Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Wu, Hao Jia ^a   Yiu, Wai Han ^a   Li, Rui Xi ^a   Wong, Dickson W L ^a   Leung, Joseph C K ^a   Chan, Loretta Y Y ^a   Zhang, Yuelin ^a   Lian, Qizhou ^a   Lin, Miao ^a   Tse, Hung Fat ^a   Lai, Kar Neng ^a   Tang, Sydney C W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; RECOMBINANT PROTEIN; RECOMBINANT SCATTER FACTOR; RECOMBINANT TSG 6; SCATTER FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; ACTA2 PROTEIN, HUMAN; ACTIN; ALBUMINOID; CCL2 PROTEIN, HUMAN; CCL5 PROTEIN, HUMAN; CELL ADHESION MOLECULE; HGF PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; TNFAIP6 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL ACTIVITY; CELL DIFFERENTIATION; CELL LINEAGE; CELL STIMULATION; COCULTURE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; GENE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; MESENCHYMAL STEM CELL; MOUSE; NEPHRITIS; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEINURIA; SIGNAL TRANSDUCTION; TNFALPHA STIMULATING GENE; TRANSCRIPTION REGULATION; UPREGULATION; BONE MARROW CELL; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE;

ACTINS; ALBUMINS; BONE MARROW CELLS; CELL ADHESION MOLECULES; CHEMOKINE CCL2; CHEMOKINE CCL5; COCULTURE TECHNIQUES; COLLAGEN TYPE IV; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; GENE EXPRESSION REGULATION; HEPATOCYTE GROWTH FACTOR; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; KIDNEY TUBULES, PROXIMAL; MESENCHYMAL STROMAL CELLS; NF-KAPPA B; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84898663936     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090883     Document Type: Article

References (42)

1. Semedo P, Correa-Costa M, Antonio Cenedeze M, Maria Avancini Costa Malheiros D, Antonia dos Reis M, et al. (2009) Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model. Stem Cells 27: 3063-3073.
2. Ninichuk V, Gross O, Segerer S, Hoffmann R, Radomska E, et al. (2006) Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice. Kidney Int 70: 121-129. (Pubitemid 44000128)
3. Asanuma H, Vanderbrink BA, Campbell MT, Hile KL, Zhang H, et al. (2011) Arterially delivered mesenchymal stem cells prevent obstruction-induced renal fibrosis. J Surg Res 168: e51-59.
4. Ezquer FE, Ezquer ME, Parrau DB, Carpio D, Yanez AJ, et al. (2008) Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice. Biol Blood Marrow Transplant 14: 631-640.
5. Lee RH, Seo MJ, Reger RL, Spees JL, Pulin AA, et al. (2006) Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci U S A 103: 17438-17443. (Pubitemid 44788987)
6. Imberti B, Morigi M, Tomasoni S, Rota C, Corna D, et al. (2007) Insulin-like growth factor-1 sustains stem cell mediated renal repair. J Am Soc Nephrol 18: 2921-2928. (Pubitemid 350058399)
7. Journal of Experimental MedicineTogel F, Zhang P, Hu Z, Westenfelder C (2009) VEGF is a mediator of the renoprotective effects of multipotent marrow stromal cells in acute kidney injury. J Cell Mol Med 13: 2109-2114.
8. Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, et al. (2009) Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 20: 1053-1067.
9. Lai KN, Chan LY, Tang SC, Leung JC (2006) Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells. Nephrol Dial Transplant 21: 1188-1197.
10. Tang S, Sheerin NS, Zhou W, Brown Z, Sacks SH (1999) Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells. J Am Soc Nephrol 10: 69-76. (Pubitemid 29034944)
11. Tang S, Lai KN, Chan TM, Lan HY, Ho SK, et al. (2001) Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells. Am J Kidney Dis 37: 94-103. (Pubitemid 32055024)
12. Tang S, Leung JC, Tsang AW, Lan HY, Chan TM, et al. (2002) Transferrin upregulates chemokine synthesis by human proximal tubular epithelial cells: implication on mechanism of tubuloglomerular communication in glomerulopathic proteinura. Kidney Int 61: 1655-1665. (Pubitemid 34437919)
13. Lai KN, Leung JC, Chan LY, Guo H, Tang SC (2007) Interaction between proximal tubular epithelial cells and infiltrating monocytes/T cells in the proteinuric state. Kidney Int 71: 526-538. (Pubitemid 46402860)
14. Tang S, Leung JC, Abe K, Chan KW, Chan LY, et al. (2003) Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest 111: 515-527. (Pubitemid 36228009)
15. Chan LY, Leung JC, Tsang AW, Tang SC, Lai KN (2005) Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy. Kidney Int 67: 602-612. (Pubitemid 40139851)
16. Tang SC, Leung JC, Chan LY, Tsang AW, Lai KN (2006) Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonist. J Am Soc Nephrol 17: 1633-1643. (Pubitemid 43794666)
17. Tang SC, Chan LY, Leung JC, Cheng AS, Chan KW, et al. (2010) Bradykinin and high glucose promote renal tubular inflammation. Nephrol Dial Transplant 25: 698-710.
18. Lin M, Yiu WH, Wu HJ, Chan LY, Leung JC, et al. (2012) Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. J Am Soc Nephrol 23: 86-102.
19. Lin M, Yiu WH, Li RX, Wu HJ, Wong DW, et al. (2013) The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy. Kidney Int 83: 887-900.
20. Zhang Y, Liao S, Yang M, Liang X, Poon MW, et al. (2012) Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension. Cell Transplant 21: 2225-2239.
21. Miura M, Miura Y, Padilla-Nash HM, Molinolo AA, Fu B, et al. (2006) Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells 24: 1095-1103. (Pubitemid 44464742)
22. Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, et al. (2011) Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-gamma and TNF-alpha. Nat Med 17: 1594-1601.
23. Donadelli R, Zanchi C, Morigi M, Buelli S, Batani C, et al. (2003) Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB- and p38 mitogen-activated protein kinase-dependent pathways. J Am Soc Nephrol 14: 2436-2446. (Pubitemid 37169329)
24. Abbate M, Zoja C, Corna D, Rottoli D, Zanchi C, et al. (2008) Complement-mediated dysfunction of glomerular filtration barrier accelerates progressive renal injury. J Am Soc Nephrol 19: 1158-1167.
25. Molitoris BA, Wagner MC (1996) Surface membrane polarity of proximal tubular cells: alterations as a basis for malfunction. Kidney Int 49: 1592-1597. (Pubitemid 26186586)
26. Lee JY, Chang JW, Yang WS, Kim SB, Park SK, et al. (2011) Albumin-induced epithelial-mesenchymal transition and ER stress are regulated through a common ROS-c-Src kinase-mTOR pathway: effect of imatinib mesylate. Am J Physiol Renal Physiol 300: F1214-1222.
27. Lee JH, Kim JH, Kim JS, Chang JW, Kim SB, et al. (2013) AMP-activated protein kinase inhibits TGF-beta-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition. Am J Physiol Renal Physiol 304: F686-697.
28. Eddy AA, Kim H, Lopez-Guisa J, Oda T, Soloway PD (2000) Interstitial fibrosis in mice with overload proteinuria: deficiency of TIMP-1 is not protective. Kidney Int 58: 618-628. (Pubitemid 30620011)
29. Levey AS, Atkins R, Coresh J, Cohen EP, Collins AJ, et al. (2007) Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes. Kidney Int 72: 247-259. (Pubitemid 47172384)
30. Nath KA (1992) Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20: 1-17.
31. de Zeeuw D, Remuzzi G, Parving HH, Keane WF, Zhang Z, et al. (2004) Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL. Kidney Int 65: 2309-2320. (Pubitemid 38670018)
32. Ruggenenti P, Perna A, Mosconi L, Pisoni R, Remuzzi G (1998) Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. "Gruppo Italiano di Studi Epidemiologici in Nefrologia" (GISEN). Kidney Int 53: 1209-1216. (Pubitemid 28316881)
33. Tang SC, Tang AW, Wong SS, Leung JC, Ho YW, et al. (2010) Long-term study of mycophenolate mofetil treatment in IgA nephropathy. Kidney Int 77: 543-549.
34. Neuss S, Becher E, Woltje M, Tietze L, Jahnen-Dechent W (2004) Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells 22: 405-414. (Pubitemid 38736624)
35. Duan HF, Wu CT, Wu DL, Lu Y, Liu HJ, et al. (2003) Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor. Mol Ther 8: 467-474. (Pubitemid 37161468)
36. Cai L, Johnstone BH, Cook TG, Liang Z, Traktuev D, et al. (2007) Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization. Stem Cells 25: 3234-3243. (Pubitemid 350294449)
37. Gong R, Rifai A, Tolbert EM, Biswas P, Centracchio JN, et al. (2004) Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES. J Am Soc Nephrol 15: 2868-2881. (Pubitemid 41103396)
38. Giannopoulou M, Dai C, Tan X, Wen X, Michalopoulos GK, et al. (2008) Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol 173: 30-41. (Pubitemid 351947953)
39. Choi H, Lee RH, Bazhanov N, Oh JY, Prockop DJ (2011) Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages. Blood 118: 330-338.
40. Lee RH, Pulin AA, Seo MJ, Kota DJ, Ylostalo J, et al. (2009) Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 5: 54-63.
41. Roddy GW, Oh JY, Lee RH, Bartosh TJ, Ylostalo J, et al. (2011) Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6. Stem Cells 29: 1572-1579.
42. Wang N, Li Q, Zhang L, Lin H, Hu J, et al. (2012) Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6. PLoS One 7: e43768.