TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension

Nature Communications

Volumn 8, Issue , 2017, Pages

  Kumar, Rahul ^a   Mickael, Claudia ^a   Kassa, Biruk ^a   Gebreab, Liya ^a   Robinson, Jeffrey C ^a   Koyanagi, Daniel E ^a   Sanders, Linda ^a   Barthel, Lea ^b   Meadows, Christina ^a   Fox, Daniel ^a   Irwin, David ^a   Li, Min ^a   McKeon, B Alexandre ^a   Riddle, Suzette ^a   Brown, R Dale ^a   Morgan, Leslie E ^a   Evans, Christopher M ^a   Hernandez Saavedra, Daniel ^a   Bandeira, Angela ^c   Maloney, James P ^a   Bull, Todd M ^a   Janssen, William J ^b   Stenmark, Kurt R ^a   Tuder, Rubin M ^a   Graham, Brian B ^a   more..

^a UNIVERSITY OF COLORADO   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 2ALPHA; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; LY ANTIGEN; LY-6C ANTIGEN, MOUSE; MESSENGER RNA;

BLOOD; DISEASE INCIDENCE; GENE EXPRESSION; HYPOXIA; IMMUNE SYSTEM; PAH; RODENT;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CONTROLLED STUDY; DRUG TARGETING; GENE SILENCING; HUMAN; HUMAN TISSUE; HYPOXIA-INDUCED PULMONARY HYPERTENSION; LUNG; MALE; MONOCYTE; MOUSE; NEWBORN; NONHUMAN; PATHOGENESIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCLERODERMA; ANIMAL; BLOOD; BONE MARROW CELL; BOVINE; C57BL MOUSE; COMPLICATION; GENETICS; HYPOXIA; IMMUNOLOGY; METABOLISM; PARASITOLOGY; PATHOLOGY; PHYSIOLOGY; PULMONARY HYPERTENSION; SCHISTOSOMA; SIGNAL TRANSDUCTION; TH2 CELL; VASCULARIZATION;

MUS; SCHISTOSOMA;

ANIMALS; ANTIGENS, LY; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE MARROW CELLS; CATTLE; HUMANS; HYPERTENSION, PULMONARY; HYPOXIA; LUNG; MICE, INBRED C57BL; MONOCYTES; RNA, MESSENGER; SCHISTOSOMA; SIGNAL TRANSDUCTION; TH2 CELLS; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

EID: 85019989040     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms15494     Document Type: Article

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