HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases

Redox Biology

Volumn 13, Issue , 2017, Pages 266-277

  Kung, Po Hsiung ^a   Hsieh, Pei Wen ^b,d   Lin, Ying Ting ^a   Lee, Jia Hau ^a   Chen, I Hua ^a   Wu, Chin Chung ^a,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Anti thrombotic agents; HPW RX40; Nitrostyrene; Platelets; Protein disulfide isomerase

Indexed keywords

2 METHOXY 4 (2 NITROVINYL)PHENYL 2,3 DICHLOROBENZOATE; ANTITHROMBOCYTIC AGENT; FERROUS CHLORIDE; FIBRINOGEN RECEPTOR; PADGEM PROTEIN; PROTEIN DISULFIDE ISOMERASE; PROTEIN ERP5; PROTEIN ERP57; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; 2-METHOXY-4-(2-NITROVINYL)PHENYL 2,3-DICHLOROBENZOATE; CHLOROBENZOIC ACID DERIVATIVE; ENZYME INHIBITOR; PROTEIN BINDING; STYRENE DERIVATIVE;

A-549 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CAROTID ARTERY OBSTRUCTION; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; IN VITRO STUDY; IN VIVO STUDY; MALE; MDA-MB-231 CELL LINE; MOLECULAR DOCKING; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; C57BL MOUSE; CHEMISTRY; IMMUNOLOGY; METABOLISM; MOUSE; THROMBOCYTE; TUMOR CELL LINE;

ANIMALS; BINDING SITES; BLOOD PLATELETS; CELL LINE, TUMOR; CHLOROBENZOATES; ENZYME INHIBITORS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR DOCKING SIMULATION; PLATELET ACTIVATION; PROTEIN BINDING; PROTEIN DISULFIDE-ISOMERASES; STYRENES;

EID: 85020316931     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2017.05.019     Document Type: Article

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