CLL2-1, a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-I (CalDAG-GEFI)

Free Radical Biology and Medicine

Volumn 78, Issue , 2015, Pages 101-110

  Liao, Chieh Yu ^a   Lee, Chia Lin ^b   Wang, Hui Chun ^a   Liang, Shih Shin ^a   Kung, Po Hsiung ^a   Wu, Yang Chang ^b   Chang, Fang Rong ^a   Wu, Chin Chung ^a,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

1,4 Phenanthrenequinone; CalDAG GEFI; CLL2 1; Platelet aggregation; Thiol modification

Indexed keywords

5,6,7 TRIMETHOXY 1,4 PHENANTHRENEQUINONE; ANTITHROMBOCYTIC AGENT; CALCIUM; CALCIUM DIACYLGLYCEROL GUANINE NUCLEOTIDE EXCHANGE FACTOR I; CLL2 1; FIBRINOGEN RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PADGEM PROTEIN; PHENANTHRENEQUINONE; THIOL REAGENT; UNCLASSIFIED DRUG; 1,4-PHENANTHRENEQUINONE; 5,6,7-TRIMETHOXY-1,4-PHENANTHRENEQUINONE; PHENANTHRENE DERIVATIVE; QUINONE DERIVATIVE; RASGRP2 PROTEIN, HUMAN; THIOL DERIVATIVE;

ANTICOAGULATION; ARTICLE; CALCIUM CELL LEVEL; CHEMICAL STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HEK293 CELL LINE; HUMAN; HUMAN CELL; OLIGOMERIZATION; PLASMID; PROTEIN EXPRESSION; THROMBOCYTE AGGREGATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; METABOLISM; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CALCIUM; CELLS, CULTURED; CHROMATOGRAPHY, LIQUID; FLOW CYTOMETRY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; PHENANTHRENES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; QUINONES; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFHYDRYL COMPOUNDS;

EID: 84914178383     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.10.512     Document Type: Article

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