메뉴 건너뛰기




Volumn 20, Issue 2, 2014, Pages 569-577

Effects of pentoxifylline on nonalcoholic fatty liver disease: A meta-analysis

Author keywords

Meta analysis; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Pentoxifylline

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; INTERLEUKIN 6; PENTOXIFYLLINE; PLACEBO; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; URSODEOXYCHOLIC ACID; BIOLOGICAL MARKER;

EID: 84892838265     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i2.569     Document Type: Article
Times cited : (98)

References (41)
  • 1
    • 34249668818 scopus 로고    scopus 로고
    • Epidemiology and natural history of NAFLD and NASH
    • [PMID: 17544968 DOI: 10.1016/j.cld.2007.02.009]
    • Ong JP, Younossi ZM. Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis 2007; 11: 1-16, vii [PMID: 17544968 DOI: 10.1016/j.cld.2007.02.009]
    • (2007) Clin Liver Dis , vol.11
    • Ong, J.P.1    Younossi, Z.M.2
  • 2
    • 24044536090 scopus 로고    scopus 로고
    • Recent concepts in non-alcoholic fatty liver disease
    • [PMID: 16108837 DOI: 10.1111/j.1464-5491.2005.01748.x]
    • Adams LA, Angulo P. Recent concepts in non-alcoholic fatty liver disease. Diabet Med 2005; 22: 1129-1133 [PMID: 16108837 DOI: 10.1111/j.1464-5491.2005.01748.x]
    • (2005) Diabet Med , vol.22 , pp. 1129-1133
    • Adams, L.A.1    Angulo, P.2
  • 3
    • 0035883890 scopus 로고    scopus 로고
    • Metformin in non-alcoholic steatohepatitis
    • [PMID: 11567710 DOI: 10.1016/ S0140-6736(01)06042-1]
    • Marchesini G, Brizi M, Bianchi G, Tomassetti S, Zoli M, Melchionda N. Metformin in non-alcoholic steatohepatitis. Lancet 2001; 358: 893-894 [PMID: 11567710 DOI: 10.1016/ S0140-6736(01)06042-1]
    • (2001) Lancet , vol.358 , pp. 893-894
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3    Tomassetti, S.4    Zoli, M.5    Melchionda, N.6
  • 6
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • [PMID: 10453959 DOI: 10.1016/S0168-8278(99)80243-8]
    • Basaranoglu M, Acbay O, Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol 1999; 31: 384 [PMID: 10453959 DOI: 10.1016/S0168-8278(99)80243-8]
    • (1999) J Hepatol , vol.31 , pp. 384
    • Basaranoglu, M.1    Acbay, O.2    Sonsuz, A.3
  • 7
    • 2342456307 scopus 로고    scopus 로고
    • Pravastatin in patients with nonalcoholic steatohepatitis: Results of a pilot study
    • [PMID: 15135271 DOI: 10.1016/j.atherosclerosis.2004.01.008]
    • Rallidis LS, Drakoulis CK, Parasi AS. Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study. Atherosclerosis 2004; 174: 193-196 [PMID: 15135271 DOI: 10.1016/j.atherosclerosis.2004.01.008]
    • (2004) Atherosclerosis , vol.174 , pp. 193-196
    • Rallidis, L.S.1    Drakoulis, C.K.2    Parasi, A.S.3
  • 8
    • 47149086771 scopus 로고    scopus 로고
    • Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial
    • [PMID: 18537181 DOI: 10.1002/ hep.22336]
    • Nobili V, Manco M, Devito R, Di Ciommo V, Comparcola D, Sartorelli MR, Piemonte F, Marcellini M, Angulo P. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial. Hepatology 2008; 48: 119-128 [PMID: 18537181 DOI: 10.1002/ hep.22336]
    • (2008) Hepatology , vol.48 , pp. 119-128
    • Nobili, V.1    Manco, M.2    Devito, R.3    Di Ciommo, V.4    Comparcola, D.5    Sartorelli, M.R.6    Piemonte, F.7    Marcellini, M.8    Angulo, P.9
  • 9
    • 0242487635 scopus 로고    scopus 로고
    • N-acetylcysteine in the treatment of non-alcoholic steatohepatitis
    • [PMID: 12974918 DOI: 10.1046/ j.1440-1746.2003.03156.x]
    • Pamuk GE, Sonsuz A. N-acetylcysteine in the treatment of non-alcoholic steatohepatitis. J Gastroenterol Hepatol 2003; 18: 1220-1221 [PMID: 12974918 DOI: 10.1046/ j.1440-1746.2003.03156.x]
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1220-1221
    • Pamuk, G.E.1    Sonsuz, A.2
  • 10
    • 61549116530 scopus 로고    scopus 로고
    • Effect of rimonabant on the high-triglyceride/ low-HDLcholesterol dyslipidemia, intraabdominal adiposity, and liver fat: The ADAGIO-Lipids trial
    • [PMID: 19112166 DOI: 10.1161/ATVBAHA. 108.176362]
    • Després JP, Ross R, Boka G, Alméras N, Lemieux I. Effect of rimonabant on the high-triglyceride/ low-HDLcholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial. Arterioscler Thromb Vasc Biol 2009; 29: 416-423 [PMID: 19112166 DOI: 10.1161/ATVBAHA. 108.176362]
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 416-423
    • Després, J.P.1    Ross, R.2    Boka, G.3    Alméras, N.4    Lemieux, I.5
  • 11
    • 77953229020 scopus 로고    scopus 로고
    • L-carnitine supplementation to diet: A new tool in treatment of nonalcoholic steatohepatitis--a randomized and controlled clinical trial
    • [PMID: 20068559 DOI: 10.1038/ajg.2009.719]
    • Malaguarnera M, Gargante MP, Russo C, Antic T, Vacante M, Malaguarnera M, Avitabile T, Li Volti G, Galvano F. L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis--a randomized and controlled clinical trial. Am J Gastroenterol 2010; 105: 1338-1345 [PMID: 20068559 DOI: 10.1038/ajg.2009.719]
    • (2010) Am J Gastroenterol , vol.105 , pp. 1338-1345
    • Malaguarnera, M.1    Gargante, M.P.2    Russo, C.3    Antic, T.4    Vacante, M.5    Malaguarnera, M.6    Avitabile, T.7    Li Volti, G.8    Galvano, F.9
  • 14
    • 84876725499 scopus 로고    scopus 로고
    • Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study
    • [PMID: 23396737]
    • Wong VW, Won GL, Chim AM, Chu WC, Yeung DK, Li KC, Chan HL. Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study. Ann Hepatol 2013; 12: 256-262 [PMID: 23396737]
    • (2013) Ann Hepatol , vol.12 , pp. 256-262
    • Wong, V.W.1    Won, G.L.2    Chim, A.M.3    Chu, W.C.4    Yeung, D.K.5    Li, K.C.6    Chan, H.L.7
  • 15
    • 0028265114 scopus 로고
    • Pentoxifylline
    • [PMID: 8157787 DOI: 10.1016/ S0190-9622(94)70069-9]
    • Samlaska CP, Winfield EA. Pentoxifylline. J Am Acad Dermatol 1994; 30: 603-621 [PMID: 8157787 DOI: 10.1016/ S0190-9622(94)70069-9]
    • (1994) J Am Acad Dermatol , vol.30 , pp. 603-621
    • Samlaska, C.P.1    Winfield, E.A.2
  • 16
    • 0026827946 scopus 로고
    • Pharmacological approaches to the treatment of intermittent claudication
    • [PMID: 1596595 DOI: 10.2165/0000251 2-199202020-00006]
    • Bevan EG, Waller PC, Ramsay LE. Pharmacological approaches to the treatment of intermittent claudication. Drugs Aging 1992; 2: 125-136 [PMID: 1596595 DOI: 10.2165/0000251 2-199202020-00006]
    • (1992) Drugs Aging , vol.2 , pp. 125-136
    • Bevan, E.G.1    Waller, P.C.2    Ramsay, L.E.3
  • 17
    • 77949312039 scopus 로고    scopus 로고
    • Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways
    • [PMID: 19294507 DOI: 10.1007/s10620-009-0780-x]
    • Hepgül G, Tanrikulu S, Unalp HR, Akguner T, Erbil Y, Olgaç V, Ademoǧlu E. Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways. Dig Dis Sci 2010; 55: 617-625 [PMID: 19294507 DOI: 10.1007/s10620-009-0780-x]
    • (2010) Dig Dis Sci , vol.55 , pp. 617-625
    • Hepgül, G.1    Tanrikulu, S.2    Unalp, H.R.3    Akguner, T.4    Erbil, Y.5    Olgaç, V.6    Ademoǧlu, E.7
  • 18
    • 0025463360 scopus 로고
    • The effects of pentoxifylline on lipopolysaccharide (LPS) fever, plasma interleukin 6 (IL 6), and tumor necrosis factor (TNF) in the rat
    • [PMID: 2104230 DOI: 10.1016/1043-4666(90) 90032-O]
    • LeMay LG, Vander AJ, Kluger MJ. The effects of pentoxifylline on lipopolysaccharide (LPS) fever, plasma interleukin 6 (IL 6), and tumor necrosis factor (TNF) in the rat. Cytokine 1990; 2: 300-306 [PMID: 2104230 DOI: 10.1016/1043-4666(90) 90032-O]
    • (1990) Cytokine , vol.2 , pp. 300-306
    • LeMay, L.G.1    Vander, A.J.2    Kluger, M.J.3
  • 19
    • 0026046962 scopus 로고
    • Effects of pentoxifylline in endotoxinemia in human volunteers
    • [PMID: 1924429]
    • Zabel P, Schönharting MM, Schade UF, Schlaak M. Effects of pentoxifylline in endotoxinemia in human volunteers. Prog Clin Biol Res 1991; 367: 207-213 [PMID: 1924429]
    • (1991) Prog Clin Biol Res , vol.367 , pp. 207-213
    • Zabel, P.1    Schönharting, M.M.2    Schade, U.F.3    Schlaak, M.4
  • 20
    • 34548494820 scopus 로고    scopus 로고
    • Effects of pentoxifylline on TNF-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis
    • [PMID: 17436095 DOI: 10.1007/s10620-006-9723-y]
    • Duman DG, Ozdemir F, Birben E, Keskin O, Ekşioǧlu-Demiralp E, Celikel C, Kalayci O, Kalayci C. Effects of pentoxifylline on TNF-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis. Dig Dis Sci 2007; 52: 2520-2524 [PMID: 17436095 DOI: 10.1007/s10620-006-9723-y]
    • (2007) Dig Dis Sci , vol.52 , pp. 2520-2524
    • Duman, D.G.1    Ozdemir, F.2    Birben, E.3    Keskin, O.4    Ekşioǧlu-Demiralp, E.5    Celikel, C.6    Kalayci, O.7    Kalayci, C.8
  • 21
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoholic steatohepatitis
    • [PMID: 11078773 DOI: 10.1056/NEJM200011163432007]
    • Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 2000; 343: 1467-1476 [PMID: 11078773 DOI: 10.1056/NEJM200011163432007]
    • (2000) N Engl J Med , vol.343 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 22
    • 0035121972 scopus 로고    scopus 로고
    • Is bacterial ash the flash that ignites NASH?
    • [PMID: 11156629 DOI: 10.1136/gut.48.2.206]
    • Farrell GC. Is bacterial ash the flash that ignites NASH? Gut 2001; 48: 148-149 [PMID: 11156629 DOI: 10.1136/gut.48.2.206]
    • (2001) Gut , vol.48 , pp. 148-149
    • Farrell, G.C.1
  • 23
    • 69749088832 scopus 로고    scopus 로고
    • A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)
    • [PMID: 19669304 DOI: 10.1007/s12072-008-9058-1]
    • Lee YM, Sutedja DS, Wai CT, Dan YY, Aung MO, Zhou L, Cheng CL, Wee A, Lim SG. A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH). Hepatol Int 2008; 2: 196-201 [PMID: 19669304 DOI: 10.1007/s12072-008-9058-1]
    • (2008) Hepatol Int , vol.2 , pp. 196-201
    • Lee, Y.M.1    Sutedja, D.S.2    Wai, C.T.3    Dan, Y.Y.4    Aung, M.O.5    Zhou, L.6    Cheng, C.L.7    Wee, A.8    Lim, S.G.9
  • 24
    • 0742318861 scopus 로고    scopus 로고
    • The comparative effects of pentoxifylline and ursodeoxycholic acid on IL-1 β, Il-6, Il-8 and TNF-α levels in nonalcoholic fatty liver
    • Tuncer İ, Uygan İ, Dülger H, Türkdoǧan K, Şekeroǧlu MR, Kösem M. The comparative effects of pentoxifylline and ursodeoxycholic acid on IL-1 β, Il-6, Il-8 and TNF-α levels in nonalcoholic fatty liver. E J Med 2003; 8: 27-32
    • (2003) E J Med , vol.8 , pp. 27-32
    • Tuncer, I.1    Uygan, I.2    Dülger, H.3    Türkdoǧan, K.4    Şekeroǧlu, M.R.5    Kösem, M.6
  • 25
    • 34047271926 scopus 로고    scopus 로고
    • Therapeutic options in nonalcoholic steatohepatitis (NASH). Are all agents alike? Results of a preliminary study
    • [PMID: 17410287]
    • Georgescu EF, Georgescu M. Therapeutic options in nonalcoholic steatohepatitis (NASH). Are all agents alike? Results of a preliminary study. J Gastrointestin Liver Dis 2007; 16: 39-46 [PMID: 17410287]
    • (2007) J Gastrointestin Liver Dis , vol.16 , pp. 39-46
    • Georgescu, E.F.1    Georgescu, M.2
  • 26
    • 80055028155 scopus 로고    scopus 로고
    • Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial
    • [PMID: 21748765 DOI: 10.1002/hep.24544]
    • Zein CO, Yerian LM, Gogate P, Lopez R, Kirwan JP, Feldstein AE, McCullough AJ. Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. Hepatology 2011; 54: 1610-1619 [PMID: 21748765 DOI: 10.1002/hep.24544]
    • (2011) Hepatology , vol.54 , pp. 1610-1619
    • Zein, C.O.1    Yerian, L.M.2    Gogate, P.3    Lopez, R.4    Kirwan, J.P.5    Feldstein, A.E.6    McCullough, A.J.7
  • 28
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • [PMID: 16250043 DOI: 10.1002/ hep.20920]
    • Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005; 42: 987-1000 [PMID: 16250043 DOI: 10.1002/ hep.20920]
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 29
    • 80052726161 scopus 로고    scopus 로고
    • Decrease of aminotransferase levels in obese women is related to body weight reduction, irrespective of type of diet
    • [PMID: 21911890]
    • Rodríguez-Hernández H, Cervantes-Huerta M, Rodríguez-Moran M, Guerrero-Romero F. Decrease of aminotransferase levels in obese women is related to body weight reduction, irrespective of type of diet. Ann Hepatol 2011; 10: 486-492 [PMID: 21911890]
    • (2011) Ann Hepatol , vol.10 , pp. 486-492
    • Rodríguez-Hernández, H.1    Cervantes-Huerta, M.2    Rodríguez-Moran, M.3    Guerrero-Romero, F.4
  • 30
    • 33748179703 scopus 로고    scopus 로고
    • Weight loss as a treatment for nonalcoholic fatty liver disease
    • [PMID: 16540766]
    • Clark JM. Weight loss as a treatment for nonalcoholic fatty liver disease. J Clin Gastroenterol 2006; 40 Suppl 1: S39-S43 [PMID: 16540766]
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL. 1
    • Clark, J.M.1
  • 31
    • 67650901984 scopus 로고    scopus 로고
    • Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: A systematic review
    • [PMID: 19412008 DOI: 10.1097/MPG.0b013e31818e04d1]
    • Socha P, Horvath A, Vajro P, Dziechciarz P, Dhawan A, Szajewska H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. J Pediatr Gastroenterol Nutr 2009; 48: 587-596 [PMID: 19412008 DOI: 10.1097/MPG.0b013e31818e04d1]
    • (2009) J Pediatr Gastroenterol Nutr , vol.48 , pp. 587-596
    • Socha, P.1    Horvath, A.2    Vajro, P.3    Dziechciarz, P.4    Dhawan, A.5    Szajewska, H.6
  • 32
    • 79953763871 scopus 로고    scopus 로고
    • Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease
    • [PMID: 21477300 DOI: 10.1186/1476-511X-10-49]
    • Li W, Zheng L, Sheng C, Cheng X, Qing L, Qu S. Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease. Lipids Health Dis 2011; 10: 49 [PMID: 21477300 DOI: 10.1186/1476-511X-10-49]
    • (2011) Lipids Health Dis , vol.10 , pp. 49
    • Li, W.1    Zheng, L.2    Sheng, C.3    Cheng, X.4    Qing, L.5    Qu, S.6
  • 34
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: A key component of the obesity-diabetes link
    • [PMID: 7926300 DOI: 10.2337/diabetes. 43.11.1271]
    • Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 1994; 43: 1271-1278 [PMID: 7926300 DOI: 10.2337/diabetes. 43.11.1271]
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 35
    • 0038039463 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha: A key regulator of adipose tissue mass
    • [PMID: 12773114 DOI: 10.1677/joe.0.1770351]
    • Warne JP. Tumour necrosis factor alpha: a key regulator of adipose tissue mass. J Endocrinol 2003; 177: 351-355 [PMID: 12773114 DOI: 10.1677/joe.0.1770351]
    • (2003) J Endocrinol , vol.177 , pp. 351-355
    • Warne, J.P.1
  • 37
    • 79952231349 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: Distinct clinicopathologic meanings
    • [PMID: 21319198 DOI: 10.1002/hep.24127]
    • Brunt EM, Kleiner DE, Wilson LA, Belt P, Neuschwander-Tetri BA. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology 2011; 53: 810-820 [PMID: 21319198 DOI: 10.1002/hep.24127]
    • (2011) Hepatology , vol.53 , pp. 810-820
    • Brunt, E.M.1    Kleiner, D.E.2    Wilson, L.A.3    Belt, P.4    Neuschwander-Tetri, B.A.5
  • 38
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot study
    • [PMID: 8675165 DOI: 10.1002/hep.510230624]
    • Laurin J, Lindor KD, Crippin JS, Gossard A, Gores GJ, Ludwig J, Rakela J, McGill DB. Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study. Hepatology 1996; 23: 1464-1467 [PMID: 8675165 DOI: 10.1002/hep.510230624]
    • (1996) Hepatology , vol.23 , pp. 1464-1467
    • Laurin, J.1    Lindor, K.D.2    Crippin, J.S.3    Gossard, A.4    Gores, G.J.5    Ludwig, J.6    Rakela, J.7    McGill, D.B.8
  • 39
    • 0029972267 scopus 로고    scopus 로고
    • Effect of taurine on the fatty liver of children with simple obesity
    • [PMID: 8915401 DOI: 10.1007/978-1-4899-0182-8_67]
    • Obinata K, Maruyama T, Hayashi M, Watanabe T, Nittono H. Effect of taurine on the fatty liver of children with simple obesity. Adv Exp Med Biol 1996; 403: 607-613 [PMID: 8915401 DOI: 10.1007/978-1-4899-0182-8_67]
    • (1996) Adv Exp Med Biol , vol.403 , pp. 607-613
    • Obinata, K.1    Maruyama, T.2    Hayashi, M.3    Watanabe, T.4    Nittono, H.5
  • 40
    • 0034049790 scopus 로고    scopus 로고
    • Lack of efficacy of ursodeoxycholic acid for the treatment of liver abnormalities in obese children
    • [PMID: 10839869]
    • Vajro P, Franzese A, Valerio G, Iannucci MP, Aragione N. Lack of efficacy of ursodeoxycholic acid for the treatment of liver abnormalities in obese children. J Pediatr 2000; 136: 739-743 [PMID: 10839869]
    • (2000) J Pediatr , vol.136 , pp. 739-743
    • Vajro, P.1    Franzese, A.2    Valerio, G.3    Iannucci, M.P.4    Aragione, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.