Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy

Metabolism: Clinical and Experimental

Volumn 63, Issue 5, 2014, Pages 716-726

  Xu, Ying ^a   Huang, Jing ^a   Xin, Wei ^a   Chen, Liyong ^b   Zhao, Xu ^a   Lv, Zhimei ^a   Liu, Yi ^b,c   Wan, Qiang ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Academy of Clinical Medicine   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Diabetes; Epithelial to mesenchymal transition; Lipotoxicity; Proximal tubular epithelial cells; oxidation

Indexed keywords

ACETYL COA CARBOXYLASE 2; ACETYL COENZYME A CARBOXYLASE; ALPHA SMOOTH MUSCLE ACTIN; GLUCOSE; MALONYL COENZYME A; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CELL CULTURE; CELL FUNCTION; CELL STRUCTURE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; EPITHELIAL MESENCHYMAL TRANSITION; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INTERVENTION STUDY; KIDNEY PROXIMAL TUBULE; LENTIVIRINAE; LIPID METABOLISM; LIPID STORAGE; LIPOTOXICITY; PHENOTYPE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; VIRAL GENE DELIVERY SYSTEM;

DIABETES; EPITHELIAL TO MESENCHYMAL TRANSITION; LIPOTOXICITY; PROXIMAL TUBULAR EPITHELIAL CELLS; Β-OXIDATION;

ACETYL-COA CARBOXYLASE; CELLS, CULTURED; CYTOPROTECTION; DIABETIC NEPHROPATHIES; EPITHELIAL-MESENCHYMAL TRANSITION; FATTY ACIDS; GENE SILENCING; GENETIC THERAPY; GLUCOSE; HUMANS; LIPID METABOLISM; MALONYL COENZYME A; TRIGLYCERIDES;

EID: 84899426857     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.02.010     Document Type: Article

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