The roles and mechanisms of PAR4 and P2Y 12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation

British Journal of Pharmacology

Volumn 161, Issue 3, 2010, Pages 643-658

  Wu, Chin Chung ^a   Wu, Shih Yun ^a   Liao, Chieh Yu ^a   Teng, Che Ming ^b   Wu, Yang Chang ^a   Kuo, Sheng Chu ^c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

ADP P2Y 12 receptor; phosphatidylinositol 3 kinase; platelets; proteinase activated receptors; thrombin

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 METHYLTHIOADENOSINE 5' MONOPHOSPHATE TRIETHYLAMMONIUM SALT; CALCIUM; DUAL SPECIFICITY PHOSPHATASE 2; FIBRINOGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE B INHIBITOR V; PROTEIN KINASE C; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; PURINERGIC P2Y12 RECEPTOR; SH 6; THROMBIN; THROMBOXANE A2; UNCLASSIFIED DRUG; WORTMANNIN; YD 3;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; WESTERN BLOTTING;

ANDROSTADIENES; BLOOD PLATELETS; CALCIUM; HUMANS; INDAZOLES; PHOSPHATIDYLINOSITOL 3-KINASE; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN KINASE C; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RECEPTORS, THROMBIN; SIGNAL TRANSDUCTION; THROMBIN;

EID: 77956327249     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00921.x     Document Type: Article

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