메뉴 건너뛰기




Volumn 170, Issue 12, 2004, Pages 1340-1348

Impaired transforming growth factor-β signaling in idiopathic pulmonary arterial hypertension

Author keywords

Endothelial cells; Pulmonary hypertension; Smad; Smooth muscle cells; Transforming growth factor

Indexed keywords

SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 10644256482     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200311-1602OC     Document Type: Article
Times cited : (115)

References (35)
  • 1
    • 0034904703 scopus 로고    scopus 로고
    • Severe pulmonary hypertension after the discovery of the familial primary pulmonary hypertension gene
    • Tuder RM, Yeager ME, Geraci M, Golpon HA, Voelkel NF. Severe pulmonary hypertension after the discovery of the familial primary pulmonary hypertension gene. Eur Respir J 2001;17:1065-1069.
    • (2001) Eur Respir J , vol.17 , pp. 1065-1069
    • Tuder, R.M.1    Yeager, M.E.2    Geraci, M.3    Golpon, H.A.4    Voelkel, N.F.5
  • 5
    • 0035910729 scopus 로고    scopus 로고
    • Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension
    • Yeager ME, Halley GR, Golpon HA, Voelkel NF, Tuder RM. Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension. Circ Res 2001;88:e8-e11.
    • (2001) Circ Res , vol.88
    • Yeager, M.E.1    Halley, G.R.2    Golpon, H.A.3    Voelkel, N.F.4    Tuder, R.M.5
  • 8
    • 0034644472 scopus 로고    scopus 로고
    • TGF-β signaling in growth control, cancer, and heritable disorders
    • Massague J, Blain SW, Lo RS. TGF-β signaling in growth control, cancer, and heritable disorders. Cell 2000;103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 9
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-β signaling
    • Massague J, Chen YG. Controlling TGF-β signaling. Genes Dev 2000;14:627-644.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 10
    • 0031863899 scopus 로고    scopus 로고
    • TGF-β signaling, Smads, and tumor suppressors
    • Padgett RW, Das P, Krishna S. TGF-β signaling, Smads, and tumor suppressors. Bioessays 1998;20:382-390.
    • (1998) Bioessays , vol.20 , pp. 382-390
    • Padgett, R.W.1    Das, P.2    Krishna, S.3
  • 11
    • 0037046175 scopus 로고    scopus 로고
    • Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of Type II bone morphogenetic protein receptor
    • Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of Type II bone morphogenetic protein receptor. Circulation 2002;105:1672-1678.
    • (2002) Circulation , vol.105 , pp. 1672-1678
    • Atkinson, C.1    Stewart, S.2    Upton, P.D.3    Machado, R.4    Thomson, J.R.5    Trembath, R.C.6    Morrell, N.W.7
  • 12
    • 10644272004 scopus 로고    scopus 로고
    • Impaired TGF-β receptor signaling in plexiform lesions of lungs with primary pulmonary hypertension (PPH)
    • Richter A, Yeager M, Voelkel NF, Tuder RM. Impaired TGF-β receptor signaling in plexiform lesions of lungs with primary pulmonary hypertension (PPH) [abstract]. Am J Respir Crit Care Med 2003;167:A710.
    • (2003) Am J Respir Crit Care Med , vol.167
    • Richter, A.1    Yeager, M.2    Voelkel, N.F.3    Tuder, R.M.4
  • 15
  • 18
    • 0028282859 scopus 로고
    • Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
    • Tuder RM, Groves BM, Badesch DB, Voelkel NF. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 1994;144:275-285.
    • (1994) Am J Pathol , vol.144 , pp. 275-285
    • Tuder, R.M.1    Groves, B.M.2    Badesch, D.B.3    Voelkel, N.F.4
  • 19
    • 0032777126 scopus 로고    scopus 로고
    • Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell specific markers: Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth
    • Cool CD, Stewart JS, Werahera P, Miller GJ, Williams RL, Voelkel NF, Tuder RM. Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell specific markers: evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth. Am J Pathol 1999;155:411-419.
    • (1999) Am J Pathol , vol.155 , pp. 411-419
    • Cool, C.D.1    Stewart, J.S.2    Werahera, P.3    Miller, G.J.4    Williams, R.L.5    Voelkel, N.F.6    Tuder, R.M.7
  • 21
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi YG, Massague J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.G.1    Massague, J.2
  • 22
    • 0035797566 scopus 로고    scopus 로고
    • Genetic clues to the cause of primary pulmonary hypertension
    • Loscalzo J. Genetic clues to the cause of primary pulmonary hypertension. N Engl J Med 2001;345:367-371.
    • (2001) N Engl J Med , vol.345 , pp. 367-371
    • Loscalzo, J.1
  • 23
    • 0028308114 scopus 로고
    • Vascular remodeling in primary pulmonary hypertension: Potential role for transforming growth factor-β
    • Botney MD, Bahadori L, Gold LI. Vascular remodeling in primary pulmonary hypertension: potential role for transforming growth factor-β. Am J Pathol 1994;144:286-295.
    • (1994) Am J Pathol , vol.144 , pp. 286-295
    • Botney, M.D.1    Bahadori, L.2    Gold, L.I.3
  • 24
    • 0032588657 scopus 로고    scopus 로고
    • Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-β-induced cell cycle arrest of gastric carcinoma cells
    • Kang SH, Bang YJ, Jong HS, Seo JY, Kim NK, Kim SJ. Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-β-induced cell cycle arrest of gastric carcinoma cells. Br J Cancer 1999; 80:1144-1149.
    • (1999) Br J Cancer , vol.80 , pp. 1144-1149
    • Kang, S.H.1    Bang, Y.J.2    Jong, H.S.3    Seo, J.Y.4    Kim, N.K.5    Kim, S.J.6
  • 25
    • 17544372403 scopus 로고    scopus 로고
    • 1 down-regulates vascular endothelial growth factor receptor2/flk-1 expression in vascular endothelial cells
    • 1 down-regulates vascular endothelial growth factor receptor2/flk-1 expression in vascular endothelial cells. J Biol Chem 1996;271:11500-11505.
    • (1996) J Biol Chem , vol.271 , pp. 11500-11505
    • Mandriota, S.J.1    Menoud, P.-A.2    Pepper, M.S.3
  • 27
    • 0037076796 scopus 로고    scopus 로고
    • Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: In vitro analysis
    • Frid MG, Kale VA, Stenmark KR. Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis. Circ Res 2002;90:1189-1196.
    • (2002) Circ Res , vol.90 , pp. 1189-1196
    • Frid, M.G.1    Kale, V.A.2    Stenmark, K.R.3
  • 30
    • 10644228015 scopus 로고    scopus 로고
    • Mutations in BMPRII decrease pulmonary microvascular endothelial cell survival and increase smooth muscle cell growth: Double jeopardy for pulmonary hypertension
    • Teichert-Kuliszewska K, Wijeysundera HV, Karoubi G, Stewart DJ. Mutations in BMPRII decrease pulmonary microvascular endothelial cell survival and increase smooth muscle cell growth: double jeopardy for pulmonary hypertension. Cardiovasc Pathol 2004;13:S79.
    • (2004) Cardiovasc Pathol , vol.13
    • Teichert-Kuliszewska, K.1    Wijeysundera, H.V.2    Karoubi, G.3    Stewart, D.J.4
  • 31
    • 0037007226 scopus 로고    scopus 로고
    • Balancing the activation state of the endothelium via two distinct TGF-β Type I receptors
    • Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P. Balancing the activation state of the endothelium via two distinct TGF-β Type I receptors. EMBO J 2002;21:1743-1753.
    • (2002) EMBO J , vol.21 , pp. 1743-1753
    • Goumans, M.J.1    Valdimarsdottir, G.2    Itoh, S.3    Rosendahl, A.4    Sideras, P.5    Ten Dijke, P.6
  • 33
    • 0033595704 scopus 로고    scopus 로고
    • Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
    • Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K. Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science 1999; 286:771-774.
    • (1999) Science , vol.286 , pp. 771-774
    • Stroschein, S.L.1    Wang, W.2    Zhou, S.3    Zhou, Q.4    Luo, K.5
  • 34
    • 0033607240 scopus 로고    scopus 로고
    • SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling
    • Sun Y, Liu X, Ng-Eaton E, Lodish HF, Weinberg RA. SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling. Proc Natl Acad Sci USA 1999;6:12442-12447.
    • (1999) Proc Natl Acad Sci USA , vol.6 , pp. 12442-12447
    • Sun, Y.1    Liu, X.2    Ng-Eaton, E.3    Lodish, H.F.4    Weinberg, R.A.5
  • 35
    • 0036006811 scopus 로고    scopus 로고
    • The ever-increasing complexity of TGF-β signaling
    • Roberts AB. The ever-increasing complexity of TGF-β signaling. Cytokine Growth Factor Rev 2002;13:3-5.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 3-5
    • Roberts, A.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.