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Volumn 15, Issue 7, 2017, Pages 972-985

New Pharmacologic Agents That Target Inflammation and Fibrosis in Nonalcoholic Steatohepatitis–Related Kidney Disease

Author keywords

CKD; eGFR; Fibrosis; NASH; Renal Function

Indexed keywords

2 (2 CHLOROPHENYL) 4 [3 (DIMETHYLAMINO)PHENYL] 5 METHYL 1H PYRAZOLO[4,3 C]PYRIDINE 3,6(2H,5H) DIONE; ALEGLITAZAR; ALISKIREN; APOPTOSIS SIGNAL REGULATING KINASE 1; CHAPERONIN 60; DIMINAZENE; ELAFIBRANOR; FARNESOID X RECEPTOR; FIBRIC ACID DERIVATIVE; HEAT SHOCK PROTEIN 100; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; INT 131; MERCAPTAMINE; MICRORNA 103; MICRORNA 107; MITOGLITAZONE; OBETICHOLIC ACID; OLIGONUCLEOTIDE; PEMAFIBRATE; PENTOXYFILLINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHODIESTERASE INHIBITOR; PIOGLITAZONE; SELADELPAR; SOLITHROMYCIN; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID;

EID: 85020658831     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2016.08.002     Document Type: Article
Times cited : (29)

References (133)
  • 1
    • 80555136061 scopus 로고    scopus 로고
    • Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    • Musso, G., Gambino, R., Cassader, M., et al. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med 43 (2011), 617–649.
    • (2011) Ann Med , vol.43 , pp. 617-649
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 2
    • 84905401784 scopus 로고    scopus 로고
    • Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis
    • Musso, G., Gambino, R., Tabibian, J.H., et al. Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis. PLoS Med, 11, 2014, e1001680.
    • (2014) PLoS Med , vol.11 , pp. e1001680
    • Musso, G.1    Gambino, R.2    Tabibian, J.H.3
  • 3
    • 85020624771 scopus 로고    scopus 로고
    • In female patients with NAFLD presence of type 2 diabetes and chronic kidney disease are independently associated with the risk of mortality
    • Stepanova, M., Se Avila, L., Birerdinc, A., et al. In female patients with NAFLD presence of type 2 diabetes and chronic kidney disease are independently associated with the risk of mortality. Hepatology 62 (2015), 1282–1283A.
    • (2015) Hepatology , vol.62 , pp. 1282-1283A
    • Stepanova, M.1    Se Avila, L.2    Birerdinc, A.3
  • 4
    • 84959922452 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is the most rapidly growing indication for simultaneous liver kidney transplantation in the United States
    • Singal, A.K., Hasanin, M., Kaif, M., et al. Nonalcoholic steatohepatitis is the most rapidly growing indication for simultaneous liver kidney transplantation in the United States. Transplantation 100 (2016), 607–612.
    • (2016) Transplantation , vol.100 , pp. 607-612
    • Singal, A.K.1    Hasanin, M.2    Kaif, M.3
  • 5
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
    • Musso, G., Cassader, M., Rosina, F., et al. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia 55 (2012), 885–904.
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3
  • 6
    • 84930077401 scopus 로고    scopus 로고
    • Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis
    • Palmer, S.C., Mavridis, D., Navarese, E., et al. Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis. Lancet 385 (2015), 2047–2056.
    • (2015) Lancet , vol.385 , pp. 2047-2056
    • Palmer, S.C.1    Mavridis, D.2    Navarese, E.3
  • 7
    • 84953277546 scopus 로고    scopus 로고
    • Aliskiren reduces hepatic steatosis and epididymal fat mass and increases skeletal muscle insulin sensitivity in high-fat diet-fed mice
    • Lee, K.C., Hsieh, Y.C., Yang, Y.Y., et al. Aliskiren reduces hepatic steatosis and epididymal fat mass and increases skeletal muscle insulin sensitivity in high-fat diet-fed mice. Sci Rep, 6, 2016, 18899.
    • (2016) Sci Rep , vol.6 , pp. 18899
    • Lee, K.C.1    Hsieh, Y.C.2    Yang, Y.Y.3
  • 8
    • 84886880818 scopus 로고    scopus 로고
    • Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet
    • Lee, K.C., Chan, C.C., Yang, Y.Y., et al. Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. PLoS One, 8, 2013, e77817.
    • (2013) PLoS One , vol.8 , pp. e77817
    • Lee, K.C.1    Chan, C.C.2    Yang, Y.Y.3
  • 9
    • 84908395841 scopus 로고    scopus 로고
    • Aliskiren attenuates oxidative stress and improves tubular status in non-diabetic patients with chronic kidney disease-placebo controlled, randomized, cross-over study
    • Renke, M., Lizakowski, S., Tylicki, L., et al. Aliskiren attenuates oxidative stress and improves tubular status in non-diabetic patients with chronic kidney disease-placebo controlled, randomized, cross-over study. Adv Med Sci 59 (2014), 256–260.
    • (2014) Adv Med Sci , vol.59 , pp. 256-260
    • Renke, M.1    Lizakowski, S.2    Tylicki, L.3
  • 10
    • 84879043544 scopus 로고    scopus 로고
    • Oral angiotensin-(1-7) prevented obesity and hepatic inflammation by inhibition of resistin/TLR4/MAPK/NF-κB in rats fed with high-fat diet
    • Santos, S.H., Andrade, J.M., Fernandes, L.R., et al. Oral angiotensin-(1-7) prevented obesity and hepatic inflammation by inhibition of resistin/TLR4/MAPK/NF-κB in rats fed with high-fat diet. Peptides 46 (2013), 47–52.
    • (2013) Peptides , vol.46 , pp. 47-52
    • Santos, S.H.1    Andrade, J.M.2    Fernandes, L.R.3
  • 11
    • 84925438687 scopus 로고    scopus 로고
    • Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy
    • Velkoska, E., Patel, S.K., Griggs, K., et al. Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy. PLoS One, 10, 2015, e0118758.
    • (2015) PLoS One , vol.10 , pp. e0118758
    • Velkoska, E.1    Patel, S.K.2    Griggs, K.3
  • 12
    • 85010403930 scopus 로고    scopus 로고
    • Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease
    • Epub ahead of print
    • Trojanowicz, B., Ulrich, C., Kohler, F., et al. Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease. Nephrol Dial Transplant, 2016 Epub ahead of print.
    • (2016) Nephrol Dial Transplant
    • Trojanowicz, B.1    Ulrich, C.2    Kohler, F.3
  • 13
    • 84940724584 scopus 로고    scopus 로고
    • ACE2 therapy using adeno-associated viral vector inhibits liver fibrosis in mice
    • Mak, K.Y., Chin, R., Cunningham, S.C., et al. ACE2 therapy using adeno-associated viral vector inhibits liver fibrosis in mice. Mol Ther 23 (2015), 1434–1443.
    • (2015) Mol Ther , vol.23 , pp. 1434-1443
    • Mak, K.Y.1    Chin, R.2    Cunningham, S.C.3
  • 14
    • 84931267196 scopus 로고    scopus 로고
    • Angiotensin converting enzyme 2 activator DIZE modulates metabolic profile in mice decreasing lipogenesis
    • de Macêdo, S.M., Guimarares, T.A., Andrade, J.M., et al. Angiotensin converting enzyme 2 activator DIZE modulates metabolic profile in mice decreasing lipogenesis. Protein Pept Lett 22 (2015), 332–340.
    • (2015) Protein Pept Lett , vol.22 , pp. 332-340
    • de Macêdo, S.M.1    Guimarares, T.A.2    Andrade, J.M.3
  • 15
    • 85008654753 scopus 로고    scopus 로고
    • Angiotensin-(1–7) improves non-alcoholic steatohepatitis via an adiponectin-independent mechanism
    • Epub ahead of print
    • Tang, A., Li, C., Zou, N., et al. Angiotensin-(1–7) improves non-alcoholic steatohepatitis via an adiponectin-independent mechanism. Hepatol Res, 2016 Epub ahead of print.
    • (2016) Hepatol Res
    • Tang, A.1    Li, C.2    Zou, N.3
  • 16
    • 85016161807 scopus 로고    scopus 로고
    • Targeting inflammation in diabetic kidney disease: early clinical trials
    • Perez-Gomez, M.V., Sanchez-Niño, M.D., Sanz, A.B., et al. Targeting inflammation in diabetic kidney disease: early clinical trials. Expert Opin Investig Drugs 13 (2016), 1–14.
    • (2016) Expert Opin Investig Drugs , vol.13 , pp. 1-14
    • Perez-Gomez, M.V.1    Sanchez-Niño, M.D.2    Sanz, A.B.3
  • 17
    • 84892838265 scopus 로고    scopus 로고
    • Effects of pentoxifylline on nonalcoholic fatty liver disease: a meta-analysis
    • Du, J., Ma, Y.Y., Yu, C.H., et al. Effects of pentoxifylline on nonalcoholic fatty liver disease: a meta-analysis. World J Gastroenterol 20 (2014), 569–577.
    • (2014) World J Gastroenterol , vol.20 , pp. 569-577
    • Du, J.1    Ma, Y.Y.2    Yu, C.H.3
  • 18
    • 84924173941 scopus 로고    scopus 로고
    • Effect of pentoxifylline on renal function and urinary albumin excretion in patients with diabetic kidney disease: the PREDIAN trial
    • Navarro-Gonzalez, J.F., Mora-Fernandez, C., Muros de Fuentes, F.M., et al. Effect of pentoxifylline on renal function and urinary albumin excretion in patients with diabetic kidney disease: the PREDIAN trial. J Am Soc Nephrol 26 (2015), 220–229.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 220-229
    • Navarro-Gonzalez, J.F.1    Mora-Fernandez, C.2    Muros de Fuentes, F.M.3
  • 19
    • 84962853148 scopus 로고    scopus 로고
    • Effect of pentoxifylline on renal outcomes in chronic kidney disease patients: a systematic review and meta-analysis
    • Leporini, C., Pisano, A., Russo, E., et al. Effect of pentoxifylline on renal outcomes in chronic kidney disease patients: a systematic review and meta-analysis. Pharmacol Res 107 (2016), 315–332.
    • (2016) Pharmacol Res , vol.107 , pp. 315-332
    • Leporini, C.1    Pisano, A.2    Russo, E.3
  • 20
    • 84866742003 scopus 로고    scopus 로고
    • The effect of cysteamine bitartrate on adiponectin multimerization in non-alcoholic fatty liver disease and healthy subjects
    • Dohil, R., Meyer, L., Schmeltzer, S., et al. The effect of cysteamine bitartrate on adiponectin multimerization in non-alcoholic fatty liver disease and healthy subjects. J Pediatr 161 (2012), 639–645.
    • (2012) J Pediatr , vol.161 , pp. 639-645
    • Dohil, R.1    Meyer, L.2    Schmeltzer, S.3
  • 21
    • 84891790934 scopus 로고    scopus 로고
    • Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD
    • Okamura, D.M., Bahrami, N.M., Ren, S., et al. Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD. J Am Soc Nephrol 25 (2014), 43–54.
    • (2014) J Am Soc Nephrol , vol.25 , pp. 43-54
    • Okamura, D.M.1    Bahrami, N.M.2    Ren, S.3
  • 22
    • 84997079995 scopus 로고    scopus 로고
    • In children with nonalcoholic fatty liver disease, cysteamine bitartrate delayed release improves liver enzymes but does not reduce disease activity scores
    • Schwimmer, J.B., Lavine, J.E., Wilson, L.A., et al. In children with nonalcoholic fatty liver disease, cysteamine bitartrate delayed release improves liver enzymes but does not reduce disease activity scores. Gastroenterology 151 (2016), 1125–1138.
    • (2016) Gastroenterology , vol.151 , pp. 1125-1138
    • Schwimmer, J.B.1    Lavine, J.E.2    Wilson, L.A.3
  • 23
    • 84925284486 scopus 로고    scopus 로고
    • Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
    • Kang, H.M., Ahn, S.H., Choi, P., et al. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Nat Med 21 (2015), 37–46.
    • (2015) Nat Med , vol.21 , pp. 37-46
    • Kang, H.M.1    Ahn, S.H.2    Choi, P.3
  • 24
    • 84899426857 scopus 로고    scopus 로고
    • Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy
    • Xu, Y., Huang, J., Xin, W., et al. Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy. Metabolism 63 (2014), 716–726.
    • (2014) Metabolism , vol.63 , pp. 716-726
    • Xu, Y.1    Huang, J.2    Xin, W.3
  • 25
    • 84894847603 scopus 로고    scopus 로고
    • Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy
    • Herman-Edelstein, M., Scherzer, P., Tobar, A., et al. Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy. J Lipid Res 55 (2014), 561–572.
    • (2014) J Lipid Res , vol.55 , pp. 561-572
    • Herman-Edelstein, M.1    Scherzer, P.2    Tobar, A.3
  • 26
    • 84955267511 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
    • Musso, G., Cassader, M., Gambino, R., Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies. Nat Rev Drug Discov 15 (2016), 249–274.
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 249-274
    • Musso, G.1    Cassader, M.2    Gambino, R.3
  • 27
    • 84988944839 scopus 로고    scopus 로고
    • Fatty liver and chronic kidney disease: novel mechanistic insights and therapeutic opportunities
    • Epub ahead of print
    • Musso, G., Cassader, M., Cohney, S., et al. Fatty liver and chronic kidney disease: novel mechanistic insights and therapeutic opportunities. Diabetes Care, 2016 Epub ahead of print.
    • (2016) Diabetes Care
    • Musso, G.1    Cassader, M.2    Cohney, S.3
  • 28
    • 84858216690 scopus 로고    scopus 로고
    • Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study
    • Ting, R.D., Keech, A.C., Drury, P.L., et al. Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study. Diabetes Care 35 (2012), 218–225.
    • (2012) Diabetes Care , vol.35 , pp. 218-225
    • Ting, R.D.1    Keech, A.C.2    Drury, P.L.3
  • 29
    • 84938098177 scopus 로고    scopus 로고
    • Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model
    • Li, X., Li, J., Lu, X., et al. Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model. Int J Mol Med 36 (2015), 767–775.
    • (2015) Int J Mol Med , vol.36 , pp. 767-775
    • Li, X.1    Li, J.2    Lu, X.3
  • 30
    • 84888285959 scopus 로고    scopus 로고
    • Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Staels, B., Rubenstrunk, A., Noel, B., et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology 58 (2013), 1941–1952.
    • (2013) Hepatology , vol.58 , pp. 1941-1952
    • Staels, B.1    Rubenstrunk, A.2    Noel, B.3
  • 31
    • 84872027781 scopus 로고    scopus 로고
    • Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation
    • Collino, M., Benetti, E., Rogazzo, M., et al. Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation. Biochem Pharmacol 85 (2013), 257–264.
    • (2013) Biochem Pharmacol , vol.85 , pp. 257-264
    • Collino, M.1    Benetti, E.2    Rogazzo, M.3
  • 32
    • 84869472895 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-δ activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes
    • Lee, E.Y., Kim, G.T., Hyun, M., et al. Peroxisome proliferator-activated receptor-δ activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes. Nephrol Dial Transplant 27 (2012), 4069–4079.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 4069-4079
    • Lee, E.Y.1    Kim, G.T.2    Hyun, M.3
  • 33
    • 80052539818 scopus 로고    scopus 로고
    • MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin
    • Bays, H.E., MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin. J Clin Endocrinol Metab 96 (2011), 2889–2897.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2889-2897
    • Bays, H.E.1
  • 34
    • 84978325426 scopus 로고    scopus 로고
    • The hepatic and extrahepatic profile of resolution of steatohepatitis induced by GFT-505
    • Sanyal, A.J., Harrison, S.A., Francque, S.M., et al. The hepatic and extrahepatic profile of resolution of steatohepatitis induced by GFT-505. Hepatology, 62, 2015, 1252A.
    • (2015) Hepatology , vol.62 , pp. 1252A
    • Sanyal, A.J.1    Harrison, S.A.2    Francque, S.M.3
  • 35
    • 77951621387 scopus 로고    scopus 로고
    • Effect of thiazolidinediones on albuminuria and proteinuria in diabetes: a meta-analysis
    • Sarafidis, P.A., Stafylas, P.C., Georgianos, P.I., et al. Effect of thiazolidinediones on albuminuria and proteinuria in diabetes: a meta-analysis. Am J Kidney Dis 55 (2010), 835–847.
    • (2010) Am J Kidney Dis , vol.55 , pp. 835-847
    • Sarafidis, P.A.1    Stafylas, P.C.2    Georgianos, P.I.3
  • 36
    • 84903550477 scopus 로고    scopus 로고
    • Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone?
    • DePaoli, A.M., Higgins, L.S., Henry, R.R., et al. Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone?. Diabetes Care 37 (2014), 1918–1923.
    • (2014) Diabetes Care , vol.37 , pp. 1918-1923
    • DePaoli, A.M.1    Higgins, L.S.2    Henry, R.R.3
  • 37
    • 84875462925 scopus 로고    scopus 로고
    • Clinical proof-of-concept study with MSDC-0160, a prototype mTOT-modulating insulin sensitizer
    • Colca, J.R., VanderLugt, J.T., Adams, W.J., et al. Clinical proof-of-concept study with MSDC-0160, a prototype mTOT-modulating insulin sensitizer. Clin Pharmacol Ther 93 (2013), 352–359.
    • (2013) Clin Pharmacol Ther , vol.93 , pp. 352-359
    • Colca, J.R.1    VanderLugt, J.T.2    Adams, W.J.3
  • 38
    • 85013690608 scopus 로고    scopus 로고
    • Modulating mitochondrial pyruvate carrier activity decreases hepatic fibrosis in a mouse model of NASH
    • McCommis, K.S., McDonald, W.G., Colca, J.R., et al. Modulating mitochondrial pyruvate carrier activity decreases hepatic fibrosis in a mouse model of NASH. Diabetes, 65, 2016, A36.
    • (2016) Diabetes , vol.65 , pp. A36
    • McCommis, K.S.1    McDonald, W.G.2    Colca, J.R.3
  • 39
    • 85020675513 scopus 로고    scopus 로고
    • VL DRX-065, the stabilized R-enantiomer of pioglitazone is without PPARg agonist activity and exhibits the beneficial in vivo pharmacodynamic effects for the treatment of NASH
    • DeWitt, S.H., Jacques, V., Van der Ploeg, L.H., VL DRX-065, the stabilized R-enantiomer of pioglitazone is without PPARg agonist activity and exhibits the beneficial in vivo pharmacodynamic effects for the treatment of NASH. Hepatology 62 (2015), 281A–282A.
    • (2015) Hepatology , vol.62 , pp. 281A-282A
    • DeWitt, S.H.1    Jacques, V.2    Van der Ploeg, L.H.3
  • 40
    • 85020660765 scopus 로고    scopus 로고
    • Saroglitazar shows therapeutic benefits in mouse model of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) (abstract 1957-P). American Diabetes Association 75th Scientific Sessions, June 5–9, Boston, MA.
    • Mukul R. Saroglitazar shows therapeutic benefits in mouse model of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) (abstract 1957-P). American Diabetes Association 75th Scientific Sessions, June 5–9, 2015, Boston, MA.
    • (2015)
    • Mukul, R.1
  • 41
    • 85020647859 scopus 로고    scopus 로고
    • To assess the effect of 4mg saroglitazar on patients of diabetes dyslipidemia with nonalcoholic fatty liver disease for 24 weeks at diabetes care CentreView session detail (abstract 712-P). American Diabetes Association 75th Scientific Sessions, June 5–9, Boston, MA.
    • Banshi D. To assess the effect of 4mg saroglitazar on patients of diabetes dyslipidemia with nonalcoholic fatty liver disease for 24 weeks at diabetes care CentreView session detail (abstract 712-P). American Diabetes Association 75th Scientific Sessions, June 5–9, 2015, Boston, MA.
    • (2015)
    • Banshi, D.1
  • 42
    • 84928430938 scopus 로고    scopus 로고
    • Effects of the dual peroxisome proliferator-activated receptor-α/γ agonist aleglitazar on renal function in patients with stage 3 chronic kidney disease and type 2 diabetes: a phase IIb, randomized study
    • Ruilope, L., Hanefeld, M., Lincoff, A.M., et al. Effects of the dual peroxisome proliferator-activated receptor-α/γ agonist aleglitazar on renal function in patients with stage 3 chronic kidney disease and type 2 diabetes: a phase IIb, randomized study. BMC Nephrol, 15, 2014, 180.
    • (2014) BMC Nephrol , vol.15 , pp. 180
    • Ruilope, L.1    Hanefeld, M.2    Lincoff, A.M.3
  • 43
    • 84956970185 scopus 로고    scopus 로고
    • Farnesoid X receptor protects against kidney injury in uninephrectomized obese mice
    • Gai, Z., Gui, T., Hiller, C., et al. Farnesoid X receptor protects against kidney injury in uninephrectomized obese mice. J Biol Chem 291 (2016), 2397–2411.
    • (2016) J Biol Chem , vol.291 , pp. 2397-2411
    • Gai, Z.1    Gui, T.2    Hiller, C.3
  • 44
    • 71449109826 scopus 로고    scopus 로고
    • The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria
    • Wang, X.X., The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria. Am J Physiol Renal Physiol 297 (2009), F1587–F1596.
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F1587-F1596
    • Wang, X.X.1
  • 45
    • 70349306439 scopus 로고    scopus 로고
    • Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine
    • Li, J., Wilson, A., Gao, X., et al. Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine. J Pharmacol Exp Ther 331 (2009), 234–243.
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 234-243
    • Li, J.1    Wilson, A.2    Gao, X.3
  • 46
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri, B., Loomba, R., Sanyal, A.J., et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 385 (2015), 956–965.
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.1    Loomba, R.2    Sanyal, A.J.3
  • 47
    • 84929607068 scopus 로고    scopus 로고
    • Obeticholic acid and resveratrol in nonalcoholic fatty liver disease: all that is gold does not glitter, not all those who wander are lost
    • Musso, G., Obeticholic acid and resveratrol in nonalcoholic fatty liver disease: all that is gold does not glitter, not all those who wander are lost. Hepatology 61 (2015), 2104–2106.
    • (2015) Hepatology , vol.61 , pp. 2104-2106
    • Musso, G.1
  • 48
    • 84959118263 scopus 로고    scopus 로고
    • Role of microRNA 21 in diabetes and associated/related diseases
    • Sekar, D., Venugopal, B., Sekar, P., et al. Role of microRNA 21 in diabetes and associated/related diseases. Gene 582 (2016), 14–18.
    • (2016) Gene , vol.582 , pp. 14-18
    • Sekar, D.1    Venugopal, B.2    Sekar, P.3
  • 49
    • 79959845414 scopus 로고    scopus 로고
    • MicroRNAs 103 and 107 regulate insulin sensitivity
    • Trajkovski, M., Hausser, J., Soutschek, J., et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474 (2011), 649–653.
    • (2011) Nature , vol.474 , pp. 649-653
    • Trajkovski, M.1    Hausser, J.2    Soutschek, J.3
  • 50
    • 84955250545 scopus 로고    scopus 로고
    • Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo
    • Bhatia, H., Pattnaik, B.R., Datta, M., Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo. Int J Obes (Lond) 40 (2016), 861–869.
    • (2016) Int J Obes (Lond) , vol.40 , pp. 861-869
    • Bhatia, H.1    Pattnaik, B.R.2    Datta, M.3
  • 51
    • 84978909292 scopus 로고    scopus 로고
    • MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease
    • Takeuchi-Yorimoto, A., Yamaura, Y., Kanki, M., et al. MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease. Toxicol Lett 258 (2016), 159–167.
    • (2016) Toxicol Lett , vol.258 , pp. 159-167
    • Takeuchi-Yorimoto, A.1    Yamaura, Y.2    Kanki, M.3
  • 52
    • 84922876430 scopus 로고    scopus 로고
    • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis
    • Dattaroy, D., Pourhoseini, S., Das, S., et al. Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 308 (2015), G298–G312.
    • (2015) Am J Physiol Gastrointest Liver Physiol , vol.308 , pp. G298-G312
    • Dattaroy, D.1    Pourhoseini, S.2    Das, S.3
  • 53
    • 84863116324 scopus 로고    scopus 로고
    • MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways
    • Chau, B.N., Xin, C., Hartner, J., et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med, 4, 2012, 121ra18.
    • (2012) Sci Transl Med , vol.4 , pp. 121ra18
    • Chau, B.N.1    Xin, C.2    Hartner, J.3
  • 54
    • 84894601419 scopus 로고    scopus 로고
    • Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy
    • Bao, H., Hu, S., Zhang, C., et al. Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy. Biochem Biophys Res Commun 444 (2014), 455–460.
    • (2014) Biochem Biophys Res Commun , vol.444 , pp. 455-460
    • Bao, H.1    Hu, S.2    Zhang, C.3
  • 55
    • 84995342296 scopus 로고    scopus 로고
    • MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway
    • Epub ahead of print
    • Wu, H., Ng, R., Chen, X., et al. MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway. Gut, 2015 Epub ahead of print.
    • (2015) Gut
    • Wu, H.1    Ng, R.2    Chen, X.3
  • 56
    • 84929262086 scopus 로고    scopus 로고
    • microRNA-107 functions as a candidate tumor suppressor gene in renal clear cell carcinoma involving multiple genes
    • e1–11
    • Song, N., Ma, X., Li, H., et al. microRNA-107 functions as a candidate tumor suppressor gene in renal clear cell carcinoma involving multiple genes. Urol Oncol, 33, 2015, 205 e1–11.
    • (2015) Urol Oncol , vol.33 , pp. 205
    • Song, N.1    Ma, X.2    Li, H.3
  • 57
    • 84975757558 scopus 로고    scopus 로고
    • Heat shock proteins in the kidney
    • Sreedharan, R., Van Why, S.K., Heat shock proteins in the kidney. Pediatr Nephrol 31 (2016), 1561–1570.
    • (2016) Pediatr Nephrol , vol.31 , pp. 1561-1570
    • Sreedharan, R.1    Van Why, S.K.2
  • 58
    • 84905017714 scopus 로고    scopus 로고
    • Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease
    • Wheeler, M.C., Gekakis, N., Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease. J Lipid Res 55 (2014), 1702–1710.
    • (2014) J Lipid Res , vol.55 , pp. 1702-1710
    • Wheeler, M.C.1    Gekakis, N.2
  • 59
    • 84953343433 scopus 로고    scopus 로고
    • Targeting HSP90 ameliorates nephropathy and atherosclerosis through suppression of NF-κB and STAT signaling pathways in diabetic mice
    • Lazaro, I., Oguiza, A., Recio, C., et al. Targeting HSP90 ameliorates nephropathy and atherosclerosis through suppression of NF-κB and STAT signaling pathways in diabetic mice. Diabetes 64 (2015), 3600–3613.
    • (2015) Diabetes , vol.64 , pp. 3600-3613
    • Lazaro, I.1    Oguiza, A.2    Recio, C.3
  • 60
    • 84868553748 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor
    • Noh, H., Kim, H.J., Yu, M.R., et al. Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor. Lab Invest 92 (2012), 1583–1596.
    • (2012) Lab Invest , vol.92 , pp. 1583-1596
    • Noh, H.1    Kim, H.J.2    Yu, M.R.3
  • 61
    • 84950335496 scopus 로고    scopus 로고
    • The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice
    • Abu-Elsaad, N.M., Serrya, M.S., El-Karef, A.M., et al. The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice. Pharmacol Rep 68 (2016), 275–282.
    • (2016) Pharmacol Rep , vol.68 , pp. 275-282
    • Abu-Elsaad, N.M.1    Serrya, M.S.2    El-Karef, A.M.3
  • 62
    • 36249016888 scopus 로고    scopus 로고
    • Suppression of renal tubulointerstitial fibrosis by small interfering RNA targeting heat shock protein 47
    • Xia, Z., Abe, K., Furusu, A., et al. Suppression of renal tubulointerstitial fibrosis by small interfering RNA targeting heat shock protein 47. Am J Nephrol 28 (2008), 34–46.
    • (2008) Am J Nephrol , vol.28 , pp. 34-46
    • Xia, Z.1    Abe, K.2    Furusu, A.3
  • 63
    • 84901056473 scopus 로고    scopus 로고
    • Role of NADPH oxidases in liver fibrosis
    • Paik, Y.H., Kim, J., Aoyama, T., et al. Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal 20 (2014), 2854–2872.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 2854-2872
    • Paik, Y.H.1    Kim, J.2    Aoyama, T.3
  • 64
    • 84944726859 scopus 로고    scopus 로고
    • Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease
    • Gorin, Y., Wauquier, F., Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease. Mol Cells 38 (2015), 285–296.
    • (2015) Mol Cells , vol.38 , pp. 285-296
    • Gorin, Y.1    Wauquier, F.2
  • 65
    • 84901835198 scopus 로고    scopus 로고
    • Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy
    • Jha, J.C., Gray, S.P., Barit, D., et al. Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy. J Am Soc Nephrol 25 (2014), 1237–1254.
    • (2014) J Am Soc Nephrol , vol.25 , pp. 1237-1254
    • Jha, J.C.1    Gray, S.P.2    Barit, D.3
  • 66
    • 84941653396 scopus 로고    scopus 로고
    • Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation
    • Lan, T., Kisseleva, T., Brenner, D.A., Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation. PLoS One, 10, 2015, e0129743.
    • (2015) PLoS One , vol.10 , pp. e0129743
    • Lan, T.1    Kisseleva, T.2    Brenner, D.A.3
  • 67
    • 84866950669 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent
    • Aoyama, T., Paik, Y.H., Watanabe, S., et al. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology 56 (2012), 2316–2327.
    • (2012) Hepatology , vol.56 , pp. 2316-2327
    • Aoyama, T.1    Paik, Y.H.2    Watanabe, S.3
  • 68
    • 84862776938 scopus 로고    scopus 로고
    • Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase
    • Schroder, K., Zhang, M., Benkhoff, S., et al. Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res 110 (2012), 1217–1225.
    • (2012) Circ Res , vol.110 , pp. 1217-1225
    • Schroder, K.1    Zhang, M.2    Benkhoff, S.3
  • 69
    • 84900796050 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1 as a therapeutic target
    • Kawarazaki, Y., Ichijo, H., Naguro, I., Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets 18 (2014), 651–664.
    • (2014) Expert Opin Ther Targets , vol.18 , pp. 651-664
    • Kawarazaki, Y.1    Ichijo, H.2    Naguro, I.3
  • 70
    • 52049105198 scopus 로고    scopus 로고
    • Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition
    • Yamamoto, E., Dong, Y.F., Kataoka, K., et al. Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition. Hypertension 52 (2008), 573–580.
    • (2008) Hypertension , vol.52 , pp. 573-580
    • Yamamoto, E.1    Dong, Y.F.2    Kataoka, K.3
  • 71
    • 84913528759 scopus 로고    scopus 로고
    • ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney
    • Ma, F.Y., Tesch, G.H., Nikolic-Paterson, D.J., ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney. Am J Physiol Renal Physiol 307 (2014), F1263–F1273.
    • (2014) Am J Physiol Renal Physiol , vol.307 , pp. F1263-F1273
    • Ma, F.Y.1    Tesch, G.H.2    Nikolic-Paterson, D.J.3
  • 72
    • 84956596940 scopus 로고    scopus 로고
    • ASK1 inhibitor halts progression of diabetic nephropathy in Nos3-deficient mice
    • Tesch, G.H., Ma, F.Y., Han, Y., et al. ASK1 inhibitor halts progression of diabetic nephropathy in Nos3-deficient mice. Diabetes 64 (2015), 3903–3913.
    • (2015) Diabetes , vol.64 , pp. 3903-3913
    • Tesch, G.H.1    Ma, F.Y.2    Han, Y.3
  • 73
    • 84978412213 scopus 로고    scopus 로고
    • Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet
    • Liu, Z., Dou, W., Ni, Z., et al. Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet. Mol Med Rep 14 (2016), 1323–1331.
    • (2016) Mol Med Rep , vol.14 , pp. 1323-1331
    • Liu, Z.1    Dou, W.2    Ni, Z.3
  • 74
    • 84879090781 scopus 로고    scopus 로고
    • Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model
    • Shimozono, R., Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol 84 (2013), 62–70.
    • (2013) Mol Pharmacol , vol.84 , pp. 62-70
    • Shimozono, R.1
  • 75
    • 84906690102 scopus 로고    scopus 로고
    • Effect of redox modulating NRF2 activators on chronic kidney disease
    • Choi, B.H., Kang, K.S., Kwak, M.K., Effect of redox modulating NRF2 activators on chronic kidney disease. Molecules 19 (2014), 12727–12759.
    • (2014) Molecules , vol.19 , pp. 12727-12759
    • Choi, B.H.1    Kang, K.S.2    Kwak, M.K.3
  • 76
    • 84983558993 scopus 로고    scopus 로고
    • The NLRP3 inflammasome in kidney disease and autoimmunity
    • Hutton, H.L., Ooi, J.D., Holdsworth, S.R., et al. The NLRP3 inflammasome in kidney disease and autoimmunity. Nephrology (Carlton) 21 (2016), 736–744.
    • (2016) Nephrology (Carlton) , vol.21 , pp. 736-744
    • Hutton, H.L.1    Ooi, J.D.2    Holdsworth, S.R.3
  • 77
    • 85020644673 scopus 로고    scopus 로고
    • Blocking the NLRP3 inflammasome prevents inflammatory recruitment and fibrotic progression in experimental NASH
    • Mridha, A.R., Wree, A., Avril, A., et al. Blocking the NLRP3 inflammasome prevents inflammatory recruitment and fibrotic progression in experimental NASH. Hepatology 62 (2015), 235–236A.
    • (2015) Hepatology , vol.62 , pp. 235-236A
    • Mridha, A.R.1    Wree, A.2    Avril, A.3
  • 78
    • 84855643283 scopus 로고    scopus 로고
    • Bindarit: an anti-inflammatory small molecule that modulates the NFkappaB pathway
    • Mora, E., Guglielmotti, A., Biondi, G., et al. Bindarit: an anti-inflammatory small molecule that modulates the NFkappaB pathway. Cell Cycle 11 (2012), 159–169.
    • (2012) Cell Cycle , vol.11 , pp. 159-169
    • Mora, E.1    Guglielmotti, A.2    Biondi, G.3
  • 80
    • 84946567180 scopus 로고    scopus 로고
    • Inhibition of mitogen-activated protein kinases/nuclear factor κB-dependent inflammation by a novel chalcone protects the kidney from high fat diet-induced injuries in mice
    • Fang, Q., Deng, L., Wang, L., et al. Inhibition of mitogen-activated protein kinases/nuclear factor κB-dependent inflammation by a novel chalcone protects the kidney from high fat diet-induced injuries in mice. J Pharmacol Exp Ther 355 (2015), 235–246.
    • (2015) J Pharmacol Exp Ther , vol.355 , pp. 235-246
    • Fang, Q.1    Deng, L.2    Wang, L.3
  • 81
    • 84940447736 scopus 로고    scopus 로고
    • In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin
    • Furfaro, L.L., Spiller, O.B., Keelan, J.A., et al. In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin. Int J Antimicrob Agents 46 (2015), 319–324.
    • (2015) Int J Antimicrob Agents , vol.46 , pp. 319-324
    • Furfaro, L.L.1    Spiller, O.B.2    Keelan, J.A.3
  • 82
    • 85016156233 scopus 로고    scopus 로고
    • Mechanism of action of the anti-NASH effects of solithromycin in a predictive NASH HCC mouse model
    • Fernandes, P., Oldach, D., Pierre, M., et al. Mechanism of action of the anti-NASH effects of solithromycin in a predictive NASH HCC mouse model. Hepatology, 62, 2015, 1301A.
    • (2015) Hepatology , vol.62 , pp. 1301A
    • Fernandes, P.1    Oldach, D.2    Pierre, M.3
  • 83
    • 84875413952 scopus 로고    scopus 로고
    • A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition
    • Kobayashi, Y., Wada, H., Rossios, C., et al. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition. J Pharmacol Exp Ther 345 (2013), 76–84.
    • (2013) J Pharmacol Exp Ther , vol.345 , pp. 76-84
    • Kobayashi, Y.1    Wada, H.2    Rossios, C.3
  • 84
    • 84896707511 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice
    • Baeck, C., Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice. Hepatology 59 (2014), 1060–1072.
    • (2014) Hepatology , vol.59 , pp. 1060-1072
    • Baeck, C.1
  • 85
    • 84898663936 scopus 로고    scopus 로고
    • Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis
    • Wu, H.J., Yiu, W.H., Li, R.X., et al. Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis. PLoS One, 9, 2014, e90883.
    • (2014) PLoS One , vol.9 , pp. e90883
    • Wu, H.J.1    Yiu, W.H.2    Li, R.X.3
  • 86
    • 84977139510 scopus 로고    scopus 로고
    • Antifibrotic effects of the dual CCR2/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis
    • Lefebvre, E., Moyle, G., Reshef, R., et al. Antifibrotic effects of the dual CCR2/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis. PLoS One, 11, 2016, e0158156.
    • (2016) PLoS One , vol.11 , pp. e0158156
    • Lefebvre, E.1    Moyle, G.2    Reshef, R.3
  • 87
    • 84939483610 scopus 로고    scopus 로고
    • The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial
    • de Zeeuw, D., Bekker, P., Henkel, E., et al. The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial. Lancet Diabetes Endocrinol 3 (2015), 687–696.
    • (2015) Lancet Diabetes Endocrinol , vol.3 , pp. 687-696
    • de Zeeuw, D.1    Bekker, P.2    Henkel, E.3
  • 88
    • 84893650001 scopus 로고    scopus 로고
    • Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis
    • Hammerich, L., Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology 59 (2014), 630–642.
    • (2014) Hepatology , vol.59 , pp. 630-642
    • Hammerich, L.1
  • 89
    • 85020675589 scopus 로고    scopus 로고
    • Improvement in hepatic steatosis in NASH in response to synbiotic supplementation
    • Ferolla, S.M., Couto, C.A., Armiliato, G.N., et al. Improvement in hepatic steatosis in NASH in response to synbiotic supplementation. Hepatology, 62, 2015, 1280A.
    • (2015) Hepatology , vol.62 , pp. 1280A
    • Ferolla, S.M.1    Couto, C.A.2    Armiliato, G.N.3
  • 90
    • 84925883568 scopus 로고    scopus 로고
    • SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial
    • Rossi, M., SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial. BMC Nephrol, 15, 2014, 106.
    • (2014) BMC Nephrol , vol.15 , pp. 106
    • Rossi, M.1
  • 91
    • 84871637171 scopus 로고    scopus 로고
    • Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH
    • Mizrahi, M., Shabat, Y., Ben Ya'acov, A., et al. Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH. J Inflamm Res 5 (2012), 141–150.
    • (2012) J Inflamm Res , vol.5 , pp. 141-150
    • Mizrahi, M.1    Shabat, Y.2    Ben Ya'acov, A.3
  • 92
    • 84893967901 scopus 로고    scopus 로고
    • Role of Toll-like receptors in diabetic nephropathy
    • Mudaliar, H., Pollock, C., Panchapakesan, U., Role of Toll-like receptors in diabetic nephropathy. Clin Sci (Lond) 126 (2014), 685–694.
    • (2014) Clin Sci (Lond) , vol.126 , pp. 685-694
    • Mudaliar, H.1    Pollock, C.2    Panchapakesan, U.3
  • 93
    • 85020641089 scopus 로고    scopus 로고
    • A TLR4 antagonist decreases hepatic inflammation in response to endotoxin in fatty livers
    • Oregui, A., Culberson, C., Norris, E., et al. A TLR4 antagonist decreases hepatic inflammation in response to endotoxin in fatty livers. J Hepatol, 22, 2015, 166A.
    • (2015) J Hepatol , vol.22 , pp. 166A
    • Oregui, A.1    Culberson, C.2    Norris, E.3
  • 94
    • 84954384684 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatophepatitis
    • Armstrong, M.J., Hull, D., Guo, K., et al. Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatophepatitis. J Hepatol 64 (2016), 399–440.
    • (2016) J Hepatol , vol.64 , pp. 399-440
    • Armstrong, M.J.1    Hull, D.2    Guo, K.3
  • 95
    • 84969801284 scopus 로고    scopus 로고
    • Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial
    • Cui, J., Philo, L., Nguyen, P., et al. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial. J Hepatol 65 (2016), 369–376.
    • (2016) J Hepatol , vol.65 , pp. 369-376
    • Cui, J.1    Philo, L.2    Nguyen, P.3
  • 96
    • 84937525579 scopus 로고    scopus 로고
    • GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial
    • Gögebakan, Ö., Osterhoff, M.A., Schüler, R., GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial. Diabetologia 58 (2015), 1759–1768.
    • (2015) Diabetologia , vol.58 , pp. 1759-1768
    • Gögebakan, Ö.1    Osterhoff, M.A.2    Schüler, R.3
  • 97
    • 84903207650 scopus 로고    scopus 로고
    • Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions
    • Nasteska, D., Harada, N., Suzuki, K., Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions. Diabetes 63 (2014), 2332–2343.
    • (2014) Diabetes , vol.63 , pp. 2332-2343
    • Nasteska, D.1    Harada, N.2    Suzuki, K.3
  • 98
    • 84885000482 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor agonist, liraglutide, attenuates the progression of overt diabetic nephropathy in type 2 diabetic patients
    • Imamura, S., Hirai, K., Hirai, A., The glucagon-like peptide-1 receptor agonist, liraglutide, attenuates the progression of overt diabetic nephropathy in type 2 diabetic patients. Tohoku J Exp Med 231 (2013), 57–61.
    • (2013) Tohoku J Exp Med , vol.231 , pp. 57-61
    • Imamura, S.1    Hirai, K.2    Hirai, A.3
  • 99
    • 84890476805 scopus 로고    scopus 로고
    • Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction
    • Groop, P.H., Cooper, M.E., Perkovic, V., et al. Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction. Diabetes Care 36 (2013), 3460–3468.
    • (2013) Diabetes Care , vol.36 , pp. 3460-3468
    • Groop, P.H.1    Cooper, M.E.2    Perkovic, V.3
  • 100
    • 84943249540 scopus 로고    scopus 로고
    • Minireview: roles of fibroblast growth factors 19 and 21 in metabolic regulation and chronic diseases
    • Zhang, F., Yu, L., Lin, X., et al. Minireview: roles of fibroblast growth factors 19 and 21 in metabolic regulation and chronic diseases. Mol Endocrinol 29 (2015), 1400–1413.
    • (2015) Mol Endocrinol , vol.29 , pp. 1400-1413
    • Zhang, F.1    Yu, L.2    Lin, X.3
  • 101
    • 34948821192 scopus 로고    scopus 로고
    • FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver
    • Huang, X., Yang, C., Luo, Y., et al. FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 56 (2007), 2501–2510.
    • (2007) Diabetes , vol.56 , pp. 2501-2510
    • Huang, X.1    Yang, C.2    Luo, Y.3
  • 102
    • 18344394556 scopus 로고    scopus 로고
    • Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
    • Tomlinson, E., Fu, L., John, L., Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 143 (2002), 1741–1747.
    • (2002) Endocrinology , vol.143 , pp. 1741-1747
    • Tomlinson, E.1    Fu, L.2    John, L.3
  • 103
    • 84861230343 scopus 로고    scopus 로고
    • Preliminary evidence of a reduced serum level of fibroblast growth factor 19 in patients with biopsy-proven nonalcoholic fatty liver disease
    • Eren, F., Kurt, R., Ermis, F., et al. Preliminary evidence of a reduced serum level of fibroblast growth factor 19 in patients with biopsy-proven nonalcoholic fatty liver disease. Clin Biochem 45 (2012), 655–658.
    • (2012) Clin Biochem , vol.45 , pp. 655-658
    • Eren, F.1    Kurt, R.2    Ermis, F.3
  • 104
    • 84890099702 scopus 로고    scopus 로고
    • Impaired postprandial fibroblast growth factor (FGF)-19 response in patients with stage 5 chronic kidney diseases is ameliorated following antioxidative therapy
    • Li, M., Qureshi, A.R., Ellis, E., et al. Impaired postprandial fibroblast growth factor (FGF)-19 response in patients with stage 5 chronic kidney diseases is ameliorated following antioxidative therapy. Nephrol Dial Transplant 28 (2013), iv212–iv219.
    • (2013) Nephrol Dial Transplant , vol.28 , pp. iv212-iv219
    • Li, M.1    Qureshi, A.R.2    Ellis, E.3
  • 105
    • 84903474977 scopus 로고    scopus 로고
    • Separating tumorigenicity from bile acid regulatory activity for endocrine hormone FGF19
    • Zhou, M., Wang, X., Phung, V., et al. Separating tumorigenicity from bile acid regulatory activity for endocrine hormone FGF19. Cancer Res 74 (2014), 3306–3316.
    • (2014) Cancer Res , vol.74 , pp. 3306-3316
    • Zhou, M.1    Wang, X.2    Phung, V.3
  • 106
    • 80051670219 scopus 로고    scopus 로고
    • Hepatic consequences of vascular adhesion protein-1 expression
    • Weston, C.J., Adams, D.H., Hepatic consequences of vascular adhesion protein-1 expression. J Neural Transm 118 (2011), 1055–1064.
    • (2011) J Neural Transm , vol.118 , pp. 1055-1064
    • Weston, C.J.1    Adams, D.H.2
  • 107
    • 84961291855 scopus 로고    scopus 로고
    • Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis
    • Weston, C.J., Shepherd, E.L., Claridge, L.C., et al. Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. J Clin Invest 125 (2015), 501–520.
    • (2015) J Clin Invest , vol.125 , pp. 501-520
    • Weston, C.J.1    Shepherd, E.L.2    Claridge, L.C.3
  • 108
    • 84908076425 scopus 로고    scopus 로고
    • Semicarbazide-sensitive amine oxidase (SSAO) inhibition ameliorates kidney fibrosis in a unilateral ureteral obstruction murine model
    • Wong, M.Y., Saad, S., Zhang, J., et al. Semicarbazide-sensitive amine oxidase (SSAO) inhibition ameliorates kidney fibrosis in a unilateral ureteral obstruction murine model. Am J Physiol Renal Physiol 307 (2014), F908–F916.
    • (2014) Am J Physiol Renal Physiol , vol.307 , pp. F908-F916
    • Wong, M.Y.1    Saad, S.2    Zhang, J.3
  • 109
    • 84946131285 scopus 로고    scopus 로고
    • Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition
    • Katagiri, D., Hamasaki, Y., Doi, K., et al. Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition. Kidney Int 89 (2016), 374–385.
    • (2016) Kidney Int , vol.89 , pp. 374-385
    • Katagiri, D.1    Hamasaki, Y.2    Doi, K.3
  • 110
    • 79954954319 scopus 로고    scopus 로고
    • Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver
    • Iacobini, C., Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver. J Hepatol 54 (2011), 975–983.
    • (2011) J Hepatol , vol.54 , pp. 975-983
    • Iacobini, C.1
  • 111
    • 84896493202 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma
    • DePeralta, D.K., Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology 59 (2014), 1577–1590.
    • (2014) Hepatology , vol.59 , pp. 1577-1590
    • DePeralta, D.K.1
  • 112
    • 10744225343 scopus 로고    scopus 로고
    • Galectin-3-positive cell infiltration in human diabetic nephropathy
    • Kikuchi, Y., Kobayashi, S., Hemmi, N., et al. Galectin-3-positive cell infiltration in human diabetic nephropathy. Nephrol Dial Transplant 19 (2004), 602–607.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 602-607
    • Kikuchi, Y.1    Kobayashi, S.2    Hemmi, N.3
  • 113
    • 84920268893 scopus 로고    scopus 로고
    • The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries
    • Calvier, L., Martinez-Martinez, E., Miana, M., et al. The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries. JACC Heart Fail 3 (2015), 59–67.
    • (2015) JACC Heart Fail , vol.3 , pp. 59-67
    • Calvier, L.1    Martinez-Martinez, E.2    Miana, M.3
  • 114
    • 84884310000 scopus 로고    scopus 로고
    • Elevated galectin-3 precedes the development of CKD
    • O'Seaghdha, C.M., Hwang, S.J., Ho, J.E., et al. Elevated galectin-3 precedes the development of CKD. J Am Soc Nephrol 24 (2013), 1470–1477.
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1470-1477
    • O'Seaghdha, C.M.1    Hwang, S.J.2    Ho, J.E.3
  • 115
    • 84930923324 scopus 로고    scopus 로고
    • Galectin-3, renal function, and clinical outcomes: results from the LURIC and 4D studies
    • Drechsler, C., Delgado, G., Wanner, C., et al. Galectin-3, renal function, and clinical outcomes: results from the LURIC and 4D studies. J Am Soc Nephrol 26 (2015), 2213–2221.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 2213-2221
    • Drechsler, C.1    Delgado, G.2    Wanner, C.3
  • 116
    • 84924044033 scopus 로고    scopus 로고
    • Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy
    • Frenay, A.R., Yu, L., van der Velde, A.R., et al. Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy. Am J Physiol Renal Physiol 308 (2015), F500–F509.
    • (2015) Am J Physiol Renal Physiol , vol.308 , pp. F500-F509
    • Frenay, A.R.1    Yu, L.2    van der Velde, A.R.3
  • 117
    • 84893191346 scopus 로고    scopus 로고
    • Therapy of experimental NASH and fibrosis with galectin inhibitors
    • Traber, P.G., Eliezer Zomer, E., Therapy of experimental NASH and fibrosis with galectin inhibitors. PLoS One, 8, 2013, e83481.
    • (2013) PLoS One , vol.8 , pp. e83481
    • Traber, P.G.1    Eliezer Zomer, E.2
  • 118
    • 84885155926 scopus 로고    scopus 로고
    • Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease
    • Traber, P.G., Chou, H., Zomer, E., et al. Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS One, 8, 2013, e75361.
    • (2013) PLoS One , vol.8 , pp. e75361
    • Traber, P.G.1    Chou, H.2    Zomer, E.3
  • 119
    • 84927788389 scopus 로고    scopus 로고
    • Early phase 1 clinical trial results of GR-MD-02, a galectin-3 inhibitor, in patients having non-alcoholic steatohepatitis (NASH) with advanced fibrosis (abstr 57). November 7-11, 2014; Boston, Massachusetts
    • Harrison, S.A., Early phase 1 clinical trial results of GR-MD-02, a galectin-3 inhibitor, in patients having non-alcoholic steatohepatitis (NASH) with advanced fibrosis (abstr 57). November 7-11, 2014; Boston, Massachusetts. Hepatology, 60, 2014, 225A.
    • (2014) Hepatology , vol.60 , pp. 225A
    • Harrison, S.A.1
  • 120
    • 84874329045 scopus 로고    scopus 로고
    • Increased adiposity, dysregulated glucose metabolism and systemic inflammation in galectin-3 KO mice
    • Pang, J., Increased adiposity, dysregulated glucose metabolism and systemic inflammation in galectin-3 KO mice. PLoS One, 8, 2013, e57915.
    • (2013) PLoS One , vol.8 , pp. e57915
    • Pang, J.1
  • 121
    • 84884680414 scopus 로고    scopus 로고
    • Rho kinase inhibition in diabetic kidney disease
    • Komers, R., Rho kinase inhibition in diabetic kidney disease. Br J Clin Pharmacol 76 (2013), 551–559.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 551-559
    • Komers, R.1
  • 122
    • 84975747692 scopus 로고    scopus 로고
    • Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes
    • Hirsova, P., Ibrahim, S.H., Krishnan, A., et al. Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes. Gastroenterology 150 (2016), 956–967.
    • (2016) Gastroenterology , vol.150 , pp. 956-967
    • Hirsova, P.1    Ibrahim, S.H.2    Krishnan, A.3
  • 123
    • 84892570134 scopus 로고    scopus 로고
    • Fasudil hydrochloride hydrate, a rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes
    • Zhou, H., Fang, C., Zhang, L., et al. Fasudil hydrochloride hydrate, a rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes. Chin Med J (Engl) 127 (2014), 225–231.
    • (2014) Chin Med J (Engl) , vol.127 , pp. 225-231
    • Zhou, H.1    Fang, C.2    Zhang, L.3
  • 124
    • 84957558704 scopus 로고    scopus 로고
    • ROCK1 induces endothelial-to-mesenchymal transition in glomeruli to aggravate albuminuria in diabetic nephropathy
    • Peng, H., Li, Y., Wang, C., et al. ROCK1 induces endothelial-to-mesenchymal transition in glomeruli to aggravate albuminuria in diabetic nephropathy. Sci Rep, 6, 2016, 20304.
    • (2016) Sci Rep , vol.6 , pp. 20304
    • Peng, H.1    Li, Y.2    Wang, C.3
  • 125
    • 84946763088 scopus 로고    scopus 로고
    • Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction
    • Baba, I., Egi, Y., Utsumi, H., et al. Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction. Mol Med Rep 12 (2015), 8010–8020.
    • (2015) Mol Med Rep , vol.12 , pp. 8010-8020
    • Baba, I.1    Egi, Y.2    Utsumi, H.3
  • 126
    • 84913580141 scopus 로고    scopus 로고
    • Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism
    • Zanin-Zhorov, A., Weiss, J.M., Nyuydzefe, M.S., et al. Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proc Natl Acad Sci U S A 111 (2014), 16814–16819.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 16814-16819
    • Zanin-Zhorov, A.1    Weiss, J.M.2    Nyuydzefe, M.S.3
  • 127
    • 84924591524 scopus 로고    scopus 로고
    • ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration
    • Zandi, S., Nakao, S., Chun, K.H., et al. ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration. Cell Rep 10 (2015), 1173–1186.
    • (2015) Cell Rep , vol.10 , pp. 1173-1186
    • Zandi, S.1    Nakao, S.2    Chun, K.H.3
  • 128
    • 84961994366 scopus 로고    scopus 로고
    • New insight into the anti-liver fibrosis effect of multitargeted tyrosine kinase inhibitors: from molecular target to clinical trials
    • Qu, K., Huang, Z., Lin, T., et al. New insight into the anti-liver fibrosis effect of multitargeted tyrosine kinase inhibitors: from molecular target to clinical trials. Front Pharmacol, 6, 2016, 300.
    • (2016) Front Pharmacol , vol.6 , pp. 300
    • Qu, K.1    Huang, Z.2    Lin, T.3
  • 129
    • 84896493202 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma
    • Fuchs, B.C., Hoshida, Y., Fujii, T., et al. Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology 59 (2014), 1577–1590.
    • (2014) Hepatology , vol.59 , pp. 1577-1590
    • Fuchs, B.C.1    Hoshida, Y.2    Fujii, T.3
  • 130
    • 84954191252 scopus 로고    scopus 로고
    • EGFR signaling in renal fibrosis
    • Zhuang, S., Liu, N., EGFR signaling in renal fibrosis. Kidney Int(Suppl 4), 2014, 70–74.
    • (2014) Kidney Int , pp. 70-74
    • Zhuang, S.1    Liu, N.2
  • 131
    • 84954288448 scopus 로고    scopus 로고
    • Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker
    • Ju, W., Nair, V., Smith, S., et al. Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker. Sci Transl Med, 7, 2015, 316ra193.
    • (2015) Sci Transl Med , vol.7 , pp. 316ra193
    • Ju, W.1    Nair, V.2    Smith, S.3
  • 132
    • 84969920394 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition with erlotinib ameliorates anti-Thy 1.1-induced experimental glomerulonephritis
    • Rintala, J.M., Savikko, J., Rintala, S.E., et al. Epidermal growth factor receptor inhibition with erlotinib ameliorates anti-Thy 1.1-induced experimental glomerulonephritis. J Nephrol 29 (2016), 359–365.
    • (2016) J Nephrol , vol.29 , pp. 359-365
    • Rintala, J.M.1    Savikko, J.2    Rintala, S.E.3
  • 133
    • 84946202841 scopus 로고    scopus 로고
    • Plumbagin ameliorates CCl 4-induced hepatic fibrosis in rats via the epidermal growth factor receptor signaling pathway
    • Chen, S., Chen, Y., Chen, B., et al. Plumbagin ameliorates CCl 4-induced hepatic fibrosis in rats via the epidermal growth factor receptor signaling pathway. Evid Based Complement Alternat Med, 2015, 2015, 645727.
    • (2015) Evid Based Complement Alternat Med , vol.2015 , pp. 645727
    • Chen, S.1    Chen, Y.2    Chen, B.3


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