Synthesis and pharmacological evaluation of novel β-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity

Biochemical Pharmacology

Volumn 74, Issue 4, 2007, Pages 601-611

  Wang, Wei Ya ^a   Hsieh, Pei Wen ^a   Wu, Yang Chang ^a   Wu, Chin Chung ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

nitrostyrene; Antiplatelet agents; Protein tyrosine kinase inhibitors

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 3,4 DIMETHOXY BETA NITROSTYRENE; 3,4 METHYLENEDIOXY BETA NITROSTYRENE; 3,4 METHYLENEDIOXYCINNAMIC ACID; ADENOSINE TRIPHOSPHATE; BETA NITRO 4 HYDROXY 3 METHOXYSTYRENE; CINNAMIC ACID DERIVATIVE; COLLAGEN; FIBRINOGEN RECEPTOR; FOCAL ADHESION KINASE; GENISTEIN; ISOSAFROLE; NITROSTYRENE; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STYRENE DERIVATIVE; THROMBIN; TYRPHOSTIN; TYRPHOSTIN A47; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BLOOD PLATELETS; BLOTTING, WESTERN; CALCIUM; DIOXOLANES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; INTEGRIN BETA3; MOLECULAR STRUCTURE; NEPHELOMETRY AND TURBIDIMETRY; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN KINASE C; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; STYRENES; TYROSINE;

EID: 34447277604     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.06.001     Document Type: Article

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