Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b′x Domain

Journal of Biological Chemistry

Volumn 290, Issue 39, 2015, Pages 23543-23552

  Lin, Lin ^a   Gopal, Srila ^a   Sharda, Anish ^a   Passam, Freda ^a   Bowley, Sheryl R ^a   Stopa, Jack ^a   Xue, Guangpu ^b   Yuan, Cai ^b   Furie, Barbara C ^a   Flaumenhaft, Robert ^a   Huang, Mingdong ^a   Furie, Bruce ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BLOOD VESSELS; PHENOLS; PROTEINS; SULFUR COMPOUNDS; X RAY SCATTERING;

ANTI-THROMBOTIC EFFECT; ANTITHROMBOTIC AGENTS; CONFORMATIONAL FLEXIBILITY; EXTRACELLULAR PROTEINS; FLUORESCENCE ENHANCEMENT; ISOTHERMAL CALORIMETRY; PROTEIN DISULFIDE ISOMERASES; THROMBUS FORMATION;

FLAVONOIDS;

ANTICOAGULANT AGENT; ISOQUERCETIN; PROTEIN DISULFIDE ISOMERASE; QUERCETIN DERIVATIVE; RUTOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BINDING SITE; BLOOD CLOTTING; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; IC50; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STOICHIOMETRY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CALORIMETRY; HUMAN; METABOLISM; SMALL ANGLE SCATTERING; THROMBOSIS; X RAY DIFFRACTION;

ANIMALS; BINDING SITES; CALORIMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED C57BL; PROTEIN DISULFIDE-ISOMERASES; RUTIN; SCATTERING, SMALL ANGLE; THROMBOSIS; X-RAY DIFFRACTION;

EID: 84942342394     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.666180     Document Type: Article

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