Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis

Acta Neuropathologica

Volumn 133, Issue 3, 2017, Pages 463-483

  Müller, Christian P ^a   Kalinichenko, Liubov S ^a   Tiesel, Jens ^a   Witt, Matthias ^b   Stöckl, Thomas ^a   Sprenger, Eva ^a   Fuchser, Jens ^b   Beckmann, Janine ^b   Praetner, Marc ^a   Huber, Sabine E ^a   Amato, Davide ^a   Mühle, Christiane ^a   Büttner, Christian ^a   Ekici, Arif B ^a   Smaga, Irena ^c   Pomierny Chamiolo, Lucyna ^c   Pomierny, Bartosz ^c   Filip, Malgorzata ^d   Eulenburg, Volker ^a   Gulbins, Erich ^e,f   Lourdusamy, Anbarasu ^g   Reichel, Martin ^a   Kornhuber, Johannes ^a   more..

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b BRUKER DALTONIK GMBH   (Germany)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^d INSTITUTE OF PHARMACOLOGY   (Poland)

^e UNIVERSITY OF DUISBURG ESSEN   (Germany)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^g UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Acid sphingomyelinase; Alcohol; Depression; Drug instrumentalization; Nucleus accumbens; Sphingomyelin

Indexed keywords

ALCOHOL; MONOAMINE; NEUROPEPTIDE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; ANTIDEPRESSANT AGENT; ASMASE, MOUSE; SUPEROXIDE DISMUTASE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BEHAVIOR; DEPRESSION; DRINKING BEHAVIOR; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG MECHANISM; ELECTROENCEPHALOGRAM; FEAR; HYPERACTIVITY; LIPID HOMEOSTASIS; MEMBRANE TRANSPORT; MEMORY; MOUSE; NEUROPROTECTION; NONHUMAN; NUCLEUS ACCUMBENS; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; REWARD; SEDATION; SELF MEDICATION; ANIMAL; BLOOD; C57BL MOUSE; DECISION MAKING; DRUG EFFECTS; FOOD PREFERENCE; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; HUMAN; INSTRUMENTAL CONDITIONING; METABOLISM; RIGHTING REFLEX; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTIDEPRESSIVE AGENTS; CHOICE BEHAVIOR; CONDITIONING, OPERANT; DEPRESSION; ETHANOL; FOOD PREFERENCES; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REFLEX, RIGHTING; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; SPHINGOMYELIN PHOSPHODIESTERASE; SUPEROXIDE DISMUTASE;

EID: 85008259798     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-016-1658-6     Document Type: Article

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