Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

Molecular and Cellular Neuroscience

Volumn 82, Issue , 2017, Pages 143-156

  Lindström, Veronica ^a   Gustafsson, Gabriel ^a   Sanders, Laurie H ^b   Howlett, Evan H ^b   Sigvardson, Jessica ^c   Kasrayan, Alex ^c   Ingelsson, Martin ^a   Bergström, Joakim ^a   Erlandsson, Anna ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c BioArctic Neuroscience   (Sweden)

Author keywords

Astrocytes; Glia; Mitochondria; Oligodendrocytes; Parkinson's disease; Synuclein oligomers

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA SYNUCLEIN; OLIGOMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; BRAIN TISSUE; COCULTURE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; GLIA CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; LYSOSOME; MOUSE; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CYTOPLASM; INTRACELLULAR SPACE; LEWY BODY; METABOLISM; MITOCHONDRION; NERVE CELL; PARKINSON DISEASE; PROCEDURES;

ALPHA-SYNUCLEIN; ANIMALS; ASTROCYTES; COCULTURE TECHNIQUES; CYTOPLASM; INTRACELLULAR SPACE; LEWY BODIES; MICE, INBRED C57BL; MITOCHONDRIA; NEURONS; OLIGODENDROGLIA; PARKINSON DISEASE;

EID: 85019915133     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2017.04.009     Document Type: Article

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