    Schwartz, R.S.2    Kohrt, W.M.3
  • 118
    • 0032942951 scopus 로고    scopus 로고
    • Differential effect of transdermal estrogen plus progestagen replacement therapy on insulin metabolism in postmenopausal women: relation to their insulinemic secretion
    • Cucinelli F, Paparella P, Soranna L, Barini A, Cinque B, Mancuso S, Lanzone A. Differential effect of transdermal estrogen plus progestagen replacement therapy on insulin metabolism in postmenopausal women: relation to their insulinemic secretion. Eur J Endocrinol. 1999; 140(3):215-223
    • (1999) Eur J Endocrinol , vol.140 , Issue.3 , pp. 215-223
    • Cucinelli, F.1    Paparella, P.2    Soranna, L.3    Barini, A.4    Cinque, B.5    Mancuso, S.6    Lanzone, A.7
  • 120
  • 121
    • 2442702762 scopus 로고    scopus 로고
    • Effects of low and high dose oestradiol and dydrogesterone therapy on insulin and lipoprotein metabolism in healthy postmenopausal women
    • Godsland IF, Manassiev NA, Felton CV, Proudler AJ, Crook D, Whitehead MI, Stevenson JC. Effects of low and high dose oestradiol and dydrogesterone therapy on insulin and lipoprotein metabolism in healthy postmenopausal women. Clin Endocrinol (Oxf). 2004; 60(5):541-549
    • (2004) Clin Endocrinol (Oxf) , vol.60 , Issue.5 , pp. 541-549
    • Godsland, I.F.1    Manassiev, N.A.2    Felton, C.V.3    Proudler, A.J.4    Crook, D.5    Whitehead, M.I.6    Stevenson, J.C.7
  • 124
    • 84874426941 scopus 로고    scopus 로고
    • Novel link between inflammation, endothelial dysfunction, and muscle insulin resistance
    • Mauvais-Jarvis F. Novel link between inflammation, endothelial dysfunction, and muscle insulin resistance. Diabetes. 2013;62(3):688-690
    • (2013) Diabetes , vol.62 , Issue.3 , pp. 688-690
    • Mauvais-Jarvis, F.1
  • 125
    • 0036066970 scopus 로고    scopus 로고
    • Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
    • Mauvais-Jarvis F, Kulkarni RN, Kahn CR. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf). 2002;57(1):1-9
    • (2002) Clin Endocrinol (Oxf) , vol.57 , Issue.1 , pp. 1-9
    • Mauvais-Jarvis, F.1    Kulkarni, R.N.2    Kahn, C.R.3
  • 126
    • 0033661363 scopus 로고    scopus 로고
    • A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes
    • Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR. A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes. 2000;49(12):2126-2134
    • (2000) Diabetes , vol.49 , Issue.12 , pp. 2126-2134
    • Mauvais-Jarvis, F.1    Virkamaki, A.2    Michael, M.D.3    Winnay, J.N.4    Zisman, A.5    Kulkarni, R.N.6    Kahn, C.R.7
  • 127
    • 0030901308 scopus 로고    scopus 로고
    • Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components
    • Ader M, Ni TC, Bergman RN. Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components. J Clin Invest. 1997;99(6):1187-1199
    • (1997) J Clin Invest , vol.99 , Issue.6 , pp. 1187-1199
    • Ader, M.1    Ni, T.C.2    Bergman, R.N.3
  • 128
    • 0018520840 scopus 로고
    • Glucose clamp technique: a method for quantifying insulin secretion and resistance
    • DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):E214-E223
    • (1979) Am J Physiol , vol.237 , Issue.3 , pp. E214-E223
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 129
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: betacell, muscle, liver
    • DeFronzo RA. Lilly lecture 1987. The triumvirate: betacell, muscle, liver. A collusion responsible for NIDDM. 1988;37(6):667-687
    • (1988) A collusion responsible for NIDDM , vol.37 , Issue.6 , pp. 667-687
    • DeFronzo, R.A.1
  • 130
    • 27744532581 scopus 로고    scopus 로고
    • Oestrogens and insulin secretion
    • Godsland IF. Oestrogens and insulin secretion. Diabetologia. 2005;48(11):2213-2220
    • (2005) Diabetologia , vol.48 , Issue.11 , pp. 2213-2220
    • Godsland, I.F.1
  • 131
    • 0037110453 scopus 로고    scopus 로고
    • 17beta-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: molecular mechanisms and islet functionality
    • Contreras JL, Smyth CA, Bilbao G, Young CJ, Thompson JA, EckhoffDE. 17beta-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: molecular mechanisms and islet functionality. Transplantation. 2002;74(9):1252-1259
    • (2002) Transplantation , vol.74 , Issue.9 , pp. 1252-1259
    • Contreras, J.L.1    Smyth, C.A.2    Bilbao, G.3    Young, C.J.4    Thompson, J.A.5    Eckhoff, D.E.6
  • 134
    • 84878659317 scopus 로고    scopus 로고
    • Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes
    • Liu S, Kilic G, MeyersMS, Navarro G, Wang Y, Oberholzer J, Mauvais-Jarvis F. Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia. 2013;56(2):370-381
    • (2013) Diabetologia , vol.56 , Issue.2 , pp. 370-381
    • Liu, S.1    Kilic, G.2    Meyers, M.S.3    Navarro, G.4    Wang, Y.5    Oberholzer, J.6    Mauvais-Jarvis, F.7
  • 135
    • 0023201051 scopus 로고
    • Calculated pattern of intraportal insulin appearance without independent assessment of C-peptide kinetics
    • Vølund A, Polonsky KS, Bergman RN. Calculated pattern of intraportal insulin appearance without independent assessment of C-peptide kinetics. Diabetes. 1987;36(10): 1195-1202
    • (1987) Diabetes , vol.36 , Issue.10 , pp. 1195-1202
    • Vølund, A.1    Polonsky, K.S.2    Bergman, R.N.3
  • 136
    • 0024427837 scopus 로고
    • Prehepatic beta-cell secretion during the intravenous glucose tolerance test in humans: application of a combined model of insulin and C-peptide kinetics
    • Watanabe RM, Volund A, Roy S, Bergman RN. Prehepatic beta-cell secretion during the intravenous glucose tolerance test in humans: application of a combined model of insulin and C-peptide kinetics. J Clin Endocrinol Metab. 1989;69(4):790-797
    • (1989) J Clin Endocrinol Metab , vol.69 , Issue.4 , pp. 790-797
    • Watanabe, R.M.1    Volund, A.2    Roy, S.3    Bergman, R.N.4
  • 137
    • 2942755651 scopus 로고    scopus 로고
    • Effects of tibolone and cyclic hormone replacement therapy on glucose metabolism in non-diabetic obese postmenopausal women: a randomized study
    • Morin-Papunen LC, Vauhkonen I, Ruokonen A, Tapanainen JS, Raudaskoski T. Effects of tibolone and cyclic hormone replacement therapy on glucose metabolism in non-diabetic obese postmenopausal women: a randomized study. Eur J Endocrinol. 2004;150(5): 705-714
    • (2004) Eur J Endocrinol , vol.150 , Issue.5 , pp. 705-714
    • Morin-Papunen, L.C.1    Vauhkonen, I.2    Ruokonen, A.3    Tapanainen, J.S.4    Raudaskoski, T.5


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