ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration

Cell Reports

Volumn 10, Issue 7, 2015, Pages 1173-1186

  Zandi, Souska ^a,b,c,d   Nakao, Shintaro ^a,b,c,e   Chun, Kwang Hoon ^f   Fiorina, Paolo ^b,g   Sun, Dawei ^a,b,c,h   Arita, Ryoichi ^e   Zhao, Ming ^a,b,i   Kim, Enoch ^j   Schueller, Olivier ^j   Campbell, Stewart ^b   Taher, Mahdi ^a,b,c   Melhorn, MarkIvan ^a,b,c   Schering, Alexander ^a,b,c   Gatti, Francesca ^b,g   Tezza, Sara ^b,g   Xie, Fang ^a,b,c,h   Vergani, Andrea ^b,g   Yoshida, Shigeo ^e   Ishikawa, Keijiro ^e   Yamaguchi, Muneo ^e   Sasaki, Fumiyuki ^k   Schmidt Ullrich, Ruth ^l   Hata, Yasuaki ^e   Enaida, Hiroshi ^e   Yuzawa, Mitsuko ^m   Yokomizo, Takehiko ^k   Kim, Young Bum ^b   Sweetnam, Paul ^j   Ishibashi, Tatsuro ^e   Hafezi Moghadam, Ali ^a,b,c   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^d Lindenhofspital   (Switzerland)

^e KYUSHU UNIVERSITY   (Japan)

^f Gachon University   (South Korea)

^g SAN RAFFAELE HOSPITAL   (Italy)

^h HARBIN MEDICAL UNIVERSITY   (China)

ⁱ SUN YAT SEN UNIVERSITY   (China)

^j Surface Logix Inc   (United States)

^k JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^l MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^m NIHON UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; RHO KINASE; CYTOKINE; ROCK1 PROTEIN, MOUSE; ROCK2 PROTEIN, MOUSE;

ADULT; AGE; AGE RELATED MACULAR DEGENERATION; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; NERVE CELL PLASTICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBRETINAL NEOVASCULARIZATION; UPREGULATION; AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CELL POLARITY; CHOROID; CYTOLOGY; DRUG EFFECTS; MACULAR DEGENERATION; METABOLISM; MOUSE; PATHOLOGY; VASCULARIZATION;

MUS;

AGING; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL POLARITY; CELLS, CULTURED; CHOROID; CHOROIDAL NEOVASCULARIZATION; CYTOKINES; HUMANS; MACROPHAGES; MACULAR DEGENERATION; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 84924591524     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.01.050     Document Type: Article

References (30)

1. Apte R.S., Richter J., Herndon J., Ferguson T.A. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med. 2006, 3:e310.
2. Arita R., Hata Y., Nakao S., Kita T., Miura M., Kawahara S., Zandi S., Almulki L., Tayyari F., Shimokawa H., et al. Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage. Diabetes 2009, 58:215-226.
3. Aurora A.B., Biyashev D., Mirochnik Y., Zaichuk T.A., Sánchez-Martinez C., Renault M.A., Losordo D., Volpert O.V. NF-kappaB balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement. Blood 2010, 116:475-484.
4. Bastos K.R., Alvarez J.M., Marinho C.R., Rizzo L.V., Lima M.R. Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile. J.Leukoc. Biol. 2002, 71:271-278.
5. Cammarano M.S., Minden A. Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways. J.Biol. Chem. 2001, 276:25876-25882.
6. Cao X., Shen D., Patel M.M., Tuo J., Johnson T.M., Olsen T.W., Chan C.C. Macrophage polarization in the maculae of age-related macular degeneration: a pilot study. Pathol. Int. 2011, 61:528-535.
7. Chun K.H., Araki K., Jee Y., Lee D.H., Oh B.C., Huang H., Park K.S., Lee S.W., Zabolotny J.M., Kim Y.B. Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Endocrinology 2012, 153:1649-1662.
8. Freund C., Schmidt-Ullrich R., Baurand A., Dunger S., Schneider W., Loser P., El-Jamali A., Dietz R., Scheidereit C., Bergmann M.W. Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy invivo. Circulation 2005, 111:2319-2325.
9. Gustafsson E., Brakebusch C., Hietanen K., Fässler R. Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice. J.Cell Sci. 2001, 114:671-676.
10. Henke N., Schmidt-Ullrich R., Dechend R., Park J.K., Qadri F., Wellner M., Obst M., Gross V., Dietz R., Luft F.C., et al. Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage. Circ. Res. 2007, 101:268-276.
11. Hollyfield J.G., Bonilha V.L., Rayborn M.E., Yang X., Shadrach K.G., Lu L., Ufret R.L., Salomon R.G., Perez V.L. Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat. Med. 2008, 14:194-198.
12. Huang H., Kong D., Byun K.H., Ye C., Koda S., Lee D.H., Oh B.C., Lee S.W., Lee B., Zabolotny J.M., et al. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat. Neurosci. 2012, 15:1391-1398.
13. Ishibashi T., Miller H., Orr G., Sorgente N., Ryan S.J. Morphologic observations on experimental subretinal neovascularization in the monkey. Invest. Ophthalmol. Vis. Sci. 1987, 28:1116-1130.
14. Kelly J., Ali Khan A., Yin J., Ferguson T.A., Apte R.S. Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J.Clin. Invest. 2007, 117:3421-3426.
15. Klein R., Klein B.E., Tomany S.C., Meuer S.M., Huang G.H. Ten-year incidence and progression of age-related maculopathy: The Beaver Dam eye study. Ophthalmology 2002, 109:1767-1779.
16. Lara-Castillo N., Zandi S., Nakao S., Ito Y., Noda K., She H., Ahmed M., Frimmel S., Ablonczy Z., Hafezi-Moghadam A. Atrial natriuretic peptide reduces vascular leakage and choroidal neovascularization. Am. J. Pathol. 2009, 175:2343-2350.
17. London A., Itskovich E., Benhar I., Kalchenko V., Mack M., Jung S., Schwartz M. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J.Exp. Med. 2011, 208:23-39.
18. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25:677-686.
19. Mattapallil M.J., Wawrousek E.F., Chan C.C., Zhao H., Roychoudhury J., Ferguson T.A., Caspi R.R. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest. Ophthalmol. Vis. Sci. 2012, 53:2921-2927.
20. Ohashi K., Parker J.L., Ouchi N., Higuchi A., Vita J.A., Gokce N., Pedersen A.A., Kalthoff C., Tullin S., Sams A., et al. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J.Biol. Chem. 2010, 285:6153-6160.
21. Riento K., Ridley A.J. Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 2003, 4:446-456.
22. Rikitake Y., Oyama N., Wang C.Y., Noma K., Satoh M., Kim H.H., Liao J.K. Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice. Circulation 2005, 112:2959-2965.
23. Rofagha S., Bhisitkul R.B., Boyer D.S., Sadda S.R., Zhang K. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology 2013, 120:2292-2299. SEVEN-UP Study Group.
24. Schmidt-Ullrich R., Aebischer T., Hülsken J., Birchmeier W., Klemm U., Scheidereit C. Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development 2001, 128:3843-3853.
25. Sica A., Mantovani A. Macrophage plasticity and polarization: invivo veritas. J.Clin. Invest. 2012, 122:787-795.
26. Sun D., Nakao S., Xie F., Zandi S., Bagheri A., Rezaei Kanavi M., Samiei S., Soheili Z.S., Frimmel S., Zhang Z., et al. Molecular imaging reveals elevated VEGFR-2 expression in retinal capillaries in diabetes: a novel biomarker for early diagnosis. FASEB J. 2014, Published online June 5, 2014.
27. Tabruyn S.P., Griffioen A.W. NF-kappa B: a new player in angiostatic therapy. Angiogenesis 2008, 11:101-106.
28. Takeda A., Baffi J.Z., Kleinman M.E., Cho W.G., Nozaki M., Yamada K., Kaneko H., Albuquerque R.J., Dridi S., Saito K., et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature 2009, 460:225-230.
29. Tsutsumi C., Sonoda K.H., Egashira K., Qiao H., Hisatomi T., Nakao S., Ishibashi M., Charo I.F., Sakamoto T., Murata T., Ishibashi T. The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J.Leukoc. Biol. 2003, 74:25-32.
30. Zhao H., Roychoudhury J., Doggett T.A., Apte R.S., Ferguson T.A. Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2013, 54:5321-5331.