Praziquantel reverses pulmonary hypertension and vascular remodeling in murine schistosomiasis

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 4, 2011, Pages 467-473

  Crosby, Alexi ^a   Jones, Frances M ^b   Kolosionek, Ewa ^c   Southwood, Mark ^d   Purvis, Ian ^a   Soon, Elaine ^a   Butrous, Ghazwan ^c   Dunne, David W ^b   Morrell, Nicholas W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF KENT   (United Kingdom)

^d PAPWORTH HOSPITAL   (United Kingdom)

Author keywords

Hypertension; Infection; Lung; Pulmonary

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PRAZIQUANTEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DISEASE DURATION; EGG PRODUCTION; FECES; FECES ANALYSIS; FEMALE; GENE EXPRESSION; HEART RIGHT VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; LIVER; LUNG BLOOD VESSEL; LUNG GRANULOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RIGHT VENTRICULAR SYSTOLIC PRESSURE; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION;

ANIMALS; ANTHELMINTICS; BLOOD PRESSURE; BLOOD VESSELS; CYTOKINES; DOWN-REGULATION; FEMALE; GRANULOMA; HEART VENTRICLES; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; INFLAMMATION MEDIATORS; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-8; LIVER; LUNG; MICE; MICE, INBRED C57BL; OVUM; PRAZIQUANTEL; RNA, MESSENGER; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

EID: 80051819735     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201101-0146OC     Document Type: Article

References (30)

1. Alpert J.S., Irwin R.S., Dalen J.E. Pulmonary hypertension. Curr Probl Cardiol 1981;5:1-39.
2. Ross A.G., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., McManus D.P. Schistosomiasis. N Engl J Med 2002;346:1212-1220. (Pubitemid 34984584)
3. Andrade Z.A., Andrade S.G. Pathogenesis of schistosomal pulmonary arteritis. Am J Trop Med Hyg 1970;19:305-310.
4. Bedford D.E., Aidaros S.M., Girgis B. Bilharzial heart disease in Egypt. Br Heart J 1946;8:87.
5. Chirakalwasan N., Coyle C.M., Meisner M.S.J., Chandra A. Treating a case of severe pulmonary hypertension due to schistosomiasis. Chest 2006; 130:293S-294S.
6. Cardoso de Almeida M.A., Andrade Z.A. Effect of chemotherapy on experimental pulmonary schistosomiasis. Am J Trop MedHyg 1983; 32:1049-1054. (Pubitemid 13012094)
7. Schwartz E. Pulmonary schistosomiasis. Clin Chest Med 2002;23:433-443. (Pubitemid 34651336)
8. Mentink-Kane M.M., Cheever A.W., Thompson R.W., Hari D.M., Kabatereine N.B., Vennervald B.J., Ouma J.H., Mwatha J.K., Jones F.M., Donaldson D.D., et al. IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc Natl Acad Sci USA 2004;101:586-590. (Pubitemid 38084680)
9. Smithers S.R., Terry R.J. The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 1965;55:695-700.
10. Berg E. Effects of castration and testosterone in male mice on Schistosoma mansoni. Trans R Soc Trop Med Hyg 1957;51:353-358.
11. Nakazawa M., Fantappie M.R., Freeman G.L. Jr, Eloi-Santos S., Olsen N.J., Kovacs W.J., Secor W.E., Colley D.G. Schistosoma mansoni: Susceptibility differences between male and female mice can be mediated by testosterone during early infection. Exp Parasitol 1997;85:233-240. (Pubitemid 27246116)
12. Long L., MacLeanMR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res 2006;98:818-827.
13. Morrell N.W., Atochina E.N., Morris K.G., Danilov S.M., Stenmark K.R. Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. J Clin Invest 1995;96:1823-1833.
14. Cheever A.W. Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Organ 1968;39:328-331.
15. Bell D.R. A new method for counting Schistosoma mansoni eggs in faeces: With special reference to therapeutic trials. Bull World Health Organ 1963;29:525-530.
16. Doenhoff M., Bickle Q., Long E., Bain J., McGregor A. Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. I. Demonstration of resistance to reinfection using a model system that involves perfusion of mice within three weeks of challenge. J Helminthol 1978;52:173-186. (Pubitemid 9049033)
17. Yang X., Long L., Southwood M., Rudarakanchana N., Upton P.D., Jeffery T.K., Atkinson C., Chen H., Trembath R.C., Morrell N.W. Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res 2005; 96:1053-1063. (Pubitemid 40791377)
18. Schermuly R.T., Dony E., Ghofrani H.A., Pullamsetti S., Savai R., Roth M., Sydykov A., Lai Y.J., Weissmann N., Seeger W., et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005;115:2811-2821. (Pubitemid 41434408)
19. Crosby A., Jones F.M., SouthwoodM., Stewart S., Schermuly R., Butrous G., Dunne D.W., Morrell N.W. Pulmonary vascular remodeling correlates with lung eggs and cytokines in murine schistosomiasis. Am J Respir Crit Care Med 2009;181:279-288.
20. Daley E., Emson C., Guignabert C., De Waal M.R., Louten J., Kurup V.P., Hogaboam C., Taraseviciene-Stewart L., Voelkel N.F., Rabinovitch M., et al. Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med 2008;205:361-372. (Pubitemid 351281602)
21. Soon E., Holmes A.M., Treacy C.M., Doughty N.J., Southgate L., Machado R.D., Trembath R.C., Jennings S., Barker L., Nicklin P., et al. Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation 2010;122:920-927.
22. Warren K.S. Experimental schistosomiasis. Trans R Soc Trop Med Hyg 1964;58:228-233.
23. Azmy S., Effat S. Pulmonary arteriosclerosis of a Bilharzial nature. J Egypt Med Assoc 1932;15:87.
24. Sami A.A. Pulmonary manifestations of schistosomiasis. Dis Chest 1951; 19:698-705.
25. Grander W., Eller P., Fuschelberger R., Tilg H. Bosentan treatment of portopulmonary hypertension related to liver cirrhosis owing to hepatitis C. Eur J Clin Invest 2006;36:67-70. (Pubitemid 44179785)
26. Trabelsi K., Essid M., Azzouz M.M. (Pulmonary arterial hypertension in cirrhosis). Tunis Med 2002;80:139-141.
27. Lapa M., Dias B., Jardim C., Fernandes C.J., Dourado P.M., Figueiredo M., Farias A., Tsutsui J., Terra-Filho M., Humbert M., et al. Cardiopulmonary manifestations of hepatosplenic schistosomiasis. Circulation 2009;119:1518-1523.
28. Shaw A.F.B., Ghareeb A.A. The pathogenesis of pulmonary schistzosomais in Egypt with special reference to Ayerza's disease. J Pathol 1938;46:401-424.
29. Barbosa M.M., Lamounier J.A., Oliveira E.C., Souza M.V., Marques D.S., Silva A.A., Lambertucci J. Pulmonary hypertension in Schistosomiasis mansoni. Trans R Soc Trop Med Hyg 1996;90:663-665. (Pubitemid 27011162)
30. Ferreira R.C., Domingues A.L., Bandeira A.P.,Markman Filho B., Albuqerque Filho E.S., Correiade de Araujo A.C., Batista L.J., Markman M., Campelo A.R. Prevalence of pulmonary hypertension in patients with schistosomal liver fibrosis. Ann Trop Med Parasitol 2009;103:129-143.