Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCζ in the pulmonary artery adventitia

Cardiovascular Research

Volumn 78, Issue 3, 2008, Pages 440-448

  Das, Mita ^a   Burns, Nana ^a   Wilson, Shelly J ^a   Zawada, Wojciech M ^a   Stenmark, Kurt R ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Fibroblast proliferation; Hypoxia; PKC ; Pulmonary hypertension

Indexed keywords

CELL DNA; ENZYME ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN INHIBITOR; PROTEIN KINASE C ZETA; PROTEIN KINASE C ZETA ANTIBODY; REPRESSOR PROTEIN;

ADVENTITIA; ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL WALL; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; FIBROBLAST; FIBROBLAST CULTURE; HYPOTHESIS; HYPOXIA; IMMUNOPEROXIDASE STAINING; IMMUNOREACTIVITY; LUNG PARENCHYMA; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; SIGNAL TRANSDUCTION;

ANIMALS; ANOXIA; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; CONNECTIVE TISSUE; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FIBROBLASTS; IMMUNOENZYME TECHNIQUES; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PEPTIDES; PHENOTYPE; PHOSPHORYLATION; PROTEIN KINASE C; PULMONARY ARTERY; TIME FACTORS;

EID: 44449159257     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn014     Document Type: Article

References (41)

1. Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 2006;99:675-691.
2. Das M, Dempsey EC, Bouchey D, Reyland ME, Stenmark KR. Chronic hypoxia induces exaggrerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase C isozymes. Am J Respir Cell Mol Biol 2000;22:15-25.
3. Welsh DJ, Peacock AJ, MacLean M, Harnett M. Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries. Am J Respir Crit Care Med 2001;164:282-289.
4. Marshall RP, Bellingan G, Webb S, Puddicombe A, Goldsack N, McAnulty RJ et al. Fibroproliferation occurs early in the acute respiratory distress syndrome impacts on outcome. Am J Respir Crit Care Med 2000;162:1783-1788.
5. Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S et al. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J Immunol 2004;172:2668-2677.
6. Horowitz JC, Cui Z, Moore TA, Meier TR, Reddy RC, Toews GB et al. Constitutive activation of prosurvival signaling in alveolar mesenchymal cells isolated from patients with nonresolving acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2006;290:L415-L425.
7. Das M, Bouchey DM, Moore MJ, Hopkins DC, Nemenoff RA, Stenmark KR. Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on G protein-mediated activation of mitogen-activated protein kinases. J Biol Chem 2001;276:15631-15640.
8. Frank RN. Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors. Am J Opthalmol 2002;133:693-698.
9. Li J, Qu Y, Zu P, Han S, Gao G, Xu Q et al. Increased isoform-specific membrane translocation of conventional and novel protein kinase C in human neuroblastoma SH-SY5Y cells following prolonged hypoxia. Brain Res 2006;1093:25-32.
10. Mizukami Y, Kobayashi S, Uberall F, Hellbert K, Kobayashi N, Yoshida K. Nuclear mitogen-activated protein kinase activation by protein kinase czeta during reoxygenation after ischemic hypoxia. J Biol Chem 2000;275:19921-19927.
11. Pal S, Datta K, Khosravi-Far R, Mukhopadhyay D. Role of protein kinase Czeta in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression. J Biol Chem 2001;276:2395-2403.
12. Dada L, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI. Hypoxia-induecd endocytosis of Na, K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and protein kinase czeta. J Clin Invest 2003;111:1057-1064.
13. Datta K, Li J, Bhattacharya R, Gasparian L, Wang E, Mukhopadhyay D. Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. Cancer Res 2004;64:456-462.
14. Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek Y et al. Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. J Biol Chem 2006;281:6366-6375.
15. Short MD, Fox SM, Lam CF, Stenmark KR, Das M. Protein kinase Cζ attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression. Mol Biol Cell 2006;17:1995-2008.
16. Liao DF, Monia B, Dean N, Berk BC. Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J Biol Chem 1997;272:6146-6150.
17. Stenmark KR, Fasules J, Voelkel NF, Henson J, Tucker A, Henson H et al. Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4300 m. J Appl Physiol 1987;62:821-830.
18. Das M, Dempsey EC, Reeves JT, Stenmark KR. Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia. Am J Physiol Lung Cell Mol Physiol 2002;282:L976-L986.
19. Das M, Stenmark KR, Dempsey EC. Enhanced growth of fetal and neonatal pulmonary artery adventitial fibroblasts is dependent on protein kinase C. Am J Physiol 1995;269:L660-L667.
20. Short M, Nemenoff RA, Zawada WM, Stenmark KR, Das M. Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts. Am J Physiol Cell Physiol 2004;286:C416-C425.
21. Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS et al. Regulation of protein kinase C zeta by PI3-kinase and PDK-1. Curr Biol 1998;8:1069-1077.
22. Schonwasser DC, Marais RM, Marshall CJ, Parker PJ. Activation of the mitogen activated protein kinase/extracellular signal regulated kinase pathway by conventional, novel and atypical PKC isotypes. Mol Cell Biol 1998;18:790-798.
23. Hirai T, Chida K. Protein kinase C zeta (PKCzeta): activation mechanisms and cellular functions. J Biochem (Tokyo) 2003;133:1-7.
24. Almeida JP, Coletta RD, Silva SD, Agostini M, Vargas PA, Bozzo L et al. Proliferation of fibroblasts cultured from normal gingiva and hereditary gingival fibromatosis is dependent on fatty acid synthase activity. J Periodontol 2005;76:272-278.
25. Trovato-Salinaro A, Trovato-Salinaro E, Failla M, Mastruzzo C, Tomaselli V, Gili E et al. Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis. Respir Res 2006;7:122.
26. Bellego FL, Plante S, Chakir J, Hamid Q, Ludwig MS. Differences in MAP kinase phosphorylation in response to mechanical strain in asthmatic fibroblasts. Respir Res 2006;7:68.
27. Plekhanova OS, Stepanova VV, Ratner EI, Bobik A, Tkachuk VA, Parfyonova YV. Urokinase plasminogen activator in injured adventitia increases the number of myofibroblasts and augments early proliferation. J Vasc Res 2006;43:437-446.
28. Arribas M, Valverde AM, Burks D, Klein J, Farese RV, White MF et al. Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. FEBS Lett 2003;536:161-166.
29. Magid R, Davies PF. Endothelial protein kinase C isoform identity and differential activity of PKCζ in an athero-susceptible region of porcine aorta. Cir Res 2005;97:443-449.
30. Parmentier JH, Zhang C, Estes A, Schaefer S, Malik KU. Essential role of PKC-ζ in normal and angiotensin II-accelerated neointimal growth after vascular injury. Am J Physiol Heart Circ Physiol 2006;291:H1602- H1613.
31. Zini N, Lisignoli G, Solimando L, Bavelloni A, Valmori A, Cristino S et al. Quantitative immunodetection of key elements of phosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation. Histochem Cell Biol 2005;124:131-137.
32. Parekh DB, Ziegler W, Parker PJ. Multiple pathways control protein kinase C phosphorylation. EMBO J 2000;19:496-503.
33. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase C isotypes controlled by PI3K through the protein kinases PDK1. Science 1998;281:2042-2045.
34. Dutil EM, Toker A, Newton AC. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol 1998;8:1366-1375.
35. Standaert ML, Bandyopadhyay G, Kanoh Y, Sajan MP, Farese RV. Insulin and PIP3 activates PKCzeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410)and autophosphorylation (T560) sites. Biochemistry 2001;40:249-255.
36. Le Good JA, Brindley DN. Molecular mechanisms regulating protein kinase Czeta turnover and cellular transformation. Biochem J 2004;378:83-92.
37. Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM et al. zeta PKC induces phosphorylation and inactivation of I-kappa B-alpha in vitro. EMBO J 1994;13:2842-2848.
38. Takeda H, Matozaki T, Takada T, Noguchi T, Yamao T, Tsuda M et al. M. PI-3 kinase gamma and protein kinase c-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor. EMBO J 1999;18:386-395.
39. Bapat S, Verkleij A, Post JA. Peroxynitrite activates mitogen-activated protein kinase (MAPK) via a MEK-independent pathway: a role of protein kinase C. FEBS Lett 2001;499:21-26.
40. Jorgensen K, Skrede M, Cruciani V, Mikalsen SO, Slipicevic A, Florenes VA. Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2. Biochem Biophys Res Commun 2005;329:266-274.
41. Kondoh K, Torri S, Nishida E. Control of MAP kinase signaling to the nucleus. Chromosoma 2005;114:86-91.