Prenatal and adult androgen activities in alcohol dependence

Acta Psychiatrica Scandinavica

Volumn 136, Issue 1, 2017, Pages 96-107

  Lenz, B ^a   Muhle C ^a   Braun, B ^a   Weinland, C ^a   Bouna Pyrrou, P ^a   Behrens, J ^a   Kubis, S ^a   Mikolaiczik, K ^a   Muschler, M R ^a   Saigali, S ^a   Sibach, M ^a   Tanovska, P ^a   Huber, S E ^a   Hoppe, U ^a   Eichler, A ^a   Heinrich, H ^a,b   Moll, G H ^a   Engel, A ^a   Goecke, T W ^a,c   Beckmann, M W ^a   Fasching, P A ^a   Muller C P ^a   Kornhuber, J ^a   more..

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Heckscher Klinikum   (Germany)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

alcohol; androgen effects; maternal behaviour; neuroendocrinology; substance use disorders

Indexed keywords

ALCOHOL; ANDROGEN; ANDROSTANOLONE; NICOTINE; TESTOSTERONE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL SYNDROME; ALCOHOLISM; ANDROGEN BLOOD LEVEL; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; EMOTIONALITY; EXTRAVERSION; FAMILY INCOME; FEMALE; FINGER; HORMONE ACTION; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MATERNAL STRESS; PERSONALITY TEST; POSTNATAL DEPRESSION; PREGNANT WOMAN; PRENATAL PERIOD; PRIORITY JOURNAL; SCHOOL CHILD; SMOKING; TOBACCO CONSUMPTION; ANATOMY AND HISTOLOGY; BLOOD; CROSS-SECTIONAL STUDY; DENMARK; DRINKING BEHAVIOR; LONGITUDINAL STUDY; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; SEX FACTOR; WITHDRAWAL SYNDROME;

ADULT; ALCOHOL DRINKING; ALCOHOLISM; ANDROGENS; CROSS-SECTIONAL STUDIES; DENMARK; DIHYDROTESTOSTERONE; FEMALE; FINGERS; HUMANS; LONGITUDINAL STUDIES; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEX FACTORS; SMOKING; STRESS, PSYCHOLOGICAL; SUBSTANCE WITHDRAWAL SYNDROME; TESTOSTERONE;

EID: 85017380594     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/acps.12725     Document Type: Article

References (43)

1. Grant BF, Goldstein RB, Saha TD et al. Epidemiology of DSM-5 alcohol use disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA Psychiatry 2015;72:757–766.
2. Whiteford HA, Degenhardt L, Rehm J et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 2013;382:1575–1586.
3. Kenna GA, Swift RM, Hillemacher T, Leggio L. The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humans. Neuropsychol Rev 2012;22:211–228.
4. Lenz B, Müller CP, Stoessel C et al. Sex hormone activity in alcohol addiction: integrating organizational and activational effects. Prog Neurobiol 2012;96:136–163.
5. Whiteford HA, Ferrari AJ, Degenhardt L, Feigin V, Vos T. The global burden of mental, neurological and substance use disorders: an analysis from the Global Burden of Disease Study 2010. PLoS ONE 2015;10:e0116820.
6. Brown ECZ, Steadman CJ, Lee TM, Padmanabhan V, Lehman MN, Coolen LM. Sex differences and effects of prenatal exposure to excess testosterone on ventral tegmental area dopamine neurons in adult sheep. Eur J Neurosci 2015;41:1157–1166.
7. Hermans EJ, Bos PA, Ossewaarde L, Ramsey NF, Fernández G, van Honk J. Effects of exogenous testosterone on the ventral striatal BOLD response during reward anticipation in healthy women. NeuroImage 2010;52:277–283.
8. Treutlein J, Cichon S, Ridinger M et al. Genome-wide association study of alcohol dependence. Arch Gen Psychiatry 2009;66:773–784.
9. Milivojevic V, Kranzler HR, Gelernter J, Burian L, Covault J. Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence. Alcohol Clin Exp Res 2011;35:946–952.
10. Lenz B, Schöpp E, Müller CP, Bleich S, Hillemacher T, Kornhuber J. Association of V89L SRD5A2 polymorphism with craving and serum leptin levels in male alcohol addicts. Psychopharmacology 2012;224:421–429.
11. Lombardo MV, Ashwin E, Auyeung B et al. Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans. Biol Psychiatry 2012;72:839–847.
12. Zheng Z, Cohn MJ. Developmental basis of sexually dimorphic digit ratios. Proc Natl Acad Sci USA 2011;108:16289–16294.
13. Cohen-Bendahan CCC, van de Beek C, Berenbaum SA. Prenatal sex hormone effects on child and adult sex-typed behavior: methods and findings. Neurosci Biobehav Rev 2005;29:353–384.
14. Talarovičová A, Kršková L, Blažeková J. Testosterone enhancement during pregnancy influences the 2D:4D ratio and open field motor activity of rat siblings in adulthood. Horm Behav 2009;55:235–239.
15. Manning J, Kilduff L, Cook C, Crewther B, Fink B. Digit ratio (2D:4D): a biomarker for prenatal sex steroids and adult sex steroids in challenge situations. Front Endocrinol (Lausanne) 2014;5:9.
16. Kornhuber J, Erhard G, Lenz B et al. Low digit ratio 2D:4D in alcohol dependent patients. PLoS ONE 2011;6:e19332.
17. Han C, Bae H, Lee Y-S, Won S-D, Kim DJ. The ratio of 2nd to 4th digit length in Korean alcohol-dependent patients. Clin Psychopharmacol Neurosci 2016;14:148–152.
18. Dela Cruz C, Pereira OC. Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats. J Physiol Sci 2012;62:123–131.
19. Barrett ES, Swan SH. Stress and androgen activity during fetal development. Endocrinology 2015;156:3435–3441.
20. Rizwan S, Manning JT, Brabin BJ. Maternal smoking during pregnancy and possible effects of in utero testosterone: evidence from the 2D:4D finger length ratio. Early Hum Dev 2007;83:87–90.
21. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013.
22. World Health Organization. International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10). Geneva: World Health Organization; 1992.
23. Stuppaeck CH, Barnas C, Falk M et al. Assessment of the alcohol withdrawal syndrome–validity and reliability of the translated and modified Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-A). Addiction 1994;89:1287–1292.
24. Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO. The Fagerström test for nicotine dependence: a revision of the Fagerström tolerance questionnaire. Br J Addict 1991;86:1119–1127.
25. Bleich S, Havemann-Reinecke U, Kornhuber J. Fagerström-Test für Nikotinabhängigkeit (FTNA) [Fagerström Test for Nicotine Dependence]. Göttingen: Hogrefe-Verlag; 2002.
26. Irwin M, Schuckit M, Smith TL. Clinical importance of age at onset in type 1 and type 2 primary alcoholics. Arch Gen Psychiatry 1990;47:320–324.
27. Bakdash A, Burger P, Goecke TW et al. Quantification of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in meconium from newborns for detection of alcohol abuse in a maternal health evaluation study. Anal Bioanal Chem 2010;396:2469–2477.
28. Fahrenberg J, Hampel R, Selg H. Das Freiburger Persönlichkeitsinventar (FPI-R) (7., überarbeitete und neu normierte Auflage) [The Freiburg Personality Inventory]. Göttingen: Hogrefe, 2001.
29. McFadden D, Martin GK, Stagner BB, Maloney MM. Sex differences in distortion-product and transient-evoked otoacoustic emissions compared. J Acoust Soc Am 2009;125:239–246.
30. Rosanowski F, Eysholdt U, Hoppe U. Influence of leisure-time noise on outer hair cell activity in medical students. Int Arch Occup Environ Health 2006;80:25–31.
31. Brämswig J, Dübbers A. Disorders of pubertal development. Dtsch Ärztebl Int 2009;106:295–303.
32. Mazer NA. A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: with illustrative examples from male and female populations. Steroids 2009;74:512–519.
33. Manning JT, Fink B. Digit ratio, nicotine and alcohol intake and national rates of smoking and alcohol consumption. Pers Indiv Differ 2011;50:344–348.
34. Han C, Lee Y-S, Hahm W, Won SD. The difference of the 2nd to 4th digit length ratio between type I and type II alcoholism. Korean J Biol Psychiatry 2011;18:260–266.
35. Martel MM, Gobrogge KL, Breedlove SM, Nigg JT. Masculinized finger-length ratios of boys, but not girls, are associated with attention-deficit/hyperactivity disorder. Behav Neurosci 2008;122:273–281.
36. Bergman K, Glover V, Sarkar P, Abbott DH, O'Connor TG. In utero cortisol and testosterone exposure and fear reactivity in infancy. Horm Behav 2010;57:306–312.
37. Pierucci-Lagha A, Covault J, Feinn R et al. GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology 2005;30:1193–1203.
38. Ford MM, Yoneyama N, Strong MN, Fretwell A, Tanchuck M, Finn DA. Inhibition of 5α-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice. Alcohol Clin Exp Res 2008;32:1408–1416.
39. Ford MM, Nickel JD, Finn DA. Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? Alcohol 2005;37:23–33.
40. Lilley T, Laaksonen T, Huitu O, Helle S. Maternal corticosterone but not testosterone level is associated with the ratio of second-to-fourth digit length (2D:4D) in field vole offspring (Microtus agrestis). Physiol Behav 2010;99:433–437.
41. Reynaert ML, Marrocco J, Mairesse J et al. Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner. Addict Biol 2016;21:1072–1085.
42. Campbell JC, Szumlinski KK, Kippin TE. Contribution of early environmental stress to alcoholism vulnerability. Alcohol 2009;43:547–554.
43. Fink NS, Urech C, Cavelti M, Alder J. Relaxation during pregnancy: what are the benefits for mother, fetus, and the newborn? A systematic review of the literature. J Perinat Neonatal Nurs 2012;26:296–306.