Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

Neurobiology of Disease

Volumn 70, Issue , 2014, Pages 214-223

  Sanders, Laurie H ^a   McCoy, Jennifer ^a   Hu, Xiaoping ^a   Mastroberardino, Pier G ^b   Dickinson, Bryan C ^c   Chang, Christopher J ^c   Chu, Charleen T ^a   Van Houten, Bennett ^a,d   Greenamyre, J T ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Abasic sites; Mitochondrial DNA damage; Parkinson's disease

Indexed keywords

HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; MOLECULAR MARKER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; BIOLOGICAL MARKER;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; AUTOPSY; BRAIN CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DNA DAMAGE; EMBRYO; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MESENCEPHALON; NERVE CELL; NONHUMAN; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SUBSTANTIA NIGRA; ANIMAL TISSUE; BRAIN METABOLISM; DOPAMINERGIC NERVE CELL; ENVIRONMENTAL EXPOSURE; MALE; MITOCHONDRIAL DNA DISORDER; NERVE DEGENERATION; VERY ELDERLY; ANIMAL; BRAIN CORTEX; CELL CULTURE; GENETICS; LEWIS RAT; METABOLISM; MIDDLE AGED; PARKINSONIAN DISORDERS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; ANIMALS; BIOMARKERS; CELLS, CULTURED; CEREBRAL CORTEX; DNA DAMAGE; DNA, MITOCHONDRIAL; DOPAMINERGIC NEURONS; ELECTRON TRANSPORT COMPLEX I; HUMANS; HYDROGEN PEROXIDE; MALE; MIDDLE AGED; PARKINSON DISEASE; PARKINSONIAN DISORDERS; RATS, INBRED LEW; ROTENONE; SUBSTANTIA NIGRA;

EID: 84904754260     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.06.014     Document Type: Article

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