GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial

Diabetologia

Volumn 58, Issue 8, 2015, Pages 1759-1768

  Gögebakan, Özlem ^a,b   Osterhoff, Martin A ^a,b   Schüler, Rita ^a   Pivovarova, Olga ^a,b   Kruse, Michael ^a   Seltmann, Anne Cathrin ^a   Mosig, Alexander S ^c   Rudovich, Natalia ^a,b   Nauck, Michael ^d   Pfeiffer, Andreas F H ^a,b  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

^d Diabeteszentrum Bad Lauter berg   (Germany)

Author keywords

Adipose tissue; GIP; Inflammation; MCP 1

Indexed keywords

CHEMOKINE; CYCLIC AMP; GASTRIC INHIBITORY POLYPEPTIDE; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; SODIUM CHLORIDE; INSULIN;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGED; ANIMAL CELL; ARTICLE; CALORIC INTAKE; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CROSSOVER PROCEDURE; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; HYPERINSULINEMIA; INFLAMMATION; MACROPHAGE; MALE; MICROARRAY ANALYSIS; MONOCYTE; MOUSE; NONHUMAN; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SUBCUTANEOUS FAT; TRANSCRIPTOMICS; ADOLESCENT; BLOOD; CELL CULTURE; DIET; DRUG EFFECTS; GENETICS; METABOLISM; MIDDLE AGED; SIGNAL TRANSDUCTION; YOUNG ADULT;

ADIPOCYTES; ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; CELLS, CULTURED; CHEMOKINE CCL2; CROSS-OVER STUDIES; DIET; GASTRIC INHIBITORY POLYPEPTIDE; GENE EXPRESSION; HUMANS; INFLAMMATION; INSULIN; MALE; MIDDLE AGED; OBESITY; SIGNAL TRANSDUCTION; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84937525579     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3618-4     Document Type: Article

References (37)

1. Xu H, Barnes GT, Yang Q et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821–1830
2. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808
3. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM (1994) Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest 94:1543–1549
4. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389:610–614
5. Sartipy P, Loskutoff DJ (2003) Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A 100:7265–7270
6. Suganami T, Nishida J, Ogawa Y (2005) A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 25:2062–2068
7. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH et al (2007) Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447:1116–1120
8. Arkan MC, Hevener AL, Greten FR et al (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191–198
9. Kamei N, Tobe K, Suzuki R et al (2006) Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281:26602–26614
10. Kanda H, Tateya S, Tamori Y et al (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494–1505
11. Weisberg SP, Hunter D, Huber R et al (2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116:115–124
12. Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V (1993) Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J Endocrinol 138:159–166
13. Jones IR, Owens DR, Luzio SD, Hayes TM (1989) Obesity is associated with increased post-prandial GIP levels which are not reduced by dietary restriction and weight loss. Diabete Metab 15:11–22
14. Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131–2157
15. Holst JJ, Vilsbøll T, Deacon CF (2008) The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol 297:127–136
16. Miyawaki K, Yamada Y, Ban N et al (2002) Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 8:738–742
17. Flatt PR (2008) Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes? Diabet Med 25:759–764
18. Hansotia T, Maida A, Flock G et al (2007) Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. J Clin Invest 117:143–152
19. Mazzaferri EL, Starich GH, Lardinois CK, Bowen GD (1985) Gastric inhibitory polypeptide responses to nutrients in Caucasians and American Indians with obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 61:313–321
20. Hauner H, Glatting G, Kaminska D, Pfeiffer EF (1988) Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isolated rat adipocytes. Ann Nutr Metab 32:282–288
21. Kim SJ, Nian C, McIntosh CH (2007) Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade. J Biol Chem 282:8557–8567
22. Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM (2007) Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Gastroenterology 133:1796–1805
23. Vilsbøll T, Holst JJ (2004) Incretins, insulin secretion and type 2 diabetes mellitus. Diabetologia 47:357–366
24. Rudovich N, Kaiser S, Engeli S et al (2007) GIP receptor mRNA expression in different fat tissue depots in postmenopausal non-diabetic women. Regul Pept 142:138–145
25. Timper K, Grisouard J, Sauter NS et al (2013) Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes. Am J Physiol Endocrinol Metab 304:E1–E13
26. Breitling R, Amtmann A, Herzyk P (2004) Iterative Group Analysis (iGA): a simple tool to enhance sensitivity and facilitate interpretation of microarray experiments. BMC Bioinforma 5:34
27. Zhang B, Horvath S (2005) A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol 4:Article17
28. Pivovarova O, Hornemann S, Weimer S et al (2015) Regulation of nutrition-associated receptors in blood monocytes of normal weight and obese humans. Peptides 65C:12–19
29. Ehses JA, Pelech SL, Pederson RA, McIntosh CH (2002) Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. J Biol Chem 277:37088–37097
30. Fernandez-Real JM, Pickup JC (2008) Innate immunity, insulin resistance and type 2 diabetes. Trends Endocrinol Metab 19:10–16
31. Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115:1111–1119
32. Neels JG, Olefsky JM (2006) Inflamed fat: what starts the fire? J Clin Invest 116:33–35
33. McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR (2007) GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Am J Physiol Endocrinol Metab 293:E1746–E1755
34. Jiao P, Chen Q, Shah S et al (2009) Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways. Diabetes 58:104–115
35. Gault VA, Irwin N, Green BD et al (2005) Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. Diabetes 54:2436–2446
36. Korner J, Bessler M, Inabnet W, Taveras C, Holst JJ (2007) Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding. Surg Obes Relat Dis 3:597–601
37. Mingrone G, Nolfe G, Gissey GC et al (2009) Circadian rhythms of GIP and GLP1 in glucose-tolerant and in type 2 diabetic patients after biliopancreatic diversion. Diabetologia 52:873–881