The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Kilic, Gamze ^a   Alvarez Mercado, Ana I ^b   Zarrouki, Bader ^c   Opland, Darren ^d   Liew, Chong Wee ^e   Alonso, Laura C ^f   Myers Jr , Martin G ^d   Jonas, Jean Christophe ^g   Poitout, Vincent ^c   Kulkarni, Rohit N ^e   Mauvais Jarvis, Franck ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^g UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOXAN; ESTROGEN RECEPTOR ALPHA; INSULIN RECEPTOR; MESSENGER RNA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CELL DESTRUCTION; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE EXPRESSION; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN DEFICIENCY; INSULIN RESISTANCE; JUVENILE ANIMAL; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PREOPTIC AREA; RAT; ZONA INCERTA;

ANIMALS; BLOTTING, WESTERN; BRAIN; DIABETES MELLITUS, EXPERIMENTAL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; HYPERGLYCEMIA; IMMUNOENZYME TECHNIQUES; INSULIN; INTEGRASES; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84896855066     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087941     Document Type: Article

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