Effect of selective estrogen receptor modulators on metabolic homeostasis

Biochimie

Volumn 124, Issue , 2016, Pages 92-97

  Xu, Beibei ^a   Lovre, Dragana ^a   Mauvais Jarvis, Franck ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Bazedoxifene; Diabetes; Energy metabolism; Metabolic syndrome; Selective estrogen receptor modulators; Tissue selective estrogen complex

Indexed keywords

BAZEDOXIFENE; ESTROGEN; ESTROGEN RECEPTOR; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TISSUE SELECTIVE ESTROGEN COMPLEX; UNCLASSIFIED DRUG; INDOLE DERIVATIVE;

BREAST; BREAST CANCER; CANCER RISK; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; DRUG EFFECT; ENERGY BALANCE; HOMEOSTASIS; HORMONAL THERAPY; HUMAN; ISCHEMIC HEART DISEASE; LONG TERM CARE; LUNG EMBOLISM; METABOLIC SYNDROME X; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POSTMENOPAUSE; REVIEW; THERAPEUTIC INDEX; UTERUS; WEIGHT GAIN; ANIMAL; BREAST NEOPLASMS; DISEASE MODEL; FEMALE; OSTEOPOROSIS, POSTMENOPAUSAL; PATHOLOGY;

ANIMALS; BREAST; BREAST NEOPLASMS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; ESTROGENS; FEMALE; HUMANS; INDOLES; METABOLIC SYNDROME X; OSTEOPOROSIS, POSTMENOPAUSAL; RECEPTORS, ESTROGEN; UTERUS;

EID: 84936972158     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2015.06.018     Document Type: Review

References (76)

1. M.W. Pfaffl, and et al. Tissue-specific expression pattern of estrogen receptors (ER): quantification of ER alpha and ER beta mRNA with real-time RT-PCR APMIS 109 5 2001 345 355
2. M.K. Tee, and et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta Mol. Biol. Cell 15 3 2004 1262 1272
3. G.G. Kuiper, and et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta Endocrinology 138 3 1997 863 870
4. K.S. Bramlett, and T.P. Burris Effects of selective estrogen receptor modulators (SERMs) on coactivator nuclear receptor (NR) box binding to estrogen receptors Mol. Genet. Metab. 76 3 2002 225 233
5. P. Webb, P. Nguyen, and P.J. Kushner Differential SERM effects on corepressor binding dictate ERalpha activity in vivo J. Biol. Chem. 278 9 2003 6912 6920
6. Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group Lancet 351 9114 1998 1451 1467
7. T. Fornander, and et al. Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers Lancet 1 8630 1989 117 120
8. F.E. van Leeuwen, and et al. Risk of endometrial cancer after tamoxifen treatment of breast cancer Lancet 343 8895 1994 448 452
9. V.G. Vogel Raloxifene: a selective estrogen receptor modulator for reducing the risk of invasive breast cancer in postmenopausal women Womens Health (Lond Engl) 3 2 2007 139 153
10. B. Ettinger, and et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators JAMA 282 7 1999 637 645
11. B.S. Komm, and A.A. Chines Bazedoxifene: the evolving role of third-generation selective estrogen-receptor modulators in the management of postmenopausal osteoporosis Ther. Adv. Musculoskelet. Dis. 4 1 2012 21 34
12. D.F. Archer, and et al. Bazedoxifene, a selective estrogen receptor modulator: effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women Menopause 16 6 2009 1109 1115
13. J.V. Pinkerton, and et al. Relief of vasomotor symptoms with the tissue-selective estrogen complex containing bazedoxifene/conjugated estrogens: a randomized, controlled trial Menopause 16 6 2009 1116 1124
14. J. Hejazi, and R. Rastmanesh Association between tamoxifen treatment and diabetes: a population-based study Cancer 118 23 2012 6012 author reply 6012-3
15. L.M. Sun, and et al. Association of tamoxifen use and increased diabetes among Asian women diagnosed with breast cancer Br. J. Cancer 111 9 2014 1836 1842
16. L.L. Lipscombe, and et al. Association between tamoxifen treatment and diabetes: a population-based study Cancer 118 10 2012 2615 2622
17. H. Johansson, and et al. Effect of fenretinide and low-dose tamoxifen on insulin sensitivity in premenopausal women at high risk for breast cancer Cancer Res. 68 22 2008 9512 9518
18. C. Le May, and et al. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice Proc. Natl. Acad. Sci. U. S. A. 103 24 2006 9232 9237
19. I. Jialal, W. Amess, and M. Kaur Management of hypertriglyceridemia in the diabetic patient Curr. Diab Rep. 10 4 2010 316 320
20. Y.A. Kim, and et al. Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with diabetes mellitus Chin. J. Cancer Res. 26 3 2014 341 344
21. M. Artac, and et al. Asymptomatic acute pancreatitis due to tamoxifen-induced severe hypertriglyceridemia in a patient with diabetes mellitus and breast cancer J. Chemother. 14 3 2002 309 311
22. Y. Hozumi, M. Kawano, and M. Miyata Severe hypertriglyceridemia caused by tamoxifen-treatment after breast cancer surgery Endocr. J. 44 5 1997 745 749
23. M.S. Elisaf, and et al. Tamoxifen-induced severe hypertriglyceridemia and pancreatitis Ann. Oncol. 11 8 2000 1067 1069
24. C.L. Liu, and et al. Fatty liver and transaminase changes with adjuvant tamoxifen therapy Anticancer Drugs 17 6 2006 709 713
25. M. Nishino, and et al. Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy AJR Am. J. Roentgenol. 180 1 2003 129 134
26. Y. Ogawa, and et al. Tamoxifen-induced fatty liver in patients with breast cancer Lancet 351 9104 1998 725
27. U. Coskun, F.B. Toruner, and N. Gunel Tamoxifen therapy and hepatic steatosis Neoplasma 49 1 2002 61 64
28. S. Bruno, and et al. Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial BMJ 330 7497 2005 932
29. O.A. Gudbrandsen, T.H. Rost, and R.K. Berge Causes and prevention of tamoxifen-induced accumulation of triacylglycerol in rat liver J. Lipid Res. 47 10 2006 2223 2232
30. L.K. Cole, R.L. Jacobs, and D.E. Vance Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis Hepatology 52 4 2010 1258 1265
31. C.J. Lelliott, and et al. Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis FASEB J. 19 9 2005 1108 1119
32. Y. Hozumi, M. Kawano, and V.C. Jordan In vitro study of the effect of raloxifene on lipid metabolism compared with tamoxifen Eur. J. Endocrinol. 143 3 2000 427 430
33. Y. Mu, and et al. Effects of estrogen and androgen deprivation on the progression of non-alcoholic steatohepatitis (NASH) in male Sprague-Dawley rats Hepatol. Res. 39 9 2009 910 920
34. T. Miyashita, and et al. Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models J. Toxicol. Sci. 37 5 2012 931 942
35. Y. Yoshikawa, and et al. Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries Toxicol. Appl. Pharmacol. 264 1 2012 42 50
36. A. de Conti, and et al. Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver Toxicology 325 2014 12 20
37. G.N. Wade, and H.W. Heller Tamoxifen mimics the effects of estradiol on food intake, body weight, and body composition in rats Am. J. Physiol. 264 6 Pt 2 1993 R1219 R1223
38. W.J. Wallen, M.P. Belanger, and C. Wittnich Sex hormones and the selective estrogen receptor modulator tamoxifen modulate weekly body weights and food intakes in adolescent and adult rats J. Nutr. 131 9 2001 2351 2357
39. R.V. Considine, and et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans N. Engl. J. Med. 334 5 1996 292 295
40. A. Ozet, and et al. Effects of tamoxifen on the serum leptin level in patients with breast cancer Jpn. J. Clin. Oncol. 31 9 2001 424 427
41. N. Gunel, and et al. Serum leptin levels are associated with tamoxifen-induced hepatic steatosis Curr. Med. Res. Opin. 19 1 2003 47 50
42. M. Lopez, and et al. Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA Diabetes 55 5 2006 1327 1336
43. V.G. Vogel, and et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial JAMA 295 23 2006 2727 2741
44. M. Sato, M.K. Rippy, and H.U. Bryant Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats FASEB J. 10 8 1996 905 912
45. R. Meli, and et al. Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats Endocrinology 145 7 2004 3115 3121
46. C.M. Francucci, and et al. Effects of raloxifene on body fat distribution and lipid profile in healthy post-menopausal women J. Endocrinol. Invest. 28 7 2005 623 631
47. D.E. Jacobsen, and et al. Raloxifene and body composition and muscle strength in postmenopausal women: a randomized, double-blind, placebo-controlled trial Eur. J. Endocrinol. 162 2 2010 371 376
48. R.E. Van Pelt, and et al. Estrogen or raloxifene during postmenopausal weight loss: adiposity and cardiometabolic outcomes Obes. (Silver Spring) 22 4 2014 1024 1031
49. F. Cucinelli, and et al. The effect of raloxifene on glyco-insulinemic homeostasis in healthy postmenopausal women: a randomized placebo-controlled study J. Clin. Endocrinol. Metab. 87 9 2002 4186 4192
50. A. Cagnacci, and et al. Raloxifene does not modify insulin sensitivity and glucose metabolism in postmenopausal women J. Clin. Endocrinol. Metab. 87 9 2002 4117 4121
51. M. Nagamani, and et al. Effects of raloxifene on insulin sensitivity, beta-cell function, and hepatic insulin extraction in normal postmenopausal women Fertil. Steril. 89 3 2008 614 619
52. B. Andersson, and et al. Raloxifene does not affect insulin sensitivity or glycemic control in postmenopausal women with type 2 diabetes mellitus: a randomized clinical trial J. Clin. Endocrinol. Metab. 87 1 2002 122 128
53. A. Lasco, and et al. Effects of a long-term treatment with raloxifene on insulin sensitivity in postmenopausal women Diabetologia 47 3 2004 571 574
54. B.W. Walsh, and et al. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins N. Engl. J. Med. 325 17 1991 1196 1204
55. E. Barrett-Connor, and et al. Post hoc analysis of data from the Multiple Outcomes of Raloxifene Evaluation (MORE) trial on the effects of three years of raloxifene treatment on glycemic control and cardiovascular disease risk factors in women with and without type 2 diabetes Clin. Ther. 25 3 2003 919 930
56. L. Mosca, and et al. Effect of raloxifene on serum triglycerides in postmenopausal women: influence of predisposing factors for hypertriglyceridemia Clin. Ther. 23 9 2001 1552 1565
57. M.C. Carr, and et al. Effect of raloxifene on serum triglycerides in women with a history of hypertriglyceridemia while on oral estrogen therapy Diabetes Care 28 7 2005 1555 1561
58. J. Tiano, and F. Mauvais-Jarvis Selective estrogen receptor modulation in pancreatic beta-cells and the prevention of type 2 diabetes Islets 4 2 2012 173 176
59. A. Cakmak, and et al. Raloxifene increases serum leptin levels in postmenopausal women: a prospective study Am. J. Obstet. Gynecol. 193 2 2005 347 351
60. I.V. Lambrinoudaki, and et al. Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene Maturitas 59 1 2008 62 71
61. G.A. Tommaselli, and et al. Serum leptin levels and body composition in postmenopausal women treated with tibolone and raloxifene Menopause 13 4 2006 660 668
62. G.A. Tommaselli, and et al. Effects of bilateral ovariectomy and postoperative hormonal replacement therapy with 17beta-estradiol or raloxifene on serum leptin levels Menopause 10 2 2003 160 164
63. B.S. Komm, and S. Mirkin Evolution of the tissue selective estrogen complex (TSEC) J. Cell. Physiol. 228 7 2013 1423 1427
64. R.J. Santen, and et al. Current and evolving approaches to individualizing estrogen receptor-based therapy for menopausal women J. Clin. Endocrinol. Metab. 99 3 2014 733 747
65. R.A. Lobo, and et al. Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile Fertil. Steril. 2009 1025 1038 United States
66. S.O. Skouby, and et al. Effects of conjugated estrogens/bazedoxifene on lipid and coagulation variables: a randomized placebo- and active-controlled trial Menopause 22 6 2015 640 649
67. J.H. Kim, and et al. Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice Mol. Metab. 3 2 2014 177 190
68. J. Barrera, and et al. Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract Am. J. Physiol. Endocrinol. Metab. 307 3 2014 E345 E354
69. R. Fontana, and et al. Estrogen replacement therapy regulation of energy metabolism in female mouse hypothalamus Endocrinology 155 6 2014 2213 2221
70. A. Villa, and et al. Tetradian oscillation of estrogen receptor alpha is necessary to prevent liver lipid deposition Proc. Natl. Acad. Sci. U. S. A. 109 29 2012 11806 11811
71. M.K. Badman, and et al. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states Cell Metab. 5 6 2007 426 437
72. F. Mauvais-Jarvis, D.J. Clegg, and A.L. Hevener The role of estrogens in control of energy balance and glucose homeostasis Endocr. Rev. 34 3 2013 309 338
73. T.J. de Villiers, and et al. Global Consensus Statement on menopausal hormone therapy Maturitas 74 4 2013 391 392
74. E.L. Sullivan, and et al. Selective estrogen receptor modulator promotes weight loss in ovariectomized female rhesus monkeys (Macaca mulatta) by decreasing food intake and increasing activity Am. J. Physiol. Endocrinol. Metab. 302 7 2012 E759 E767
75. F. Mauvais-Jarvis Pilot Study of Duavee in Preventing Metabolic Dysfunction in Postmenopausal Women 2014 Available from: https://clinicaltrials.gov/ct2/show/NCT02237079
76. E. Ravussin Tissue Selective Estrogen Complex to Prevent Metabolic Dysfunction in Women (TSEC) 2014 Available from: https://clinicaltrials.gov/ct2/show/NCT02274571