Animal models of psychoactive drug use and addiction – Present problems and future needs for translational approaches

Behavioural Brain Research

Volumn 352, Issue , 2018, Pages 109-115

  Müller, Christian P ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Addiction; Animal models; Drug instrumentalization; Theories of addiction; Translational gap

Indexed keywords

PSYCHOTROPIC AGENT;

ANIMAL MODEL; DRUG DEPENDENCE; DRUG USE; EFFECT SIZE; EMOTIONALITY; LEARNING; MEMORY RECONSOLIDATION; MOTIVATION; NEUROSCIENCE; NONHUMAN; PRIORITY JOURNAL; RELAPSE; REMISSION; REVIEW; RISK FACTOR; SELF MEDICATION; ADDICTION; ANIMAL; DISEASE MODEL; HUMAN; PSYCHOLOGY; TRANSLATIONAL RESEARCH;

ANIMALS; BEHAVIOR, ADDICTIVE; DISEASE MODELS, ANIMAL; HUMANS; PSYCHOTROPIC DRUGS; SUBSTANCE-RELATED DISORDERS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 85021246814     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2017.06.028     Document Type: Review

References (112)

1. Abel, E.L., Marihuana: The First Twelve Thousand Years. 1980, Plenum Press, New York.
2. Ahmed, S.H., Koob, G.F., Transition from moderate to excessive drug intake: change in hedonic set point. Science 282 (1998), 298–300.
3. Ahmed, S.H., Validation crisis in animal models of drug addiction: beyond non-disordered drug use toward drug addiction. Neurosci. Biobehav. Rev. 35 (2010), 172–184.
4. Ahmed, S.H., The science of making drug-addicted animals. Neuroscience 211 (2012), 107–125.
5. Bardo, M.T., Bevins, R.A., Conditioned place preference: what does it add to our preclinical understanding of drug reward?. Psychopharmacology (Berl.) 153 (2000), 31–43.
6. Belin, D., Mar, A.C., Dalley, J.W., Robbins, T.W., Everitt, B.J., High impulsivity predicts the switch to compulsive cocaine-taking. Science 320 (2008), 1352–1355.
7. Belin, D., Jonkman, S., Dickinson, A., Robbins, T.W., Everitt, B.J., Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction. Behav. Brain Res. 199 (2009), 89–102.
8. Bierut, L.J., Dinwiddie, S.H., Begleiter, H., Crowe, R.R., Hesselbrock, V., Nurnberger, J.I. Jr., Porjesz, B., Schuckit, M.A., Reich, T., Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism. Arch. Gen. Psychiatry 55 (1998), 982–988.
9. Blomeyer, D., Treutlein, J., Esser, G., Schmidt, M.H., Schumann, G., Laucht, M., Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. Biol. Psychiatry 63 (2008), 146–151.
10. Boyd, C.J., Teter, C.J., West, B.T., Morales, M., McCabe, S.E., Non-medical use of prescription analgesics: a three-year national longitudinal study. J. Addict. Dis. 28 (2009), 232–242.
11. Boyer, E.W., Babu, K.M., Macalino, G.E., Self-treatment of opioid withdrawal with a dietary supplement. Kratom. Am. J. Addict. 16 (2007), 352–356.
12. Boys, A., Marsden, J., Perceived functions predict intensity of use and problems in young polysubstance users. Addiction 98 (2003), 951–963.
13. Bradizza, C.M., Reifman, A., Barnes, G.M., Social and coping reasons for drinking: predicting alcohol misuse in adolescents. J. Stud. Alcohol 60 (1999), 491–499.
14. Brand, R., Wolff, W., Ziegler, M., Drugs as instruments: describing and testing a behavioral approach to the study of neuroenhancement. Front. Psychol., 7, 2016, 1226.
15. Callahan, P.M., Cunningham, K.A., Modulation of the discriminative stimulus properties of cocaine: comparison of the effects of fluoxetine with 5-HT1A and 5-HT1B receptor agonists. Neuropharmacology 36 (1997), 373–381.
16. Carey, R.J., Huston, J.P., Müller, C.P., Pharmacological inhibition of dopamine and serotonin activity blocks spontaneous and cocaine-activated behaviour. Prog. Brain Res. 172 (2008), 347–360.
17. Chen, C.Y., Anthony, J.C., Epidemiological estimates of risk in the process of becoming dependent upon cocaine: cocaine hydrochloride powder versus crack cocaine. Psychopharmacology (Berl.) 172 (2004), 78–86.
18. Clarke, T.K., Treutlein, J., Zimmermann, U.S., Kiefer, F., Skowronek, M.H., Rietschel, M., Mann, K., Schumann, G., HPA-axis activity in alcoholism: examples for a gene-environment interaction. Addict. Biol. 13 (2008), 1–14.
19. Deroche Gamonet, V., Belin, D., Piazza, P.V., Evidence for addiction-like behavior in the rat. Science 305 (2004), 1014–1017.
20. Dong, L., et al. Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. Am. J. Psychiatry 168 (2011), 1090–1098.
21. Dudley, R., Fermenting fruit and the historical ecology of ethanol ingestion: is alcoholism in modern humans an evolutionary hangover?. Addiction 97 (2002), 381–388.
22. EMCDDA, European Monitoring Centre for Drugs and Drug Addiction (2016), European Drug Report 2016: Trends and Developments., 2016, Publications Office of the European Union, Luxembourg.
23. Everitt, B.J., Robbins, T.W., Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8:11 (2005), 1481–1489.
24. Gable, R.S., Comparison of acute lethal toxicity of commonly abused psychoactive substances. Addiction 99 (2004), 686–696.
25. Glander, K.E., Nonhuman primate self-medication with wild plant foods. Etkin, N.L., (eds.) Eating on the Wild Side: The Pharmacological, Ecological, and Social Implications of Using Noncultigens, 1994, University of Arizona Press, Tuscon, 239–256.
26. Hall, W., Carter, A., Forlini, C., The brain disease model of addiction: is it supported by the evidence and has it delivered on its promises?. Lancet Psychiatry 2 (2015), 105–110.
27. Harper, C., The neurotoxicity of alcohol. Hum. Exp. Toxicol. 26 (2007), 251–257.
28. Heath, D.B., Drinking Occasions: Comparative Perspectives on Alcohol and Culture. 2000, Brunner/Mazel, Philadelphia.
29. Heilig, M., Koob, G.F., A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci. 30 (2007), 399–406.
30. Heyman, G.M., Resolving the Contradictions of Addiction. 1996, 561–610.
31. Higgins, G.A., Silenieks, L.B., Rossmann, A., Rizos, Z., Noble, K., Soko, A.D., Fletcher, P.J., The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control. Neuropsychopharmacology 37 (2012), 1177–1191.
32. Hopf, F.W., Lesscher, H.M., Rodent models for compulsive alcohol intake. Alcohol 48:3 (2014), 253–264.
33. Huffman, M.A., Animal self-medication and ethno-medicine: exploration and exploitation of the medicinal properties of plants. Proc. Nutr. Soc. 62 (2003), 371–381.
34. Huston, J.P., Silva, M.A., Topic, B., Müller, C.P., What's conditioned in conditioned place preference?. Trends Pharmacol. Sci. 34 (2013), 162–166.
35. Hyman, S.E., Malenka, R.C., Nestler, E.J., Neural mechanisms of addiction: the role of reward-related learning and memory. Annu. Rev. Neurosci. 29 (2006), 565–598.
36. Johnson, B.A., Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Biochem. Pharmacol. 75:1 (2008), 34–56.
37. Kelley, A.E., Memory and addiction: shared neural circuitry and molecular mechanisms. Neuron 44 (2004), 161–179.
38. Koob, G.F., Le Moal, M., Drug abuse: hedonic homeostatic dysregulation. Science 278 (1997), 52–58.
39. Koob, G.F., Sanna, P.P., Bloom, F.E., Neuroscience of addiction. Neuron 21 (1998), 467–476.
40. Koob, G.F., Ahmed, S.H., Boutrel, B., Chen, S.A., Kenny, P.J., Markou, A., O'Dell, L.E., Parsons, L.H., Sanna, P.P., Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci. Biobehav. Rev. 27 (2004), 739–749.
41. Koob, G.F., Mason, B.J., Existing and future drugs for the treatment of the dark side of addiction. Annu. Rev. Pharmacol. Toxicol. 56 (2016), 299–322.
42. Koukouli, F., Rooy, M., Tziotis, D., Sailor, K.A., O'Neill, H.C., Levenga, J., Witte, M., Nilges, M., Changeux, J.P., Hoeffer, C.A., Stitzel, J.A., Gutkin, B.S., DiGregorio, D.A., Maskos, U., Nicotine reverses hypofrontality in animal models of addiction and schizophrenia. Nat. Med. 23:3 (2017), 347–354.
43. Kuntsche, E., Knibbe, R., Gmel, G., Engels, R., Why do young people drink? A review of drinking motives. Clin. Psychol. Rev. 25 (2005), 841–861.
44. Le Foll, B., Goldberg, S.R., Nicotine as a typical drug of abuse in experimental animals and humans. Psychopharmacology (Berl.) 184 (2006), 367–381.
45. Lee, J.L., Di, C.P., Thomas, K.L., Everitt, B.J., Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior. Neuron 47 (2005), 795–801.
46. Lende, D.H., Leonard, T., Sterk, C.E., Elifson, K., Functional methamphetamine use: the insider's perspective. Addict. Res. Therap. 15:5 (2007), 465–477.
47. Lenz, B., Mühle, C., Braun, B., Weinland, C., Bouna-Pyrrou, P., Behrens, J., Kubis, S., Mikolaiczik, K., Muschler, M.R., Saigali, S., Sibach, M., Tanovska, P., Huber, S.E., Hoppe, U., Eichler, A., Heinrich, H., Moll, G.H., Engel, A., Goecke, T.W., Beckmann, M.W., Fasching, P.A., Müller, C.P., Kornhuber, J., Prenatal and adult androgen activities in alcohol dependence. Acta Psychiatr. Scand., 2017, 10.1111/acps.12725.
48. Leshner, A.I., Addiction is a brain disease, and it matters. Science 278 (1997), 45–47.
49. Lesscher, H.M., van Kerkhof, L.W., Vanderschuren, L.J., Inflexible and indifferent alcohol drinking in male mice. Alcohol Clin. Exp. Res. 34:7 (2010), 1219–1225.
50. Lisonbee, L.D., Villalba, J.J., Provenza, F.D., Hall, J.O., Tannins and self-medication: implications for sustainable parasite control in herbivores. Behav. Processes 82 (2009), 184–189.
51. Litten, R.Z., Egli, M., Heilig, M., Cui, C., Fertig, J.B., Ryan, M.L., Falk, D.E., Moss, H., Huebner, R., Noronha, A., Medications development to treat alcohol dependence: a vision for the next decade. Addict. Biol. 17:3 (2012), 513–527.
52. Lozano, G.A., Parasitic stress and self-medication in wild animals. Adv. Stud. Behav. 27 (1998), 291–317.
53. McCreary, A.C., Müller, C.P., Filip, M., Psychostimulants: basic and clinical pharmacology. Int. Rev. Neurobiol. 120 (2015), 41–83.
54. Mello, N.K., Behavioral studies of alcoholism. Kissin, B., Begleiter, H., (eds.) Biology of Alcoholism, 1972, Plenum Press, New York, 210–219.
55. Meyer, P.J., Ma, S.T., Robinson, T.E., A cocaine cue is more preferred and evokes more frequency-modulated 50-kHz ultrasonic vocalizations in rats prone to attribute incentive salience to a food cue. Psychopharmacology (Berl.) 219 (2012), 999–1009.
56. Mielenz, D., Reichel, M., Jia, T., Quinlan, E.B., Stöckl, T., Mettang, M., Zilske, D., Kirmizi-Alsan, E., Schönberger, P., Praetner, M., Huber, S.E., Amato, D., Schwarz, M., Purohit, P., Brachs, S., Spranger, J., Hess, A., Büttner, C., Ekici, A.B., Perez-Branguli, F., Winner, B., Rauschenberger, V., Banaschewski, T., Bokde, A.L., Büchel, C., Conrod, P.J., Desrivieres, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Martinot, J.L., Lemaitre, H., Nees, F., Paus, T., Smolka, M.N., Schambony, A., Bäuerle, T., Eulenburg, V., Alzheimer, C., Lourdusamy, A., Schumann, G., Müller, C.P., EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction. Mol. Psychiatry, 2017, 10.1038/mp.2017.63.
57. Miller, P.M., Book, S.W., Stewart, S.H., Medical treatment of alcohol dependence: a systematic review. Int. J. Psychiatry Med. 42:3 (2011), 227–266.
58. Milton, A.L., Everitt, B.J., The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction. Eur. J. Neurosci. 31 (2010), 2308–2319.
59. Müller, C.P., Episodic memories and their relevance for psychoactive drug use and addiction. Front. Behav. Neurosci., 7, 2013, 34.
60. Müller, C.P., Non addictive drug use: the way forward. Wolff, K., White, J., Karch, S., (eds.) The SAGE Handbook of Drugs & Alcohol Studies –Biological Approaches, Vol. 2, 2017, SAGE, London, 411–434 (Chapter 42).
61. Müller, C.P., Huston, J.P., Determining the region-specific contributions of 5-HT receptors to the psychostimulant effects of cocaine. Trends Pharmacol. Sci. 27 (2006), 105–112.
62. Müller, C.P., Schumann, G., Drugs as instruments: a new framework for non-addictive psychoactive drug use. Behav. Brain Sci. 34 (2011), 293–310.
63. Müller, C.P., Schumann, G., To use or not to use: expanding the view on non-addictive psychoactive drug consumption and its implications. Behav. Brain Sci. 34 (2011), 328–347.
64. Müller, C.P., Homberg, J.R., The role of serotonin in drug use and addiction. Behav. Brain Res. 277C (2015), 146–192.
65. Müller, C.P., Kornhuber, J., Biological evidence for paradoxical improvement of psychiatric disorder symptoms by addictive drugs. Trends Pharmacol. Sci. 38:6 (2017), 501–502, 10.1016/j.tips.2017.03.005.
66. Müller, C.P., De Souza-Silva, M.A., DePalma, G., Tomaz, C., Carey, R.J., Huston, J.P., The selective serotonin1A-receptor antagonist WAY 100635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increase. Behav. Brain Res. 134 (2002), 337–346.
67. Müller, C.P., Kalinichenko, L.S., Tiesel, J., Witt, M., Stöckl, T., Sprenger, E., Fuchser, J., Beckmann, J., Praetner, M., Huber, S.E., Amato, D., Mühle, C., Büttner, C., Ekici, A.B., Smaga, I., Pomierny-Chamiolo, L., Pomierny, B., Filip, M., Eulenburg, V., Gulbins, E., Lourdusamy, A., Reichel, M., Kornhuber, J., Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis. Acta Neuropathol. 133 (2017), 463–483.
68. Nathanson, J.A., Hunnicutt, E.J., Kantham, L., Scavone, C., Cocaine as a naturally occurring insecticide. Proc. Natl. Acad. Sci. U. S. A. 90 (1993), 9645–9648.
69. Nestler, E.J., Common molecular and cellular substrates of addiction and memory. Neurobiol. Learn. Mem. 78 (2002), 637–647.
70. Olmstead, M.C., Animal models of drug addiction: where do we go from here?. Q. J. Exp. Psychol. (Colchester) 59 (2006), 625–653.
71. Page, J.E., Balza, F., Nishida, T., Towers, G.H., Biologically active diterpenes from Aspilia mossambicensis, a chimpanzee medicinal plant. Phytochemistry 31:10 (1992), 3437–3439.
72. Patrick, M.E., Maggs, J.L., Short-term changes in plans to drink and importance of positive and negative alcohol consequences. J. Adolesc. 31 (2008), 307–321.
73. Piazza, P.V., Deminiere, J.M., Le, M.M., Simon, H., Factors that predict individual vulnerability to amphetamine self-administration. Science 245 (1989), 1511–1513.
74. Prus, A.J., James, J.R., Rosecrans, J.A., Conditioned place preference. Buccafusco, J.J., (eds.) Methods of Behavior Analysis in Neuroscience, 2009, CRC Press, Boca Raton (Chapter 4, Available from: http://www.ncbi.nlm.nih.gov/books/NBK5229/).
75. Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., Patra, J., Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 373 (2009), 2223–2233.
76. Ripley, T.L., Stephens, D.N., Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal. Br. J. Pharmacol. 164 (2011), 1335–1356.
77. Robbins, T.W., Ersche, K.D., Everitt, B.J., Drug addiction and the memory systems of the brain. Ann. N. Y. Acad. Sci. 1141 (2008), 1–21.
78. Robinson, T.E., Berridge, K.C., The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Brain Res. Rev. 18 (1993), 247–291.
79. Robles, M., Aregullin, M., West, J., Rodriguez, E., Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones. Planta Med. 61 (1995), 199–203.
80. Rodriguez, E., Aregullin, M., Nishida, T., Uehara, S., Wrangham, R., Abramowski, Z., Finlayson, A., Towers, G.H., Thiarubrine A, a bioactive constituent of Aspilia (Asteraceae) consumed by wild chimpanzees. Experientia 41:3 (1985), 419–420.
81. Rodriguez, E., Wrangham, R., Zoopharmacognosy: the use of medicinal plants by animals. Recent Adv. Phytochem. 27 (1993), 89–105.
82. SAMHSA, National Survey on Drug Use and Health. 2015, Substance Abuse and Mental Health Services Administration, Rockville.
83. Sanchis-Segura, C., Spanagel, R., Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict. Biol. 11 (2006), 2–38.
84. Schuckit, M.A., Smith, T.L., Danko, G.P., Pierson, J., Trim, R., Nurnberger, J.I., Kramer, J., Kuperman, S., Bierut, L.J., Hesselbrock, V., A comparison of factors associated with substance-induced versus independent depressions. J. Stud. Alcohol Drugs 68 (2007), 805–812.
85. Seif, T., Chang, S.J., Simms, J.A., Gibb, S.L., Dadgar, J., Chen, B.T., Harvey, B.K., Ron, D., Messing, R.O., Bonci, A., Hopf, F.W., Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat. Neurosci. 16:8 (2013), 1094–1100.
86. Shaham, Y., Shalev, U., Lu, L., de Wit, H., Stewart, J., The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl.) 168 (2003), 3–20.
87. Spanagel, R., Kiefer, F., Drugs for relapse prevention of alcoholism: ten years of progress. Trends Pharmacol. Sci. 29 (2008), 109–115.
88. Spanagel, R., Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol. Rev. 89 (2009), 649–705.
89. Spealman, R.D., Goldberg, S.R., Drug self-administration by laboratory animals: control by schedules of reinforcement. Annu. Rev. Pharmacol. Toxicol. 18 (1978), 313–339.
90. Streatfeild, D., Cocaine. An Unauthorized Biography. 2001, St Martin's Press, New York.
91. Sullivan, R.J., Hagen, E.H., Hammerstein, P., Revealing the paradox of drug reward in human evolution. Proc. Biol. Sci. 275 (2008), 1231–1241.
92. Tzschentke, T.M., Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade. Addict. Biol. 12 (2007), 227–462.
93. van den Brink, W., Sorensen, P., Torup, L., Mann, K., Gual, A., Long-term efficacy, tolerability and safety of nalmefene as-needed in patients with alcohol dependence: a 1-year, randomised controlled study. J. Psychopharmacol. 28 (2014), 733–744.
94. Vanderschuren, L.J.M.J., Everitt, B.J., Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305 (2004), 1017–1019.
95. Vargo, E.J., Petroczi, A., It was me on a good day: exploring the smart drug use phenomenon in england. Front. Psychol., 7, 2016, 779.
96. Villalba, J.J., Provenza, F.D., Hall, J.O., Lisonbee, L.D., Selection of tannins by sheep in response to gastrointestinal nematode infection. J. Anim. Sci. 88 (2010), 2189–2198.
97. Volkow, N.D., Morales, M., The brain on drugs: from reward to addiction. Cell 162 (2015), 712–725.
98. Volkow, N.D., Koob, G., Brain disease model of addiction: why is it so controversial?. Lancet Psychiatry 2 (2015), 677–679.
99. Volkow, N.D., Koob, G.F., McLellan, A.T., Neurobiologic advances from the brain disease model of addiction. N. Engl. J. Med. 374 (2016), 363–371.
100. Wagner, F.A., Anthony, J.C., From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. Neuropsychopharmacology 26 (2002), 479–488.
101. Waldorf, D., Reinarman, C., Murphy, S., Cocaine Changes: the Experience of Using and Quitting. 1991, University Press, Philadelphia: Temple.
102. Weinshenker, D., Schroeder, J.P., There and back again: a tale of norepinephrine and drug addiction. Neuropsychopharmacology 32:7 (2007), 1433–1451.
103. Wells, B.E., Kelly, B.C., Golub, S.A., Grov, C., Parsons, J.T., Patterns of alcohol consumption and sexual behavior among young adults in nightclubs. Am. J. Drug Alcohol Abuse 36 (2010), 39–45.
104. White, N.M., Addictive drugs as reinforcers: multiple partial actions on memory systems. Addiction 91 (1996), 921–949.
105. Whiteford, H.A., Degenhardt, L., Rehm, J., Baxter, A.J., Ferrari, A.J., Erskine, H.E., Charlson, F.J., Norman, R.E., Flaxman, A.D., Johns, N., Burstein, R., Murray, C.J., Vos, T., Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382:9904 (2013), 1575–1586.
106. Whiteford, H.A., Ferrari, A.J., Degenharddt, L., Feigin, V., Vos, T., The global burden of mental, neurological and substance use disorders: an analysis from the global burden of disease study 2010. PLoS One, 10(2), 2015, e0116820.
107. Wiegel, C., Sattler, S., Goritz, A.S., Diewald, M., Work-related stress and cognitive enhancement among university teachers. Anxiety Stress Coping 29 (2016), 100–117.
108. Wise, R.A., Brain reward circuitry: insights from unsensed incentives. Neuron 36 (2002), 229–240.
109. Wittchen, H.U., Jacobi, F., Rehm, J., Gustavsson, A., Svensson, M., Jonsson, B., Olesen, J., Allgulander, C., Alonso, J., Faravelli, C., Fratiglioni, L., Jennum, P., Lieb, R., Maercker, A., van, O.J., Preisig, M., Salvador-Carulla, L., Simon, R., Steinhausen, H.C., The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur. Neuropsychopharmacol. 21 (2011), 655–679.
110. Wrangham, R., Nishida, T., Aspilla spp. leaves: a puzzle in the feeding behavior of wild chimpanzees. Primates 24:2 (1983), 276–282.
111. Yardley, M.M., Ray, L.A., Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models. Addict. Biol. 22:3 (2017), 581–615.
112. Zuckerman, M., The psychobiological model for impulsive unsocialized sensation seeking: a comparative approach. Neuropsychobiology 34 (1996), 125–129.